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  • Louise Prakash
2011

DNA synthesis across an abasic lesion by yeast Rev1 DNA polymerase

Nair, D. T., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Feb 11 2011, In : Journal of Molecular Biology. 406, 1, p. 18-28 11 p.

Research output: Contribution to journalArticle

25 Scopus citations
2014

An iron-sulfur cluster in the polymerase domain of yeast DNA polymerase ε

Jain, R., Vanamee, E. S., Dzikovski, B. G., Buku, A., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Jan 23 2014, In : Journal of Molecular Biology. 426, 2, p. 301-308 8 p.

Research output: Contribution to journalArticle

23 Scopus citations
2012
109 Scopus citations
2019

DNA polymerase θ accomplishes translesion synthesis opposite 1, N 6 -ethenodeoxyadenosine with a remarkably high fidelity in human cells

Yoon, J. H., Johnson, R. E., Prakash, L. & Prakash, S., Mar 1 2019, In : Genes and Development. 33, 5-6, p. 282-287 6 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2011

Role of human DNA polymerase κ in extension opposite from a cis-syn thymine dimer

Vasquez-Del Carpio, R., Silverstein, T. D., Lone, S., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Apr 29 2011, In : Journal of Molecular Biology. 408, 2, p. 252-261 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
2019

Error-Prone Replication through UV Lesions by DNA Polymerase θ Protects against Skin Cancers

Yoon, J. H., McArthur, M. J., Park, J., Basu, D., Wakamiya, M., Prakash, L. & Prakash, S., Mar 7 2019, In : Cell. 176, 6, p. 1295-1309.e15

Research output: Contribution to journalArticle

18 Scopus citations
2020

Structure and mechanism of B-family DNA polymerase ζ specialized for translesion DNA synthesis

Malik, R., Kopylov, M., Gomez-Llorente, Y., Jain, R., Johnson, R. E., Prakash, L., Prakash, S., Ubarretxena-Belandia, I. & Aggarwal, A. K., Oct 1 2020, In : Nature Structural and Molecular Biology. 27, 10, p. 913-924 12 p.

Research output: Contribution to journalArticle

1 Scopus citations
2014

Identification of two functional PCNA-binding domains in human DNA polymerase κ

Yoon, J. H., Acharya, N., Park, J., Basu, D., Prakash, S. & Prakash, L., Jul 2014, In : Genes to Cells. 19, 7, p. 594-601 8 p.

Research output: Contribution to journalArticle

13 Scopus citations
2012

Structural basis for cisplatin DNA damage tolerance by human polymerase η during cancer chemotherapy

Ummat, A., Rechkoblit, O., Jain, R., Roy Choudhury, J., Johnson, R. E., Silverstein, T. D., Buku, A., Lone, S., Prakash, L., Prakash, S. & Aggarwal, A. K., Jun 1 2012, In : Nature Structural and Molecular Biology. 19, 6, p. 628-632 5 p.

Research output: Contribution to journalArticle

58 Scopus citations
17 Scopus citations

Human DNA polymerase η is pre-aligned for dNTP binding and catalysis

Ummat, A., Silverstein, T. D., Jain, R., Buku, A., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Jan 27 2012, In : Journal of Molecular Biology. 415, 4, p. 627-634 8 p.

Research output: Contribution to journalArticle

26 Scopus citations
2018

Structural basis for polymerase η–promoted resistance to the anticancer nucleoside analog cytarabine

Rechkoblit, O., Choudhury, J. R., Buku, A., Prakash, L., Prakash, S. & Aggarwal, A. K., Dec 1 2018, In : Scientific reports. 8, 1, 12702.

Research output: Contribution to journalArticle

4 Scopus citations
2011

A novel ubiquitin binding mode in the S. cerevisiae translesion synthesis DNA polymerase η

Ai, Y., Wang, J., Johnson, R. E., Haracska, L., Prakash, L. & Zhuang, Z., Jun 1 2011, In : Molecular BioSystems. 7, 6, p. 1874-1882 9 p.

Research output: Contribution to journalArticle

7 Scopus citations
2017

Mechanism of error-free DNA synthesis across N1-methyl-deoxyadenosine by human DNA polymerase-l

Jain, R., Choudhury, J. R., Buku, A., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Mar 8 2017, In : Scientific reports. 7, 43904.

Research output: Contribution to journalArticle

8 Scopus citations
2020

Corrigendum: DNA polymerase θ accomplishes translesion synthesis opposite 1,N6-ethenodeoxyadenosine with a remarkably high fidelity in human cells

Yoon, J. H., Johnson, R. E., Prakash, L. & Prakash, S., Jan 1 2020, In : Genes & development. 34, 1-2, p. 146 1 p.

