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2018
Serotonin 5-HT2C receptor activation suppresses binge intake and the reinforcing and motivational properties of high-fat food
Price, A. E., Anastasio, N. C., Stutz, S. J., Hommel, J. D. & Cunningham, K. A., Jul 27 2018, In: Frontiers in Pharmacology. 9, JUL, 821.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
2013
Elevated expression of serotonin 5-HT2A receptors in the rat ventral tegmental area enhances vulnerability to the behavioral effects of cocaine
Herin, D. V., Bubar, M. J., Seitz, P. K., Thomas, M. L., Hillman, G. R., Tarasenko, Y. I., Wu, P. & Cunningham, K. A., May 17 2013, In: Frontiers in Psychiatry. 4, FEB, Article 2.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
2019
Chronic poly-drug administration damages adult mouse brain neural stem cells
McGrath, E. L., Schlagal, C. R., Cortez, I., Dunn, T. J., Gao, J., Fox, R. G., Stutz, S. J., Kuo, Y. F., Hommel, J. D., Dineley, K. T., Cunningham, K. A., Kaphalia, B. S. & Wu, P., Nov 15 2019, In: Brain Research. 1723, 146425.Research output: Contribution to journal › Article › peer-review
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2015
Inhibitory behavioral control: a stochastic dynamic causal modeling study using network discovery analysis
Ma, L., Steinberg, J. L., Cunningham, K., Lane, S. D., Kramer, L. A., Narayana, P. A., Kosten, T. R., Bechara, A. & Moeller, F. G., Apr 1 2015, In: Brain Connectivity. 5, 3, p. 177-186 10 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Individual differences in impulsive action reflect variation in the cortical serotonin 5-HT 2A receptor system
Fink, L. H., Anastasio, N. C., Fox, R. G., Rice, K. C., Moeller, F. G. & Cunningham, K. A., Jul 13 2015, In: Neuropsychopharmacology. 40, 8, p. 1957-1968 12 p.Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
2012
Quantitative changes in intracellular calcium and extracellular-regulated kinase activation measured in parallel in CHO cells stably expressing serotonin (5-HT) 5-HT 2A or 5-HT 2C receptors
Seitz, P. K., Bremer, N. M., McGinnis, A. G., Cunningham, K. A. & Watson, C. S., Mar 7 2012, In: BMC Neuroscience. 13, 1, 25.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
2019
Coevolution of Residues Provides Evidence of a Functional Heterodimer of 5-HT2AR and 5-HT2CR Involving Both Intracellular and Extracellular Domains
Fongang, B., Cunningham, K. A., Rowicka, M. & Kudlicki, A., Aug 1 2019, In: Neuroscience. 412, p. 48-59 12 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
In vivo and in vitro analyses of novel peptidomimetic disruptors for the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog (PTEN)
Soto, C., Du, H. C., Fox, R., Yang, T., Hooson, J., Anastasio, N. C., Gilbertson, S. R., Cunningham, K. A., Cunningham, K. A. & Gilbertson, S. R., 2019, In: Frontiers in Pharmacology. 10, JULY, 907.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
2013
Synergism between a serotonin 5-HT2A receptor (5-HT 2AR) antagonist and 5-HT2CR agonist suggests new pharmacotherapeutics for cocaine addiction
Cunningham, K. A., Anastasio, N. C., Fox, R. G., Stutz, S. J., Bubar, M. J., Swinford, S. E., Watson, C. S., Gilbertson, S. R., Rice, K. C., Rosenzweig-Lipson, S. & Moeller, F. G., Jan 16 2013, In: ACS chemical neuroscience. 4, 1, p. 110-121 12 p.Research output: Contribution to journal › Article › peer-review
64 Scopus citations -
2018
A protocol for measuring cue reactivity in a rat model of cocaine use disorder
