Find Research Outputs — UTMB Health Research Expert Profiles

2015

The C-terminal domain (CTD) of human DNA glycosylase NEIL1 is required for forming BERosome repair complex with DNA replication proteins at the replicating genome: Dominant negative function of the CTD

Hegde, P. M., Dutta, A., Sengupta, S., Mitra, J., Adhikari, S., Tomkinson, A. E., Li, G. M., Boldogh, I., Hazra, T. K., Mitra, S. & Hegde, M. L., Aug 21 2015, In: Journal of Biological Chemistry. 290, 34, p. 20919-20933 15 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

2016

Facilitation of allergic sensitization and allergic airway inflammation by pollen-induced innate neutrophil recruitment

Hosoki, K., Aguilera-Aguirre, L., Brasier, A. R., Kurosky, A., Boldogh, I. & Sur, S., Jan 2016, In: American journal of respiratory cell and molecular biology. 54, 1, p. 81-90 10 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

2012

Modulatory effects of low-dose hydrogen peroxide on the function of human plasmacytoid dendritic cells

Pazmandi, K., Magyarics, Z., Boldogh, I., Csillag, A., Rajnavolgyi, E. & Bacsi, A., Feb 1 2012, In: Free Radical Biology and Medicine. 52, 3, p. 635-645 11 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

2019

Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects

Mitra, J., Guerrero, E. N., Hegde, P. M., Liachko, N. F., Wang, H., Vasquez, V., Gao, J., Pandey, A., Paul Taylor, J., Kraemer, B. C., Wu, P., Boldogh, I., Garruto, R. M., Mitra, S., Rao, K. S. & Hegde, M. L., 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 10, p. 4696-4705 10 p.

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

2015

Whole transcriptome analysis reveals a role for OGG1-initiated DNA repair signaling in airway remodeling

Aguilera-Aguirre, L., Hosoki, K., Bacsi, A., Radák, Z., Sur, S., Hegde, M. L., Tian, B., Saavedra-Molina, A., Brasier, A. R., Ba, X. & Boldogh, I., Dec 1 2015, In: Free Radical Biology and Medicine. 89, p. 20-33 14 p.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

2016

Pathophysiology of bronchoconstriction: Role of oxidatively damaged DNA repair

Bacsi, A., Pan, L., Ba, X. & Boldogh, I., 2016, In: Current opinion in allergy and clinical immunology. 16, 1, p. 59-67 9 p.

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

2013

Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins

Hegde, M. L., Hegde, P. M., Bellot, L. J., Mandal, S. M., Hazra, T. K., Li, G. M., Boldogh, I., Tomkinson, A. E. & Mitra, S., Aug 13 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 33, p. E3090-E3099

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

2012

Ragweed Subpollen Particles of Respirable Size Activate Human Dendritic Cells

Pazmandi, K., Kumar, B. V., Szabo, K., Boldogh, I., Szoor, A., Vereb, G., Veres, A., Lanyi, A., Rajnavolgyi, E. & Bacsi, A., Dec 14 2012, In: PloS one. 7, 12, e52085.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

2011

Combined exercise and insulin-like growth factor-1 supplementation induces neurogenesis in old rats, but do not attenuate age-associated DNA damage

Koltai, E., Zhao, Z., Lacza, Z., Cselenyak, A., Vacz, G., Nyakas, C., Boldogh, I., Ichinoseki-Sekine, N. & Radak, Z., Dec 1 2011, In: Rejuvenation Research. 14, 6, p. 585-596 12 p.

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

2015

BRG1 promotes the repair of DNA double-strand breaks by facilitating the replacement of RPA with RAD51

Qi, W., Wang, R., Chen, H., Wang, X., Xiao, T., Boldogh, I., Ba, X., Han, L. & Zeng, X., 2015, In: Journal of Cell Science. 128, 2, p. 317-330 14 p.

