Find Research Outputs — UTMB Health Research Expert Profiles

2019

Evaluation of Burkholderia mallei ΔtonB Δhcp1 (CLH001) as a live attenuated vaccine in murine models of glanders and melioidosis

Khakhum, N., Bharaj, P., Myers, J. N., Tapia, D., Walker, D. H., Endsley, J. J. & Torres, A. G., Jul 2019, In: PLoS neglected tropical diseases. 13, 7, e0007578.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

2014

Rickettsia prowazekii (Epidemic or Louse-Borne Typhus)

Blanton, L. S. & Walker, D. H., Aug 28 2014, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. Elsevier Inc., Vol. 2. p. 2217-2220.e1

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2012

Human ehrlichioses and rickettsioses in Cameroon

Ndip, LN., Ndip, R., Walker, D. H. & McBride, J. W., 2012, Current Topics in Tropical Medicine. p. 25-42

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2020

A single mutation (V64G) within the ring domain of Z attenuates junin virus

Hallam, S. J., Manning, J. T., Maruyama, J., Seregin, A., Huang, C., Walker, D. H., de la Torre, J. C. & Paessler, S., Sep 2020, In: PLoS neglected tropical diseases. 14, 9, p. 1-15 15 p., e0008555.

Research output: Contribution to journal › Article › peer-review

Open Access

2012

Immune Mediators of protective and pathogenic immune responses in patients with mild and fatal human monocytotropic ehrlichiosis

Ismail, N., Walker, D. H., Ghose, P. & Tang, Y. W., May 21 2012, In: BMC Immunology. 13, 26.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Systemic treatment with cpg-b after sublethal rickettsial infection induces mouse death through indoleamine 2,3-dioxygenase (ido)

Xin, L., Shelite, T. R., Gong, B., Mendell, N. L., Soong, L., Fang, R. & Walker, D. H., Mar 28 2012, In: PloS one. 7, 3, e34062.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

2014

Rickettsia typhi (Murine Typhus)

Blanton, L. S., Dumler, J. S. & Walker, D. H., Aug 28 2014, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. Elsevier Inc., Vol. 2. p. 2221-2224.e2

Research output: Chapter in Book/Report/Conference proceeding › Chapter

5 Scopus citations

2019

Ehrlichia chaffeensis outer membrane protein 1-specific human antibody-mediated immunity is defined by intracellular TRIM21-dependent innate immune activation and extracellular neutralization

Velayutham, T. S., Kumar, S., Zhang, X., Kose, N., Walker, D. H., Winslow, G., Crowe, J. E. & McBride, J. W., Dec 1 2019, In: Infection and immunity. 87, 12, e00383-19.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

2012

Contribution of NK cells to the innate phase of host protection against an intracellular bacterium targeting systemic endothelium

Fang, R., Ismail, N. & Walker, D. H., Jul 2012, In: American Journal of Pathology. 181, 1, p. 185-195 11 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

2014

Interactions of Pathogens with the Host

Walker, D., Jan 1 2014, Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms. Elsevier Inc., p. 214-216 3 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2020

The guinea pig model for tick-borne spotted fever rickettsioses: A second look

Stokes, J. V., Walker, D. H. & Varela-Stokes, A. S., Nov 2020, In: Ticks and Tick-borne Diseases. 11, 6, 101538.

Research output: Contribution to journal › Review article › peer-review

Open Access

2012

Person-to-person transmission of severe fever with thrombocytopenia syndrome virus

Liu, Y., Li, Q., Hu, W., Wu, J., Weng, Y., Mei, L., Walker, D. H., Ren, J., Wang, Y. & Yu, X. J., Feb 1 2012, In: Vector-Borne and Zoonotic Diseases. 12, 2, p. 156-160 5 p.