Research output: Contribution to journalComment/debate

Open Access
2015

Genetic control of replication through N1-methyladenine in human cells

Conde, J., Yoon, J. H., Choudhury, J. R., Prakash, L. & Prakash, S., Dec 11 2015, In : Journal of Biological Chemistry. 290, 50, p. 29794-29800 7 p.

Research output: Contribution to journalArticle

12 Scopus citations
2014

A role for DNA polymerase θ in promoting replication through oxidative DNA lesion, thymine glycol, in human cells

Yoon, J. H., Choudhury, J. R., Park, J., Prakash, S. & Prakash, L., 2014, In : Journal of Biological Chemistry. 289, 19, p. 13177-13185 9 p.

Research output: Contribution to journalArticle

34 Scopus citations
2015

A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands

Johnson, R. E., Klassen, R., Prakash, L. & Prakash, S., Jul 16 2015, In : Molecular cell. 59, 2, p. 163-175 13 p.

Research output: Contribution to journalArticle

116 Scopus citations
2014

Crystal structure of yeast DNA polymerase ε catalytic domain

Jain, R., Rajashankar, K. R., Buku, A., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Apr 14 2014, In : PloS one. 9, 4, e94835.

Research output: Contribution to journalArticle

22 Scopus citations
2017

Translesion synthesis DNA polymerases promote error-free replication through the minor-groove DNA adduct 3-deaza-3-methyladenine

Yoon, J. H., Choudhury, J. R., Park, J., Prakash, S. & Prakash, L., Nov 10 2017, In : Journal of Biological Chemistry. 292, 45, p. 18682-18688 7 p.

Research output: Contribution to journalArticle

9 Scopus citations
2018

Genetic control of predominantly error-free replication through an acrolein-derived minor-groove DNA adduct

Yoon, J. H., Hodge, R. P., Hackfeld, L. C., Park, J., Choudhury, J. R., Prakash, S. & Prakash, L., Feb 23 2018, In : Journal of Biological Chemistry. 293, 8, p. 2949-2958 10 p.

Research output: Contribution to journalArticle

3 Scopus citations
2011

Requirement of replication checkpoint protein kinases Mec1/Rad53 for postreplication repair in yeast

Gangavarapu, V., Maria, S. R. S., Prakash, S. & Prakash, L., 2011, In : mBio. 2, 3, e00079-11.

Research output: Contribution to journalArticle

12 Scopus citations
2019

Structural insights into mutagenicity of anticancer nucleoside analog cytarabine during replication by DNA polymerase η

Rechkoblit, O., Johnson, R. E., Buku, A., Prakash, L., Prakash, S. & Aggarwal, A. K., Dec 1 2019, In : Scientific reports. 9, 1, 16400.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2015

Rev1 promotes replication through UV lesions in conjunction with DNA polymerases η, ι, and κ but not DNA polymerase ζ

Yoon, J. H., Park, J., Conde, J., Wakamiya, M., Prakash, L. & Prakash, S., Dec 15 2015, In : Genes and Development. 29, 24, p. 2588-2602 15 p.

Research output: Contribution to journalArticle

23 Scopus citations
2011

PCNA binding domains in all three subunits of yeast DNA polymerase δ modulate its function in DNA replication

Acharya, N., Klassen, R., Johnson, R. E., Prakash, L. & Prakash, S., Nov 1 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 44, p. 17927-17932 6 p.

Research output: Contribution to journalArticle

40 Scopus citations
2012
5 Scopus citations
2020

Genetic evidence for reconfiguration of DNA polymerase θ active site for error-free translesion synthesis in human cells

Yoon, J. H., Johnson, R. E., Prakash, L. & Prakash, S., May 1 2020, In : Journal of Biological Chemistry. 295, 18, p. 5918-5927 10 p.

Research output: Contribution to journalArticle

Open Access
2019

Cryo-EM structure and dynamics of eukaryotic DNA polymerase δ holoenzyme

Jain, R., Rice, W. J., Malik, R., Johnson, R. E., Prakash, L., Prakash, S., Ubarretxena-Belandia, I. & Aggarwal, A. K., Oct 1 2019, In : Nature Structural and Molecular Biology. 26, 10, p. 955-962 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Translesion synthesis DNA polymerases η, ι, and ν promote mutagenic replication through the anticancer nucleoside cytarabine

Yoon, J. H., Choudhury, J. R., Prakash, L. & Prakash, S., Dec 13 2019, In : Journal of Biological Chemistry. 294, 50, p. 19048-19054 7 p.

Research output: Contribution to journalArticle

1 Scopus citations