Find Research Outputs — UTMB Health Research Expert Profiles

2017

Fibroblast growth factor receptor-1 mediates internalization of pathogenic spotted fever rickettsiae into host endothelium

Sahni, A., Patel, J., Narra, H. P., Schroeder, C. L. C., Walker, D. H. & Sahni, S. K., Aug 2017, In: PloS one. 12, 8, e0183181.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

2012

Rocky mountain spotted fever and other rickettsioses

Walker, D., May 15 2012, Schaechter's Mechanisms of Microbial Disease: Fifth Edition. Wolters Kluwer Health Adis (ESP), p. 301-307 7 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2017

Murine models of scrub typhus associated with host control of Orientia tsutsugamushi infection

Mendell, N. L., Bouyer, D. H. & Walker, D. H., Mar 10 2017, In: PLoS neglected tropical diseases. 11, 3, e0005453.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

2013

Case-Fatality ratio and effectiveness of ribavirin therapy among hospitalized patients in china who had severe fever with thrombocytopenia syndrome

Liu, W., Lu, Q. B., Cui, N., Li, H., Wang, L. Y., Liu, K., Yang, Z. D., Wang, B. J., Wang, H. Y., Zhang, Y. Y., Zhuang, L., Hu, C. Y., Yuan, C., Fan, X. J., Wang, Z., Zhang, L., Zhang, X. A., Walker, D. H. & Cao, W. C., Nov 1 2013, In: Clinical Infectious Diseases. 57, 9, p. 1292-1299 8 p.

Research output: Contribution to journal › Article › peer-review

96 Scopus citations

2012

New insight into immunity and immunopathology of Rickettsial diseases

Mansueto, P., Vitale, G., Cascio, A., Seidita, A., Pepe, I., Carroccio, A., Di Rosa, S., Rini, G. B., Cillari, E. & Walker, D. H., 2012, In: Clinical and Developmental Immunology. 2012, 967852.

Research output: Contribution to journal › Review article › peer-review

83 Scopus citations

2016

Epidemiology, molecular biology, and pathogenic mechanisms of Ehrlichia infections

Yu, X. J. & Walker, D., Jan 1 2016, Rickettsiales: Biology, Molecular Biology, Epidemiology, and Vaccine Development. Springer International Publishing, p. 225-240 16 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

2012

Contribution of NK cells to the innate phase of host protection against an intracellular bacterium targeting systemic endothelium

Fang, R., Ismail, N. & Walker, D. H., Jul 2012, In: American Journal of Pathology. 181, 1, p. 185-195 11 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

2016

MyD88 mediates instructive signaling in dendritic cells and protective inflammatory response during rickettsial infection

Bechelli, J., Smalley, C., Zhao, X., Judy, B., Valdes, P., Walker, D. H. & Fang, R., Apr 1 2016, In: Infection and immunity. 84, 4, p. 883-893 11 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

2018

Analysis of health-Care charges in murine typhus: Need for improved clinical recognition and diagnostics for acute disease

Vohra, R. F., Walker, D. H. & Blanton, L. S., 2018, In: American Journal of Tropical Medicine and Hygiene. 98, 6, p. 1594-1598 5 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

2016

Opossums and cat fleas: New insights in the ecology of murine typhus in Galveston, Texas

Blanton, L. S., Idowu, B. M., Tatsch, T. N., Henderson, J. M., Bouyer, D. H. & Walker, D. H., Aug 2016, In: American Journal of Tropical Medicine and Hygiene. 95, 2, p. 457-461 5 p.

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

2020

Ehrlichia chaffeensis and E. canis hypothetical protein immunoanalysis reveals small secreted immunodominant proteins and conformation-dependent antibody epitopes

Luo, T., Patel, J. G., Zhang, X., Walker, D. H. & McBride, J. W., Dec 1 2020, In: npj Vaccines. 5, 1, 85.

Research output: Contribution to journal › Article › peer-review

Open Access

Human monocytic ehrlichiosis, Mexico City, Mexico

Alcántara-Rodríguez, V. E., Sánchez-Montes, S., Contreras, H., Colunga-Salas, P., Fierro-Flores, L., Avalos, S., Rodríguez-Rangel, F., Becker, I. & Walker, D. H., Dec 2020, In: Emerging infectious diseases. 26, 12, p. 3016-3019 4 p.

Research output: Contribution to journal › Article › peer-review

Perspective Piece: Ideal Criteria for Accurate Mouse Models of Vector-Borne Diseases with Emphasis on Scrub Typhus and Dengue

Sarathy, V. V. & Walker, D. H., Sep 2020, In: American Journal of Tropical Medicine and Hygiene. 103, 3, p. 970-975 6 p.