Dimet, A. L., Cisneros, I. E., Fox, R. G., Stutz, S. J., Anastasio, N. C., Cunningham, K. A. & Dineley, K. T., Jun 20 2018, In: Journal of Visualized Experiments. 2018, 136, e55864.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Novel Bivalent 5-HT 2A Receptor Antagonists Exhibit High Affinity and Potency in Vitro and Efficacy in Vivo
Soto, C. A., Shashack, M. J., Fox, R. G., Bubar, M. J., Rice, K. C., Watson, C. S., Cunningham, K. A., Gilbertson, S. R. & Anastasio, N. C., Mar 21 2018, In: ACS chemical neuroscience. 9, 3, p. 514-521 8 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
2011
Serotonin (5-hydroxytryptamine) 5-HT2A receptor: Association with inherent and cocaine-evoked behavioral disinhibition in rats
Anastasio, N. C., Stoffel, E. C., Fox, R. G., Bubar, M. J., Rice, K. C., Moeller, F. G. & Cunningham, K. A., Jun 2011, In: Behavioural Pharmacology. 22, 3, p. 248-261 14 p.Research output: Contribution to journal › Article › peer-review
34 Scopus citations -
2013
Peptide inhibitors disrupt the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog to allosterically modulate cellular signaling and behavior
Anastasio, N. C., Gilbertson, S. R., Bubar, M. J., Agarkov, A., Stutz, S. J., Jeng, Y., Bremer, N. M., Smith, T. D., Fox, R. G., Swinford, S. E., Seitz, P. K., Charendoff, M. N., Craft, J. W., Laezza, F. M., Watson, C. S., Briggs, J. M. & Cunningham, K. A., Jan 23 2013, In: Journal of Neuroscience. 33, 4, p. 1615-1630 16 p.Research output: Contribution to journal › Article › peer-review
25 Scopus citations -
2012
Forced abstinence from cocaine self-administration is associated with DNA methylation changes in myelin genes in the corpus callosum: A preliminary study
Nielsen, D. A., Huang, W., Hamon, S. C., Maili, L., Witkin, B. M., Fox, R. G., Cunningham, K. A. & Moeller, F. G., 2012, In: Frontiers in Psychiatry. 3, JUN, Article 60.Research output: Contribution to journal › Article › peer-review
28 Scopus citations -
2015
Serotonin (5-HT) 5-HT2A Receptor (5-HT2AR):5-HT2CR Imbalance in Medial Prefrontal Cortex Associates with Motor Impulsivity
Anastasio, N. C., Stutz, S. J., Fink, L. H. L., Swinford-Jackson, S. E., Sears, R. M., Dileone, R. J., Rice, K. C., Moeller, F. G. & Cunningham, K. A., Jul 15 2015, In: ACS chemical neuroscience. 6, 7, p. 1248-1258 11 p.Research output: Contribution to journal › Article › peer-review
45 Scopus citations -
Serotonin 5-HT2 receptor interactions with dopamine function: implications for therapeutics in cocaine use disorder
Howell, L. L. & Cunningham, K. A., 2015, In: Pharmacological reviews. 67, 1, p. 176-197 22 p.Research output: Contribution to journal › Review article › peer-review
111 Scopus citations -
2011
Selective serotonin 5-HT2C receptor activation suppresses the reinforcing efficacy of cocaine and sucrose but differentially affects the incentive-salience value of cocaine- vs. sucrose-associated cues
Cunningham, K. A., Fox, R. G., Anastasio, N. C., Bubar, M. J., Stutz, S. J., Moeller, F. G., Gilbertson, S. R. & Rosenzweig-Lipson, S., Sep 2011, In: Neuropharmacology. 61, 3, p. 513-523 11 p.Research output: Contribution to journal › Article › peer-review
76 Scopus citations -
2013
Effects of escitalopram on attentional bias to cocaine-related stimuli and inhibitory control in cocaine-dependent subjects
Liu, S., Lane, S. D., Schmitz, J. M., Cunningham, K. A., John, V. P. & Moeller, F. G., Sep 1 2013, In: Journal of Psychopharmacology. 27, 9, p. 801-807 7 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
2019
Targeting the 5-ht2c receptor in biological context and the current state of 5-ht2c receptor ligand development
