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  • Thomas Geisbert
2014

Deep sequencing identifies noncanonical editing of Ebola and Marburg virus RNAs in infected cells

Shabman, R. S., Jabado, O. J., Mire, C. E., Stockwell, T. B., Edwards, M., Mahajan, M., Geisbert, T. W. & Basler, C. F., 2014, In : mBio. 5, 6, p. e02011

Research output: Contribution to journalArticle

2016

Targeting innate immunity for antiviral therapy through small molecule agonists of the RLR pathway

Pattabhi, S., Wilkins, C. R., Dong, R., Knoll, M. L., Posakony, J., Kaiser, S., Mire, C., Wang, M. L., Ireton, R. C., Geisbert, T., Bedard, K. M., Iadonato, S. P., Loo, Y. M. & Gale, M., 2016, In : Journal of Virology. 90, 5, p. 2372-2387 16 p.

Research output: Contribution to journalArticle

25 Scopus citations
2017

Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever

Mire, C. E., Cross, R. W., Geisbert, J. B., Borisevich, V., Agans, K. N., Deer, D. J., Heinrich, M. L., Rowland, M. M., Goba, A., Momoh, M., Boisen, M. L., Grant, D. S., Fullah, M., Khan, S. H., Fenton, K. A., Robinson, J. E., Branco, L. M., Garry, R. F. & Geisbert, T. W., Oct 1 2017, In : Nature Medicine. 23, 10, p. 1146-1149 4 p.

Research output: Contribution to journalArticle

36 Scopus citations
2019

A VP35 Mutant Ebola Virus Lacks Virulence but Can Elicit Protective Immunity to Wild-Type Virus Challenge

Woolsey, C., Menicucci, A. R., Cross, R. W., Luthra, P., Agans, K. N., Borisevich, V., Geisbert, J. B., Mire, C. E., Fenton, K. A., Jankeel, A., Anand, S., Ebihara, H., Geisbert, T. W., Messaoudi, I. & Basler, C. F., Sep 17 2019, In : Cell Reports. 28, 12, p. 3032-3046.e6

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2020

A Lethal Aerosol Exposure Model of Nipah Virus Strain Bangladesh in African Green Monkeys

Prasad, A. N., Agans, K. N., Sivasubramani, S. K., Geisbert, J. B., Borisevich, V., Mire, C. E., Lawrence, W. S., Fenton, K. A. & Geisbert, T. W., May 11 2020, In : Journal of Infectious Diseases. 221, p. S431-S435

Research output: Contribution to journalArticle

1 Scopus citations
2011

Recombinant adenovirus serotype 26 (Ad26) and Ad35 vaccine vectors bypass immunity to ad5 and protect nonhuman primates against ebolavirus challenge

Geisbert, T. W., Bailey, M., Hensley, L., Asiedu, C., Geisbert, J., Stanley, D., Honko, A., Johnson, J., Mulangu, S., Pau, M. G., Custers, J., Vellinga, J., Hendriks, J., Jahrling, P., Roederer, M., Goudsmit, J., Koup, R. & Sullivan, N. J., May 2011, In : Journal of virology. 85, 9, p. 4222-4233 12 p.

Research output: Contribution to journalArticle

117 Scopus citations
2020

Ebola

Campion, E. W., Feldmann, H., Sprecher, A. & Geisbert, T. W., May 7 2020, In : New England Journal of Medicine. 382, 19, p. 1832-1842 11 p.

Research output: Contribution to journalReview article

Open Access
3 Scopus citations
2017

Therapeutic treatment of marburg and ravn virus infection in nonhuman primates with a human monoclonal antibody

Mire, C. E., Geisbert, J. B., Borisevich, V., Fenton, K. A., Agans, K. N., Flyak, A. I., Deer, D. J., Steinkellner, H., Bohorov, O., Bohorova, N., Goodman, C., Hiatt, A., Kim, D. H., Pauly, M. H., Velasco, J., Whaley, K. J., Crowe, J. E., Zeitlin, L. & Geisbert, T. W., Apr 5 2017, In : Science Translational Medicine. 9, 384, eaai8711.

