Find Research Outputs

Search in all content

Filters for Publications

Search concepts
Selected Filters

Publication Year

  • 2020
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012

Author

  • Louise Prakash
2014

An iron-sulfur cluster in the polymerase domain of yeast DNA polymerase ε

Jain, R., Vanamee, E. S., Dzikovski, B. G., Buku, A., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Jan 23 2014, In : Journal of Molecular Biology. 426, 2, p. 301-308 8 p.

Research output: Contribution to journalArticle

23 Scopus citations
2018

Genetic control of predominantly error-free replication through an acrolein-derived minor-groove DNA adduct

Yoon, J. H., Hodge, R. P., Hackfeld, L. C., Park, J., Choudhury, J. R., Prakash, S. & Prakash, L., Feb 23 2018, In : Journal of Biological Chemistry. 293, 8, p. 2949-2958 10 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Mechanism of error-free DNA synthesis across N1-methyl-deoxyadenosine by human DNA polymerase-l

Jain, R., Choudhury, J. R., Buku, A., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Mar 8 2017, In : Scientific reports. 7, 43904.

Research output: Contribution to journalArticle

8 Scopus citations
2012
109 Scopus citations
2015

A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands

Johnson, R. E., Klassen, R., Prakash, L. & Prakash, S., Jul 16 2015, In : Molecular cell. 59, 2, p. 163-175 13 p.

Research output: Contribution to journalArticle

116 Scopus citations
2012

Human DNA polymerase η is pre-aligned for dNTP binding and catalysis

Ummat, A., Silverstein, T. D., Jain, R., Buku, A., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Jan 27 2012, In : Journal of Molecular Biology. 415, 4, p. 627-634 8 p.

Research output: Contribution to journalArticle

26 Scopus citations
2020

Corrigendum: DNA polymerase θ accomplishes translesion synthesis opposite 1,N6-ethenodeoxyadenosine with a remarkably high fidelity in human cells

Yoon, J. H., Johnson, R. E., Prakash, L. & Prakash, S., Jan 1 2020, In : Genes & development. 34, 1-2, p. 146 1 p.

Research output: Contribution to journalComment/debate

Open Access
2017

Translesion synthesis DNA polymerases promote error-free replication through the minor-groove DNA adduct 3-deaza-3-methyladenine

Yoon, J. H., Choudhury, J. R., Park, J., Prakash, S. & Prakash, L., Nov 10 2017, In : Journal of Biological Chemistry. 292, 45, p. 18682-18688 7 p.

Research output: Contribution to journalArticle

9 Scopus citations
2012

Structural basis for cisplatin DNA damage tolerance by human polymerase η during cancer chemotherapy

Ummat, A., Rechkoblit, O., Jain, R., Roy Choudhury, J., Johnson, R. E., Silverstein, T. D., Buku, A., Lone, S., Prakash, L., Prakash, S. & Aggarwal, A. K., Jun 1 2012, In : Nature Structural and Molecular Biology. 19, 6, p. 628-632 5 p.

Research output: Contribution to journalArticle

58 Scopus citations
2015

Rev1 promotes replication through UV lesions in conjunction with DNA polymerases η, ι, and κ but not DNA polymerase ζ

Yoon, J. H., Park, J., Conde, J., Wakamiya, M., Prakash, L. & Prakash, S., Dec 15 2015, In : Genes and Development. 29, 24, p. 2588-2602 15 p.

Research output: Contribution to journalArticle

23 Scopus citations
2014

Crystal structure of yeast DNA polymerase ε catalytic domain

Jain, R., Rajashankar, K. R., Buku, A., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Apr 14 2014, In : PloS one. 9, 4, e94835.

Research output: Contribution to journalArticle

22 Scopus citations
2016

Structure and mechanism of human PrimPol, a DNA polymerase with primase activity

Rechkoblit, O., Gupta, Y. K., Malik, R., Rajashankar, K. R., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Oct 2016, In : Science Advances. 2, 10, e1601317.

Research output: Contribution to journalArticle

30 Scopus citations

Response to Burgers et al.

Johnson, R. E., Klassen, R., Prakash, L. & Prakash, S., Feb 18 2016, In : Molecular cell. 61, 4, p. 494-495 2 p.

Research output: Contribution to journalLetter

5 Scopus citations

Human DNA polymerase α in binary complex with a DNA:DNA template-primer

Coloma, J., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Apr 1 2016, In : Scientific reports. 6, 23784.

Research output: Contribution to journalArticle

14 Scopus citations
2014

A role for DNA polymerase θ in promoting replication through oxidative DNA lesion, thymine glycol, in human cells

Yoon, J. H., Choudhury, J. R., Park, J., Prakash, S. & Prakash, L., 2014, In : Journal of Biological Chemistry. 289, 19, p. 13177-13185 9 p.

Research output: Contribution to journalArticle

34 Scopus citations
2012
17 Scopus citations
2018

Structural basis for polymerase η–promoted resistance to the anticancer nucleoside analog cytarabine

Rechkoblit, O., Choudhury, J. R., Buku, A., Prakash, L., Prakash, S. & Aggarwal, A. K., Dec 1 2018, In : Scientific reports. 8, 1, 12702.

Research output: Contribution to journalArticle

4 Scopus citations
2020

Structure and mechanism of B-family DNA polymerase ζ specialized for translesion DNA synthesis

Malik, R., Kopylov, M., Gomez-Llorente, Y., Jain, R., Johnson, R. E., Prakash, L., Prakash, S., Ubarretxena-Belandia, I. & Aggarwal, A. K., 2020, (Accepted/In press) In : Nature Structural and Molecular Biology.

Research output: Contribution to journalArticle

1 Scopus citations

Genetic evidence for reconfiguration of DNA polymerase θ active site for error-free translesion synthesis in human cells

Yoon, J. H., Johnson, R. E., Prakash, L. & Prakash, S., May 1 2020, In : Journal of Biological Chemistry. 295, 18, p. 5918-5927 10 p.

Research output: Contribution to journalArticle

Open Access
2015

Genetic control of replication through N1-methyladenine in human cells

Conde, J., Yoon, J. H., Choudhury, J. R., Prakash, L. & Prakash, S., Dec 11 2015, In : Journal of Biological Chemistry. 290, 50, p. 29794-29800 7 p.

Research output: Contribution to journalArticle

12 Scopus citations
2012
5 Scopus citations
2014

Identification of two functional PCNA-binding domains in human DNA polymerase κ

Yoon, J. H., Acharya, N., Park, J., Basu, D., Prakash, S. & Prakash, L., Jul 2014, In : Genes to Cells. 19, 7, p. 594-601 8 p.

Research output: Contribution to journalArticle

13 Scopus citations
2013

The Architecture of Yeast DNA Polymerase ζ

Gómez-Llorente, Y., Malik, R., Jain, R., Choudhury, J. R., Johnson, R. E., Prakash, L., Prakash, S., Ubarretxena-Belandia, I. & Aggarwal, A. K., Oct 17 2013, In : Cell Reports. 5, 1, p. 79-86 8 p.

Research output: Contribution to journalArticle

22 Scopus citations