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• 2019

  Targeting the 5-ht_2c receptor in biological context and the current state of 5-ht_2c receptor ligand development

  Wold, E. A., Wild, C. T., Cunningham, K. A. & Zhou, J., 2019, In: Current topics in medicinal chemistry. 19, 16, p. 1381-1398 18 p.

  Research output: Contribution to journal › Review article › peer-review

  • lorcaserin
  • Serotonin
  • Artificial Receptors
  • Serotonin 5-HT2 Receptor Agonists
  • Receptor, Serotonin, 5-HT2C
  12 Scopus citations
• 2018

  Cocaine evokes a profile of oxidative stress and impacts innate antiviral response pathways in astrocytes

  Cisneros, I. E., Erdenizmenli, M., Cunningham, K. A., Paessler, S. & Dineley, K. T., Jun 2018, In: Neuropharmacology. 135, p. 431-443 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Cocaine
  • Astrocytes
  • Antiviral Agents
  • Oxidative Stress
  • Zika Virus
  7 Scopus citations
• 2011

  Synthesis and evaluation of dimeric derivatives of 5-HT _2A receptor (5-HT _2AR) antagonist M-100907

  Shashack, M. J., Cunningham, K. A., Seitz, P. K., McGinnis, A., Smith, T. D., Watson, C. S. & Gilbertson, S. R., Nov 16 2011, In: ACS chemical neuroscience. 2, 11, p. 640-644 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Bioassay
  • Polyethers
  • catechol
  • Receptor, Serotonin, 5-HT2A
  • Serotonin Receptors
  14 Scopus citations
• 2014

  Variation within the serotonin (5-HT) 5-HT2C receptor system aligns with vulnerability to cocaine cue reactivity

  Anastasio, N. C., Liu, S., Maili, L., Swinford, S., Lane, S. D., Fox, R. G., Hamon, S. C., Nielsen, D. A., Cunningham, K. A. & Moeller, F. G., 2014, In: Translational psychiatry. 4, e369.

  Research output: Contribution to journal › Article › peer-review

  • Receptor, Serotonin, 5-HT2C
  • Cocaine
  • Cues
  • Serotonin
  • Cocaine-Related Disorders
  28 Scopus citations
• 2019

  Chronic poly-drug administration damages adult mouse brain neural stem cells

  McGrath, E. L., Schlagal, C. R., Cortez, I., Dunn, T. J., Gao, J., Fox, R. G., Stutz, S. J., Kuo, Y. F., Hommel, J. D., Dineley, K. T., Cunningham, K. A., Kaphalia, B. S. & Wu, P., Nov 15 2019, In: Brain Research. 1723, 146425.

  Research output: Contribution to journal › Article › peer-review

  • Neural Stem Cells
  • Brain Stem
  • Cocaine
  • Ethanol
  • Pharmaceutical Preparations

• Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts

  Wold, E. A., Chen, J., Cunningham, K. A. & Zhou, J., Oct 1 2019, In: Journal of medicinal chemistry. 62, 1, p. 88-127 40 p.

  Research output: Contribution to journal › Article › peer-review

  • G-Protein-Coupled Receptors
  • Drug Discovery
  • Pharmaceutical Chemistry
  • Drug Delivery Systems
  • Clinical Trials
  31 Scopus citations
• 2018

  Serotonin 5-HT_2C receptor activation suppresses binge intake and the reinforcing and motivational properties of high-fat food

  Price, A. E., Anastasio, N. C., Stutz, S. J., Hommel, J. D. & Cunningham, K. A., Jul 27 2018, In: Frontiers in Pharmacology. 9, JUL, 821.

  Research output: Contribution to journal › Article › peer-review

  • Receptor, Serotonin, 5-HT2C
  • 1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta(b)(1,4)diazepino(6,7,1hj)indole
  • Binge-Eating Disorder
  • Fats
  • Food
  10 Scopus citations
• 2020

  Discovery of Potent and Brain-Penetrant GPR52 Agonist that Suppresses Psychostimulant Behavior

  Wang, P., Felsing, D., Chen, H., Stutz, S. J., Murphy, R., Cunningham, K., Allen, J. & Zhou, J., Nov 25 2020, In: Journal of Medicinal Chemistry. 63, 22, p. 13951 13972 p.

  Research output: Contribution to journal › Article › peer-review

  • G-Protein-Coupled Receptors
  • Brain
  • Proof of Concept Study
  • Structure-Activity Relationship
  • Central Nervous System Diseases
• 2018

  Special Issue on Precision Medicine for Brain Cancer in ACS Chemical Neuroscience

  Nilsson, C. L. & Cunningham, K. A., Jan 17 2018, In: ACS chemical neuroscience. 9, 1, p. 5 1 p.

