Find Research Outputs — UTMB Health Research Expert Profiles

2017

Identification of airway mucosal type 2 inflammation by using clinical biomarkers in asthmatic patients

Silkoff, P. E., Laviolette, M., Singh, D., FitzGerald, J. M., Kelsen, S., Backer, V., Porsbjerg, C. M., Girodet, P. O., Berger, P., Kline, J. N., Chupp, G., Susulic, V. S., Barnathan, E. S., Baribaud, F., Loza, M. J., Strambu, I., Lam, S., Eich, A., Ludwig-Sengpiel, A., Leigh, R. & 4 others, Dransfield, M., Calhoun, W., Hussaini, A. & Chanez, P., Sep 2017, In: Journal of Allergy and Clinical Immunology. 140, 3, p. 710-719 10 p.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

2013

An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype

Holguin, F., Comhair, S. A. A., Hazen, S. L., Powers, R. W., Khatri, S. S., Bleecker, E. R., Busse, W. W., Calhoun, W. J., Castro, M., Fitzpatrick, A. M., Gaston, B., Israel, E., Jarjour, N. N., Moore, W. C., Peters, S. P., Teague, W. G., Chung, K. F., Erzurum, S. C. & Wenzel, S. E., Jan 15 2013, In: American Journal of Respiratory and Critical Care Medicine. 187, 2, p. 153-159 7 p.

Research output: Contribution to journal › Article › peer-review

97 Scopus citations

2012

Key observations from the NHLBI Asthma Clinical Research Network

Szefler, S. J., Chinchilli, V. M., Israel, E., Denlinger, L. C., Lemanske, R. F., Calhoun, W. & Peters, S. P., May 2012, In: Thorax. 67, 5, p. 450-455 6 p.

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

2016

Effects of acute ethanol exposure on cytokine production by primary airway smooth muscle cells

Kaphalia, L., Kalita, M., Kaphalia, B. & Calhoun, W., Feb 1 2016, In: Toxicology and Applied Pharmacology. 292, p. 85-93 9 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

2013

Physician-, biomarker-, and symptombased djustment of inhaled corticosteroids for asthma had similar effects

Calhoun, W. J., Jan 24 2013, In: Annals of internal medicine. 158, 2, p. JC6

Research output: Contribution to journal › Comment/debate › peer-review

2014

Clinical burden and predictors of asthma exacerbations in patients on guideline-based steps 4-6 asthma therapy in the TENOR cohort

Calhoun, W. J., Haselkorn, T., Mink, D. R., Miller, D. P., Dorenbaum, A. & Zeiger, R. S., Mar 2014, In: Journal of Allergy and Clinical Immunology: In Practice. 2, 2, p. 193-200.e3

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Conclusions and future directions

Calhoun, W. J. & Brasier, A. R., 2014, Advances in Experimental Medicine and Biology. Vol. 795. p. 335-343 9 p. (Advances in Experimental Medicine and Biology; vol. 795).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2013

Aldose Reductase Inhibition Prevents Allergic Airway Remodeling through PI3K/AKT/GSK3β Pathway in Mice

Yadav, U. C. S., Naura, A. S., Aguilera-Aguirre, L., Boldogh, I., Boulares, H. A., Calhoun, W. J., Ramana, K. V. & Srivastava, S. K., Feb 27 2013, In: PloS one. 8, 2, e57442.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Characteristics of perimenstrual asthma and its relation to asthma severity and control: Data from the Severe Asthma Research Program

Rao, C. K., Moore, C. G., Bleecker, E., Busse, W. W., Calhoun, W., Castro, M., Chung, K. F., Erzurum, S. C., Israel, E., Curran-Everett, D. & Wenzel, S. E., Apr 2013, In: Chest. 143, 4, p. 984-992 9 p.

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

2017

Diagnosis and management of asthma in adults a review

McCracken, J., Veeranki, S. P., Ameredes, B. & Calhoun, W., Jul 18 2017, In: JAMA - Journal of the American Medical Association. 318, 3, p. 279-290 12 p.

