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  • Istvan Boldogh
2014

Oxidative modification enhances the immunostimulatory effects of extracellular mitochondrial DNA on plasmacytoid dendritic cells

Pazmandi, K., Agod, Z., Kumar, B. V., Szabo, A., Fekete, T., Sogor, V., Veres, A., Boldogh, I., Rajnavolgyi, E., Lanyi, A. & Bacsi, A., 2014, In : Free Radical Biology and Medicine. 77, p. 281-290 10 p.

Research output: Contribution to journalArticle

28 Scopus citations
2015

Analysis of a panel of 48 cytokines in BAL fluids specifically identifies IL-8 levels as the only cytokine that distinguishes controlled asthma from uncontrolled asthma, and correlates inversely with FEV1

Hosoki, K., Ying, S., Corrigan, C., Qi, H., Kurosky, A., Jennings, K., Sun, Q., Boldogh, I. & Sur, S., May 2015, In : PloS one. 10, 5, e0126035.

Research output: Contribution to journalArticle

45 Scopus citations
2018

Effects of the stimuli-dependent enrichment of 8-oxoguanine DNA glycosylase1 on chromatinized DNA

Hao, W., Qi, T., Pan, L., Wang, R., Zhu, B., Aguilera-Aguirre, L., Radak, Z., Hazra, T. K., Vlahopoulos, S. A., Bacsi, A., Brasier, A. R., Ba, X. & Boldogh, I., Sep 2018, In : Redox Biology. 18, p. 43-53 11 p.

Research output: Contribution to journalArticle

13 Scopus citations
2013

Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins

Hegde, M. L., Hegde, P. M., Bellot, L. J., Mandal, S. M., Hazra, T. K., Li, G. M., Boldogh, I., Tomkinson, A. E. & Mitra, S., Aug 13 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 33, p. E3090-E3099

Research output: Contribution to journalArticle

57 Scopus citations
2014

Expression of 8-oxoguanine Glycosylase in Human Fetal Membranes

Menon, R., Polettini, J., Syed, T. A., Saade, G. R. & Boldogh, I., Jan 1 2014, In : American Journal of Reproductive Immunology. 72, 1, p. 75-84 10 p.

Research output: Contribution to journalArticle

26 Scopus citations
2017

8-Oxoguanine DNA glycosylase1–driven DNA repair—A paradoxical role in lung aging

German, P., Saenz, D., Szaniszlo, P., Aguilera-Aguirre, L., Pan, L., Hegde, M. L., Bacsi, A., Hajas, G., Radak, Z., Ba, X., Mitra, S., Papaconstantinou, J. & Boldogh, I., Jan 1 2017, In : Mechanisms of Ageing and Development. 161, p. 51-65 15 p.

Research output: Contribution to journalArticle

9 Scopus citations
2014

8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and α-smooth muscle actin polymerization

Luo, J., Hosoki, K., Bacsi, A., Radak, Z., Hegde, M. L., Sur, S., Hazra, T. K., Brasier, A. R., Ba, X. & Boldogh, I., Aug 2014, In : Free Radical Biology and Medicine. 73, p. 430-438 9 p.

Research output: Contribution to journalArticle

34 Scopus citations
2017

Exercise, oxidants, and antioxidants change the shape of the bell-shaped hormesis curve

Radak, Z., Ishihara, K., Tekus, E., Varga, C., Posa, A., Balogh, L., Boldogh, I. & Koltai, E., Aug 1 2017, In : Redox Biology. 12, p. 285-290 6 p.

Research output: Contribution to journalShort survey

58 Scopus citations
2011

Combined exercise and insulin-like growth factor-1 supplementation induces neurogenesis in old rats, but do not attenuate age-associated DNA damage

Koltai, E., Zhao, Z., Lacza, Z., Cselenyak, A., Vacz, G., Nyakas, C., Boldogh, I., Ichinoseki-Sekine, N. & Radak, Z., Dec 1 2011, In : Rejuvenation Research. 14, 6, p. 585-596 12 p.

Research output: Contribution to journalArticle

34 Scopus citations
2019

Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome

Abraham, D., Feher, J., Scuderi, G. L., Szabo, D., Dobolyi, A., Cservenak, M., Juhasz, J., Ligeti, B., Pongor, S., Gomez-Cabrera, M. C., Vina, J., Higuchi, M., Suzuki, K., Boldogh, I. & Radak, Z., Jan 1 2019, In : Experimental Gerontology. 115, p. 122-131 10 p.

