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Author

  • Partha Sarkar
2020

Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis

Chakraborty, A., Tapryal, N., Venkova, T., Mitra, J., Vasquez, V., Sarker, A. H., Duarte-Silva, S., Huai, W., Ashizawa, T., Ghosh, G., MacIel, P., Sarkar, P. S., Hegde, M. L., Chen, X. & Hazra, T. K., Apr 7 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 14, p. 8154-8165 12 p.

Research output: Contribution to journalArticle

1 Scopus citations
2012

Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3′-phosphatase in maintenance of mitochondrial genome

Mandal, S. M., Hegde, M. L., Chatterjee, A., Hegde, P. M., Szczesny, B., Banerjee, D., Boldogh, I., Gao, R., Falkenberg, M., Gustafsson, C. M., Sarkar, P. S. & Hazra, T. K., Jan 20 2012, In : Journal of Biological Chemistry. 287, 4, p. 2819-2829 11 p.

Research output: Contribution to journalArticle

55 Scopus citations
2019

Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription

Gao, R., Chakraborty, A., Geater, C., Pradhan, S., Gordon, K. L., Snowden, J., Yuan, S., Dickey, A. S., Choudhary, S., Ashizawa, T., Ellerby, L. M., La Spada, A. R., Thompson, L. M., Hazra, T. K. & Sarkar, P. S., Apr 2019, In : eLife. 8, e42988.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2018

RbFOX1/MBNL1 competition for CCUG RNA repeats binding contributes to myotonic dystrophy type 1/type 2 differences

Sellier, C., Cerro-Herreros, E., Blatter, M., Freyermuth, F., Gaucherot, A., Ruffenach, F., Sarkar, P., Puymirat, J., Udd, B., Day, J. W., Meola, G., Bassez, G., Fujimura, H., Takahashi, M. P., Schoser, B., Furling, D., Artero, R., Allain, F. H. T., Llamusi, B. & Charlet-Berguerand, N., Dec 1 2018, In : Nature communications. 9, 1, 2009.

Research output: Contribution to journalArticle

19 Scopus citations
2015

Neil2-null mice accumulate oxidized DNA bases in the transcriptionally active sequences of the genome and are susceptible to innate inflammation

Chakraborty, A., Wakamiya, M., Venkova-Canova, T., Pandita, R. K., Aguilera-Aguirre, L., Sarker, A. H., Singh, D. K., Hosoki, K., Wood, T., Sharma, G., Cardenas, V., Sarkar, P., Sur, S., Pandita, T. K., Boldogh, I. & Hazra, T., Oct 9 2015, In : Journal of Biological Chemistry. 290, 41, p. 24636-24648 13 p.

Research output: Contribution to journalArticle

33 Scopus citations
2014

Structure of the myotonic dystrophy type 2 RNA and designed small molecules that reduce toxicity

Childs-Disney, J. L., Yildirim, I., Park, H., Lohman, J. R., Guan, L., Tran, T., Sarkar, P., Schatz, G. C. & Disney, M. D., Feb 21 2014, In : ACS Chemical Biology. 9, 2, p. 538-550 13 p.

Research output: Contribution to journalArticle

40 Scopus citations
2016

Design of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10

Yang, W. Y., Gao, R., Southern, M., Sarkar, P. S. & Disney, M. D., Jun 1 2016, In : Nature communications. 7, 11647.

Research output: Contribution to journalArticle

23 Scopus citations
2015

The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis

Chatterjee, A., Saha, S., Chakraborty, A., Silva-Fernandes, A., Mandal, S. M., Neves-Carvalho, A., Liu, Y., Pandita, R. K., Hegde, M. L., Hegde, P. M., Boldogh, I., Ashizawa, T., Koeppen, A. H., Pandita, T. K., Maciel, P., Sarkar, P. S. & Hazra, T. K., 2015, In : PLoS genetics. 11, 1, e1004749.

