Find Research Outputs — UTMB Health Research Expert Profiles

2013

Elevated expression of serotonin 5-HT_2A receptors in the rat ventral tegmental area enhances vulnerability to the behavioral effects of cocaine

Herin, D. V., Bubar, M. J., Seitz, P. K., Thomas, M. L., Hillman, G. R., Tarasenko, Y. I., Wu, P. & Cunningham, K. A., May 17 2013, In: Frontiers in Psychiatry. 4, FEB, Article 2.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

2015

Serotonin transporter gene promoter polymorphism predicts relationship between years of cocaine use and impulsivity

Liu, S., Maili, L., Lane, S. D., Schmitz, J. M., Spellicy, C. J., Cunningham, K. A., Moeller, F. G. & Nielsen, D. A., Sep 7 2015, In: Psychiatric Genetics. 25, 5, p. 213-214 2 p.

Research output: Contribution to journal › Letter › peer-review

3 Scopus citations

2020

Inherent Motor Impulsivity Associates with Specific Gene Targets in the Rat Medial Prefrontal Cortex

Sholler, D. J., Merritt, C. R., Davis-Reyes, B. D., Golovko, G., Anastasio, N. C. & Cunningham, K. A., May 21 2020, In: Neuroscience. 435, p. 161-173 13 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Methylation Patterns of the HTR2A Associate With Relapse-Related Behaviors in Cocaine-Dependent Participants

Land, M. A., Ramesh, D., Miller, A. L., Pyles, R. B., Cunningham, K. A., Moeller, F. G. & Anastasio, N. C., Jun 10 2020, In: Frontiers in Psychiatry. 11, 532.

Research output: Contribution to journal › Article › peer-review

Open Access

2012

Exploration of synthetic approaches and pharmacological evaluation of PNU-69176E and its stereoisomer as 5-HT_2C receptor allosteric modulators

Ding, C., Bremer, N. M., Smith, T. D., Seitz, P. K., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Jul 18 2012, In: ACS chemical neuroscience. 3, 7, p. 538-545 8 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

2020

Editorial: Contemporary Perspective on 5-HT_2C Receptor Function and Its Pharmacological Targeting

De Deurwaerdère, P., Chagraoui, A. & Cunningham, K. A., Nov 23 2020, In: Frontiers in Pharmacology. 11, 606414.

Research output: Contribution to journal › Editorial › peer-review

Open Access

2015

Prevalence of Food Addiction among Low-Income Reproductive-Aged Women

Berenson, A. B., Laz, T. H., Pohlmeier, A. M., Rahman, M. & Cunningham, K. A., Sep 1 2015, In: Journal of Women's Health. 24, 9, p. 740-744 5 p.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Inhibitory behavioral control: a stochastic dynamic causal modeling study using network discovery analysis

Ma, L., Steinberg, J. L., Cunningham, K., Lane, S. D., Kramer, L. A., Narayana, P. A., Kosten, T. R., Bechara, A. & Moeller, F. G., Apr 1 2015, In: Brain Connectivity. 5, 3, p. 177-186 10 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

2018

Altered anterior cingulate cortex to hippocampus effective connectivity in response to drug cues in men with cocaine use disorder

Ma, L., Steinberg, J. L., Cunningham, K. A., Bjork, J. M., Lane, S. D., Schmitz, J. M., Burroughs, T., Narayana, P. A., Kosten, T. R., Bechara, A. & Moeller, F. G., Jan 30 2018, In: Psychiatry Research - Neuroimaging. 271, p. 59-66 8 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

2020

Serotonin neurobiology in cocaine use disorder

Cunningham, K. A., Howell, L. L. & Anastasio, N. C., 2020, Handbook of Behavioral Neuroscience. Elsevier B.V., p. 745-802 58 p. (Handbook of Behavioral Neuroscience; vol. 31).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2011

5-HT_2c Receptors localize to dopamine and gaba neurons in the rat mesoaccumbens pathway

Bubar, M. J., Stutz, S. J. & Cunningham, K. A., 2011, In: PloS one. 6, 6, e20508.

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

2013

Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP Isoform 1

Yan, J., Mei, F. C., Cheng, H., Lao, D. H., Hu, Y., Wei, J., Patrikeev, I., Hao, D., Stutz, S. J., Dineley, K. T., Motamedi, M., Hommel, J. D., Cunningham, K. A., Chen, J. & Cheng, X., Mar 2013, In: Molecular and cellular biology. 33, 5, p. 918-926 9 p.