Research output: Contribution to journalArticle

25 Scopus citations
2014

Systems biology approaches to understanding epithelial mesenchymal transition (EMT) in mucosal remodeling and signaling in asthma

Ijaz, T., Pazdrak, K., Kalita, M., Konig, R., Choudhary, S., Tian, B., Boldogh, I. & Brasier, A. R., Jun 2 2014, In : World Allergy Organization Journal. 7, 1, 13.

Research output: Contribution to journalReview article

51 Scopus citations
2020

The systemic role of SIRT1 in exercise mediated adaptation

Radak, Z., Suzuki, K., Posa, A., Petrovszky, Z., Koltai, E. & Boldogh, I., Aug 2020, In : Redox Biology. 35, 101467.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations
2019

Exercise effects on physiological function during aging

Radak, Z., Torma, F., Berkes, I., Goto, S., Mimura, T., Posa, A., Balogh, L., Boldogh, I., Suzuki, K., Higuchi, M. & Koltai, E., Feb 20 2019, In : Free Radical Biology and Medicine. 132, p. 33-41 9 p.

Research output: Contribution to journalReview article

20 Scopus citations
2011

Mitochondrial dysfunctions related with oxidative stress

Saavedra-Molina, A., Boldogh, I., Manzo-Avalos, S., Cortés-Rojo, C., Aguilera-Aguirre, L., Montoya-Pérez, R. & Bacsi, A., 2011, Mitochondria: Structure, Functions and Dysfunctions. Nova Science Publishers, Inc., p. 411-439 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2015

Whole transcriptome analysis reveals an 8-oxoguanine DNA glycosylase-1-driven DNA repair-dependent gene expression linked to essential biological processes

Aguilera-Aguirre, L., Hosoki, K., Bacsi, A., Radák, Z., Wood, T. G., Widen, S. G., Sur, S., Ameredes, B. T., Saavedra-Molina, A., Brasier, A. R., Ba, X. & Boldogh, I., Apr 2015, In : Free Radical Biology and Medicine. 81, p. 107-118 12 p.

Research output: Contribution to journalArticle

25 Scopus citations

Dynamic aberrant NF-κB spurs tumorigenesis: A new model encompassing the microenvironment

Vlahopoulos, S. A., Cen, O., Hengen, N., Agan, J., Moschovi, M., Critselis, E., Adamaki, M., Bacopoulou, F., Copland, J. A., Boldogh, I., Karin, M. & Chrousos, G. P., Aug 1 2015, In : Cytokine and Growth Factor Reviews. 26, 4, p. 389-403 15 p.

Research output: Contribution to journalReview article

54 Scopus citations
2017

PARP1 promotes gene expression at the post-transcriptiona level by modulating the RNA-binding protein HuR

Ke, Y., Han, Y., Guo, X., Wen, J., Wang, K., Jiang, X., Tian, X., Ba, X., Boldogh, I. & Zeng, X., Mar 8 2017, In : Nature communications. 8, 14632.

Research output: Contribution to journalArticle

23 Scopus citations

SIRT1 may play a crucial role in overload-induced hypertrophy of skeletal muscle

Koltai, E., Bori, Z., Chabert, C., Dubouchaud, H., Naito, H., Machida, S., Davies, K. J. A., Murlasits, Z., Fry, A. C., Boldogh, I. & Radak, Z., Jun 1 2017, In : Journal of Physiology. 595, 11, p. 3361-3376 16 p.

Research output: Contribution to journalArticle

18 Scopus citations
2013

Aerobic endurance capacity affects spatial memory and SIRT1 is a potent modulator of 8-oxoguanine repair

Sarga, L., Hart, N., Koch, L. G., Britton, S. L., Hajas, G., Boldogh, I., Ba, X. & Radak, Z., Nov 12 2013, In : Neuroscience. 252, p. 326-336 11 p.

Research output: Contribution to journalArticle

18 Scopus citations
2015

The C-terminal domain (CTD) of human DNA glycosylase NEIL1 is required for forming BERosome repair complex with DNA replication proteins at the replicating genome: Dominant negative function of the CTD

Hegde, P. M., Dutta, A., Sengupta, S., Mitra, J., Adhikari, S., Tomkinson, A. E., Li, G. M., Boldogh, I., Hazra, T. K., Mitra, S. & Hegde, M. L., Aug 21 2015, In : Journal of Biological Chemistry. 290, 34, p. 20919-20933 15 p.