Research output: Contribution to journal › Review article › peer-review

64 Scopus citations

2014

Introduction to asthma and phenotyping

Pillai, R. A. & Calhoun, W., 2014, Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 795. p. 5-15 11 p. (Advances in Experimental Medicine and Biology; vol. 795).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

5 Scopus citations

2013

Genome-wide association study identifies T_H1 pathway genes associated with lung function in asthmatic patients

Li, X., Hawkins, G. A., Ampleford, E. J., Moore, W. C., Li, H., Hastie, A. T., Howard, T. D., Boushey, H. A., Busse, W. W., Calhoun, W. J., Castro, M., Erzurum, S. C., Israel, E., Lemanske, R. F., Szefler, S. J., Wasserman, S. I., Wenzel, S. E., Peters, S. P., Meyers, D. A. & Bleecker, E. R., Aug 2013, In: Journal of Allergy and Clinical Immunology. 132, 2, p. 313-320.e15

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

2014

Heterogeneity of response to therapy

Calhoun, W., 2014, Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 795. p. 117-122 6 p. (Advances in Experimental Medicine and Biology; vol. 795).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2016

Biologic therapy in the management of asthma

McCracken, J. L., Tripple, J. W. & Calhoun, W. J., Aug 1 2016, In: Current opinion in allergy and clinical immunology. 16, 4, p. 375-382 8 p.

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

2019

Mucosal bromodomain-containing protein 4 mediates aeroallergen-induced inflammation and remodeling

Tian, B., Hosoki, K., Liu, Z., Yang, J., Zhao, Y., Sun, H., Zhou, J., Rytting, E., Kaphalia, L., Calhoun, W. J., Sur, S. & Brasier, A. R., Apr 2019, In: Journal of Allergy and Clinical Immunology. 143, 4, p. 1380-1394.e9

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

2013

Strategies for Tailoring Asthma Treatment in Adults-Reply

Calhoun, W. J., Boushey, H. A. & Ameredes, B. T., Jan 9 2013, In: JAMA - Journal of the American Medical Association. 309, 2, p. 136-137 2 p.

Research output: Contribution to journal › Letter › peer-review

2014

Introduction to asthma and phenotyping

Pillai, R. A. & Calhoun, W. J., 2014, Advances in Experimental Medicine and Biology. Vol. 795. p. 5-15 11 p. (Advances in Experimental Medicine and Biology; vol. 795).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2017

Race is associated with differences in airway inflammation in patients with asthma

Nyenhuis, S. M., Krishnan, J. A., Berry, A., Calhoun, W. J., Chinchilli, V. M., Engle, L., Grossman, N., Holguin, F., Israel, E., Kittles, R. A., Kraft, M., Lazarus, S. C., Lehman, E. B., Mauger, D. T., Moy, J. N., Peters, S. P., Phipatanakul, W., Smith, L. J., Sumino, K., Szefler, S. J. & 4 others, Wechsler, M. E., Wenzel, S., White, S. R. & Ackerman, S. J., Jul 2017, In: Journal of Allergy and Clinical Immunology. 140, 1, p. 257-265.e11

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

2019

Pharmacoproteomics reveal novel protective activity of bromodomain containing 4 inhibitors on vascular homeostasis in TLR3-mediated airway remodeling

Zhao, Y., Tian, B., Sun, H., Zhang, J., Zhang, Y., Ivannikov, M., Motamedi, M., Liu, Z., Zhou, J., Kaphalia, L., Calhoun, W. J., Maroto, R. & Brasier, A. R., Aug 15 2019, In: Journal of Proteomics. 205, 103415.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

2016

30-Day Readmissions in Hospitalized Adults With Asthma Exacerbations: Insights From the Nationwide Readmission Database

Veeranki, S. P., Sharma, K., Ohabughiro, M. U., Mehta, H. B., Adhikari, D., Kuo, Y. F. & Calhoun, W. J., Nov 1 2016, In: Chest. 150, 5, p. 1162-1165 4 p.