Research output: Contribution to journal › Review article › peer-review

2013

Spotted fever group Rickettsia in small rodents from areas of low endemicity for Brazilian spotted fever in the Eastern Region of Minas Gerais State, Brazil

Milagres, B. S., Padilha, A. F., Montandon, C. E., Freitas, R. N., Pacheco, R., Walker, D. H., Labruna, M. B., Mafra, C. L. & Galvão, M. A. M., May 2013, In: American Journal of Tropical Medicine and Hygiene. 88, 5, p. 937-939 3 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

2012

Pathogenesis of lassa fever

Yun, N. E. & Walker, D. H., Oct 2012, In: Viruses. 4, 10, p. 2031-2048 18 p.

Research output: Contribution to journal › Review article › peer-review

86 Scopus citations

2016

Value of autopsy emphasized in the case report of a single patient with middle east respiratory syndrome

Walker, D. H., Mar 1 2016, In: American Journal of Pathology. 186, 3, p. 507-510 4 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Scrub typhus - Scientific neglect, ever-widening impact

Walker, D. H., Sep 8 2016, In: New England Journal of Medicine. 375, 10, p. 913-915 3 p.

Research output: Contribution to journal › Short survey › peer-review

32 Scopus citations

2017

Flea-Borne Rickettsioses and Rickettsiae

Blanton, L. S. & Walker, D. H., Jan 2017, In: American Journal of Tropical Medicine and Hygiene. 96, 1, p. 53-56 4 p.

Research output: Contribution to journal › Review article › peer-review

32 Scopus citations

Mechanisms of immunity to rickettsia and implications for vaccine development

Walker, D., Jan 1 2017, In: Revista Colombiana de Ciencias Pecuarias. 30, p. 262-263 2 p.

Research output: Contribution to journal › Article › peer-review

Rickettsiae as Emerging Infectious Agents

Fang, R., Blanton, L. S. & Walker, D. H., Jun 2017, In: Clinics in Laboratory Medicine. 37, 2, p. 383-400 18 p.

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

2020

Quantitative Proteomics of the Endothelial Secretome Identifies RC0497 as Diagnostic of Acute Rickettsial Spotted Fever Infections

Zhao, Y., Fang, R., Zhang, J., Zhang, Y., Bechelli, J., Smalley, C., Valbuena, G., Walker, D. H., Oteo, J. A. & Brasier, A. R., Feb 2020, In: American Journal of Pathology. 190, 2, p. 306-322 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

2013

Approaches to vaccines against Orientia tsutsugamushi

Valbuena, G. & Walker, D. H., 2013, In: Frontiers in Cellular and Infection Microbiology. 4, JAN, Article 170.

Research output: Contribution to journal › Review article › peer-review

Open Access

43 Scopus citations

Rocky mountain spotted fever and other rickettsioses

Walker, D., Jul 8 2013, Schaechter's Mechanisms of Microbial Disease: Fifth Edition. Wolters Kluwer Health Adis (ESP), p. 301-307 7 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2020

Activation of ASC Inflammasome Driven by Toll-Like Receptor 4 Contributes to Host Immunity against Rickettsial Infection

Rumfield, C., Hyseni, I., McBride, J. W., Walker, D. H. & Fang, R., Mar 23 2020, In: Infection and immunity. 88, 4

Research output: Contribution to journal › Article › peer-review

Recent research milestones in the pathogenesis of human rickettsioses and opportunities ahead

Narra, H. P., Sahni, A., Walker, D. H. & Sahni, S. K., Jun 2020, In: Future Microbiology. 15, 9, p. 753-765 13 p.

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

2012

Systemic treatment with cpg-b after sublethal rickettsial infection induces mouse death through indoleamine 2,3-dioxygenase (ido)

Xin, L., Shelite, T. R., Gong, B., Mendell, N. L., Soong, L., Fang, R. & Walker, D. H., Mar 28 2012, In: PloS one. 7, 3, e34062.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

2016

Endothelial cell proteomic response to Rickettsia conorii infection reveals activation of the Janus Kinase (JAK)-signal transducer and activator of transcription (STAT)-inferferon stimulated gene (ISG)15 pathway and reprogramming plasma membrane integrin/cadherin signaling

Zhao, Y., Valbuena, G., Walker, D. H., Gazi, M., Hidalgo, M., DeSousa, R., Oteo, J. A., Goez, Y. & Brasier, A. R., Jan 2016, In: Molecular and Cellular Proteomics. 15, 1, p. 289-304 16 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

2020

A single mutation (V64G) within the ring domain of Z attenuates junin virus

Hallam, S. J., Manning, J. T., Maruyama, J., Seregin, A., Huang, C., Walker, D. H., de la Torre, J. C. & Paessler, S., Sep 2020, In: PLoS neglected tropical diseases. 14, 9, p. 1-15 15 p., e0008555.