Research output: Contribution to journal › Article › peer-review

154 Scopus citations

2019

Atg5 supports Rickettsia australis infection in macrophages in vitro and in vivo

Bechelli, J., Vergara, L., Smalley, C., Buzhdygan, T. P., Bender, S., Zhang, W., Liu, Y., Popov, V. L., Wang, J., Garg, N., Hwang, S., Walker, D. H. & Fang, R., Jan 1 2019, In: Infection and immunity. 87, 1, e00651.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

2014

Ehrlichia chaffeensis (Human Monocytotropic Ehrlichiosis), Anaplasma phagocytophilum (Human Granulocytotropic Anaplasmosis), and Other Anaplasmataceae

Dumler, J. S. & Walker, D. H., Aug 28 2014, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. Elsevier Inc., Vol. 2. p. 2227-2233.e3

Research output: Chapter in Book/Report/Conference proceeding › Chapter

9 Scopus citations

2013

Recent molecular insights into rickettsial pathogenesis and immunity

Sahni, S. K., Narra, H. P., Sahni, A. & Walker, D. H., Oct 2013, In: Future Microbiology. 8, 10, p. 1265-1288 24 p.

Research output: Contribution to journal › Review article › peer-review

59 Scopus citations

2020

Quantitative Proteomics of the Endothelial Secretome Identifies RC0497 as Diagnostic of Acute Rickettsial Spotted Fever Infections

Zhao, Y., Fang, R., Zhang, J., Zhang, Y., Bechelli, J., Smalley, C., Valbuena, G., Walker, D. H., Oteo, J. A. & Brasier, A. R., Feb 2020, In: American Journal of Pathology. 190, 2, p. 306-322 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

2019

A biosafety level-2 dose-dependent lethal mouse model of spotted fever rickettsiosis: Rickettsia parkeri atlantic rainforest strain

Londoño, A. F., Mendell, N. L., Walker, D. H. & Bouyer, D. H., Jun 2019, In: PLoS neglected tropical diseases. 13, 6, e0007054.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2013

Approaches to vaccines against Orientia tsutsugamushi

Valbuena, G. & Walker, D. H., 2013, In: Frontiers in Cellular and Infection Microbiology. 4, JAN, Article 170.

Research output: Contribution to journal › Review article › peer-review

Open Access

43 Scopus citations

2019

Pathogenesis of Rickettsial Diseases: Pathogenic and Immune Mechanisms of an Endotheliotropic Infection

Sahni, A., Fang, R., Sahni, S. K. & Walker, D. H., 2019, In: Annual Review of Pathology: Mechanisms of Disease. 14, p. 127-152 26 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

2014

Quantitative study of Rickettsia massiliae in Rhipicephalus sanguineus organs

Milhano, N., Popov, V., Vilhena, M., Bouyer, D. H., de Sousa, R. & Walker, D. H., Oct 1 2014, In: Ticks and Tick-borne Diseases. 5, 6, p. 709-714 6 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Pathogenesis of Infectious Diseases and Mechanisms of Immunity

McBride, J. & Walker, D., Dec 9 2014, Vaccinology: An Essential Guide. Wiley Blackwell, p. 59-72 14 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

The pathogenesis of severe fever with thrombocytopenia syndrome virus infection in alpha/beta interferon knockout mice: Insights into the pathologic mechanisms of a new viral hemorrhagic fever

Liu, Y., Wu, B., Paessler, S., Walker, D. H., Tesh, R. B. & Yu, X. J., Feb 2014, In: Journal of virology. 88, 3, p. 1781-1786 6 p.

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Strong Type 1, but Impaired Type 2, Immune Responses Contribute to Orientia tsutsugamushi-Induced Pathology in Mice

Soong, L., Wang, H., Shelite, T. R., Liang, Y., Mendell, N. L., Sun, J., Gong, B., Valbuena, G. A., Bouyer, D. H. & Walker, D. H., Sep 1 2014, In: PLoS neglected tropical diseases. 8, 9

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

2020

Ehrlichia chaffeensis and E. canis hypothetical protein immunoanalysis reveals small secreted immunodominant proteins and conformation-dependent antibody epitopes

Luo, T., Patel, J. G., Zhang, X., Walker, D. H. & McBride, J. W., Dec 1 2020, In: npj Vaccines. 5, 1, 85.

Research output: Contribution to journal › Article › peer-review

Open Access

2013

Approaches to vaccines against Orientia tsutsugamushi

Valbuena, G. & Walker, D. H., 2013, In: Frontiers in cellular and infection microbiology. 4, JAN, Article 170.