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

2018

PPARγ agonism attenuates cocaine cue reactivity

Miller, W. R., Fox, R. G., Stutz, S. J., Lane, S. D., Denner, L., Cunningham, K. A. & Dineley, K. T., Jan 2018, In: Addiction Biology. 23, 1, p. 55-68 14 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Biophysical validation of serotonin 5-HT_2A and 5-HT_2C receptor interaction

Felsing, D. E., Anastasio, N. C., Miszkiel, J. M., Gilbertson, S. R., Allen, J. A. & Cunningham, K. A., Aug 2018, In: PloS one. 13, 8, e0203137.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Serotonin 5-HT_2C receptor activation suppresses binge intake and the reinforcing and motivational properties of high-fat food

Price, A. E., Anastasio, N. C., Stutz, S. J., Hommel, J. D. & Cunningham, K. A., Jul 27 2018, In: Frontiers in Pharmacology. 9, JUL, 821.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Innovative Therapeutic Intervention for Opioid Use Disorder

Moeller, F. G. & Cunningham, K. A., Jan 1 2018, In: Neuropsychopharmacology. 43, 1, p. 220-221 2 p.

Research output: Contribution to journal › Short survey › peer-review

5 Scopus citations

2013

Effects of escitalopram on attentional bias to cocaine-related stimuli and inhibitory control in cocaine-dependent subjects

Liu, S., Lane, S. D., Schmitz, J. M., Cunningham, K. A., John, V. P. & Moeller, F. G., Sep 1 2013, In: Journal of Psychopharmacology. 27, 9, p. 801-807 7 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

2015

Serotonin (5-HT) 5-HT_2A Receptor (5-HT_2AR):5-HT_2CR Imbalance in Medial Prefrontal Cortex Associates with Motor Impulsivity

Anastasio, N. C., Stutz, S. J., Fink, L. H. L., Swinford-Jackson, S. E., Sears, R. M., Dileone, R. J., Rice, K. C., Moeller, F. G. & Cunningham, K. A., Jul 15 2015, In: ACS chemical neuroscience. 6, 7, p. 1248-1258 11 p.

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

5-HT_2C receptor desensitization moderates anxiety in 5-HTT deficient mice: From behavioral to cellular evidence

Martin, C. B. P., Martin, V. S., Trigo, J. M., Chevarin, C., Maldonado, R., Fink, L. H., Cunningham, K. A., Hamon, M., Lanfumey, L. & Mongeau, R., 2015, In: International Journal of Neuropsychopharmacology. 18, 3

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

2012

Forced abstinence from cocaine self-administration is associated with DNA methylation changes in myelin genes in the corpus callosum: A preliminary study

Nielsen, D. A., Huang, W., Hamon, S. C., Maili, L., Witkin, B. M., Fox, R. G., Cunningham, K. A. & Moeller, F. G., 2012, In: Frontiers in Psychiatry. 3, JUN, Article 60.

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

2013

Peptide inhibitors disrupt the serotonin 5-HT_2C receptor interaction with phosphatase and tensin homolog to allosterically modulate cellular signaling and behavior

Anastasio, N. C., Gilbertson, S. R., Bubar, M. J., Agarkov, A., Stutz, S. J., Jeng, Y., Bremer, N. M., Smith, T. D., Fox, R. G., Swinford, S. E., Seitz, P. K., Charendoff, M. N., Craft, J. W., Laezza, F. M., Watson, C. S., Briggs, J. M. & Cunningham, K. A., Jan 23 2013, In: Journal of Neuroscience. 33, 4, p. 1615-1630 16 p.

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

2015

Serotonin 5-HT2 receptor interactions with dopamine function: implications for therapeutics in cocaine use disorder

Howell, L. L. & Cunningham, K. A., 2015, In: Pharmacological reviews. 67, 1, p. 176-197 22 p.