Research output: Contribution to journal › Letter › peer-review

6 Scopus citations

2014

Heterogeneity of asthma in society

Divekar, R. & Calhoun, W., 2014, Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 795. p. 31-41 11 p. (Advances in Experimental Medicine and Biology; vol. 795).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Heterogeneity of asthma in society

Divekar, R. & Calhoun, W. J., 2014, Advances in Experimental Medicine and Biology. Vol. 795. p. 31-41 11 p. (Advances in Experimental Medicine and Biology; vol. 795).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2016

Longitudinal stability of asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study

The ADEPT Investigators, 2016, In: Respiratory Research. 17, 1, p. 1-12 12 p., 43.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

2012

Severe asthma: Lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program

Jarjour, N. N., Erzurum, S. C., Bleecker, E. R., Calhoun, W. J., Castro, M., Comhair, S. A. A., Chung, K. F., Curran-Everett, D., Dweik, R. A., Fain, S. B., Fitzpatrick, A. M., Gaston, B. M., Israel, E., Hastie, A., Hoffman, E. A., Holguin, F., Levy, B. D., Meyers, D. A., Moore, W. C., Peters, S. P. & 4 others, Sorkness, R. L., Teague, W. G., Wenzel, S. E. & Busse, W. W., Feb 15 2012, In: American Journal of Respiratory and Critical Care Medicine. 185, 4, p. 356-362 7 p.

Research output: Contribution to journal › Review article › peer-review

168 Scopus citations

2014

Assessing and Evaluating Multidisciplinary Translational Teams: A Mixed Methods Approach

Wooten, K. C., Rose, R. M., Ostir, G. V., Calhoun, W. J., Ameredes, B. T. & Brasier, A. R., 2014, In: Evaluation and the Health Professions. 37, 1, p. 33-49 17 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data

Wu, W., Bleecker, E., Moore, W., Busse, W. W., Castro, M., Chung, K. F., Calhoun, W. J., Erzurum, S., Gaston, B., Israel, E., Curran-Everett, D. & Wenzel, S. E., May 2014, In: Journal of Allergy and Clinical Immunology. 133, 5, p. 1280-1288 9 p.

Research output: Contribution to journal › Article › peer-review

149 Scopus citations

2013

Predictors of response to tiotropium versus salmeterol in asthmatic adults

Peters, S. P., Bleecker, E. R., Kunselman, S. J., Icitovic, N., Moore, W. C., Pascual, R., Ameredes, B. T., Boushey, H. A., Calhoun, W. J., Castro, M., Cherniack, R. M., Craig, T., Denlinger, L. C., Engle, L. L., Dimango, E. A., Israel, E., Kraft, M., Lazarus, S. C., Lemanske, R. F., Lugogo, N. & 10 others, Martin, R. J., Meyers, D. A., Ramsdell, J., Sorkness, C. A., Sutherland, E. R., Wasserman, S. I., Walter, M. J., Wechsler, M. E., Chinchilli, V. M. & Szefler, S. J., Nov 2013, In: Journal of Allergy and Clinical Immunology. 132, 5, p. 1068-1074.e1

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

2014

The spectrum of asthma: an introduction.

Calhoun, W. J., 2014, In: Advances in experimental medicine and biology. 795, p. 1-4 4 p.

Research output: Contribution to journal › Editorial › peer-review

2012

Benralizumab - A humanized mAb to IL-5Rα with enhanced antibody-dependent cell-mediated cytotoxicity - A novel approach for the treatment of asthma

Ghazi, A., Trikha, A. & Calhoun, W. J., Jan 1 2012, In: Expert Opinion on Biological Therapy. 12, 1, p. 113-118 6 p.

Research output: Contribution to journal › Review article › peer-review

108 Scopus citations

2019

Chronic Respiratory Disease and Cognitive Impairment in Older Mexican Adults

Veeranki, S., Downer, B., Jupiter, D., Kuo, Y. F., Raji, M., Calhoun, W. & Wong, R., Nov 1 2019, In: Neurology India. 67, 6, p. 1539-1542 4 p.

Research output: Contribution to journal › Article › peer-review

Forced Oscillometry: A New Tool for Assessing Airway Function—Is It Ready for Prime Time?