Research output: Contribution to journalArticle

29 Scopus citations
2018

Post-exposure treatments for Ebola and Marburg virus infections

Cross, R. W., Mire, C. E., Feldmann, H. & Geisbert, T. W., Jun 1 2018, In : Nature Reviews Drug Discovery. 17, 6, p. 413-434 22 p.

Research output: Contribution to journalReview article

48 Scopus citations
2011

Vesicular stomatitis virus-based Ebola vaccines with improved cross-protective efficacy

Marzi, A., Ebihara, H., Callison, J., Groseth, A., Williams, K. J., Geisbert, T. W. & Feldmann, H., Nov 1 2011, In : Journal of Infectious Diseases. 204, SUPPL. 3, p. S1066-S1074

Research output: Contribution to journalArticle

69 Scopus citations
2017

Infection with the Makona variant results in a delayed and distinct host immune response compared to previous Ebola virus variants

Versteeg, K., Menicucci, A. R., Woolsey, C., Mire, C. E., Geisbert, J. B., Cross, R. W., Agans, K. N., Jeske, D., Messaoudi, I. & Geisbert, T. W., Dec 1 2017, In : Scientific reports. 7, 1, 9730.

Research output: Contribution to journalArticle

13 Scopus citations
2011

Progress in filovirus vaccine development: Evaluating the potential for clinical use

Falzarano, D., Geisbert, T. W. & Feldmann, H., Jan 1 2011, In : Expert review of vaccines. 10, 1, p. 63-77 15 p.

Research output: Contribution to journalReview article

77 Scopus citations
2016

Ebola virus vaccines – reality or fiction?

Mire, C. E., Geisbert, T. W., Feldmann, H. & Marzi, A., Nov 1 2016, In : Expert review of vaccines. 15, 11, p. 1421-1430 10 p.

Research output: Contribution to journalReview article

22 Scopus citations
2015

Comparison of the Pathogenesis of the Angola and Ravn Strains of Marburg Virus in the Outbred Guinea Pig Model

Cross, R., Fenton, K. A., Geisbert, J. B., Ebihara, H., Mire, C. & Geisbert, T., Oct 1 2015, In : Journal of Infectious Diseases. 212, p. S258-S270

Research output: Contribution to journalArticle

25 Scopus citations
2017

Evaluation of medical countermeasures against ebolaviruses in nonhuman primate models

Mire, C. & Geisbert, T., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1628. p. 293-307 15 p. (Methods in Molecular Biology; vol. 1628).

Research output: Chapter in Book/Report/Conference proceedingChapter

2011

Label-free multiplexed virus detection using spectral reflectance imaging

Lopez, C. A., Daaboul, G. G., Vedula, R. S., Özkumur, E., Bergstein, D. A., Geisbert, T. W., Fawcett, H. E., Goldberg, B. B., Connor, J. H. & Ünlü, M. S., Apr 15 2011, In : Biosensors and Bioelectronics. 26, 8, p. 3432-3437 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

Single immunization with a monovalent vesicular stomatitis virus-based vaccine protects nonhuman primates against heterologous challenge with bundibugyo ebolavirus

Falzarano, D., Feldmann, F., Grolla, A., Leung, A., Ebihara, H., Strong, J. E., Marzi, A., Takada, A., Jones, S., Gren, J., Geisbert, J., Jones, S. M., Geisbert, T. W. & Feldmann, H., Nov 1 2011, In : Journal of Infectious Diseases. 204, SUPPL. 3, p. S1082-S1089

Research output: Contribution to journalArticle

40 Scopus citations
2012

Recombinant vesicular stomatitis virus vaccine vectors expressing filovirus glycoproteins lack neurovirulence in nonhuman primates

Mire, C. E., Miller, A. D., Carville, A., Westmoreland, S. V., Geisbert, J. B., Mansfield, K. G., Feldmann, H., Hensley, L. E. & Geisbert, T. W., Mar 2012, In : PLoS neglected tropical diseases. 6, 3, e1567.