Research output: Contribution to journalArticle

24 Scopus citations

Mitochondrial biogenesis-associated factors underlie the magnitude of response to aerobic endurance training in rats

Marton, O., Koltai, E., Takeda, M., Koch, L. G., Britton, S. L., Davies, K. J. A., Boldogh, I. & Radak, Z., Jan 1 2015, In : Pflugers Archiv European Journal of Physiology. 467, 4, p. 779-788 10 p.

Research output: Contribution to journalArticle

21 Scopus citations
2019

Roles of DNA repair enzyme OGG1 in innate immunity and its significance for lung cancer

Vlahopoulos, S., Adamaki, M., Khoury, N., Zoumpourlis, V. & Boldogh, I., Feb 2019, In : Pharmacology and Therapeutics. 194, p. 59-72 14 p.

Research output: Contribution to journalReview article

11 Scopus citations
2011

Preferential repair of oxidized base damage in the transcribed genes of mammalian cells

Banerjee, D., Mandal, S. M., Das, A., Hegde, M. L., Das, S., Bhakat, K. K., Boldogh, I., Sarkar, P. S., Mitra, S. & Hazra, T. K., Feb 25 2011, In : Journal of Biological Chemistry. 286, 8, p. 6006-6016 11 p.

Research output: Contribution to journalArticle

90 Scopus citations
2014

Exercise increases markers of spermatogenesis in rats selectively bred for low running capacity

Torma, F., Koltai, E., Nagy, E., Ziaaldini, M. M., Posa, A., Koch, L. G., Britton, S. L., Boldogh, I. & Radak, Z., Dec 10 2014, In : PloS one. 9, 12, e11407.

Research output: Contribution to journalArticle

13 Scopus citations
2015

Ataxia telangiectasia mutated kinase mediates NF-κB serine 276 phosphorylation and interferon expression via the IRF7-RIG-I amplification loop in paramyxovirus infection

Fang, L., Choudhary, S., Tian, B., Boldogh, I., Yang, C., Ivanciuc, T., Ma, Y., Garofalo, R. P. & Brasier, A. R., Jan 1 2015, In : Journal of virology. 89, 5, p. 2628-2642 15 p.

Research output: Contribution to journalArticle

19 Scopus citations

8-Oxoguanine DNA glycosylase-1-driven DNA base excision repair: Role in asthma pathogenesis

Ba, X., Aguilera-Aguirre, L., Sur, S. & Boldogh, I., Feb 13 2015, In : Current opinion in allergy and clinical immunology. 15, 1, p. 89-97 9 p.

Research output: Contribution to journalReview article

16 Scopus citations
2013

8-Oxoguanine DNA glycosylase-1 links DNA repair to cellular signaling via the activation of the small GTPase Rac1

Hajas, G., Bacsi, A., Aguilera-Aguirre, L., Hegde, M. L., Tapas, K. H., Sur, S., Radak, Z., Ba, X. & Boldogh, I., 2013, In : Free Radical Biology and Medicine. 61, p. 384-394 11 p.

Research output: Contribution to journalArticle

55 Scopus citations
2014

New perspectives on oxidized genome damage and repair inhibition by pro-oxidant metals in neurological diseases

Mitra, J., Guerrero, E. N., Hegde, P. M., Wang, H., Boldogh, I., Rao, K. S., Mitra, S. & Hegde, M. L., Sep 1 2014, In : Biomolecules. 4, 3, p. 678-703 26 p.

Research output: Contribution to journalReview article

21 Scopus citations
2018

OGG1-initiated base excision repair exacerbates oxidative stress-induced parthanatos

Wang, R., Li, C., Qiao, P., Xue, Y., Zheng, X., Chen, H., Zeng, X., Liu, W., Boldogh, I. & Ba, X., Jun 1 2018, In : Cell Death and Disease. 9, 6, 628.

Research output: Contribution to journalArticle

14 Scopus citations
2015

Oxidative stress damage-associated molecular signaling pathways differentiate spontaneous preterm birth and preterm premature rupture of the membranes

Dutta, E. H., Behnia, F., Boldogh, I., Saade, G., Taylor, B. D., Kacerovský, M. & Menon, R., Aug 28 2015, In : Molecular Human Reproduction. 22, 2, p. 143-157 15 p., gav074.