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

2012

Hypolipidemic activity of eryngium carlinae on streptozotocin-induced diabetic rats

Noriega-Cisneros, R., Ortiz-Vila, O., Esquivel-Gutiérrez, E., Clemente-Guerrero, M., Manzo-Avalos, S., Salgado-Garciglia, R., Cortés-Rojo, C., Boldogh, I. & Saavedra-Molina, A., 2012, In: Biochemistry Research International. 603501.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

2019

Exercise effects on physiological function during aging

Radak, Z., Torma, F., Berkes, I., Goto, S., Mimura, T., Posa, A., Balogh, L., Boldogh, I., Suzuki, K., Higuchi, M. & Koltai, E., Feb 20 2019, In: Free Radical Biology and Medicine. 132, p. 33-41 9 p.

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

2016

Oxidized guanine base lesions function in 8-oxoguanine DNA glycosylase-1-mediated epigenetic regulation of nuclear factor κB-driven gene expression

Pan, L., Zhu, B., Hao, W., Zeng, X., Vlahopoulos, S. A., Hazra, T. K., Hegde, M. L., Radak, Z., Bacsi, A., Brasier, A. R., Ba, X. & Boldogh, I., Dec 2 2016, In: Journal of Biological Chemistry. 291, 49, p. 25553-25566 14 p.

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

2013

Aldose Reductase Inhibition Prevents Allergic Airway Remodeling through PI3K/AKT/GSK3β Pathway in Mice

Yadav, U. C. S., Naura, A. S., Aguilera-Aguirre, L., Boldogh, I., Boulares, H. A., Calhoun, W. J., Ramana, K. V. & Srivastava, S. K., Feb 27 2013, In: PloS one. 8, 2, e57442.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

2011

Electron transport chain dysfunction by H₂O₂ is linked to increased reactive oxygen species production and iron mobilization by lipoperoxidation: Studies using Saccharomyces cerevisiae mitochondria

Cortés-Rojo, C., Estrada-Villagómez, M., Calderón-Cortés, E., Clemente-Guerrero, M., Mejía-Zepeda, R., Boldogh, I. & Saavedra-Molina, A., Apr 2011, In: Journal of Bioenergetics and Biomembranes. 43, 2, p. 135-147 13 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

2012

Enhancement of NEIL1 protein-initiated oxidized DNA base excision repair by heterogeneous nuclear ribonucleoprotein U (hnRNP-U) via direct interaction

Hegde, M. L., Banerjee, S., Hegde, P. M., Bellot, L. J., Hazra, T. K., Boldogh, I. & Mitra, S., Oct 5 2012, In: Journal of Biological Chemistry. 287, 41, p. 34202-34211 10 p.

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

2013

Redox-regulating sirtuins in aging, caloric restriction, and exercise

Radak, Z., Koltai, E., Taylor, A. W., Higuchi, M., Kumagai, S., Ohno, H., Goto, S. & Boldogh, I., May 2013, In: Free Radical Biology and Medicine. 58, p. 87-97 11 p.

Research output: Contribution to journal › Review article › peer-review

67 Scopus citations

Activation of cellular signaling by 8-oxoguanine DNA glycosylase-1-initiated DNA base excision repair

German, P., Szaniszlo, P., Hajas, G., Radak, Z., Bacsi, A., Hazra, T. K., Hegde, M. L., Ba, X. & Boldogh, I., Oct 2013, In: DNA Repair. 12, 10, p. 856-863 8 p.

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

2015

17-beta estradiol inhibits oxidative stress-induced accumulation of AIF into nucleolus and PARP1-dependent cell death via estrogen receptor alpha

Batnasan, E., Wang, R., Wen, J., Ke, Y., Li, X., Bohio, A. A., Zeng, X., Huo, H., Han, L., Boldogh, I. & Ba, X., Jan 5 2015, In: Toxicology Letters. 232, 1, p. 1-9 9 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

2013

Systems approaches to modeling chronic mucosal inflammation

Kalita, M., Tian, B., Gao, B., Choudhary, S., Wood, T. G., Carmical, J. R., Boldogh, I., Mitra, S., Minna, J. D. & Brasier, A. R., Nov 18 2013, In: BioMed Research International. 2013, 505864.