Research output: Contribution to journalArticle

68 Scopus citations
2015

Multiple circulating infections can mimic the early stages of viral hemorrhagic fevers and possible human exposure to filoviruses in sierra leone prior to the 2014 outbreak

Boisen, M. L., Schieffelin, J. S., Goba, A., Oottamasathien, D., Jones, A. B., Shaffer, J. G., Hastie, K. M., Hartnett, J. N., Momoh, M., Fullah, M., Gabiki, M., Safa, S., Zandonatti, M., Fusco, M., Bornholdt, Z., Abelson, D., Gire, S. K., Andersen, K. G., Tariyal, R., Stremlau, M. & 13 others, Cross, R. W., Geisbert, J. B., Pitts, K. R., Geisbert, T. W., Kulakoski, P., Wilson, R. B., Henderson, L., Sabeti, P. C., Grant, D. S., Garry, R. F., Saphire, E. O., Branco, L. M. & Khan, S. H., Feb 1 2015, In : Viral Immunology. 28, 1, p. 19-31 13 p.

Research output: Contribution to journalArticle

27 Scopus citations
2016

Inhibition of the host antiviral response by Nipah virus: Current understanding and future perspectives

Satterfield, B. A., Geisbert, T. & Mire, C., May 1 2016, In : Future Virology. 11, 5, p. 331-344 14 p.

Research output: Contribution to journalArticle

5 Scopus citations
2018

Marburg and Ebola Viruses - Marking 50 Years since Their Discovery

Becker, S., Feldmann, H., Geisbert, T. & Kawaoka, Y., Nov 22 2018, In : Journal of Infectious Diseases. 218, p. S1

Research output: Contribution to journalEditorial

2014

Durability of a vesicular stomatitis virus-based marburg virus vaccine in nonhuman primates

Mire, C. E., Geisbert, J. B., Agans, K. N., Satterfield, B. A., Versteeg, K. M., Fritz, E. A., Feldmann, H., Hensley, L. E. & Geisbert, T. W., Apr 23 2014, In : PloS one. 9, 4, e94355.

Research output: Contribution to journalArticle

42 Scopus citations
2019

Vesicular Stomatitis Virus-Based Vaccine Protects Mice against Crimean-Congo Hemorrhagic Fever

Rodriguez, S. E., Cross, R. W., Fenton, K. A., Bente, D. A., Mire, C. E. & Geisbert, T. W., Dec 1 2019, In : Scientific reports. 9, 1, 7755.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations
2016

Molecular Diagnostic Field Test for Point-of-Care Detection of Ebola Virus Directly from Blood

Benzine, J. W., Brown, K. M., Agans, K. N., Godiska, R., Mire, C. E., Gowda, K., Converse, B., Geisbert, T. W., Mead, D. A. & Chander, Y., Oct 15 2016, In : Journal of Infectious Diseases. 214, p. S234-S242

Research output: Contribution to journalArticle

15 Scopus citations
2015

The broad-spectrum antiviral favipiravir protects Guinea pigs from lethal Lassa virus infection post-disease onset

Safronetz, D., Rosenke, K., Westover, J. B., Martellaro, C., Okumura, A., Furuta, Y., Geisbert, J., Saturday, G., Komeno, T., Geisbert, T. W., Feldmann, H. & Gowen, B. B., Oct 12 2015, In : Scientific reports. 5, 14775.