  Research output: Contribution to journal › Editorial › peer-review
  2 Scopus citations
• 2011

  Relationship between attentional bias to cocaine-related stimuli and impulsivity in cocaine-dependent subjects

  Liu, S., Lane, S. D., Schmitz, J. M., Waters, A. J., Cunningham, K. A. & Moeller, F. G., Mar 2011, In: American Journal of Drug and Alcohol Abuse. 37, 2, p. 117-122 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Attentional Bias
  • Impulsive Behavior
  • Cocaine
  • Short-Term Memory
  • Newspapers
  56 Scopus citations
• 2020

  Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT_2CReceptor-Positive Allosteric Modulators with Enhanced Drug-like Properties

  Wold, E. A., Garcia, E. J., Wild, C. T., Miszkiel, J. M., Soto, C. A., Chen, J., Pazdrak, K., Fox, R. G., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Jul 23 2020, In: Journal of medicinal chemistry. 63, 14, p. 7529-7544 16 p.

  Research output: Contribution to journal › Article › peer-review

  • 4-phenylpiperidine
  • Receptor, Serotonin, 5-HT2C
  • Serotonin
  • Pharmaceutical Preparations
  • Serotonin 5-HT2 Receptor Agonists
  2 Scopus citations

• Serotonin neurobiology in cocaine use disorder

  Cunningham, K. A., Howell, L. L. & Anastasio, N. C., 2020, Handbook of Behavioral Neuroscience. Elsevier B.V., p. 745-802 58 p. (Handbook of Behavioral Neuroscience; vol. 31).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Neurobiology
  • Cocaine
  • Serotonin
  • Serotonin Receptors
  • Brain Diseases
• 2019

  Positive-allosteric modulation of the 5-HT_2C receptor: implications for neuropsychopharmacology and neurotherapeutics

  Zhou, J. & Cunningham, K. A., Jan 1 2019, In: Neuropsychopharmacology. 44, 1, p. 230-231 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review
  6 Scopus citations
• 2020

  Suppression of cocaine relapse-like behaviors upon pimavanserin and lorcaserin co-administration

  Anastasio, N. C., Sholler, D. J., Fox, R. G., Stutz, S. J., Merritt, C. R., Bjork, J. M., Moeller, F. G. & Cunningham, K. A., May 15 2020, In: Neuropharmacology. 168, 108009.

  Research output: Contribution to journal › Article › peer-review

  • pimavanserin
  • lorcaserin
  • Cocaine
  • Recurrence
  • Self Administration
  4 Scopus citations
• 2019

  Convergent neural connectivity in motor impulsivity and high-fat food binge-like eating in male Sprague-Dawley rats

  Anastasio, N. C., Stutz, S. J., Price, A. E., Davis-Reyes, B. D., Sholler, D. J., Ferguson, S. M., Neumaier, J. F., Moeller, F. G., Hommel, J. D. & Cunningham, K. A., Sep 1 2019, In: Neuropsychopharmacology. 44, 10, p. 1752-1761 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Bulimia
  • Impulsive Behavior
  • Sprague Dawley Rats
  • Fats
  • Food
  7 Scopus citations

• Leave the Ordinary Elsewhere: Novel Serotonin Mechanisms to Address 21st Century Public Health Challenges

  Sholler, D. J. & Cunningham, K. A., Jul 17 2019, In: ACS chemical neuroscience. 10, 7, p. 3045-3046 2 p.

  Research output: Contribution to journal › Editorial › peer-review

• Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT _2C Receptor

  Wild, C. T., Miszkiel, J. M., Wold, E. A., Soto, C. A., Ding, C., Hartley, R. M., White, M. A., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Oct 1 2019, In: Journal of medicinal chemistry. 62, 1, p. 288-305 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Receptor, Serotonin, 5-HT2C
  • Serotonin
  • 1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta(b)(1,4)diazepino(6,7,1hj)indole
  • Cocaine
  • Allosteric Site
  13 Scopus citations

• The 5-HT_2A receptor (5-HT_2AR) regulates impulsive action and cocaine cue reactivity in Male Sprague-Dawley rats

  Sholler, D. J., Stutz, S. J., Fox, R. G., Boone, E. L., Wang, Q., Rice, K. C., Gerard Moeller, F., Anastasio, N. C. & Cunningham, K. A., Jan 2019, In: Journal of Pharmacology and Experimental Therapeutics. 368, 1, p. 41-49 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Receptor, Serotonin, 5-HT2A
  • Cocaine
  • Cues
  • Sprague Dawley Rats
  • pimavanserin
  9 Scopus citations
• 2018