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

2015

Analysis of a panel of 48 cytokines in BAL fluids specifically identifies IL-8 levels as the only cytokine that distinguishes controlled asthma from uncontrolled asthma, and correlates inversely with FEV₁

Hosoki, K., Ying, S., Corrigan, C., Qi, H., Kurosky, A., Jennings, K., Sun, Q., Boldogh, I. & Sur, S., May 2015, In: PloS one. 10, 5, e0126035.

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

2011

Apoptosis induced by persistent single-strand breaks in mitochondrial genome: Critical role of EXOG (5′-exo/endonuclease) in their repair

Tann, A. W., Boldogh, I., Meiss, G., Qian, W., Van Houten, B., Mitra, S. & Szczesny, B., Sep 16 2011, In: Journal of Biological Chemistry. 286, 37, p. 31975-31983 9 p.

Research output: Contribution to journal › Article › peer-review

104 Scopus citations

Preferential repair of oxidized base damage in the transcribed genes of mammalian cells

Banerjee, D., Mandal, S. M., Das, A., Hegde, M. L., Das, S., Bhakat, K. K., Boldogh, I., Sarkar, P. S., Mitra, S. & Hazra, T. K., Feb 25 2011, In: Journal of Biological Chemistry. 286, 8, p. 6006-6016 11 p.

Research output: Contribution to journal › Article › peer-review

91 Scopus citations

2015

Mitochondrial biogenesis-associated factors underlie the magnitude of response to aerobic endurance training in rats

Marton, O., Koltai, E., Takeda, M., Koch, L. G., Britton, S. L., Davies, K. J. A., Boldogh, I. & Radak, Z., Jan 1 2015, In: Pflugers Archiv European Journal of Physiology. 467, 4, p. 779-788 10 p.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

2013

Down-regulation of 8-oxoguanine DNA glycosylase 1 expression in the airway epithelium ameliorates allergic lung inflammation

Bacsi, A., Aguilera-Aguirre, L., Szczesny, B., Radak, Z., Hazra, T. K., Sur, S., Ba, X. & Boldogh, I., Jan 1 2013, In: DNA Repair. 12, 1, p. 18-26 9 p.

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

2012

Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2

Dey, S., Maiti, A. K., Hegde, M. L., Hegde, P. M., Boldogh, I., Sarkar, P. S., Abdel-Rahman, S. Z., Sarker, A. H., Hang, B., Xie, J., Tomkinson, A. E., Zhou, M., Shen, B., Wang, G., Wu, C., Yu, D., Lin, D., Cardenas, V. & Hazra, T. K., Jun 1 2012, In: DNA Repair. 11, 6, p. 570-578 9 p.

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

2015

Neil2-null mice accumulate oxidized DNA bases in the transcriptionally active sequences of the genome and are susceptible to innate inflammation

Chakraborty, A., Wakamiya, M., Venkova-Canova, T., Pandita, R. K., Aguilera-Aguirre, L., Sarker, A. H., Singh, D. K., Hosoki, K., Wood, T. G., Sharma, G., Cardenas, V., Sarkar, P. S., Sur, S., Pandita, T. K., Boldogh, I. & Hazra, T. K., Oct 9 2015, In: Journal of Biological Chemistry. 290, 41, p. 24636-24648 13 p.

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

2016

Myeloid differentiation protein 2 facilitates pollen- and cat dander-induced innate and allergic airway inflammation

Hosoki, K., Boldogh, I., Aguilera-Aguirre, L., Sun, Q., Itazawa, T., Hazra, T., Brasier, A. R., Kurosky, A. & Sur, S., May 1 2016, In: Journal of Allergy and Clinical Immunology. 137, 5, p. 1506-1513.e2

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

2012

Alternaria-induced release of IL-18 from damaged airway epithelial cells: An NF-κB dependent mechanism of Th2 differentiation?