Research output: Contribution to journal › Article › peer-review

2020

Human monocytic ehrlichiosis, Mexico City, Mexico

Alcántara-Rodríguez, V. E., Sánchez-Montes, S., Contreras, H., Colunga-Salas, P., Fierro-Flores, L., Avalos, S., Rodríguez-Rangel, F., Becker, I. & Walker, D. H., Dec 2020, In: Emerging infectious diseases. 26, 12, p. 3016-3019 4 p.

Research output: Contribution to journal › Article › peer-review

2014

Inactivation of sam-methyltransferase is the mechanism of attenuation of a historic louse borne typhus vaccine strain

Liu, Y., Wu, B., Weinstock, G., Walker, D. H. & Yu, X. J., Nov 20 2014, In: PloS one. 9, 11, e113285.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

2013

Spotted fever group Rickettsia in small rodents from areas of low endemicity for Brazilian spotted fever in the Eastern Region of Minas Gerais State, Brazil

Milagres, B. S., Padilha, A. F., Montandon, C. E., Freitas, R. N., Pacheco, R., Walker, D. H., Labruna, M. B., Mafra, C. L. & Galvão, M. A. M., May 2013, In: American Journal of Tropical Medicine and Hygiene. 88, 5, p. 937-939 3 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

2012

Pathogenesis of lassa fever

Yun, N. E. & Walker, D. H., Oct 2012, In: Viruses. 4, 10, p. 2031-2048 18 p.

Research output: Contribution to journal › Review article › peer-review

86 Scopus citations

2013

Compartmentalized, functional role of angiogenin during spotted fever group rickettsia-induced endothelial barrier dysfunction: Evidence of possible mediation by host tRNA-derived small noncoding RNAs

Gong, B., Lee, Y. S., Lee, I., Shelite, T. R., Kunkeaw, N., Xu, G., Lee, K., Jeon, S. H., Johnson, B. H., Chang, Q., Ha, T., Mendell, N. L., Cheng, X., Bouyer, D. H., Boor, P. J., Ksiazek, T. G. & Walker, D. H., Jun 23 2013, In: BMC Infectious Diseases. 13, 1, 285.

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

2014

Ehrlichia

Thirumalapura, N. R. & Walker, D., Nov 26 2014, Molecular Medical Microbiology: Second Edition. Elsevier Ltd, Vol. 3. p. 2011-2032 22 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2019

Seek and you shall find — Unknown pathogens?

Vasilakis, N. & Walker, D. H., May 30 2019, In: New England Journal of Medicine. 380, 22, p. 2174-2175 2 p.

Research output: Contribution to journal › Comment/debate › peer-review

2014

Principles of Diagnosis of Infectious Diseases

Walker, D., Jan 1 2014, Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms. Elsevier Inc., p. 222-225 4 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2012

Letters to the editor

Walker, D., Mar 2012, In: Archives of Pathology and Laboratory Medicine. 136, 3, p. 235-236 2 p.

Research output: Contribution to journal › Letter › peer-review

2019

Rickettsiae Within the Fleas of Feral Cats in Galveston, Texas

Blanton, L. S., Vohra, R. F., Fistein, L., Quade, B., Walker, D. H. & Bouyer, D. H., Sep 2019, In: Vector-Borne and Zoonotic Diseases. 19, 9, p. 647-651 5 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

A cluster of cases of rocky mountain spotted fever in an area of Colombia not known to be endemic for this disease

Londoño, A. F., Arango-Ferreira, C., Acevedo-Gutiérrez, L. Y., Paternina, L. E., Montes, C., Ruiz, I., Labruna, M. B., Díaz, F. J., Walker, D. H. & Rodas, J. D., 2019, In: American Journal of Tropical Medicine and Hygiene. 101, 2, p. 336-342 7 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

2012

Rickettsia, orientia, ehrlichia, anaplasma and coxiella: Typhus; spotted fevers; scrub typhus; ehrlichioses; Q fever

Walker, D. & Yu, X. J., Jul 23 2012, Medical Microbiology: Eighteenth Edition. Elsevier Inc., p. 390-399 10 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

New insight into immunity and immunopathology of Rickettsial diseases

Mansueto, P., Vitale, G., Cascio, A., Seidita, A., Pepe, I., Carroccio, A., Di Rosa, S., Rini, G. B., Cillari, E. & Walker, D. H., 2012, In: Clinical and Developmental Immunology. 2012, 967852.