Research output: Contribution to journalArticle

56 Scopus citations
2019
Open Access
2016

Monoclonal antibody therapy for junin virus infection

Zeitlin, L., Geisbert, J. B., Deer, D. J., Fenton, K. A., Bohorov, O., Bohorova, N., Goodman, C., Kim, D., Hiatt, A., Pauly, M. H., Velasco, J., Whaley, K. J., Altmann, F., Gruber, C., Steinkellner, H., Honko, A. N., Kuehne, A. I., Aman, M. J., Sahandi, S., Enterlein, S. & 3 others, Zhan, X., Enria, D. & Geisbert, T. W., Apr 19 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 16, p. 4458-4463 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Field Validation of the ReEBOV Antigen Rapid Test for Point-of-Care Diagnosis of Ebola Virus Infection

Boisen, M. L., Cross, R. W., Hartnett, J. N., Goba, A., Momoh, M., Fullah, M., Gbakie, M., Safa, S., Fonnie, M., Baimba, F., Koroma, V. J., Geisbert, J. B., McCormick, S., Nelson, DI. K. S., Millett, M. M., Oottamasathien, D., Jones, A. B., Pham, H., Brown, B. L., Shaffer, J. G. & 11 others, Schieffelin, J. S., Kargbo, B., Gbetuwa, M., Gevao, S. M., Wilson, R. B., Pitts, K. R., Geisbert, T. W., Branco, L. M., Khan, S. H., Grant, D. S. & Garry, R. F., Oct 15 2016, In : Journal of Infectious Diseases. 214, p. S203-S209

Research output: Contribution to journalArticle

16 Scopus citations

Differential Regulation of Interferon Responses by Ebola and Marburg Virus VP35 Proteins

Edwards, M. R., Liu, G., Mire, C. E., Sureshchandra, S., Luthra, P., Yen, B., Shabman, R. S., Leung, D. W., Messaoudi, I., Geisbert, T. W., Amarasinghe, G. K. & Basler, C. F., Feb 23 2016, In : Cell Reports. 14, 7, p. 1632-1640 9 p.

Research output: Contribution to journalArticle

39 Scopus citations
2014

Deep sequencing identifies noncanonical editing of Ebola and Marburg virus RNAS in infected cells

Shabman, R. S., Jabado, O. J., Mire, C. E., Stockwell, T. B., Edwards, M., Mahajan, M., Geisbert, T. W. & Basler, C. F., Sep 25 2014, In : mBio. 5, 6, e02011-14.

Research output: Contribution to journalArticle

44 Scopus citations
2018

Predicting outcome and improving treatment for Lassa fever

Geisbert, T., Jan 1 2018, (Accepted/In press) In : The Lancet Infectious Diseases.

Research output: Contribution to journalArticle

5 Scopus citations
2011

CD8 + cellular immunity mediates rAd5 vaccine protection against Ebola virus infection of nonhuman primates

Sullivan, N. J., Hensley, L., Asiedu, C., Geisbert, T. W., Stanley, D., Johnson, J., Honko, A., Olinger, G., Bailey, M., Geisbert, J. B., Reimann, K. A., Bao, S., Rao, S., Roederer, M., Jahrling, P. B., Koup, R. A. & Nabel, G. J., Sep 1 2011, In : Nature Medicine. 17, 9, p. 1128-1131 4 p.

Research output: Contribution to journalArticle

146 Scopus citations
2015

Lipid nanoparticle siRNA treatment of Ebola-virus-Makona-infected nonhuman primates

Thi, E. P., Mire, C., Lee, A. C. H., Geisbert, J. B., Zhou, J. Z., Agans, K. N., Snead, N. M., Deer, D. J., Barnard, T. R., Fenton, K. A., Maclachlan, I. & Geisbert, T., May 21 2015, In : Nature. 521, 7552, p. 362-365 4 p.

Research output: Contribution to journalArticle

157 Scopus citations
2014

Viral-vectored vaccines to control pathogenic filoviruses

Mire, C. & Geisbert, T., Jul 1 2014, Novel Technologies for Vaccine Development. Springer-Verlag Wien, Vol. 9783709118184. p. 33-60 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2019

Use of reverse genetics to inform Ebola outbreak responses

Cross, R. W. & Geisbert, T. W., Sep 2019, In : The Lancet Infectious Diseases. 19, 9, p. 925-927 3 p.