Wold, E. A., Wild, C. T., Cunningham, K. A. & Zhou, J., 2019, In: Current topics in medicinal chemistry. 19, 16, p. 1381-1398 18 p.Research output: Contribution to journal › Review article › peer-review
10 Scopus citations -
2018
Editors' Favorites of 2017
Lindsley, C. W., Cunningham, K. A., Hooker, J. M. & Andrews, A. M., Jan 17 2018, In: ACS chemical neuroscience. 9, 1, p. 1-4 4 p.Research output: Contribution to journal › Review article › peer-review
1 Scopus citations -
2019
Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts
Wold, E. A., Chen, J., Cunningham, K. A. & Zhou, J., Oct 1 2019, In: Journal of medicinal chemistry. 62, 1, p. 88-127 40 p.Research output: Contribution to journal › Article › peer-review
28 Scopus citations -
Leave the Ordinary Elsewhere: Novel Serotonin Mechanisms to Address 21st Century Public Health Challenges
Sholler, D. J. & Cunningham, K. A., Jul 17 2019, In: ACS chemical neuroscience. 10, 7, p. 3045-3046 2 p.Research output: Contribution to journal › Editorial › peer-review
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Anterior insula activity regulates the associated behaviors of high fat food binge intake and cue reactivity in male rats
Price, A. E., Stutz, S. J., Hommel, J. D., Anastasio, N. C. & Cunningham, K. A., Feb 1 2019, In: Appetite. 133, p. 231-239 9 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Serotonin 5-HT2C Receptor Cys23Ser Single Nucleotide Polymorphism Associates with Receptor Function and Localization In Vitro
Land, M. A., Chapman, H. L., Davis-Reyes, B. D., Felsing, D. E., Allen, J. A., Moeller, F. G., Elferink, L. A., Cunningham, K. A. & Anastasio, N. C., Dec 1 2019, In: Scientific reports. 9, 1, 16737.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2018
Innovative Therapeutic Intervention for Opioid Use Disorder
Moeller, F. G. & Cunningham, K. A., Jan 1 2018, In: Neuropsychopharmacology. 43, 1, p. 220-221 2 p.Research output: Contribution to journal › Short survey › peer-review
5 Scopus citations -
Cocaine evokes a profile of oxidative stress and impacts innate antiviral response pathways in astrocytes
Cisneros, I. E., Erdenizmenli, M., Cunningham, K. A., Paessler, S. & Dineley, K. T., Jun 2018, In: Neuropharmacology. 135, p. 431-443 13 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
2019
Endogenous Serotonin 5-HT2A and 5-HT2C Receptors Associate in the Medial Prefrontal Cortex
Price, A. E., Sholler, D. J., Stutz, S. J., Anastasio, N. C. & Cunningham, K. A., Jul 17 2019, In: ACS chemical neuroscience. 10, 7, p. 3241-3248 8 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
2013
Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP Isoform 1
Yan, J., Mei, F. C., Cheng, H., Lao, D. H., Hu, Y., Wei, J., Patrikeev, I., Hao, D., Stutz, S. J., Dineley, K. T., Motamedi, M., Hommel, J. D., Cunningham, K. A., Chen, J. & Cheng, X., Mar 2013, In: Molecular and cellular biology. 33, 5, p. 918-926 9 p.Research output: Contribution to journal › Article › peer-review
59 Scopus citations -
2011
5-HT2c Receptors localize to dopamine and gaba neurons in the rat mesoaccumbens pathway
Bubar, M. J., Stutz, S. J. & Cunningham, K. A., 2011, In: PloS one. 6, 6, e20508.Research output: Contribution to journal › Article › peer-review
75 Scopus citations -
2019
Translating pharmacology into therapeutics to fight the opioid crisis
Marek, G. J., Cunningham, K. A. & Rasmussen, K., 2019, In: Journal of Pharmacology and Experimental Therapeutics. 371, 2, p. 394-395 2 p.Research output: Contribution to journal › Editorial › peer-review
Open Access -
2018
PPARγ agonism attenuates cocaine cue reactivity