Murai, H., Qi, H., Choudhury, B., Wild, J., Dharajiya, N., Vaidya, S., Kalita, A., Bacsi, A., Corry, D., Kurosky, A., Brasier, A., Boldogh, I. & Sur, S., Feb 7 2012, In: PloS one. 7, 2, e30280.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

2011

Protective effects of resveratrol on calcium-induced oxidative stress in rat heart mitochondria

Gutiérrez-Pérez, A., Cortés-Rojo, C., Noriega-Cisneros, R., Calderón-Cortés, E., Manzo-Avalos, S., Clemente-Guerrero, M., Godínez-Hernández, D., Boldogh, I. & Saavedra-Molina, A., Apr 2011, In: Journal of Bioenergetics and Biomembranes. 43, 2, p. 101-107 7 p.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Aldose reductase deficiency in mice protects from ragweed pollen extract (RWE)-induced allergic asthma

Yadav, U. C. S., Aguilera-Aguirre, L., Boldogh, I., Ramana, K. V. & Srivastava, S. K., Nov 3 2011, In: Respiratory Research. 12, 145.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

2016

The rate of training response to aerobic exercise affects brain function of rats

Marton, O., Koltai, E., Takeda, M., Mimura, T., Pajk, M., Abraham, D., Koch, L. G., Britton, S. L., Higuchi, M., Boldogh, I. & Radak, Z., Oct 1 2016, In: Neurochemistry International. 99, p. 16-23 8 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

2012

Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3′-phosphatase in maintenance of mitochondrial genome

Mandal, S. M., Hegde, M. L., Chatterjee, A., Hegde, P. M., Szczesny, B., Banerjee, D., Boldogh, I., Gao, R., Falkenberg, M., Gustafsson, C. M., Sarkar, P. S. & Hazra, T. K., Jan 20 2012, In: Journal of Biological Chemistry. 287, 4, p. 2819-2829 11 p.

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

2016

The Potential Role of 8-Oxoguanine DNA Glycosylase-Driven DNA Base Excision Repair in Exercise-Induced Asthma

Belanger, K. A. K., Ameredes, B. T., Boldogh, I. & Aguilera-Aguirre, L., 2016, In: Mediators of inflammation. 2016, 3762561.

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

2012

Human DNA glycosylase NEIL1's interactions with downstream repair proteins is critical for efficient repair of oxidized DNA base damage and enhanced cell survival

Hegde, M. L., Hegde, P. M., Arijit, D., Boldogh, I. & Mitra, S., Dec 2012, In: Biomolecules. 2, 4, p. 564-578 15 p.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

2015

8-Oxoguanine DNA glycosylase-1-driven DNA base excision repair: Role in asthma pathogenesis

Ba, X., Aguilera-Aguirre, L., Sur, S. & Boldogh, I., Feb 13 2015, In: Current opinion in allergy and clinical immunology. 15, 1, p. 89-97 9 p.

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

2013

Aerobic endurance capacity affects spatial memory and SIRT1 is a potent modulator of 8-oxoguanine repair

Sarga, L., Hart, N., Koch, L. G., Britton, S. L., Hajas, G., Boldogh, I., Ba, X. & Radak, Z., Nov 12 2013, In: Neuroscience. 252, p. 326-336 11 p.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

2015

Dynamic aberrant NF-κB spurs tumorigenesis: A new model encompassing the microenvironment

Vlahopoulos, S. A., Cen, O., Hengen, N., Agan, J., Moschovi, M., Critselis, E., Adamaki, M., Bacopoulou, F., Copland, J. A., Boldogh, I., Karin, M. & Chrousos, G. P., Aug 1 2015, In: Cytokine and Growth Factor Reviews. 26, 4, p. 389-403 15 p.

Research output: Contribution to journal › Review article › peer-review

57 Scopus citations

The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis

Chatterjee, A., Saha, S., Chakraborty, A., Silva-Fernandes, A., Mandal, S. M., Neves-Carvalho, A., Liu, Y., Pandita, R. K., Hegde, M. L., Hegde, P. M., Boldogh, I., Ashizawa, T., Koeppen, A. H., Pandita, T. K., Maciel, P., Sarkar, P. S. & Hazra, T. K., 2015, In: PLoS genetics. 11, 1, e1004749.