Ram, J., Pineda-Cely, J. & Calhoun, W. J., Nov 1 2019, In: Journal of Allergy and Clinical Immunology: In Practice. 7, 8, p. 2861-2862 2 p.

Research output: Contribution to journal › Editorial › peer-review

1 Scopus citations

2013

P2X₇-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy

Denlinger, L. C., Manthei, D. M., Seibold, M. A., Ahn, K., Bleecker, E., Boushey, H. A., Calhoun, W. J., Castro, M., Chinchili, V. M., Fahy, J. V., Hawkins, G. A., Icitovic, N., Israel, E., Jarjour, N. N., King, T., Kraft, M., Lazarus, S. C., Lehman, E., Martin, R. J., Meyers, D. A. & 8 others, Peters, S. P., Sheerar, D., Shi, L., Sutherland, E. R., Szefler, S. J., Wechsler, M. E., Sorkness, C. A. & Lemanske, R. F., Jan 1 2013, In: American Journal of Respiratory and Critical Care Medicine. 187, 1, p. 28-33 6 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

2014

Conclusions and future directions

Calhoun, W. & Brasier, A. R., 2014, Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 795. p. 335-343 9 p. (Advances in Experimental Medicine and Biology; vol. 795).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

2013

The CTSA as an Exemplar Framework for Developing Multidisciplinary Translational Teams

Calhoun, W. J., Wooten, K., Bhavnani, S., Anderson, K. E., Freeman, J. & Brasier, A. R., Feb 2013, In: Clinical and translational science. 6, 1, p. 60-71 12 p.

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

2016

Impact of Age and Sex on Outcomes and Hospital Cost of Acute Asthma in the United States, 2011-2012

Zein, J. G., Udeh, B. L., Teague, W. G., Koroukian, S. M., Schlitz, N. K., Bleecker, E. R., Busse, W. B., Calhoun, W. J., Castro, M., Comhair, S. A., Fitzpatrick, A. M., Israel, E., Wenzel, S. E., Holguin, F., Gaston, B. M. & Erzurum, S. C., Jun 2016, In: PloS one. 11, 6, e0157301.

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

2019

Why do asthma patients cough? New insights into cough in allergic asthma

Puebla-Neira, D. & Calhoun, W. J., Sep 2019, In: Journal of Allergy and Clinical Immunology. 144, 3, p. 656-657 2 p.

Research output: Contribution to journal › Editorial › peer-review

2016

Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study

For the ADEPT (Airways Disease Endotyping for Personalized Therapeutics) & U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease Outcome Consortium) investigators, Dec 15 2016, In: Respiratory Research. 17, 1, 165.

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Improving Quality of Acute Asthma Care in US Hospitals: Changes Between 1999-2000 and 2012-2013

Hasegawa, K., Tsugawa, Y., Clark, S., Eastin, C. D., Gabriel, S., Herrera, V., Bittner, J. C., Camargo, C. A., Ahn, J., Aurora, T., Brenner, B., Brown, M. A., Calhoun, W., Gough, J. E., Gharib, A., Heidt, J., Khosravi, M., Moore, W. C., Mould-Millman, N. K., Nonas, S. & 11 others, Nowak, R., Pei, V., Press, V. G., Probst, B. D., Ramratnam, S. K., Tallar, M., Teuber, S. S., Trent, S. A., Villarreal, R., Watase, T. & Youngquist, S., Jul 1 2016, In: Chest. 150, 1, p. 112-122 11 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

2017

Activation of Human Peripheral Blood Eosinophils by Cytokines in a Comparative Time-Course Proteomic/Phosphoproteomic Study

Soman, K. V., Stafford, S. J., Pazdrak, K., Wu, Z., Luo, X., White, W. I., Wiktorowicz, J. E., Calhoun, W. J. & Kurosky, A., Aug 4 2017, In: Journal of Proteome Research. 16, 8, p. 2663-2679 17 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

2012

Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: The BASALT randomized controlled trial