Research output: Contribution to journal › Review article › peer-review

83 Scopus citations

2013

Review article: Unresolved problems related to scrub typhus: A seriously neglected life-threatening disease

Paris, D. H., Shelite, T. R., Day, N. P. & Walker, D. H., Aug 2013, In: American Journal of Tropical Medicine and Hygiene. 89, 2, p. 301-307 7 p.

Research output: Contribution to journal › Review article › peer-review

133 Scopus citations

Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses

Gong, B., Shelite, T., Mei, F. C., Ha, T., Hu, Y., Xu, G., Chang, Q., Wakamiya, M., Ksiazek, T. G., Boor, P. J., Bouyer, D. H., Popov, V. L., Chen, J., Walker, D. H. & Cheng, X., Nov 26 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 48, p. 19615-19620 6 p.

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

2018

Chlamydial, Mycoplasmal, Rickettsial, and Ehrlichial Diseases

Walker, D. H., 2018, Pulmonary Pathology: A Volume in the Series: Foundations in Diagnostic Pathology. Elsevier Inc., p. 315-326 12 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2019

Burkholderia pseudomallei ΔtonB Δhcp1 live attenuated vaccine strain elicits full protective immunity against aerosolized melioidosis infection

Khakhum, N., Bharaj, P., Myers, J. N., Tapia, D., Kilgore, P. B., Ross, B. N., Walker, D. H., Endsley, J. J. & Torresa, A. G., Jan 1 2019, In: mSphere. 4, 1, e00570-18.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

2014

A Hematogenously Disseminated Orientia tsutsugamsushi-Infected Murine Model of Scrub Typhus

Shelite, T. R., Saito, T. B., Mendell, N. L., Gong, B., Xu, G., Soong, L., Valbuena, G., Bouyer, D. H. & Walker, D. H., Jul 2014, In: PLoS neglected tropical diseases. 8, 7, e2966.

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

2012

Rocky mountain spotted fever and other rickettsioses

Walker, D., May 15 2012, Schaechter's Mechanisms of Microbial Disease: Fifth Edition. Wolters Kluwer Health Adis (ESP), p. 301-307 7 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2020

Activation of ASC Inflammasome Driven by Toll-Like Receptor 4 Contributes to Host Immunity against Rickettsial Infection

Rumfield, C., Hyseni, I., McBride, J. W., Walker, D. H. & Fang, R., Mar 23 2020, In: Infection and immunity. 88, 4

Research output: Contribution to journal › Article › peer-review

Recent research milestones in the pathogenesis of human rickettsioses and opportunities ahead

Narra, H. P., Sahni, A., Walker, D. H. & Sahni, S. K., Jun 2020, In: Future Microbiology. 15, 9, p. 753-765 13 p.

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

2013

Rocky mountain spotted fever and other rickettsioses

Walker, D., Jul 8 2013, Schaechter's Mechanisms of Microbial Disease: Fifth Edition. Wolters Kluwer Health Adis (ESP), p. 301-307 7 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2014

Rickettsia rickettsii and Other Spotted Fever Group Rickettsiae (Rocky Mountain Spotted Fever and Other Spotted Fevers)

Walker, D. H. & Blanton, L. S., Aug 28 2014, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. Elsevier Inc., Vol. 2. p. 2198-2205 8 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Scopus citations

2018

Analysis of health-Care charges in murine typhus: Need for improved clinical recognition and diagnostics for acute disease

Vohra, R. F., Walker, D. H. & Blanton, L. S., 2018, In: American Journal of Tropical Medicine and Hygiene. 98, 6, p. 1594-1598 5 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

2014

Diseases Caused by Fungi

Walker, D. H. & McGinnis, M. R., Jan 1 2014, Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms. Elsevier Inc., p. 217-221 5 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

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