  Altered anterior cingulate cortex to hippocampus effective connectivity in response to drug cues in men with cocaine use disorder

  Ma, L., Steinberg, J. L., Cunningham, K. A., Bjork, J. M., Lane, S. D., Schmitz, J. M., Burroughs, T., Narayana, P. A., Kosten, T. R., Bechara, A. & Moeller, F. G., Jan 30 2018, In: Psychiatry Research - Neuroimaging. 271, p. 59-66 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Gyrus Cinguli
  • Cocaine
  • Cues
  • Hippocampus
  • Attentional Bias
  5 Scopus citations
• 2014

  Frontiers of biomolecular exploration in brain disorders

  Nilsson, C. L. & Cunningham, K. A., Jan 2014, In: Neuropsychopharmacology. 39, 1, p. 1-4 4 p.

  Research output: Contribution to journal › Review article › peer-review
• 2020

  Editorial: Contemporary Perspective on 5-HT_2C Receptor Function and Its Pharmacological Targeting

  De Deurwaerdère, P., Chagraoui, A. & Cunningham, K. A., Nov 23 2020, In: Frontiers in Pharmacology. 11, 606414.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access
• 2019

  Cingulo-hippocampal effective connectivity positively correlates with drug-cue attentional bias in opioid use disorder

  Ma, L., Steinberg, J. L., Bjork, J. M., Taylor, B. A., Arias, A. J., Terplan, M., Anastasio, N. C., Zuniga, E. A., Lennon, M., Cunningham, K. A. & Moeller, F. G., Dec 30 2019, In: Psychiatry Research - Neuroimaging. 294, 110977.

  Research output: Contribution to journal › Article › peer-review

  • Attentional Bias
  • Opioid Analgesics
  • Cues
  • Pharmaceutical Preparations
  • Gyrus Cinguli
  2 Scopus citations
• 2011

  5-HT_2c Receptors localize to dopamine and gaba neurons in the rat mesoaccumbens pathway

  Bubar, M. J., Stutz, S. J. & Cunningham, K. A., 2011, In: PloS one. 6, 6, e20508.

  Research output: Contribution to journal › Article › peer-review

  • Receptor, Serotonin, 5-HT2C
  • Ventral Tegmental Area
  • Rats
  • Dopaminergic Neurons
  • dopamine
  76 Scopus citations
• 2014

  Serotonin at the nexus of impulsivity and cue reactivity in cocaine addiction

  Cunningham, K. A. & Anastasio, N. C., 2014, In: Neuropharmacology. 76, PART B, p. 460-478 19 p.

  Research output: Contribution to journal › Review article › peer-review

  • Nexus
  • Cocaine-Related Disorders
  • Impulsive Behavior
  • Cues
  • Serotonin
  84 Scopus citations
• 2011

  Selective serotonin 5-HT_2C receptor activation suppresses the reinforcing efficacy of cocaine and sucrose but differentially affects the incentive-salience value of cocaine- vs. sucrose-associated cues

  Cunningham, K. A., Fox, R. G., Anastasio, N. C., Bubar, M. J., Stutz, S. J., Moeller, F. G., Gilbertson, S. R. & Rosenzweig-Lipson, S., Sep 2011, In: Neuropharmacology. 61, 3, p. 513-523 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Receptor, Serotonin, 5-HT2C
  • Cocaine
  • Sucrose
  • 1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta(b)(1,4)diazepino(6,7,1hj)indole
  • Cues
  77 Scopus citations
• 2020

  Inherent Motor Impulsivity Associates with Specific Gene Targets in the Rat Medial Prefrontal Cortex

  Sholler, D. J., Merritt, C. R., Davis-Reyes, B. D., Golovko, G., Anastasio, N. C. & Cunningham, K. A., May 21 2020, In: Neuroscience. 435, p. 161-173 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Impulsive Behavior
  • Prefrontal Cortex
  • Genes
  • Calcium Channels
  • leucyl-cystinyl aminopeptidase
  1 Scopus citations
• 2018

  Synthesis and activity of functionalizable derivatives of the serotonin (5-HT) 5-HT_2A receptor (5-HT_2AR) antagonist M100907

  Gilbertson, S. R., Chen, Y. C., Soto, C. A., Yang, Y., Rice, K. C., Cunningham, K. A. & Anastasio, N. C., May 1 2018, In: Bioorganic and Medicinal Chemistry Letters. 28, 8, p. 1381-1385 5 p.

