Find Research outputs — UTMB Health Research Expert Profiles

2015

Rapid-response impulsivity: Definitions, measurement issues, and clinical implications

Hamilton, K. R., Littlefield, A. K., Anastasio, N. C., Cunningham, K. A., Fink, L. H. L., Wing, V. C., Mathias, C. W., Lane, S. D., Schütz, C. G., Swann, A. C., Lejuez, C. W., Clark, L., Moeller, F. G. & Potenza, M. N., Apr 1 2015, In: Personality Disorders: Theory, Research, and Treatment. 6, 2, p. 168-181 14 p.

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Evaluation of the dopamine β-hydroxylase (DβH) inhibitor nepicastat in participants who meet criteria for cocaine use disorder

De La Garza, R., Bubar, M. J., Carbone, C. L., Moeller, F. G., Newton, T. F., Anastasio, N. C., Harper, T. A., Ware, D. L., Fuller, M. A., Holstein, G. J., Jayroe, J. B., Bandak, S. I., Reiman, K. Z., Neale, A. C., Pickford, L. B. & Cunningham, K. A., Jun 3 2015, In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 59, p. 40-48 9 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

2019

Leave the Ordinary Elsewhere: Novel Serotonin Mechanisms to Address 21st Century Public Health Challenges

Sholler, D. J. & Cunningham, K. A., Jul 17 2019, In: ACS chemical neuroscience. 10, 7, p. 3045-3046 2 p.

Research output: Contribution to journal › Editorial › peer-review

2012

Exploration of synthetic approaches and pharmacological evaluation of PNU-69176E and its stereoisomer as 5-HT_2C receptor allosteric modulators

Ding, C., Bremer, N. M., Smith, T. D., Seitz, P. K., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Jul 18 2012, In: ACS chemical neuroscience. 3, 7, p. 538-545 8 p.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

2015

Serotonin transporter gene promoter polymorphism predicts relationship between years of cocaine use and impulsivity

Liu, S., Maili, L., Lane, S. D., Schmitz, J. M., Spellicy, C. J., Cunningham, K. A., Moeller, F. G. & Nielsen, D. A., Sep 7 2015, In: Psychiatric Genetics. 25, 5, p. 213-214 2 p.

Research output: Contribution to journal › Letter › peer-review

3 Scopus citations

2020

Discovery of Potent and Brain-Penetrant GPR52 Agonist that Suppresses Psychostimulant Behavior

Wang, P., Felsing, D., Chen, H., Stutz, S. J., Murphy, R., Cunningham, K., Allen, J. & Zhou, J., Nov 25 2020, In: Journal of Medicinal Chemistry. 63, 22, p. 13951 13972 p.

Research output: Contribution to journal › Article › peer-review

Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT_2CReceptor-Positive Allosteric Modulators with Enhanced Drug-like Properties

Wold, E. A., Garcia, E. J., Wild, C. T., Miszkiel, J. M., Soto, C. A., Chen, J., Pazdrak, K., Fox, R. G., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Jul 23 2020, In: Journal of medicinal chemistry. 63, 14, p. 7529-7544 16 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

2015

Serotonin 5-HT2 receptor interactions with dopamine function: implications for therapeutics in cocaine use disorder

Howell, L. L. & Cunningham, K. A., 2015, In: Pharmacological reviews. 67, 1, p. 176-197 22 p.

Research output: Contribution to journal › Review article › peer-review

117 Scopus citations

2012

Forced abstinence from cocaine self-administration is associated with DNA methylation changes in myelin genes in the corpus callosum: A preliminary study

Nielsen, D. A., Huang, W., Hamon, S. C., Maili, L., Witkin, B. M., Fox, R. G., Cunningham, K. A. & Moeller, F. G., 2012, In: Frontiers in Psychiatry. 3, JUN, Article 60.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

2019

Coevolution of Residues Provides Evidence of a Functional Heterodimer of 5-HT_2AR and 5-HT_2CR Involving Both Intracellular and Extracellular Domains

Fongang, B., Cunningham, K. A., Rowicka, M. & Kudlicki, A., Aug 1 2019, In: Neuroscience. 412, p. 48-59 12 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

2013

Effects of escitalopram on attentional bias to cocaine-related stimuli and inhibitory control in cocaine-dependent subjects