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

2013

Senescence of primary amniotic cells via oxidative DNA damage

Menon, R., Boldogh, I., Urrabaz-Garza, R., Polettini, J., Syed, T. A., Saade, G. R., Papaconstantinou, J. & Taylor, R. N., Dec 27 2013, In: PloS one. 8, 12, e83416.

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

8-Oxoguanine DNA glycosylase-1 links DNA repair to cellular signaling via the activation of the small GTPase Rac1

Hajas, G., Bacsi, A., Aguilera-Aguirre, L., Hegde, M. L., Tapas, K. H., Sur, S., Radak, Z., Ba, X. & Boldogh, I., 2013, In: Free Radical Biology and Medicine. 61, p. 384-394 11 p.

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

2015

Genetic Evidence for XPC-KRAS Interactions During Lung Cancer Development

Zhang, X., He, N., Gu, D., Wickliffe, J., Salazar, J., Boldogh, I. & Xie, J., Oct 20 2015, In: Journal of Genetics and Genomics. 42, 10, p. 589-596 8 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

2012

Biochemical identification of a hydroperoxide derivative of the free 8-oxo-7,8-dihydroguanine base

Hajas, G., Bacsi, A., Aguilerra-Aguirre, L., German, P., Radak, Z., Sur, S., Hazra, T. K. & Boldogh, I., Feb 15 2012, In: Free Radical Biology and Medicine. 52, 4, p. 749-756 8 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

2019

Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome

Abraham, D., Feher, J., Scuderi, G. L., Szabo, D., Dobolyi, A., Cservenak, M., Juhasz, J., Ligeti, B., Pongor, S., Gomez-Cabrera, M. C., Vina, J., Higuchi, M., Suzuki, K., Boldogh, I. & Radak, Z., Jan 2019, In: Experimental Gerontology. 115, p. 122-131 10 p.

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Targeting inducible epigenetic reprogramming pathways in chronic airway remodeling

Brasier, A. R. & Boldogh, I., 2019, In: Drugs in Context. 8, 2019-8-3.

Research output: Contribution to journal › Review article › peer-review

Open Access

Oxidized base 8-oxoguanine, a product of DNA repair processes, contributes to dendritic cell activation

Pázmándi, K., Sütő, M., Fekete, T., Varga, A., Boldizsár, E., Boldogh, I. & Bácsi, A., Nov 1 2019, In: Free Radical Biology and Medicine. 143, p. 209-220 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

2011

Mitochondrial dysfunctions related with oxidative stress

Saavedra-Molina, A., Boldogh, I., Manzo-Avalos, S., Cortés-Rojo, C., Aguilera-Aguirre, L., Montoya-Pérez, R. & Bacsi, A., 2011, Mitochondria: Structure, Functions and Dysfunctions. Nova Science Publishers, Inc., p. 411-439 29 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2015

Innate responses to pollen allergens

Hosoki, K., Boldogh, I. & Sur, S., Feb 13 2015, In: Current opinion in allergy and clinical immunology. 15, 1, p. 79-88 10 p.

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

2013

Novel recombinant human lactoferrin: Differential activation of oxidative stress related gene expression

Kruzel, M. L., Actor, J. K., Zimecki, M., Wise, J., Płoszaj, P., Mirza, S., Kruzel, M., Hwang, S. A., Ba, X. & Boldogh, I., Dec 2013, In: Journal of Biotechnology. 168, 4, p. 666-675 10 p.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

2019

Roles of DNA repair enzyme OGG1 in innate immunity and its significance for lung cancer

Vlahopoulos, S., Adamaki, M., Khoury, N., Zoumpourlis, V. & Boldogh, I., Feb 2019, In: Pharmacology and Therapeutics. 194, p. 59-72 14 p.

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

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