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  • Pei-Yong Shi
2016

Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling

Lim, S. P., Noble, C. G., Seh, C. C., Soh, T. S., El Sahili, A., Chan, G. K. Y., Lescar, J., Arora, R., Benson, T., Nilar, S., Manjunatha, U., Wan, K. F., Dong, H., Xie, X., Shi, P. Y. & Yokokawa, F., Aug 2016, In : PLoS pathogens. 12, 8, e1005737.

Research output: Contribution to journalArticle

56 Scopus citations
2013

Membrane topology and function of dengue virus NS2A protein

Xie, X., Gayen, S., Kang, C. B., Yuan, Z. & Shi, P. Y., Apr 2013, In : Journal of virology. 87, 8, p. 4609-4622 14 p.

Research output: Contribution to journalArticle

111 Scopus citations
2020

A replication-defective Japanese encephalitis virus (JEV) vaccine candidate with NS1 deletion confers dual protection against JEV and West Nile virus in mice

Li, N., Zhang, Z. R., Zhang, Y. N., Liu, J., Deng, C. L., Shi, P. Y., Yuan, Z. M., Ye, H. Q. & Zhang, B., Dec 1 2020, In : npj Vaccines. 5, 1, 73.

Research output: Contribution to journalArticle

Open Access
2015

Determinants of dengue virus NS4A protein oligomerization

Lee, C. M., Xie, X., Zou, J., Li, S. H., Qi Lee, M. Y., Dong, H., Qin, C. F., Kang, C. & Shi, P. Y., 2015, In : Journal of virology. 89, 12, p. 6171-6183 13 p.

Research output: Contribution to journalArticle

22 Scopus citations
2019

Dengue NS2A Protein Orchestrates Virus Assembly

Xie, X., Zou, J., Zhang, X., Zhou, Y., Routh, A. L., Kang, C., Popov, V. L., Chen, X., Wang, Q. Y., Dong, H. & Shi, P. Y., Nov 13 2019, In : Cell Host and Microbe. 26, 5, p. 606-622.e8

Research output: Contribution to journalArticle

6 Scopus citations
2015

Targeting dengue virus NS4B protein for drug discovery

Xie, X., Zou, J., Wang, Q. Y. & Shi, P. Y., Jun 2015, In : Antiviral research. 118, p. 39-45 7 p., 3603.

Research output: Contribution to journalReview article

41 Scopus citations

The search for nucleoside/nucleotide analog inhibitors of dengue virus

Chen, Y. L., Yokokawa, F. & Shi, P-Y., Aug 10 2015, In : Antiviral Research. 122, p. 12-19 8 p., 3670.

Research output: Contribution to journalArticle

40 Scopus citations
2013

A crystal structure of the dengue virus non-structural protein 5 (NS5) polymerase delineates interdomain amino acid residues that enhance its thermostability and de novo initiation activities

Lim, S. P., Koh, J. H. K., Seh, C. C., Liew, C. W., Davidson, A. D., Chua, L. S., Chandrasekaran, R., Cornvik, T. C., Shi, P. Y. & Lescar, J., Oct 25 2013, In : Journal of Biological Chemistry. 288, 43, p. 31105-31114 10 p.

Research output: Contribution to journalArticle

50 Scopus citations
2014

Anti-dengue-virus activity and structure-activity relationship studies of lycorine derivatives

Wang, P., Li, L. F., Wang, Q. Y., Shang, L. Q., Shi, P. Y. & Yin, Z., Jul 2014, In : ChemMedChem. 9, 7, p. 1522-1533 12 p.

Research output: Contribution to journalArticle

27 Scopus citations
2018

Treatment of human glioblastoma with a live attenuated Zika virus vaccine candidate

Chen, Q., Wu, J., Ye, Q., Ma, F., Zhu, Q., Wu, Y., Shan, C., Xie, X., Li, D., Zhan, X., Li, C., Li, X. F., Qin, X., Zhao, T., Wu, H., Shi, P. Y., Man, J. & Qin, C. F., Sep 1 2018, In : mBio. 9, 5, e01683-18.

Research output: Contribution to journalArticle

19 Scopus citations
2013

Rational design of a flavivirus vaccine by abolishing viral RNA 2′-O methylation

Li, S. H., Dong, H., Li, X. F., Xie, X., Zhao, H., Deng, Y. Q., Wang, X. Y., Ye, Q., Zhu, S. Y., Wang, H. J., Zhang, B., Leng, Q. B., Zuest, R., Qin, E. D., Qin, C. F. & Shi, P. Y., May 2013, In : Journal of virology. 87, 10, p. 5812-5819 8 p.

Research output: Contribution to journalArticle

63 Scopus citations
2019

Axl promotes zika virus entry and modulates the antiviral state of human sertoli cells

Strange, D. P., Jiyarom, B., Zarandi, N. P., Xie, X., Baker, C., Sadri-Ardekani, H., Shi, P. Y. & Verma, S., Jul 1 2019, In : mBio. 10, 4, e01372-19.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations
2011

Keratinocytes are cell targets of west nile virus in vivo

Lim, P. Y., Behr, M. J., Chadwick, C. M., Shi, P. Y. & Bernard, K. A., May 1 2011, In : Journal of virology. 85, 10, p. 5197-5201 5 p.

Research output: Contribution to journalArticle

71 Scopus citations
2016

Zika Virus: Diagnosis, Therapeutics, and Vaccine

Shan, C., Xie, X., Barrett, A., Garcia-Blanco, M., Tesh, R. B., Vasconcelos, P. F. D. C., Vasilakis, N., Weaver, S. & Shi, P-Y., Mar 11 2016, In : ACS Infectious Diseases. 2, 3, p. 170-172 3 p.

Research output: Contribution to journalArticle

53 Scopus citations
2014

Dimerization of flavivirus NS4B protein

Zou, J., Xie, X., Lee, L. T., Chandrasekaran, R., Reynaud, A., Yap, L., Wang, Q. Y., Dong, H., Kang, C., Yuan, Z., Lescar, J. & Shi, P. Y., Mar 2014, In : Journal of virology. 88, 6, p. 3379-3391 13 p.

Research output: Contribution to journalArticle

40 Scopus citations
2020

Reserve genetic approaches for the development of Zika vaccines and therapeutics

Fontes-Garfias, C. R., Baker, C. K. & Shi, P. Y., Oct 2020, In : Current Opinion in Virology. 44, p. 7-15 9 p.

Research output: Contribution to journalReview article

2018

Characterization of a candidate tetravalent vaccine based on 2’-O-methyltransferase mutants

Züst, R., Li, S. H., Xie, X., Velumani, S., Chng, M., Toh, Y. X., Zou, J., Dong, H., Shan, C., Pang, J., Qin, C. F., Newell, E. W., Shi, P. Y. & Fink, K., Jan 2018, In : PloS one. 13, 1, e0189262.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Dengue subgenomic flaviviral RNA disrupts immunity in mosquito salivary glands to increase virus transmission

Pompon, J., Manuel, M., Ng, G. K., Wong, B., Shan, C., Manokaran, G., Soto-Acosta, R., Bradrick, S. S., Ooi, E. E., Missé, D., Shi, P. Y. & Garcia-Blanco, M. A., Jul 2017, In : PLoS pathogens. 13, 7, e1006535.

Research output: Contribution to journalArticle

36 Scopus citations

Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes

Liu, Y., Liu, J., Du, S., Shan, C., Nie, K., Zhang, R., Li, X. F., Zhang, R., Wang, T., Qin, C. F., Wang, P., Shi, P. Y. & Cheng, G., May 25 2017, In : Nature. 545, 7655, p. 482-486 5 p.

Research output: Contribution to journalArticle

171 Scopus citations
2013

Conformational flexibility of the dengue virus RNA-Dependent RNA polymerase revealed by a complex with an inhibitor

Noble, C. G., Lim, S. P., Chen, Y. L., Liew, C. W., Yap, L., Lescar, J. & Shi, P. Y., May 2013, In : Journal of virology. 87, 9, p. 5291-5295 5 p.

Research output: Contribution to journalArticle

66 Scopus citations
2018

Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection

Luo, H., Winkelmann, E. R., Zhu, S., Ru, W., Mays, E., Silvas, J. A., Vollmer, L. L., Gao, J., Peng, B. H., Bopp, N. E., Cromer, C., Shan, C., Xie, G., Li, G., Tesh, R., Popov, V. L., Shi, P. Y., Sun, S. C., Wu, P., Klein, R. S. & 4 others, Tang, S. J., Zhang, W., Aguilar, P. V. & Wang, T., Nov 1 2018, In : Journal of Clinical Investigation. 128, 11, p. 4980-4991 12 p.

Research output: Contribution to journalArticle

8 Scopus citations
2015

The dengue virus NS5 protein as a target for drug discovery

Lim, S. P., Noble, C. G. & Shi, P-Y., Jul 1 2015, In : Antiviral Research. 119, p. 57-67 11 p.

Research output: Contribution to journalArticle

89 Scopus citations
2016

Zika Virus Replicons for Drug Discovery

Xie, X., Zou, J., Shan, C., Yang, Y., Kum, D. B., Dallmeier, K., Neyts, J. & Shi, P. Y., Oct 1 2016, In : EBioMedicine. 12, p. 156-160 5 p.

Research output: Contribution to journalArticle

40 Scopus citations
2011

Anti-infectives: Can cellular screening deliver?

Keller, T. H., Shi, P. Y. & Wang, Q. Y., Aug 1 2011, In : Current Opinion in Chemical Biology. 15, 4, p. 529-533 5 p.

Research output: Contribution to journalReview article

22 Scopus citations
2016

Zika virus: History, emergence, biology, and prospects for control

Weaver, S., Costa, F., Garcia-Blanco, M., Ko, A. I., Ribeiro, G. S., Saade, G., Shi, P-Y. & Vasilakis, N., Jun 1 2016, In : Antiviral Research. 130, p. 69-80 12 p.

Research output: Contribution to journalArticle

349 Scopus citations
2014

Flavivirus NS5 prevents the InSTATement of IFN

Shi, P. Y., Sep 10 2014, In : Cell Host and Microbe. 16, 3, p. 269-271 3 p.

Research output: Contribution to journalShort survey

10 Scopus citations
2018

A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein

Li, A., Yu, J., Lu, M., Ma, Y., Attia, Z., Shan, C., Xue, M., Liang, X., Craig, K., Makadiya, N., He, J. J., Jennings, R., Shi, P. Y., Peeples, M. E., Liu, S. L., Boyaka, P. N. & Li, J., Dec 1 2018, In : Nature communications. 9, 1, 3067.

Research output: Contribution to journalArticle

20 Scopus citations
2015

Stabilization of dengue virus polymerase in de novo initiation assay provides advantages for compound screening

Niyomrattanakit, P., Wan, K. F., Chung, K. Y., Abas, S. N., Seh, C. C., Dong, H., Lim, C. C., Chao, A. T., Lee, C. B., Nilar, S., Lescar, J., Shi, P. Y., Beer, D. & Lim, S. P., Jul 1 2015, In : Antiviral research. 119, p. 36-46 11 p.

Research output: Contribution to journalArticle

11 Scopus citations
2016

Therapeutic potential of spirooxindoles as antiviral agents

Ye, N., Chen, H., Wold, E. A., Shi, P. Y. & Zhou, J., Jun 10 2016, In : ACS Infectious Diseases. 2, 6, p. 382-392 11 p.

Research output: Contribution to journalReview article

163 Scopus citations
2014

Dengue in China: not a passing problem

Qin, C. F. & Shi, P. Y., Dec 11 2014, In : Science China Life Sciences. 57, 12, p. 1230-1231 2 p.

Research output: Contribution to journalArticle

13 Scopus citations

The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus Replication

Li, X. D., Shan, C., Deng, C. L., Ye, H. Q., Shi, P. Y., Yuan, Z. M., Gong, P. & Zhang, B., May 2014, In : PLoS neglected tropical diseases. 8, 5, e2891.

Research output: Contribution to journalArticle

25 Scopus citations
2011

Inhibition of dengue virus by targeting viral NS4B protein

Xie, X., Wang, Q. Y., Xu, H. Y., Qing, M., Kramer, L., Yuan, Z. & Shi, P. Y., Nov 1 2011, In : Journal of virology. 85, 21, p. 11183-11195 13 p.

Research output: Contribution to journalArticle

84 Scopus citations
2018

An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction

Xia, H., Luo, H., Shan, C., Muruato, A. E., Nunes, B. T. D., Medeiros, D. B. A., Zou, J., Xie, X., Giraldo, M. I., Vasconcelos, P. F. C., Weaver, S. C., Wang, T., Rajsbaum, R. & Shi, P. Y., Dec 1 2018, In : Nature communications. 9, 1, 414.

Research output: Contribution to journalArticle

79 Scopus citations
2016

Adenosine analog NITD008 is a potent inhibitor of zika virus

Deng, Y. Q., Zhang, N. N., Li, C. F., Tian, M., Hao, J. N., Xie, X. P., Shi, P. Y. & Qin, C. F., 2016, In : Open Forum Infectious Diseases. 3, 4

Research output: Contribution to journalArticle

76 Scopus citations
2017

Zika in the Americas, year 2: What have we learned? What gaps remain? A report from the Global Virus Network

Aliota, M. T., Bassit, L., Bradrick, S. S., Cox, B., Garcia-Blanco, M. A., Gavegnano, C., Friedrich, T. C., Golos, T. G., Griffin, D. E., Haddow, A. D., Kallas, E. G., Kitron, U., Lecuit, M., Magnani, D. M., Marrs, C., Mercer, N., McSweegan, E., Ng, L. F. P., O'Connor, D. H., Osorio, J. E. & 11 others, Ribeiro, G. S., Ricciardi, M., Rossi, S. L., Saade, G., Schinazi, R. F., Schott-Lerner, G. O., Shan, C., Shi, P. Y., Watkins, D. I., Vasilakis, N. & Weaver, S. C., Aug 2017, In : Antiviral research. 144, p. 223-246 24 p.

Research output: Contribution to journalReview article

60 Scopus citations

Reverse genetics of Zika virus

Shan, C., Xie, X. & Shi, P-Y., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1602. p. 47-58 12 p. (Methods in Molecular Biology; vol. 1602).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

West Nile virus NS1 antagonizes interferon beta production by targeting RIG-I and MDA5

Zhang, H. L., Ye, H. Q., Liu, S. Q., Deng, C. L., Li, X. D., Shi, P. Y. & Zhang, B., Sep 1 2017, In : Journal of virology. 91, 18, e02396-16.

Research output: Contribution to journalArticle

27 Scopus citations
2014

Development of a FACS-based assay for evaluating antiviral potency of compound in dengue infected peripheral blood mononuclear cells

Fu, Y., Chen, Y. L., Herve, M., Gu, F., Shi, P. Y. & Blasco, F., Feb 2014, In : Journal of Virological Methods. 196, p. 18-24 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

A positively selected mutation in the WNV 2K peptide confers resistance to superinfection exclusion in vivo

Campbell, C. L., Smith, D. R., Sanchez-Vargas, I., Zhang, B., Shi, P. Y. & Ebel, G. D., Sep 2014, In : Virology. 464-465, 1, p. 228-232 5 p.

Research output: Contribution to journalArticle

10 Scopus citations

Modulation of inflammation and pathology during dengue virus infection by p38 MAPK inhibitor SB203580

Fu, Y., Yip, A., Seah, P. G., Blasco, F., Shi, P. Y. & Hervé, M., Jan 1 2014, In : Antiviral research. 110, p. 151-157 7 p.

Research output: Contribution to journalArticle

22 Scopus citations
2018

Erratum to: Targeting vesicle size (Nature Materials, (2018), 17, 11, (955-956), 10.1038/s41563-018-0200-8)

Fei, Z. & Shi, P-Y., Jan 1 2018, (Accepted/In press) In : Nature Materials.