Calhoun, W. J., Ameredes, B. T., King, T. S., Icitovic, N., Bleecker, E. R., Castro, M., Cherniack, R. M., Chinchilli, V. M., Craig, T., Denlinger, L., DiMango, E. A., Engle, L. L., Fahy, J. V., Grant, J. A., Israel, E., Jarjour, N., Kazani, S. D., Kraft, M., Kunselman, S. J., Lazarus, S. C. & 15 others, Lemanske, R. F., Lugogo, N., Martin, R. J., Meyers, D. A., Moore, W. C., Pascual, R., Peters, S. P., Ramsdell, J., Sorkness, C. A., Sutherland, E. R., Szefler, S. J., Wasserman, S. I., Walter, M. J., Wechsler, M. E. & Boushey, H. A., Sep 5 2012, In: JAMA - Journal of the American Medical Association. 308, 10, p. 987-997 11 p.

Research output: Contribution to journal › Article › peer-review

123 Scopus citations

2016

Cytokine-induced glucocorticoid resistance from eosinophil activation: Protein phosphatase 5 modulation of glucocorticoid receptor phosphorylation and signaling

Pazdrak, K., Straub, C., Maroto, R., Stafford, S., White, W. I., Calhoun, W. J. & Kurosky, A., Nov 15 2016, In: Journal of Immunology. 197, 10, p. 3782-3791 10 p.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

2014

Heterogeneity of response to therapy

Calhoun, W. J., 2014, Advances in Experimental Medicine and Biology. Vol. 795. p. 117-122 6 p. (Advances in Experimental Medicine and Biology; vol. 795).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2012

Strategies for molecular classification of asthma using bipartite network analysis of cytokine expression

Pillai, R. R., Divekar, R., Brasier, A., Bhavnani, S. & Calhoun, W. J., Oct 1 2012, In: Current Allergy and Asthma Reports. 12, 5, p. 388-395 8 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

2019

Ethanol Exposure Impairs AMPK Signaling and Phagocytosis in Human Alveolar Macrophages: Role of Ethanol Metabolism

Kaphalia, L., Srinivasan, M. P., Kakumanu, R. D., Kaphalia, B. S. & Calhoun, W. J., 2019, In: Alcoholism: Clinical and Experimental Research. 43, 8, p. 1682-1694 13 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

2017

Biologic Therapy in Chronic Obstructive Pulmonary Disease

Tripple, J., McCracken, J. & Calhoun, W., May 1 2017, In: Immunology and Allergy Clinics of North America. 37, 2, p. 345-355 11 p.

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

2014

Ethanol metabolism, oxidative stress, and endoplasmic reticulum stress responses in the lungs of hepatic alcohol dehydrogenase deficient deer mice after chronic ethanol feeding

Kaphalia, L., Boroumand, N., Hyunsu, J., Kaphalia, B. S. & Calhoun, W. J., Jun 1 2014, In: Toxicology and Applied Pharmacology. 277, 2, p. 109-117 9 p.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

2013

Symptom-based controller therapy: A new paradigm for asthma management

Divekar, R., Ameredes, B. T. & Calhoun, W. J., Oct 2013, In: Current Allergy and Asthma Reports. 13, 5, p. 427-433 7 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

2012

Sleep quality and asthma control and quality of life in non-severe and severe asthma

Luyster, F. S., Teodorescu, M., Bleecker, E., Busse, W., Calhoun, W., Castro, M., Chung, K. F., Erzurum, S., Israel, E., Strollo, P. J. & Wenzel, S. E., Dec 2012, In: Sleep and Breathing. 16, 4, p. 1129-1137 9 p.

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

2013

Alcoholic lung injury: Metabolic, biochemical and immunological aspects

Kaphalia, L. & Calhoun, W. J., Oct 4 2013, In: Toxicology Letters. 222, 2, p. 171-179 9 p.

Research output: Contribution to journal › Review article › peer-review

55 Scopus citations

2017

Post-transplant native pneumonectomy for interstitial fibrosis and small cell lung cancer

Li, R. T., Zahedi, S., Trieu, J., Lea, A. S., Calhoun, W. J., Duarte, A. G., Zhao, J. & Okereke, I. C., Dec 1 2017, In: Journal of Thoracic Disease. 9, 12, p. E1096-E1099

Research output: Contribution to journal › Article › peer-review

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