Research output: Contribution to journal › Review article › peer-review

111 Scopus citations

Evaluation of the dopamine β-hydroxylase (DβH) inhibitor nepicastat in participants who meet criteria for cocaine use disorder

De La Garza, R., Bubar, M. J., Carbone, C. L., Moeller, F. G., Newton, T. F., Anastasio, N. C., Harper, T. A., Ware, D. L., Fuller, M. A., Holstein, G. J., Jayroe, J. B., Bandak, S. I., Reiman, K. Z., Neale, A. C., Pickford, L. B. & Cunningham, K. A., Jun 3 2015, In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 59, p. 40-48 9 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

2011

Synthesis and evaluation of dimeric derivatives of 5-HT _2A receptor (5-HT _2AR) antagonist M-100907

Shashack, M. J., Cunningham, K. A., Seitz, P. K., McGinnis, A., Smith, T. D., Watson, C. S. & Gilbertson, S. R., Nov 16 2011, In: ACS chemical neuroscience. 2, 11, p. 640-644 5 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

2018

Synthesis and activity of functionalizable derivatives of the serotonin (5-HT) 5-HT_2A receptor (5-HT_2AR) antagonist M100907

Gilbertson, S. R., Chen, Y. C., Soto, C. A., Yang, Y., Rice, K. C., Cunningham, K. A. & Anastasio, N. C., May 1 2018, In: Bioorganic and Medicinal Chemistry Letters. 28, 8, p. 1381-1385 5 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

2013

Synergism between a serotonin 5-HT_2A receptor (5-HT _2AR) antagonist and 5-HT_2CR agonist suggests new pharmacotherapeutics for cocaine addiction

Cunningham, K. A., Anastasio, N. C., Fox, R. G., Stutz, S. J., Bubar, M. J., Swinford, S. E., Watson, C. S., Gilbertson, S. R., Rice, K. C., Rosenzweig-Lipson, S. & Moeller, F. G., Jan 16 2013, In: ACS chemical neuroscience. 4, 1, p. 110-121 12 p.

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

2015

Rapid-response impulsivity: Definitions, measurement issues, and clinical implications

Hamilton, K. R., Littlefield, A. K., Anastasio, N. C., Cunningham, K. A., Fink, L. H. L., Wing, V. C., Mathias, C. W., Lane, S. D., Schütz, C. G., Swann, A. C., Lejuez, C. W., Clark, L., Moeller, F. G. & Potenza, M. N., Apr 1 2015, In: Personality Disorders: Theory, Research, and Treatment. 6, 2, p. 168-181 14 p.

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

2018

Editors' Favorites of 2017

Lindsley, C. W., Cunningham, K. A., Hooker, J. M. & Andrews, A. M., Jan 17 2018, In: ACS chemical neuroscience. 9, 1, p. 1-4 4 p.

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

2011

Serotonin (5-hydroxytryptamine) 5-HT2A receptor: Association with inherent and cocaine-evoked behavioral disinhibition in rats

Anastasio, N. C., Stoffel, E. C., Fox, R. G., Bubar, M. J., Rice, K. C., Moeller, F. G. & Cunningham, K. A., Jun 2011, In: Behavioural Pharmacology. 22, 3, p. 248-261 14 p.

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

2020

Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT_2CReceptor-Positive Allosteric Modulators with Enhanced Drug-like Properties

Wold, E. A., Garcia, E. J., Wild, C. T., Miszkiel, J. M., Soto, C. A., Chen, J., Pazdrak, K., Fox, R. G., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Jul 23 2020, In: Journal of medicinal chemistry. 63, 14, p. 7529-7544 16 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

2012

Increased intra-individual reaction time variability in cocaine-dependent subjects: Role of cocaine-related cues

Liu, S., Lane, S. D., Schmitz, J. M., Green, C. E., Cunningham, K. A. & Moeller, F. G., Feb 2012, In: Addictive Behaviors. 37, 2, p. 193-197 5 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

2011

Relationship between attentional bias to cocaine-related stimuli and impulsivity in cocaine-dependent subjects

Liu, S., Lane, S. D., Schmitz, J. M., Waters, A. J., Cunningham, K. A. & Moeller, F. G., Mar 2011, In: American Journal of Drug and Alcohol Abuse. 37, 2, p. 117-122 6 p.