  Research output: Contribution to journal › Article › peer-review

  • volinanserin
  • Serotonin 5-HT2 Receptor Antagonists
  • Receptor, Serotonin, 5-HT2A
  • Serotonin
  • Derivatives
  5 Scopus citations

• Novel Bivalent 5-HT _2A Receptor Antagonists Exhibit High Affinity and Potency in Vitro and Efficacy in Vivo

  Soto, C. A., Shashack, M. J., Fox, R. G., Bubar, M. J., Rice, K. C., Watson, C. S., Cunningham, K. A., Gilbertson, S. R. & Anastasio, N. C., Mar 21 2018, In: ACS chemical neuroscience. 9, 3, p. 514-521 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Receptor, Serotonin, 5-HT2A
  • Serotonin
  • In Vitro Techniques
  • volinanserin
  • Ligands
  8 Scopus citations
• 2014

  Multi-well plate immunoassays for measuring signaling protein activations/deactivations and membrane vs. intracellular receptor levels

  Watson, C. S., Jeng, Y. J., Bulayeva, N. N., Finnerty, C. C., Koong, L. Y., Zivadinovic, D., Alyea, R. A., Midoro-Horiuti, T., Goldblum, R. M., Anastasio, N. C., Cunningham, K. A., Seitz, P. K. & Smith, T. D., 2014, In: Methods in Molecular Biology. 1204, p. 123-133 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Immunoassay
  • Membranes
  • Neurotransmitter Agents
  • Proteins
  • Antigens
  2 Scopus citations
• 2019

  In vivo and in vitro analyses of novel peptidomimetic disruptors for the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog (PTEN)

  Soto, C., Du, H. C., Fox, R., Yang, T., Hooson, J., Anastasio, N. C., Gilbertson, S. R., Cunningham, K. A., Cunningham, K. A. & Gilbertson, S. R., 2019, In: Frontiers in Pharmacology. 10, JULY, 907.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Receptor, Serotonin, 5-HT2C
  • Peptidomimetics
  • Tensins
  • Phosphoric Monoester Hydrolases
  • In Vitro Techniques
  3 Scopus citations
• 2020

  Methylation Patterns of the HTR2A Associate With Relapse-Related Behaviors in Cocaine-Dependent Participants

  Land, M. A., Ramesh, D., Miller, A. L., Pyles, R. B., Cunningham, K. A., Moeller, F. G. & Anastasio, N. C., Jun 10 2020, In: Frontiers in Psychiatry. 11, 532.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cocaine
  • Methylation
  • Recurrence
  • Cues
  • Impulsive Behavior
• 2018

  Editors' Favorites of 2017

  Lindsley, C. W., Cunningham, K. A., Hooker, J. M. & Andrews, A. M., Jan 17 2018, In: ACS chemical neuroscience. 9, 1, p. 1-4 4 p.

  Research output: Contribution to journal › Review article › peer-review
  1 Scopus citations
• 2020

  Fentanyl self-administration impacts brain immune responses in male Sprague-Dawley rats

  Ezeomah, C., Cunningham, K. A., Stutz, S. J., Fox, R. G., Bukreyeva, N., Dineley, K. T., Paessler, S. & Cisneros, I. E., Jul 2020, In: Brain, Behavior, and Immunity. 87, p. 725-738 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Self Administration
  • Fentanyl
  • Interferons
  • Sprague Dawley Rats
  • Brain
  1 Scopus citations
• 2019

  Coevolution of Residues Provides Evidence of a Functional Heterodimer of 5-HT_2AR and 5-HT_2CR Involving Both Intracellular and Extracellular Domains

  Fongang, B., Cunningham, K. A., Rowicka, M. & Kudlicki, A., Aug 1 2019, In: Neuroscience. 412, p. 48-59 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Substance-Related Disorders
  • Single Nucleotide Polymorphism
  • serotonin 5 receptor
  • Proteins
  • Appetite
  1 Scopus citations
• 2011

  Serotonin (5-hydroxytryptamine) 5-HT2A receptor: Association with inherent and cocaine-evoked behavioral disinhibition in rats

  Anastasio, N. C., Stoffel, E. C., Fox, R. G., Bubar, M. J., Rice, K. C., Moeller, F. G. & Cunningham, K. A., Jun 2011, In: Behavioural Pharmacology. 22, 3, p. 248-261 14 p.