Research output: Contribution to journalArticle

39 Scopus citations
2013

Klotho ameliorates chemically induced endoplasmic reticulum (ER) stress signaling

Banerjee, S., Zhao, Y., Sarkar, P. S., Rosenblatt, K. P., Tilton, R. G. & Choudhary, S., May 2013, In : Cellular Physiology and Biochemistry. 31, 4-5, p. 659-672 14 p.

Research output: Contribution to journalArticle

25 Scopus citations
2016

Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes

Chakraborty, A., Tapryal, N., Venkova, T., Horikoshi, N., Pandita, R. K., Sarker, A. H., Sarkar, P. S., Pandita, T. K. & Hazra, T. K., Oct 5 2016, In : Nature communications. 7, 13049.

Research output: Contribution to journalArticle

59 Scopus citations
2013

Paradoxical effects of repeat interruptions on spinocerebellar ataxia type 10 expansions and repeat instability

McFarland, K. N., Liu, J., Landrian, I., Gao, R., Sarkar, P. S., Raskin, S., Moscovich, M., Gatto, E. M., Teive, H. A. G., Ochoa, A., Rasmussen, A. & Ashizawa, T., Nov 2013, In : European Journal of Human Genetics. 21, 11, p. 1272-1276 5 p.

Research output: Contribution to journalArticle

21 Scopus citations
2012

Transgenic mice with SCA10 pentanucleotide repeats show motor phenotype and susceptibility to seizure: A toxic RNA gain-of-function model

White, M., Xia, G., Gao, R., Wakamiya, M., Sarkar, P. S., McFarland, K. & Ashizawa, T., Mar 2012, In : Journal of Neuroscience Research. 90, 3, p. 706-714 9 p.

Research output: Contribution to journalArticle

31 Scopus citations
2015

Inactivation of PNKP by Mutant ATXN3 Triggers Apoptosis by Activating the DNA Damage-Response Pathway in SCA3

Gao, R., Liu, Y., Silva-Fernandes, A., Fang, X., Paulucci-Holthauzen, A., Chatterjee, A., Zhang, H. L., Matsuura, T., Choudhary, S., Ashizawa, T., Koeppen, A. H., Maciel, P., Hazra, T. K. & Sarkar, P. S., 2015, In : PLoS genetics. 11, 1, e1004834.

Research output: Contribution to journalArticle

31 Scopus citations
2012

Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2

Dey, S., Maiti, A. K., Hegde, M. L., Hegde, P. M., Boldogh, I., Sarkar, P. S., Abdel-Rahman, S. Z., Sarker, A. H., Hang, B., Xie, J., Tomkinson, A. E., Zhou, M., Shen, B., Wang, G., Wu, C., Yu, D., Lin, D., Cardenas, V. & Hazra, T. K., Jun 1 2012, In : DNA Repair. 11, 6, p. 570-578 9 p.

Research output: Contribution to journalArticle

26 Scopus citations
2016

Glucocorticoids increase skeletal muscle NF-κB inducing kinase (NIK): Links to muscle atrophy

Fry, C. S., Nayeem, S. Z., Dillon, E. L., Sarkar, P. S., Tumurbaatar, B., Urban, R. J., Wright, T. J., Sheffield-Moore, M., Tilton, R. G. & Choudhary, S., Nov 1 2016, In : Physiological reports. 4, 21, e13014.

Research output: Contribution to journalArticle

8 Scopus citations
2014

Ethanol suppresses PGC-1α expression by interfering with the cAMP-CREB pathway in neuronal cells

Liu, Z., Liu, Y., Gao, R., Li, H., Dunn, T., Wu, P., Smith, R. G., Sarkar, P. S. & Fang, X., Aug 6 2014, In : PloS one. 9, 8, e104247.

Research output: Contribution to journalArticle

15 Scopus citations
2013

Purkinje cell loss is the major brain pathology of spinocerebellar ataxia type 10

Xia, G., McFarland, K. N., Wang, K., Sarkar, P. S., Yachnis, A. T. & Ashizawa, T., Dec 2013, In : Journal of Neurology, Neurosurgery and Psychiatry. 84, 12, p. 1409-1411 3 p.

Research output: Contribution to journalLetter

11 Scopus citations