Miller, W. R., Fox, R. G., Stutz, S. J., Lane, S. D., Denner, L., Cunningham, K. A. & Dineley, K. T., Jan 2018, In: Addiction Biology. 23, 1, p. 55-68 14 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
2019
Convergent neural connectivity in motor impulsivity and high-fat food binge-like eating in male Sprague-Dawley rats
Anastasio, N. C., Stutz, S. J., Price, A. E., Davis-Reyes, B. D., Sholler, D. J., Ferguson, S. M., Neumaier, J. F., Moeller, F. G., Hommel, J. D. & Cunningham, K. A., Sep 1 2019, In: Neuropsychopharmacology. 44, 10, p. 1752-1761 10 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
2015
Inhibitory behavioral control: A stochastic dynamic causal modeling study comparing cocaine dependent subjects and controls
Ma, L., Steinberg, J. L., Cunningham, K. A., Lane, S. D., Bjork, J. M., Neelakantan, H., Price, A. E., Narayana, P. A., Kosten, T. R., Bechara, A. & Moeller, F. G., 2015, In: NeuroImage: Clinical. 7, p. 837-847 11 p.Research output: Contribution to journal › Article › peer-review
23 Scopus citations -
2018
Biophysical validation of serotonin 5-HT2A and 5-HT2C receptor interaction
Felsing, D. E., Anastasio, N. C., Miszkiel, J. M., Gilbertson, S. R., Allen, J. A. & Cunningham, K. A., Aug 2018, In: PloS one. 13, 8, e0203137.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
2011
Synthesis and evaluation of dimeric derivatives of 5-HT 2A receptor (5-HT 2AR) antagonist M-100907
Shashack, M. J., Cunningham, K. A., Seitz, P. K., McGinnis, A., Smith, T. D., Watson, C. S. & Gilbertson, S. R., Nov 16 2011, In: ACS chemical neuroscience. 2, 11, p. 640-644 5 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
2019
Cingulo-hippocampal effective connectivity positively correlates with drug-cue attentional bias in opioid use disorder
Ma, L., Steinberg, J. L., Bjork, J. M., Taylor, B. A., Arias, A. J., Terplan, M., Anastasio, N. C., Zuniga, E. A., Lennon, M., Cunningham, K. A. & Moeller, F. G., Dec 30 2019, In: Psychiatry Research - Neuroimaging. 294, 110977.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
2018
Synthesis and activity of functionalizable derivatives of the serotonin (5-HT) 5-HT2A receptor (5-HT2AR) antagonist M100907
Gilbertson, S. R., Chen, Y. C., Soto, C. A., Yang, Y., Rice, K. C., Cunningham, K. A. & Anastasio, N. C., May 1 2018, In: Bioorganic and Medicinal Chemistry Letters. 28, 8, p. 1381-1385 5 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
2012
Increased intra-individual reaction time variability in cocaine-dependent subjects: Role of cocaine-related cues
Liu, S., Lane, S. D., Schmitz, J. M., Green, C. E., Cunningham, K. A. & Moeller, F. G., Feb 2012, In: Addictive Behaviors. 37, 2, p. 193-197 5 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
2015
5-HT2C receptor desensitization moderates anxiety in 5-HTT deficient mice: From behavioral to cellular evidence
Martin, C. B. P., Martin, V. S., Trigo, J. M., Chevarin, C., Maldonado, R., Fink, L. H., Cunningham, K. A., Hamon, M., Lanfumey, L. & Mongeau, R., 2015, In: International Journal of Neuropsychopharmacology. 18, 3Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
2019
Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT 2C Receptor
Wild, C. T., Miszkiel, J. M., Wold, E. A., Soto, C. A., Ding, C., Hartley, R. M., White, M. A., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Oct 1 2019, In: Journal of medicinal chemistry. 62, 1, p. 288-305 18 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
The 5-HT2A receptor (5-HT2AR) regulates impulsive action and cocaine cue reactivity in Male Sprague-Dawley rats