  Research output: Contribution to journal › Article › peer-review

  • serotonin 5 receptor
  • Receptor, Serotonin, 5-HT2A
  • Impulsive Behavior
  • Cocaine
  • volinanserin
  34 Scopus citations
• 2019

  Endogenous Serotonin 5-HT_2A and 5-HT_2C Receptors Associate in the Medial Prefrontal Cortex

  Price, A. E., Sholler, D. J., Stutz, S. J., Anastasio, N. C. & Cunningham, K. A., Jul 17 2019, In: ACS chemical neuroscience. 10, 7, p. 3241-3248 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Receptor, Serotonin, 5-HT2C
  • Receptor, Serotonin, 5-HT2A
  • Prefrontal Cortex
  • Serotonin
  • Rats
  7 Scopus citations

• Serotonin 5-HT_2C Receptor Cys23Ser Single Nucleotide Polymorphism Associates with Receptor Function and Localization In Vitro

  Land, M. A., Chapman, H. L., Davis-Reyes, B. D., Felsing, D. E., Allen, J. A., Moeller, F. G., Elferink, L. A., Cunningham, K. A. & Anastasio, N. C., Dec 1 2019, In: Scientific reports. 9, 1, 16737.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Receptor, Serotonin, 5-HT2C
  • Single Nucleotide Polymorphism
  • In Vitro Techniques
  • Alleles
  • Pharmacology
  1 Scopus citations

• Translating pharmacology into therapeutics to fight the opioid crisis

  Marek, G. J., Cunningham, K. A. & Rasmussen, K., 2019, In: Journal of Pharmacology and Experimental Therapeutics. 371, 2, p. 394-395 2 p.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access
• 2018

  A protocol for measuring cue reactivity in a rat model of cocaine use disorder

  Dimet, A. L., Cisneros, I. E., Fox, R. G., Stutz, S. J., Anastasio, N. C., Cunningham, K. A. & Dineley, K. T., Jun 20 2018, In: Journal of Visualized Experiments. 2018, 136, e55864.

  Research output: Contribution to journal › Article › peer-review

  • Rats
  • Cocaine
  • Cues
  • Drug therapy
  • Self Administration
  4 Scopus citations

• Biophysical validation of serotonin 5-HT_2A and 5-HT_2C receptor interaction

  Felsing, D. E., Anastasio, N. C., Miszkiel, J. M., Gilbertson, S. R., Allen, J. A. & Cunningham, K. A., Aug 2018, In: PloS one. 13, 8, e0203137.

  Research output: Contribution to journal › Article › peer-review

  • Receptor, Serotonin, 5-HT2C
  • Receptor, Serotonin, 5-HT2A
  • serotonin
  • Serotonin
  • receptors
  11 Scopus citations

• Innovative Therapeutic Intervention for Opioid Use Disorder

  Moeller, F. G. & Cunningham, K. A., Jan 1 2018, In: Neuropsychopharmacology. 43, 1, p. 220-221 2 p.

  Research output: Contribution to journal › Short survey › peer-review
  5 Scopus citations
• 2014

  Functional status of the serotonin 5-HT 2C receptor (5-HT 2C R) drives interlocked phenotypes that precipitate relapse-like behaviors in cocaine dependence

  Anastasio, N. C., Stutz, S. J., Fox, R. G., Sears, R. M., Emeson, R. B., Dileone, R. J., O'Neil, R. T., Fink, L. H., Li, D., Green, T. A., Gerard Moeller, F. & Cunningham, K. A., Jan 2014, In: Neuropsychopharmacology. 39, 2, p. 360-372 13 p.

  Research output: Contribution to journal › Article › peer-review

  • serotonin 5 receptor
  • Cocaine-Related Disorders
  • Drive
  • Serotonin
  • Phenotype
  49 Scopus citations
• 2018

  PPARγ agonism attenuates cocaine cue reactivity

  Miller, W. R., Fox, R. G., Stutz, S. J., Lane, S. D., Denner, L., Cunningham, K. A. & Dineley, K. T., Jan 2018, In: Addiction Biology. 23, 1, p. 55-68 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Peroxisome Proliferator-Activated Receptors
  • Cocaine
  • Cues
  • 2-chloro-5-nitrobenzanilide
  • Craving
  12 Scopus citations
• 2019

  Anterior insula activity regulates the associated behaviors of high fat food binge intake and cue reactivity in male rats

  Price, A. E., Stutz, S. J., Hommel, J. D., Anastasio, N. C. & Cunningham, K. A., Feb 1 2019, In: Appetite. 133, p. 231-239 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Cues
  • Eating
  • Fats
  • Bulimia
  • Food
  3 Scopus citations