Research output: Contribution to journalArticle

72 Scopus citations
2013

Senescence of primary amniotic cells via oxidative DNA damage

Menon, R., Boldogh, I., Urrabaz-Garza, R., Polettini, J., Syed, T. A., Saade, G. R., Papaconstantinou, J. & Taylor, R. N., Dec 27 2013, In : PloS one. 8, 12, e83416.

Research output: Contribution to journalArticle

58 Scopus citations
2011

Age-dependent changes in 8-oxoguanine-DNA glycosylase activity are modulated by adaptive responses to physical exercise in human skeletal muscle

Radak, Z., Bori, Z., Koltai, E., Fatouros, I. G., Jamurtas, A. Z., Douroudos, I. I., Terzis, G., Nikolaidis, M. G., Chatzinikolaou, A., Sovatzidis, A., Kumagai, S., Naito, H. & Boldogh, I., Jul 15 2011, In : Free Radical Biology and Medicine. 51, 2, p. 417-423 7 p.

Research output: Contribution to journalArticle

66 Scopus citations

Electron transport chain dysfunction by H2O2 is linked to increased reactive oxygen species production and iron mobilization by lipoperoxidation: Studies using Saccharomyces cerevisiae mitochondria

Cortés-Rojo, C., Estrada-Villagómez, M., Calderón-Cortés, E., Clemente-Guerrero, M., Mejía-Zepeda, R., Boldogh, I. & Saavedra-Molina, A., Apr 2011, In : Journal of Bioenergetics and Biomembranes. 43, 2, p. 135-147 13 p.

Research output: Contribution to journalArticle

6 Scopus citations
2017

Pollen-induced oxidative DNA damage response regulates miRNAs controlling allergic inflammation

Aguilera-Aguirre, L., Hao, W., Pan, L., Li, X., Saavedra-Molina, A., Bacsi, A., Radak, Z., Sur, S., Brasier, A. R., Ba, X. & Boldogh, I., Dec 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 313, 6, p. L1058-L1068

Research output: Contribution to journalArticle

4 Scopus citations
2020

Poly(ADP-ribosyl)ation enhances HuR oligomerization and contributes to pro-inflammatory gene mRNA stabilization

Ke, Y., Lv, X., Fu, X., Zhang, J., Bohio, A. A., Zeng, X., Hao, W., Wang, R., Boldogh, I. & Ba, X., 2020, (Accepted/In press) In : Cellular and Molecular Life Sciences.

Research output: Contribution to journalArticle

Open Access
2018

The establishment of methods for free PAR generation and PAR reader detection

Ke, Y., Wang, K., Xu, H., Wang, C., Zhang, J., Zeng, X., Wang, R., Boldogh, I. & Ba, X., Jan 1 2018, (Accepted/In press) In : Molecular and Cellular Probes.

Research output: Contribution to journalArticle

1 Scopus citations
2020

Enzymatically inactive OGG1 binds to DNA and steers base excision repair toward gene transcription

Hao, W., Wang, J., Zhang, Y., Wang, C., Xia, L., Zhang, W., Zafar, M., Kang, J. Y., Wang, R., Ali Bohio, A., Pan, L., Zeng, X., Wei, M., Boldogh, I. & Ba, X., Jun 1 2020, In : FASEB Journal. 34, 6, p. 7427-7441 15 p.

Research output: Contribution to journalArticle

Open Access
2018

The roles of base excision repair enzyme OGG1 in gene expression

Wang, R., Hao, W., Pan, L., Boldogh, I. & Ba, X., Oct 1 2018, In : Cellular and Molecular Life Sciences. 75, 20, p. 3741-3750 10 p.

Research output: Contribution to journalReview article

13 Scopus citations
2020

Exercise, redox system and neurodegenerative diseases

Quan, H., Koltai, E., Suzuki, K., Aguiar, A. S., Pinho, R., Boldogh, I., Berkes, I. & Radak, Z., Oct 1 2020, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1866, 10, 165778.