Sholler, D. J., Stutz, S. J., Fox, R. G., Boone, E. L., Wang, Q., Rice, K. C., Gerard Moeller, F., Anastasio, N. C. & Cunningham, K. A., Jan 2019, In: Journal of Pharmacology and Experimental Therapeutics. 368, 1, p. 41-49 9 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
2012
Exploration of synthetic approaches and pharmacological evaluation of PNU-69176E and its stereoisomer as 5-HT2C receptor allosteric modulators
Ding, C., Bremer, N. M., Smith, T. D., Seitz, P. K., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Jul 18 2012, In: ACS chemical neuroscience. 3, 7, p. 538-545 8 p.Research output: Contribution to journal › Article › peer-review
20 Scopus citations -
2015
Serotonin transporter gene promoter polymorphism predicts relationship between years of cocaine use and impulsivity
Liu, S., Maili, L., Lane, S. D., Schmitz, J. M., Spellicy, C. J., Cunningham, K. A., Moeller, F. G. & Nielsen, D. A., Sep 7 2015, In: Psychiatric Genetics. 25, 5, p. 213-214 2 p.Research output: Contribution to journal › Letter › peer-review
3 Scopus citations -
2018
Altered anterior cingulate cortex to hippocampus effective connectivity in response to drug cues in men with cocaine use disorder
Ma, L., Steinberg, J. L., Cunningham, K. A., Bjork, J. M., Lane, S. D., Schmitz, J. M., Burroughs, T., Narayana, P. A., Kosten, T. R., Bechara, A. & Moeller, F. G., Jan 30 2018, In: Psychiatry Research - Neuroimaging. 271, p. 59-66 8 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
2019
Positive-allosteric modulation of the 5-HT2C receptor: implications for neuropsychopharmacology and neurotherapeutics
Zhou, J. & Cunningham, K. A., Jan 1 2019, In: Neuropsychopharmacology. 44, 1, p. 230-231 2 p.Research output: Contribution to journal › Comment/debate › peer-review
6 Scopus citations -
2015
Prevalence of Food Addiction among Low-Income Reproductive-Aged Women
Berenson, A. B., Laz, T. H., Pohlmeier, A. M., Rahman, M. & Cunningham, K. A., Sep 1 2015, In: Journal of Women's Health. 24, 9, p. 740-744 5 p.Research output: Contribution to journal › Article › peer-review
23 Scopus citations -
Rapid-response impulsivity: Definitions, measurement issues, and clinical implications
Hamilton, K. R., Littlefield, A. K., Anastasio, N. C., Cunningham, K. A., Fink, L. H. L., Wing, V. C., Mathias, C. W., Lane, S. D., Schütz, C. G., Swann, A. C., Lejuez, C. W., Clark, L., Moeller, F. G. & Potenza, M. N., Apr 1 2015, In: Personality Disorders: Theory, Research, and Treatment. 6, 2, p. 168-181 14 p.Research output: Contribution to journal › Article › peer-review
69 Scopus citations -
2012
Influence of methamphetamine on genital herpes simplex virus type 2 infection in a mouse model
Valencia, F., Bubar, M. J., Milligan, G., Cunningham, K. A. & Bourne, N., Sep 2012, In: Sexually Transmitted Diseases. 39, 9, p. 720-725 6 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
2018
Special Issue on Precision Medicine for Brain Cancer in ACS Chemical Neuroscience
Nilsson, C. L. & Cunningham, K. A., Jan 17 2018, In: ACS chemical neuroscience. 9, 1, p. 5 1 p.Research output: Contribution to journal › Editorial › peer-review
2 Scopus citations -
2015
Evaluation of the dopamine β-hydroxylase (DβH) inhibitor nepicastat in participants who meet criteria for cocaine use disorder
De La Garza, R., Bubar, M. J., Carbone, C. L., Moeller, F. G., Newton, T. F., Anastasio, N. C., Harper, T. A., Ware, D. L., Fuller, M. A., Holstein, G. J., Jayroe, J. B., Bandak, S. I., Reiman, K. Z., Neale, A. C., Pickford, L. B. & Cunningham, K. A., Jun 3 2015, In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 59, p. 40-48 9 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations