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• 2019

  Blood-Brain Barrier Dysfunction After Smoke Inhalation Injury, With and Without Skin Burn

  Randolph, A. C., Fukuda, S., Ihara, K., Enkhbaatar, P. & Micci, M. A., May 1 2019, In: Shock (Augusta, Ga.). 51, 5, p. 634-649 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Smoke Inhalation Injury
  • Blood-Brain Barrier
  • Smoke
  • Skin
  • Periodic Acid
  4 Scopus citations
• 2014

  Human mesenchymal stem cells reduce the severity of acute lung injury in a sheep model of bacterial pneumonia

  Asmussen, S., Ito, H., Traber, D. L., Lee, J. W., Cox, R. A., Hawkins, H. K., McAuley, D. F., McKenna, D. H., Traber, L. D., Zhuo, H., Wilson, J., Herndon, D. N., Prough, D. S., Liu, K. D., Matthay, M. A. & Enkhbaatar, P., Sep 2014, In: Thorax. 69, 9, p. 819-825 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Bacterial Pneumonia
  • Acute Lung Injury
  • Mesenchymal Stem Cells
  • Sheep
  • Adult Respiratory Distress Syndrome
  82 Scopus citations
• 2016

  Cellular Therapy for Sepsis: A New Hope?∗

  Enkhbaatar, P., Dec 1 2016, In: Critical care medicine. 44, 12, p. 2296-2298 3 p.

  Research output: Contribution to journal › Editorial › peer-review
  1 Scopus citations
• 2011

  Cardiopulmonary effects of low-dose arginine vasopressin in ovine acute lung injury

  Westphal, M., Rehberg, S., Maybauer, M. O., Maybauer, D. M., Enkhbaatar, P., Westphal-Varghese, B. B., Schmalstieg, F. C., Morita, N., Cox, R. A., Traber, L. D., Hawkins, H., Whorton, E. & Traber, D. L., Feb 2011, In: Critical care medicine. 39, 2, p. 357-363 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Arginine Vasopressin
  • Acute Lung Injury
  • Sheep
  • Nitrosative Stress
  • 3-nitrotyrosine
  17 Scopus citations

• A cute lung injury-induced collagen deposition is associated with elevated asymmetric dimethylarginine and arginase activity

  Sousse, L. E., Yamamoto, Y., Enkhbaatar, P., Rehberg, S. W., Wells, S. M., Leonard, S., Traber, M. G., Yu, Y. M., Cox, R. A., Hawkins, H. K., Traber, L. D., Herndon, D. N. & Traber, D. L., Mar 2011, In: Shock. 35, 3, p. 282-288 7 p.

  Research output: Contribution to journal › Article › peer-review

  • N,N-dimethylarginine
  • Arginase
  • Lung Injury
  • Collagen
  • Lung
  19 Scopus citations

• Pseudomonas aeruginosa is associated with increased lung cytokines and asymmetric dimethylarginine compared with methicillin-resistant staphylococcus aureus

  Sousse, L. E., Jonkam, C. C., Traber, D. L., Hawkins, H. K., Rehberg, S. W., Traber, L. D., Herndon, D. N. & Enkhbaatar, P., Nov 2011, In: Shock. 36, 5, p. 466-470 5 p.

  Research output: Contribution to journal › Article › peer-review

  • N,N-dimethylarginine
  • Methicillin-Resistant Staphylococcus aureus
  • Pseudomonas aeruginosa
  • Arginase
  • Sepsis
  10 Scopus citations
• 2014

  No correlation between initial arterial carboxyhemoglobin level and degree of lung injury following ovine burn and smoke inhalation

  Lange, M., Cox, R. A., Traber, D. L., Hamahata, A., Nakano, Y., Traber, L. D. & Enkhbaatar, P., Apr 2014, In: Experimental Lung Research. 40, 3, p. 99-104 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Inhalation Burns
  • Carboxyhemoglobin
  • Lung Injury
  • Smoke
  • Sheep
  3 Scopus citations
• 2013

  Antithrombin attenuates myocardial dysfunction and reverses systemic fluid accumulation following burn and smoke inhalation injury: A randomized, controlled, experimental study

  Rehberg, S., Yamamoto, Y., Bartha, E., Sousse, L. E., Jonkam, C., Zhu, Y., Traber, L. D., Cox, R. A., Traber, D. L. & Enkhbaatar, P., May 11 2013, In: Critical Care. 17, 3, R86.

  Research output: Contribution to journal › Article › peer-review

  • Smoke Inhalation Injury
  • Antithrombins
  • Animals
  • Sheep
  • Oxygen Consumption
  6 Scopus citations
• 2019

  Surgical anatomy of the ovine sural nerve for facial nerve regeneration and reconstruction research

  Niimi, Y., Fukuda, S., Gilbert, R. S., Baljinnyam, T., Niimi, Y., Matsumine, H., Liu, K., Jacob, S., Hawkins, H. K., Cox, R. A., Herndon, D. N., Prough, D. S. & Enkhbaatar, P., Dec 1 2019, In: Scientific reports. 9, 1, 10564.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • nerve regeneration
  • nerve tissue
  • saphenous vein
  2 Scopus citations

• Modulation of Peroxynitrite Reduces Norepinephrine Requirements in Ovine MRSA Septic Shock

  Fukuda, S., Ihara, K., Andersen, C. R., Randolph, A. C., Nelson, C. L., Zeng, Y., Kim, J., Dewitt, D. S., Rojas, J. D., Koutrouvelis, A., Herndon, D. N., Prough, D. S. & Enkhbaatar, P., Nov 1 2019, In: Shock. 52, 5, p. E92-E99

  Research output: Contribution to journal › Article › peer-review

  • Peroxynitrous Acid
  • Septic Shock
  • Methicillin-Resistant Staphylococcus aureus
  • Sheep
  • Norepinephrine
  3 Scopus citations
• 2015

  Topically applied metal chelator reduces thermal injury progression in a rat model of brass comb burn

  Wang, C. Z., Ayadi, A. E., Goswamy, J., Finnerty, C. C., Mifflin, R., Sousse, L., Enkhbaatar, P., Papaconstantinou, J., Herndon, D. N. & Ansari, N. H., 2015, In: Burns. 41, 8, p. 1775-1787 13 p.

  Research output: Contribution to journal › Article › peer-review

  • brass
  • Comb and Wattles
  • Aldehyde Dehydrogenase
  • Chelating Agents
  • Burns
  9 Scopus citations
• 2016

  Effect of hemorrhage rate on early hemodynamic responses in conscious sheep

  Scully, C. G., Daluwatte, C., Marques, N. R., Khan, M., Salter, M., Wolf, J., Nelson, C., Salsbury, J., Enkhbaatar, P., Kinsky, M., Kramer, G. C. & Strauss, D. G., Apr 1 2016, In: Physiological reports. 4, 7, p. 1-15 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Sheep
  • Hemodynamics
  • Hemorrhage
  • Arterial Pressure
  • Oximetry
  12 Scopus citations
• 2011

  Mechanistic aspects of inducible nitric oxide synthase-induced lung injury in burn trauma

  Enkhbaatar, P., Wang, J., Saunders, F., Lange, M., Hamahata, A., Rehberg, S., Parkinson, J. F., Traber, L. D., Herndon, D. N. & Traber, D. L., Jun 2011, In: Burns. 37, 4, p. 638-645 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Lung Injury
  • Nitric Oxide Synthase Type II
  • Smoke
  • Acute Lung Injury
  • Inhalation Burns
  18 Scopus citations
• 2013

  Time course of early histopathological lung changes in an ovine model of acute lung injury and pulmonary infection

  Lange, M., Cox, R. A., Traber, D. L., Hamahata, A., Nakano, Y., Traber, L. D. & Enkhbaatar, P., Jan 1 2013, In: Experimental Lung Research. 39, 4-5, p. 201-206 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Acute Lung Injury
  • Sheep
  • Animals
  • Lung
  • Infection
  1 Scopus citations
• 2014

  Advantages and pitfalls of combining intravenous antithrombin with nebulized heparin and tissue plasminogen activator in acute respiratory distress syndrome

  Rehberg, S., Yamamoto, Y., Sousse, L. E., Jonkam, C., Cox, R. A., Prough, D. S. & Enkhbaatar, P., Jan 2014, In: Journal of Trauma and Acute Care Surgery. 76, 1, p. 126-133 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Antithrombins
  • Adult Respiratory Distress Syndrome
  • Tissue Plasminogen Activator
  • Heparin
  • Pulmonary Gas Exchange
  5 Scopus citations
• 2016

  Closed-loop Control of FiO2 Rapidly Identifies Need for Rescue Ventilation and Reduces ARDS Severity in a Conscious Sheep Model of Burn and Smoke Inhalation Injury

  Liu, N. T., Salter, M. G., Khan, M., Branson, R. D., Enkhbaatar, P., Kramer, G., Salinas, J., Marques, N. R. & Kinsky, M., Jul 7 2016, (Accepted/In press) In: Shock.

  Research output: Contribution to journal › Article › peer-review

  • Smoke Inhalation Injury
  • Adult Respiratory Distress Syndrome
  • Standard of Care
  • Sheep
  • Ventilation
  6 Scopus citations

• Nebulized Epinephrine Limits Pulmonary Vascular Hyperpermeability to Water and Protein in Ovine with Burn and Smoke Inhalation Injury

  Lopez, E., Fujiwara, O., Lima-Lopez, F., Suman, O., Mlcak, R. P., Hawkins, H. K., Cox, R. A., Herndon, D., Prough, D. & Enkhbaatar, P., Feb 1 2016, In: Critical Care Medicine. 44, 2, p. e89-e96

  Research output: Contribution to journal › Article › peer-review

  • Smoke Inhalation Injury
  • Epinephrine
  • Sheep
  • Water
  • Blood Vessels
  16 Scopus citations
• 2013

  Activated protein C: From excitement to disappointment?

  Enkhbaatar, P., Oct 1 2013, In: Critical care medicine. 41, 10, p. 2463-2464 2 p.

  Research output: Contribution to journal › Editorial › peer-review
• 2016

  Pathophysiology, research challenges, and clinical management of smoke inhalation injury

  Enkhbaatar, P., Pruitt, B. A., Suman, O., Mlcak, R., Wolf, S. E., Sakurai, H. & Herndon, D. N., Oct 1 2016, In: The Lancet. 388, 10052, p. 1437-1446 10 p.

  Research output: Contribution to journal › Review article › peer-review

  • Smoke Inhalation Injury
  • Burn Units
  • Burns
  • Direction compound
  • Morbidity
  34 Scopus citations
• 2014

  Preliminary evidence of early bone resorption in a sheep model of acute burn injury: An observational study

  Klein, G. L., Xie, Y., Qin, Y. X., Lin, L., Hu, M., Enkhbaatar, P. & Bonewald, L. F., 2014, In: Journal of Bone and Mineral Metabolism. 32, 2, p. 136-141 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Bone Resorption
  • Sheep
  • Observational Studies
  • Wounds and Injuries
  • Bone and Bones
  18 Scopus citations
• 2013

  Antithrombin attenuates vascular leakage via inhibiting neutrophil activation in acute lung injury

  Rehberg, S., Yamamoto, Y., Sousse, L. E., Jonkam, C., Zhu, Y., Traber, L. D., Cox, R. A., Prough, D. S., Traber, D. L. & Enkhbaatar, P., Dec 2013, In: Critical care medicine. 41, 12, p. e439-e446

  Research output: Contribution to journal › Article › peer-review

  • Neutrophil Activation
  • Antithrombin III
  • Antithrombins
  • Acute Lung Injury
  • Syndecan-4
  24 Scopus citations

• Heterogeneity of the effects of combined nitric oxide synthase inhibition on organ perfusion in ovine sepsis

  Lange, M., Hamahata, A., Traber, D. L., Nakano, Y., Traber, L. D. & Enkhbaatar, P., Dec 1 2013, In: Burns. 39, 8, p. 1565-1570 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Nitric Oxide Synthase
  • Sheep
  • Sepsis
  • Perfusion
  • Nitric Oxide Synthase Type I
• 2011

  Direct delivery of low-dose 7-Nitroindazole into the bronchial artery attenuates pulmonary pathophysiology after smoke inhalation and burn injury in an ovine model

  Hamahata, A., Enkhbaatar, P., Lange, M., Cox, R. A., Hawkins, H. K., Sakurai, H., Traber, L. D. & Traber, D. L., Dec 1 2011, In: Shock. 36, 6, p. 575-579 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Inhalation Burns
  • Smoke Inhalation Injury
  • 7-nitroindazole
  • Bronchial Arteries
  • Sheep
  10 Scopus citations
• 2014

  The selective vasopressin type 1a receptor agonist selepressin (FE 202158) blocks vascular leak in ovine severe sepsis

  Maybauer, M. O., Maybauer, D. M., Enkhbaatar, P., Laporte, R., Winiewska, H., Traber, L. D., Lin, C., Fan, J., Hawkins, H. K., Cox, R. A., Winiewski, K., Schteingart, C. D., Landry, D. W., Rivière, P. J. M. & Traber, D. L., Jul 2014, In: Critical care medicine. 42, 7, p. e525-e533

  Research output: Contribution to journal › Article › peer-review

  • Phe(2)-Ile(3)-Hgn(4)-Orn(iPr)(8)-vasopressin
  • Vasopressin Receptors
  • Sheep
  • Sepsis
  • Arginine Vasopressin
  45 Scopus citations
• 2013

  Multiple versus single injections of fluorescent microspheres for the determination of regional organ blood flow in septic sheep