Research output: Contribution to journalComment/debate

1 Scopus citations
2018

Small animal models of filovirus disease: recent advances and future directions

Cross, R. W., Fenton, K. & Geisbert, T. W., Nov 2 2018, In : Expert Opinion on Drug Discovery. 13, 11, p. 1027-1040 14 p.

Research output: Contribution to journalReview article

4 Scopus citations
2017

Neutralizing the Threat: Pan-Ebolavirus Antibodies Close the Loop

Mire, C. E. & Geisbert, T. W., Aug 2017, In : Trends in Molecular Medicine. 23, 8, p. 669-671 3 p.

Research output: Contribution to journalShort survey

6 Scopus citations
2015

Lack of Marburg Virus Transmission from Experimentally Infected to Susceptible In-Contact Egyptian Fruit Bats

Paweska, J. T., Van Vuren, P. J., Fenton, K. A., Graves, K., Grobbelaar, A. A., Moolla, N., Leman, P., Weyer, J., Storm, N., McCulloch, S. D., Scott, T. P., Markotter, W., Odendaal, L., Clift, S. J., Geisbert, T. W., Hale, M. J. & Kemp, A., Oct 1 2015, In : Journal of Infectious Diseases. 212, p. S109-S118

Research output: Contribution to journalArticle

29 Scopus citations
2011

Pathogenesis of marburg hemorrhagic fever in cynomolgus macaques

Hensley, L. E., Alves, D. A., Geisbert, J. B., Fritz, E. A., Reed, C., Larsen, T. & Geisbert, T. W., Nov 1 2011, In : Journal of Infectious Diseases. 204, SUPPL. 3, p. S1021-S1031

Research output: Contribution to journalArticle

54 Scopus citations
2017

Assessment of the potential for host-targeted iminosugars UV-4 and UV-5 activity against filovirus infections in vitro and in vivo

Warfield, K. L., Warren, T. K., Qiu, X., Wells, J., Mire, C. E., Geisbert, J. B., Stuthman, K. S., Garza, N. L., Van Tongeren, S. A., Shurtleff, A. C., Agans, K. N., Wong, G., Callahan, M. V., Geisbert, T. W., Klose, B., Ramstedt, U. & Treston, A. M., Feb 1 2017, In : Antiviral research. 138, p. 22-31 10 p.

Research output: Contribution to journalArticle

9 Scopus citations
2016

Pathogenic Differences between Nipah Virus Bangladesh and Malaysia Strains in Primates: Implications for Antibody Therapy

Mire, C. E., Satterfield, B. A., Geisbert, J. B., Agans, K. N., Borisevich, V., Yan, L., Chan, Y. P., Cross, R. W., Fenton, K. A., Broder, C. C. & Geisbert, T. W., Aug 3 2016, In : Scientific reports. 6, 30916.

Research output: Contribution to journalArticle

40 Scopus citations
2018

Field validation of recombinant antigen immunoassays for diagnosis of Lassa fever

Boisen, M. L., Hartnett, J. N., Shaffer, J. G., Goba, A., Momoh, M., Sandi, J. D., Fullah, M., Nelson, D. K. S., Bush, D. J., Rowland, M. M., Heinrich, M. L., Koval, A. P., Cross, R. W., Barnes, K. G., Lachenauer, A. E., Lin, A. E., Nekoui, M., Kotliar, D., Winnicki, S. M., Siddle, K. J. & 18 others, Gbakie, M., Fonnie, M., Koroma, V. J., Kanneh, L., Kulakosky, P. C., Hastie, K. M., Wilson, R. B., Andersen, K. G., Folarin, O. O., Happi, C. T., Sabeti, P. C., Geisbert, T. W., Saphire, E. O., Khan, S. H., Grant, D. S., Schieffelin, J. S., Branco, L. M. & Garry, R. F., Dec 1 2018, In : Scientific reports. 8, 1, 5939.