Liu, S., Lane, S. D., Schmitz, J. M., Cunningham, K. A., John, V. P. & Moeller, F. G., Sep 2013, In: Journal of Psychopharmacology. 27, 9, p. 801-807 7 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

2020

Suppression of cocaine relapse-like behaviors upon pimavanserin and lorcaserin co-administration

Anastasio, N. C., Sholler, D. J., Fox, R. G., Stutz, S. J., Merritt, C. R., Bjork, J. M., Moeller, F. G. & Cunningham, K. A., May 15 2020, In: Neuropharmacology. 168, 108009.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

2013

Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP Isoform 1

Yan, J., Mei, F. C., Cheng, H., Lao, D. H., Hu, Y., Wei, J., Patrikeev, I., Hao, D., Stutz, S. J., Dineley, K. T., Motamedi, M., Hommel, J. D., Cunningham, K. A., Chen, J. & Cheng, X., Mar 2013, In: Molecular and cellular biology. 33, 5, p. 918-926 9 p.

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

2019

Chronic poly-drug administration damages adult mouse brain neural stem cells

McGrath, E. L., Schlagal, C. R., Cortez, I., Dunn, T. J., Gao, J., Fox, R. G., Stutz, S. J., Kuo, Y. F., Hommel, J. D., Dineley, K. T., Cunningham, K. A., Kaphalia, B. S. & Wu, P., Nov 15 2019, In: Brain Research. 1723, 146425.

Research output: Contribution to journal › Article › peer-review

2012

Influence of methamphetamine on genital herpes simplex virus type 2 infection in a mouse model

Valencia, F., Bubar, M. J., Milligan, G., Cunningham, K. A. & Bourne, N., Sep 2012, In: Sexually Transmitted Diseases. 39, 9, p. 720-725 6 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

2020

Inherent Motor Impulsivity Associates with Specific Gene Targets in the Rat Medial Prefrontal Cortex

Sholler, D. J., Merritt, C. R., Davis-Reyes, B. D., Golovko, G., Anastasio, N. C. & Cunningham, K. A., May 21 2020, In: Neuroscience. 435, p. 161-173 13 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

2019

Endogenous Serotonin 5-HT_2A and 5-HT_2C Receptors Associate in the Medial Prefrontal Cortex

Price, A. E., Sholler, D. J., Stutz, S. J., Anastasio, N. C. & Cunningham, K. A., Jul 17 2019, In: ACS chemical neuroscience. 10, 7, p. 3241-3248 8 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts

Wold, E. A., Chen, J., Cunningham, K. A. & Zhou, J., Oct 1 2019, In: Journal of medicinal chemistry. 62, 1, p. 88-127 40 p.

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Positive-allosteric modulation of the 5-HT_2C receptor: implications for neuropsychopharmacology and neurotherapeutics

Zhou, J. & Cunningham, K. A., Jan 1 2019, In: Neuropsychopharmacology. 44, 1, p. 230-231 2 p.

Research output: Contribution to journal › Comment/debate › peer-review

6 Scopus citations

2013

Serotonin2C receptors in the ventral pallidum regulate motor function in rats

Graves, S. M., Viskniskki, A. A., Cunningham, K. A. & Celeste Napier, T., Aug 7 2013, In: NeuroReport. 24, 11, p. 605-608 4 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

2015

Serotonin (5-HT) 5-HT_2A Receptor (5-HT_2AR):5-HT_2CR Imbalance in Medial Prefrontal Cortex Associates with Motor Impulsivity

Anastasio, N. C., Stutz, S. J., Fink, L. H. L., Swinford-Jackson, S. E., Sears, R. M., Dileone, R. J., Rice, K. C., Moeller, F. G. & Cunningham, K. A., Jul 15 2015, In: ACS chemical neuroscience. 6, 7, p. 1248-1258 11 p.

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

2013

Synergism between a serotonin 5-HT_2A receptor (5-HT _2AR) antagonist and 5-HT_2CR agonist suggests new pharmacotherapeutics for cocaine addiction

Cunningham, K. A., Anastasio, N. C., Fox, R. G., Stutz, S. J., Bubar, M. J., Swinford, S. E., Watson, C. S., Gilbertson, S. R., Rice, K. C., Rosenzweig-Lipson, S. & Moeller, F. G., Jan 16 2013, In: ACS chemical neuroscience. 4, 1, p. 110-121 12 p.