Research output: Contribution to journalReview article

Open Access
2017

NF-κB mediates mesenchymal transition, remodeling, and pulmonary fibrosis in response to chronic inflammation by viral RNA patterns

Tian, B., Patrikeev, I., Ochoa, L., Vargas, G., Belanger, K. A. K., Litvinov, J., Boldogh, I., Ameredes, B. T., Motamedi, M. & Brasier, A. R., Apr 2017, In : American journal of respiratory cell and molecular biology. 56, 4, p. 506-520 15 p.

Research output: Contribution to journalArticle

23 Scopus citations
2011

Aldose reductase deficiency in mice protects from ragweed pollen extract (RWE)-induced allergic asthma

Yadav, U. C. S., Aguilera-Aguirre, L., Boldogh, I., Ramana, K. V. & Srivastava, S. K., Nov 3 2011, In : Respiratory Research. 12, 145.

Research output: Contribution to journalArticle

7 Scopus citations
2013

Systems approaches to modeling chronic mucosal inflammation

Kalita, M., Tian, B., Gao, B., Choudhary, S., Wood, T. G., Carmical, J. R., Boldogh, I., Mitra, S., Minna, J. D. & Brasier, A. R., Nov 18 2013, In : BioMed Research International. 2013, 505864.

Research output: Contribution to journalArticle

27 Scopus citations
2015

Innate responses to pollen allergens

Hosoki, K., Boldogh, I. & Sur, S., Feb 13 2015, In : Current opinion in allergy and clinical immunology. 15, 1, p. 79-88 10 p.

Research output: Contribution to journalReview article

16 Scopus citations
2014

Eating habits modulate short term memory and epigenetical regulation of brain derived neurotrophic factor in hippocampus of low- and high running capacity rats

Torma, F., Bori, Z., Koltai, E., Felszeghy, K., Vacz, G., Koch, L., Britton, S., Boldogh, I. & Radak, Z., Aug 2014, In : Brain Research Bulletin. 107, p. 54-60 7 p.

Research output: Contribution to journalArticle

2 Scopus citations
2011

Protective effects of resveratrol on calcium-induced oxidative stress in rat heart mitochondria

Gutiérrez-Pérez, A., Cortés-Rojo, C., Noriega-Cisneros, R., Calderón-Cortés, E., Manzo-Avalos, S., Clemente-Guerrero, M., Godínez-Hernández, D., Boldogh, I. & Saavedra-Molina, A., Apr 1 2011, In : Journal of Bioenergetics and Biomembranes. 43, 2, p. 101-107 7 p.

Research output: Contribution to journalArticle

16 Scopus citations
2013

Down-regulation of 8-oxoguanine DNA glycosylase 1 expression in the airway epithelium ameliorates allergic lung inflammation

Bacsi, A., Aguilera-Aguirre, L., Szczesny, B., Radak, Z., Hazra, T. K., Sur, S., Ba, X. & Boldogh, I., Jan 1 2013, In : DNA Repair. 12, 1, p. 18-26 9 p.

Research output: Contribution to journalArticle

47 Scopus citations
2019

Targeting inducible epigenetic reprogramming pathways in chronic airway remodeling

Brasier, A. R. & Boldogh, I., 2019, In : Drugs in Context. 8, 2019-8-3.

Research output: Contribution to journalReview article

Open Access
2017

Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?

Wang, H., Dharmalingam, P., Vasquez, V., Mitra, J., Boldogh, I., Rao, K. S., Kent, T. A., Mitra, S. & Hegde, M. L., Jan 1 2017, In : Mechanisms of Ageing and Development. 161, p. 163-176 14 p.

Research output: Contribution to journalReview article

10 Scopus citations
2014

Innate inflammation induced by the 8-oxoguanine DNA glycosylase-1-KRAS-NF-κB pathway

Aguilera-Aguirre, L., Bacsi, A., Radak, Z., Hazra, T. K., Mitra, S., Sur, S., Brasier, A. R., Ba, X. & Boldogh, I., Nov 1 2014, In : Journal of Immunology. 193, 9, p. 4643-4653 11 p.

Research output: Contribution to journalArticle

57 Scopus citations

The redox-associated adaptive response of brain to physical exercise

Radak, Z., Ihasz, F., Koltai, E., Goto, S., Taylor, A. W. & Boldogh, I., Jan 1 2014, In : Free Radical Research. 48, 1, p. 84-92 9 p.

Research output: Contribution to journalReview article

30 Scopus citations