Research output: Contribution to journalArticle

10 Scopus citations
2015

Safety of recombinant VSV-Ebola virus vaccine vector in pigs

De Wit, E., Marzi, A., Bushmaker, T., Brining, D., Scott, D., Richt, J. A., Geisbert, T. W. & Feldmann, H., Jan 1 2015, In : Emerging infectious diseases. 21, 4, p. 702-704 3 p.

Research output: Contribution to journalArticle

13 Scopus citations
2017

Persistence of Ebola virus RNA in seminal fluid

Geisbert, T., Jan 1 2017, In : The Lancet Global Health. 5, 1, p. e12-e13

Research output: Contribution to journalComment/debate

2012

Immunization strategies against henipaviruses

Broder, C. C., Geisbert, T. W., Xu, K., Nikolov, D. B., Wang, L. F., Middleton, D., Pallister, J. & Bossart, K. N., Nov 8 2012, Henipavirus: Ecology, Molecular Virology, and Pathogenesis. Lee, B. & Rota, P. (eds.). p. 197-223 27 p. (Current Topics in Microbiology and Immunology; vol. 359).

Research output: Chapter in Book/Report/Conference proceedingChapter

20 Scopus citations
2020

Rational design of universal immunotherapy for TfR1-tropic arenaviruses

Cohen-Dvashi, H., Amon, R., Agans, K. N., Cross, R. W., Borenstein-Katz, A., Mateo, M., Baize, S., Padler-Karavani, V., Geisbert, T. W. & Diskin, R., Dec 1 2020, In : Nature communications. 11, 1, 67.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Quadrivalent VesiculoVax vaccine protects nonhuman primates from viral-induced hemorrhagic fever and death

Cross, R. W., Xu, R., Matassov, D., Hamm, S., Latham, T. E., Gerardi, C. S., Nowak, R. M., Geisbert, J. B., Ota-Setlik, A., Agans, K. N., Luckay, A., Witko, S. E., Soukieh, L., Deer, D. J., Mire, C. E., Feldmann, H., Happi, C., Fenton, K. A., Eldridge, J. H. & Geisbert, T. W., Jan 2 2020, In : Journal of Clinical Investigation. 130, 1, p. 539-551 13 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Postexposure Efficacy of Recombinant Vesicular Stomatitis Virus Vectors Against High and Low Doses of Marburg Virus Variant Angola in Nonhuman Primates

Woolsey, C., Geisbert, J. B., Matassov, D., Agans, K. N., Borisevich, V., Cross, R. W., Deer, D. J., Fenton, K. A., Eldridge, J. H., Mire, C. E. & Geisbert, T. W., Nov 22 2018, In : Journal of Infectious Diseases. 218, p. S582-S587

Research output: Contribution to journalArticle

6 Scopus citations
2014

Protection against lethal marburg virus infection mediated by lipid encapsulated small interfering RNA

Ursic-Bedoya, R., Mire, C. E., Robbins, M., Geisbert, J. B., Judge, A., MacLachlan, I. & Geisbert, T. W., Feb 15 2014, In : Journal of Infectious Diseases. 209, 4, p. 562-570 9 p.

Research output: Contribution to journalArticle

32 Scopus citations
2020

Resistance of Cynomolgus Monkeys to Nipah and Hendra Virus Disease Is Associated with Cell-Mediated and Humoral Immunity

Prasad, A. N., Woolsey, C., Geisbert, J. B., Agans, K. N., Borisevich, V., Deer, D. J., Mire, C. E., Cross, R. W., Fenton, K. A., Broder, C. C. & Geisbert, T. W., May 11 2020, In : Journal of Infectious Diseases. 221, p. S436-S447

Research output: Contribution to journalArticle

Open Access
2 Scopus citations