Research output: Contribution to journalArticle

2015

Genomic analysis and growth characteristic of dengue viruses from Makassar, Indonesia

Sasmono, R. T., Wahid, I., Trimarsanto, H., Yohan, B., Wahyuni, S., Hertanto, M., Yusuf, I., Mubin, H., Ganda, I. J., Latief, R., Bifani, P. J., Shi, P. Y. & Schreiber, M. J., Jun 1 2015, In : Infection, Genetics and Evolution. 32, p. 165-177 13 p.

Research output: Contribution to journalArticle

42 Scopus citations
2014

Unraveling a flavivirus enigma

Shi, P. Y., Jan 1 2014, In : Science. 343, 6173, p. 849-850 2 p.

Research output: Contribution to journalShort survey

6 Scopus citations
2013

A Single Amino Acid Substitution in the Core Protein of West Nile Virus Increases Resistance to Acidotropic Compounds

Martín-Acebes, M. A., Blázquez, A. B., de Oya, N. J., Escribano-Romero, E., Shi, P. Y. & Saiz, J. C., Jul 18 2013, In : PloS one. 8, 7, e69479.

Research output: Contribution to journalArticle

10 Scopus citations
2011

Development and characterization of a stable luciferase dengue virus for high-throughput screening

Zou, G., Xu, H. Y., Qing, M., Wang, Q. Y. & Shi, P. Y., Jul 1 2011, In : Antiviral research. 91, 1, p. 11-19 9 p.

Research output: Contribution to journalArticle

70 Scopus citations
2013

West Nile virus drug discovery

Lim, S. P. & Shi, P. Y., Dec 3 2013, In : Viruses. 5, 12, p. 2977-3006 30 p.

Research output: Contribution to journalReview article

26 Scopus citations
2011

The 5′ and 3′ downstream AUG region elements are required for mosquito-borne flavivirus RNA replication

Friebe, P., Shi, P. Y. & Harris, E., Feb 2011, In : Journal of virology. 85, 4, p. 1900-1905 6 p.

Research output: Contribution to journalArticle

51 Scopus citations
2013

Crystal structure of enterovirus 71 RNA-dependent RNA polymerase complexed with its protein primer VPg: Implication for a trans mechanism of VPg uridylylation

Chen, C., Wang, Y., Shan, C., Sun, Y., Xu, P., Zhou, H., Yang, C., Shi, P. Y., Rao, Z., Zhang, B. & Lou, Z., May 1 2013, In : Journal of virology. 87, 10, p. 5755-5768 14 p.

Research output: Contribution to journalArticle

42 Scopus citations
2016

Characterization of a 2016 Clinical Isolate of Zika Virus in Non-human Primates

Li, X. F., Dong, H. L., Huang, X. Y., Qiu, Y. F., Wang, H. J., Deng, Y. Q., Zhang, N. N., Ye, Q., Zhao, H., Liu, Z. Y., Fan, H., An, X. P., Sun, S. H., Gao, B., Fa, Y. Z., Tong, Y. G., Zhang, F. C., Gao, G. F., Cao, W. C., Shi, P. Y. & 1 others, Qin, C. F., Oct 1 2016, In : EBioMedicine. 12, p. 170-177 8 p.

Research output: Contribution to journalArticle

83 Scopus citations
2011

Inhibition of dengue virus through suppression of host pyrimidine biosynthesis

Wang, Q. Y., Bushell, S., Qing, M., Xu, H. Y., Bonavia, A., Nunes, S., Zhou, J., Poh, M. K., de Sessions, P. F., Niyomrattanakit, P., Dong, H., Hoffmaster, K., Goh, A., Nilar, S., Schul, W., Jones, S., Kramer, L., Compton, T. & Shi, P. Y., Jul 2011, In : Journal of virology. 85, 13, p. 6548-6556 9 p.

Research output: Contribution to journalArticle

99 Scopus citations