  Lange, M., Hamahata, A., Traber, D. L., Nakano, Y., Traber, L. D. & Enkhbaatar, P., Dec 17 2013, In: Laboratory Animals. 47, 3, p. 203-209 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Regional Blood Flow
  • microparticles
  • Microspheres
  • blood flow
  • Sheep
  3 Scopus citations
• 2011

  The angiotensin-converting enzyme inhibitor captopril inhibits poly(adp-ribose) polymerase activation and exerts beneficial effects in an ovine model of burn and smoke injury

  Asmussen, S., Bartha, E., Olah, G., Sbrana, E., Rehberg, S. W., Yamamoto, Y., Enkhbaatar, P., Hawkins, H. K., Ito, H., Cox, R. A., Traber, L. D., Traber, D. L. & Szabo, C., Oct 2011, In: Shock. 36, 4, p. 402-409 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Ribose
  • Captopril
  • Angiotensin-Converting Enzyme Inhibitors
  • Smoke
  • Sheep
  12 Scopus citations
• 2015

  Integrity of airway epithelium in pediatric burn autopsies: Association with age and extent of burn injury

  Cox, R. A., Jacob, S., Andersen, C. R., Mlcak, R., Sousse, L., Zhu, Y., Cotto, C., Finnerty, C. C., Enkhbaatar, P., Herndon, D. N. & Hawkins, H. K., Nov 2015, In: Burns. 41, 7, p. 1435-1441 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Autopsy
  • Epithelium
  • Tissue Fixation
  • Pediatrics
  • Wounds and Injuries
  6 Scopus citations
• 2011

  Predictive role of arterial carboxyhemoglobin concentrations in ovine burn and smoke inhalation-induced lung injury

  Lange, M., Cox, R. A., Enkhbaatar, P., Whorton, E. B., Nakano, Y., Hamahata, A., Jonkam, C., Esechie, A., Von Borzyskowski, S., Traber, L. D. & Traber, D. L., May 1 2011, In: Experimental Lung Research. 37, 4, p. 239-245 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Inhalation Burns
  • Carboxyhemoglobin
  • Lung Injury
  • Smoke
  • Sheep
  11 Scopus citations

• Preclinical evaluation of epinephrine nebulization to reduce airway hyperemia and improve oxygenation after smoke inhalation injury

  Lange, M., Hamahata, A., Traber, D. L., Cox, R. A., Kulp, G. A., Nakano, Y., Traber, L. D., Herndon, D. N. & Enkhbaatar, P., Apr 2011, In: Critical care medicine. 39, 4, p. 718-724 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Smoke Inhalation Injury
  • Hyperemia
  • Epinephrine
  • Lung
  • Inhalation
  25 Scopus citations
• 2013

  Beta-1 blockade in sepsis: What to expect?

  Enkhbaatar, P., Sep 1 2013, In: Critical care medicine. 41, 9, 1 p.

  Research output: Contribution to journal › Editorial › peer-review

• Effect of bronchodilators on bronchial gland cell proliferation after inhalation and burn injury in sheep

  Jacob, S., Zhu, Y., Jonkam, C., Asmussen, S., Traber, L., Herndon, D. N., Palmieri, T. L., Enkhbaatar, P., Traber, D. L., Hawkins, H. K. & Cox, R. A., Jul 2013, In: Journal of Burn Care and Research. 34, 4, p. 386-393 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Inhalation Burns
  • Bronchodilator Agents
  • Sheep
  • Cell Proliferation
  • Tiotropium Bromide
  4 Scopus citations
• 2011

  Specific inhibition of nitric oxide synthases at different time points in a murine model of pulmonary sepsis

  Lange, M., Hamahata, A., Traber, D. L., Nakano, Y., Traber, L. D. & Enkhbaatar, P., Jan 21 2011, In: Biochemical and Biophysical Research Communications. 404, 3, p. 877-881 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Nitric Oxide Synthase
  • Sepsis
  • Liver
  • Malondialdehyde
  • Lung
  21 Scopus citations
• 2015

  Comparison of gene expression by sheep and human blood stimulated with the TLR4 agonists lipopolysaccharide and monophosphoryl lipid A

  Enkhbaatar, P., Nelson, C., Salsbury, J. R., Carmical, J. R., Torres, K. E. O., Herndon, D., Prough, D. S., Luan, L. & Sherwood, E. R., Dec 1 2015, In: PloS one. 10, 12, A525.