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Peptide inhibitors disrupt the serotonin 5-HT_2C receptor interaction with phosphatase and tensin homolog to allosterically modulate cellular signaling and behavior

Anastasio, N. C., Gilbertson, S. R., Bubar, M. J., Agarkov, A., Stutz, S. J., Jeng, Y., Bremer, N. M., Smith, T. D., Fox, R. G., Swinford, S. E., Seitz, P. K., Charendoff, M. N., Craft, J. W., Laezza, F. M., Watson, C. S., Briggs, J. M. & Cunningham, K. A., Jan 23 2013, In: Journal of Neuroscience. 33, 4, p. 1615-1630 16 p.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

2020

Serotonin neurobiology in cocaine use disorder

Cunningham, K. A., Howell, L. L. & Anastasio, N. C., 2020, Handbook of Behavioral Neuroscience. Elsevier B.V., p. 745-802 58 p. (Handbook of Behavioral Neuroscience; vol. 31).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2012

Quantitative changes in intracellular calcium and extracellular-regulated kinase activation measured in parallel in CHO cells stably expressing serotonin (5-HT) 5-HT _2Aor 5-HT _2Creceptors

Seitz, P. K., Bremer, N. M., McGinnis, A. G., Cunningham, K. A. & Watson, C. S., Mar 7 2012, In: BMC Neuroscience. 13, 1, 25.

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

2015

Individual differences in impulsive action reflect variation in the cortical serotonin 5-HT _2A receptor system

Fink, L. H., Anastasio, N. C., Fox, R. G., Rice, K. C., Moeller, F. G. & Cunningham, K. A., Jul 13 2015, In: Neuropsychopharmacology. 40, 8, p. 1957-1968 12 p.

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

2013

Elevated expression of serotonin 5-HT_2A receptors in the rat ventral tegmental area enhances vulnerability to the behavioral effects of cocaine

Herin, D. V., Bubar, M. J., Seitz, P. K., Thomas, M. L., Hillman, G. R., Tarasenko, Y. I., Wu, P. & Cunningham, K. A., May 17 2013, In: Frontiers in Psychiatry. 4, FEB, Article 2.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

2019

Convergent neural connectivity in motor impulsivity and high-fat food binge-like eating in male Sprague-Dawley rats

Anastasio, N. C., Stutz, S. J., Price, A. E., Davis-Reyes, B. D., Sholler, D. J., Ferguson, S. M., Neumaier, J. F., Moeller, F. G., Hommel, J. D. & Cunningham, K. A., Sep 1 2019, In: Neuropsychopharmacology. 44, 10, p. 1752-1761 10 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

2020

Editorial: Contemporary Perspective on 5-HT_2C Receptor Function and Its Pharmacological Targeting

De Deurwaerdère, P., Chagraoui, A. & Cunningham, K. A., Nov 23 2020, In: Frontiers in Pharmacology. 11, 606414.

Research output: Contribution to journal › Editorial › peer-review

Open Access

Methylation Patterns of the HTR2A Associate With Relapse-Related Behaviors in Cocaine-Dependent Participants

Land, M. A., Ramesh, D., Miller, A. L., Pyles, R. B., Cunningham, K. A., Moeller, F. G. & Anastasio, N. C., Jun 10 2020, In: Frontiers in Psychiatry. 11, 532.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

The 5-HT_2A receptor (5-HT_2AR) regulates impulsive action and cocaine cue reactivity in Male Sprague-Dawley rats

Sholler, D. J., Stutz, S. J., Fox, R. G., Boone, E. L., Wang, Q., Rice, K. C., Gerard Moeller, F., Anastasio, N. C. & Cunningham, K. A., Jan 2019, In: Journal of Pharmacology and Experimental Therapeutics. 368, 1, p. 41-49 9 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

2015

Inhibitory behavioral control: A stochastic dynamic causal modeling study comparing cocaine dependent subjects and controls

Ma, L., Steinberg, J. L., Cunningham, K. A., Lane, S. D., Bjork, J. M., Neelakantan, H., Price, A. E., Narayana, P. A., Kosten, T. R., Bechara, A. & Moeller, F. G., 2015, In: NeuroImage: Clinical. 7, p. 837-847 11 p.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