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

2020

Suppression of cocaine relapse-like behaviors upon pimavanserin and lorcaserin co-administration

Anastasio, N. C., Sholler, D. J., Fox, R. G., Stutz, S. J., Merritt, C. R., Bjork, J. M., Moeller, F. G. & Cunningham, K. A., May 15 2020, In: Neuropharmacology. 168, 108009.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Fentanyl self-administration impacts brain immune responses in male Sprague-Dawley rats

Ezeomah, C., Cunningham, K. A., Stutz, S. J., Fox, R. G., Bukreyeva, N., Dineley, K. T., Paessler, S. & Cisneros, I. E., Jul 2020, In: Brain, Behavior, and Immunity. 87, p. 725-738 14 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

2018

Cocaine evokes a profile of oxidative stress and impacts innate antiviral response pathways in astrocytes

Cisneros, I. E., Erdenizmenli, M., Cunningham, K. A., Paessler, S. & Dineley, K. T., Jun 2018, In: Neuropharmacology. 135, p. 431-443 13 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Novel Bivalent 5-HT _2A Receptor Antagonists Exhibit High Affinity and Potency in Vitro and Efficacy in Vivo

Soto, C. A., Shashack, M. J., Fox, R. G., Bubar, M. J., Rice, K. C., Watson, C. S., Cunningham, K. A., Gilbertson, S. R. & Anastasio, N. C., Mar 21 2018, In: ACS chemical neuroscience. 9, 3, p. 514-521 8 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Special Issue on Precision Medicine for Brain Cancer in ACS Chemical Neuroscience

Nilsson, C. L. & Cunningham, K. A., Jan 17 2018, In: ACS chemical neuroscience. 9, 1, p. 5 1 p.

Research output: Contribution to journal › Editorial › peer-review

2 Scopus citations

2015

Individual differences in impulsive action reflect variation in the cortical serotonin 5-HT _2A receptor system

Fink, L. H., Anastasio, N. C., Fox, R. G., Rice, K. C., Moeller, F. G. & Cunningham, K. A., Jul 13 2015, In: Neuropsychopharmacology. 40, 8, p. 1957-1968 12 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

2012

Quantitative changes in intracellular calcium and extracellular-regulated kinase activation measured in parallel in CHO cells stably expressing serotonin (5-HT) 5-HT _2Aor 5-HT _2Creceptors

Seitz, P. K., Bremer, N. M., McGinnis, A. G., Cunningham, K. A. & Watson, C. S., Mar 7 2012, In: BMC Neuroscience. 13, 1, 25.

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

2020

Discovery of Potent and Brain-Penetrant GPR52 Agonist that Suppresses Psychostimulant Behavior

Wang, P., Felsing, D., Chen, H., Stutz, S. J., Murphy, R., Cunningham, K., Allen, J. & Zhou, J., Nov 25 2020, In: Journal of Medicinal Chemistry. 63, 22, p. 13951 13972 p.

Research output: Contribution to journal › Article › peer-review

2018

A protocol for measuring cue reactivity in a rat model of cocaine use disorder

Dimet, A. L., Cisneros, I. E., Fox, R. G., Stutz, S. J., Anastasio, N. C., Cunningham, K. A. & Dineley, K. T., Jun 20 2018, In: Journal of Visualized Experiments. 2018, 136, e55864.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

2013

Serotonin2C receptors in the ventral pallidum regulate motor function in rats

Graves, S. M., Viskniskki, A. A., Cunningham, K. A. & Celeste Napier, T., Aug 7 2013, In: NeuroReport. 24, 11, p. 605-608 4 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

2012

Influence of methamphetamine on genital herpes simplex virus type 2 infection in a mouse model

Valencia, F., Bubar, M. J., Milligan, G., Cunningham, K. A. & Bourne, N., Sep 2012, In: Sexually Transmitted Diseases. 39, 9, p. 720-725 6 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

2015

Inhibitory behavioral control: A stochastic dynamic causal modeling study comparing cocaine dependent subjects and controls

Ma, L., Steinberg, J. L., Cunningham, K. A., Lane, S. D., Bjork, J. M., Neelakantan, H., Price, A. E., Narayana, P. A., Kosten, T. R., Bechara, A. & Moeller, F. G., 2015, In: NeuroImage: Clinical. 7, p. 837-847 11 p.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

2011

Selective serotonin 5-HT_2C receptor activation suppresses the reinforcing efficacy of cocaine and sucrose but differentially affects the incentive-salience value of cocaine- vs. sucrose-associated cues

Cunningham, K. A., Fox, R. G., Anastasio, N. C., Bubar, M. J., Stutz, S. J., Moeller, F. G., Gilbertson, S. R. & Rosenzweig-Lipson, S., Sep 2011, In: Neuropharmacology. 61, 3, p. 513-523 11 p.

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

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