  Research output: Contribution to journal › Article › peer-review

  • monophosphoryl lipid A
  • lipid A
  • Gene expression
  • lipopolysaccharides
  • agonists
  7 Scopus citations
• 2014

  Healing efficacy of sea buckthorn (Hippophae rhamnoides L.) seed oil in an ovine burn wound model

  Ito, H., Asmussen, S., Traber, D. L., Cox, R. A., Hawkins, H. K., Connelly, R., Traber, L. D., Walker, T. W., Malgerud, E., Sakurai, H. & Enkhbaatar, P., May 2014, In: Burns. 40, 3, p. 511-519 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Hippophae
  • Seeds
  • Oils
  • Sheep
  • Fascia
  24 Scopus citations
• 2011

  Beneficial effects of concomitant neuronal and inducible nitric oxide synthase inhibition in ovine burn and inhalation injury

  Lange, M., Hamahata, A., Enkhbaatar, P., Cox, R. A., Nakano, Y., Westphal, M., Traber, L. D., Herndon, D. N. & Traber, D. L., Jun 2011, In: Shock. 35, 6, p. 626-631 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Inhalation Burns
  • Nitric Oxide Synthase Type I
  • Nitric Oxide Synthase Type II
  • Sheep
  • Lung
  19 Scopus citations

• Beneficial pulmonary effects of a metalloporphyrinic peroxynitrite decomposition catalyst in burn and smoke inhalation injury

  Lange, M., Szabo, C., Enkhbaatar, P., Connelly, R., Horvath, E., Hamahata, A., Cox, R. A., Esechie, A., Nakano, Y., Traber, L. D., Herndon, D. N. & Traber, D. L., Feb 2011, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 300, 2, p. L167-L175

  Research output: Contribution to journal › Article › peer-review

  • (5,10,15,20-tetrakis(N-(benzyl-4'-carboxylate)-2-pyridinium)-21H,23H-porphine)iron(III)
  • Smoke Inhalation Injury
  • Peroxynitrous Acid
  • Sheep
  • Lung
  23 Scopus citations
• 2016

  A Comparison of the Pharmacokinetics and Pulmonary Lymphatic Exposure of a Generation 4 PEGylated Dendrimer Following Intravenous and Aerosol Administration to Rats and Sheep

  Ryan, G. M., Bischof, R. J., Enkhbaatar, P., McLeod, V. M., Chan, L. J., Jones, S. A., Owen, D. J., Porter, C. J. H. & Kaminskas, L. M., Feb 1 2016, In: Pharmaceutical Research. 33, 2, p. 510-525 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Pharmacokinetics
  • Dendrimers
  • Rats
  • Aerosols
  • Intravenous Administration
  17 Scopus citations
• 2013

  The immunobiology of toll-like receptor 4 agonists: From endotoxin tolerance to immunoadjuvants

  Bohannon, J. K., Hernandez, A., Enkhbaatar, P., Adams, W. L. & Sherwood, E. R., Dec 2013, In: Shock. 40, 6, p. 451-462 12 p.

  Research output: Contribution to journal › Review article › peer-review

  • Immunologic Adjuvants
  • Lipid A
  • Toll-Like Receptor 4
  • Endotoxins
  • monophosphoryl lipid A
  72 Scopus citations
• 2011

  Impact of bronchial circulation on bronchial exudates following combined burn and smoke inhalation injury in sheep

  Morita, N., Enkhbaatar, P., Maybauer, D. M., Maybauer, M. O., Westphal, M., Murakami, K., Hawkins, H. K., Cox, R. A., Traber, L. D. & Traber, D. L., May 2011, In: Burns. 37, 3, p. 465-473 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Smoke Inhalation Injury
  • Exudates and Transudates
  • Sheep
  • Ligation
  • Bronchial Arteries
  20 Scopus citations
• 2014

  Tiotropium bromide suppresses smoke inhalation and burn injury-induced ERK 1/2 and SMAD 2/3 signaling in sheep bronchial submucosal glands

  Jacob, S., Zhu, Y., Asmussen, S., Ito, H., Herndon, D. N., Enkhbaatar, P., Hawkins, H. K. & Cox, R. A., May 2014, In: Toxicology Mechanisms and Methods. 24, 4, p. 250-258 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Inhalation Burns
  • Smoke Inhalation Injury
  • Tiotropium Bromide
  • Smoke
  • Sheep
• 2013

  AMP-activated protein kinase signaling pathway in toxic smoke inhalation injury: Nice to demonstrate, nice to know, but is there a therapeutic relevance?

  Rehberg, S., Enkhbaatar, P. & Traber, D. L., Jan 1 2013, In: Critical care medicine. 41, 1, p. 349-350 2 p.

  Research output: Contribution to journal › Editorial › peer-review
  2 Scopus citations