2019

Cingulo-hippocampal effective connectivity positively correlates with drug-cue attentional bias in opioid use disorder

Ma, L., Steinberg, J. L., Bjork, J. M., Taylor, B. A., Arias, A. J., Terplan, M., Anastasio, N. C., Zuniga, E. A., Lennon, M., Cunningham, K. A. & Moeller, F. G., Dec 30 2019, In: Psychiatry Research - Neuroimaging. 294, 110977.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Translating pharmacology into therapeutics to fight the opioid crisis

Marek, G. J., Cunningham, K. A. & Rasmussen, K., 2019, In: Journal of Pharmacology and Experimental Therapeutics. 371, 2, p. 394-395 2 p.

Research output: Contribution to journal › Editorial › peer-review

Open Access

Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT _2C Receptor

Wild, C. T., Miszkiel, J. M., Wold, E. A., Soto, C. A., Ding, C., Hartley, R. M., White, M. A., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Oct 1 2019, In: Journal of medicinal chemistry. 62, 1, p. 288-305 18 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Serotonin 5-HT_2C Receptor Cys23Ser Single Nucleotide Polymorphism Associates with Receptor Function and Localization In Vitro

Land, M. A., Chapman, H. L., Davis-Reyes, B. D., Felsing, D. E., Allen, J. A., Moeller, F. G., Elferink, L. A., Cunningham, K. A. & Anastasio, N. C., Dec 1 2019, In: Scientific reports. 9, 1, 16737.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2012

Increased intra-individual reaction time variability in cocaine-dependent subjects: Role of cocaine-related cues

Liu, S., Lane, S. D., Schmitz, J. M., Green, C. E., Cunningham, K. A. & Moeller, F. G., Feb 2012, In: Addictive Behaviors. 37, 2, p. 193-197 5 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

2019

Targeting the 5-ht_2c receptor in biological context and the current state of 5-ht_2c receptor ligand development

Wold, E. A., Wild, C. T., Cunningham, K. A. & Zhou, J., 2019, In: Current topics in medicinal chemistry. 19, 16, p. 1381-1398 18 p.

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

2015

Prevalence of Food Addiction among Low-Income Reproductive-Aged Women

Berenson, A. B., Laz, T. H., Pohlmeier, A. M., Rahman, M. & Cunningham, K. A., Sep 1 2015, In: Journal of Women's Health. 24, 9, p. 740-744 5 p.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

2019

In vivo and in vitro analyses of novel peptidomimetic disruptors for the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog (PTEN)

Soto, C., Du, H. C., Fox, R., Yang, T., Hooson, J., Anastasio, N. C., Gilbertson, S. R., Cunningham, K. A., Cunningham, K. A. & Gilbertson, S. R., 2019, In: Frontiers in Pharmacology. 10, JULY, 907.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

2015

Inhibitory behavioral control: a stochastic dynamic causal modeling study using network discovery analysis

Ma, L., Steinberg, J. L., Cunningham, K., Lane, S. D., Kramer, L. A., Narayana, P. A., Kosten, T. R., Bechara, A. & Moeller, F. G., Apr 1 2015, In: Brain Connectivity. 5, 3, p. 177-186 10 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

5-HT_2C receptor desensitization moderates anxiety in 5-HTT deficient mice: From behavioral to cellular evidence

Martin, C. B. P., Martin, V. S., Trigo, J. M., Chevarin, C., Maldonado, R., Fink, L. H., Cunningham, K. A., Hamon, M., Lanfumey, L. & Mongeau, R., Feb 2015, In: International Journal of Neuropsychopharmacology. 18, 3

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

2019

Anterior insula activity regulates the associated behaviors of high fat food binge intake and cue reactivity in male rats

Price, A. E., Stutz, S. J., Hommel, J. D., Anastasio, N. C. & Cunningham, K. A., Feb 1 2019, In: Appetite. 133, p. 231-239 9 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

2020

Fentanyl self-administration impacts brain immune responses in male Sprague-Dawley rats

Ezeomah, C., Cunningham, K. A., Stutz, S. J., Fox, R. G., Bukreyeva, N., Dineley, K. T., Paessler, S. & Cisneros, I. E., Jul 2020, In: Brain, Behavior, and Immunity. 87, p. 725-738 14 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

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