Research output: Contribution to journal › Article › peer-review

Open Access

2012

Immune Mediators of protective and pathogenic immune responses in patients with mild and fatal human monocytotropic ehrlichiosis

Ismail, N., Walker, D. H., Ghose, P. & Tang, Y. W., May 21 2012, In: BMC Immunology. 13, 26.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

2017

CD8⁺T cells provide immune protection against murine disseminated endotheliotropic Orientia tsutsugamushi infection

Xu, G., Mendell, N. L., Liang, Y., Shelite, T. R., Goez-Rivillas, Y., Soong, L., Bouyer, D. H. & Walker, D. H., Jul 19 2017, In: PLoS neglected tropical diseases. 11, 7, e0005763.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

2012

Human ehrlichioses and rickettsioses in Cameroon

Ndip, LN., Ndip, R., Walker, D. H. & McBride, J. W., 2012, Current Topics in Tropical Medicine. p. 25-42

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2013

Compartmentalized, functional role of angiogenin during spotted fever group rickettsia-induced endothelial barrier dysfunction: Evidence of possible mediation by host tRNA-derived small noncoding RNAs

Gong, B., Lee, Y. S., Lee, I., Shelite, T. R., Kunkeaw, N., Xu, G., Lee, K., Jeon, S. H., Johnson, B. H., Chang, Q., Ha, T., Mendell, N. L., Cheng, X., Bouyer, D. H., Boor, P. J., Ksiazek, T. G. & Walker, D. H., Jun 23 2013, In: BMC Infectious Diseases. 13, 1, 285.

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

2016

Fatal monocytic ehrlichiosis in woman, Mexico, 2013

Sosa-Gutierrez, C. G., Solorzano-Santos, F., Walker, D. H., Torres, J., Serrano, C. A. & Gordillo-Perez, G., May 2016, In: Emerging infectious diseases. 22, 5, p. 871-874 4 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

2013

Pathogenesis of the viral hemorrhagic fevers

Paessler, S. & Walker, D. H., Jan 2013, In: Annual Review of Pathology: Mechanisms of Disease. 8, p. 411-440 30 p.

Research output: Contribution to journal › Review article › peer-review

152 Scopus citations

2020

Human rickettsiosis caused by rickettsia parkeri strain Atlantic rainforest, Urabá, Colombia

Arboleda, M., Acevedo-Gutiérrez, L. Y., Ávila, A., Ospina, D., Díaz, F. J., Walker, D. H. & Rodas, J. D., Dec 2020, In: Emerging infectious diseases. 26, 12, p. 3048-3050 3 p.

Research output: Contribution to journal › Article › peer-review

2013

Mice lacking functional STAT1 are highly susceptible to lethal infection with Lassa virus

Yun, N. E., Seregin, A. V., Walker, D. H., Popov, V. L., Walker, A. G., Smith, J. N., Miller, M., de la Torre, J. C., Smith, J. K., Borisevich, V., Fair, J. N., Wauquier, N., Grant, D. S., Bockarie, B., Bente, D. & Paessler, S., 2013, In: Journal of virology. 87, 19, p. 10908-10911 4 p.

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

2012

Letters to the editor

Walker, D., Mar 2012, In: Archives of Pathology and Laboratory Medicine. 136, 3, p. 235-236 2 p.

Research output: Contribution to journal › Letter › peer-review

2018

Chlamydial, Mycoplasmal, Rickettsial, and Ehrlichial Diseases

Walker, D. H., 2018, Pulmonary Pathology: A Volume in the Series: Foundations in Diagnostic Pathology. Elsevier Inc., p. 315-326 12 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2016

Rickettsia

Walker, D., Oct 6 2016, International Encyclopedia of Public Health. Elsevier Inc., p. 370-377 8 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Rickettsia australis activates inflammasome in human and murine macrophages

Smalley, C., Bechelli, J., Rockx-Brouwer, D., Saito, T., Azar, S. R., Ismail, N., Walker, D. H. & Fang, R., Jun 2016, In: PloS one. 11, 6, e0157231.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

2012

Rickettsia, orientia, ehrlichia, anaplasma and coxiella: Typhus; spotted fevers; scrub typhus; ehrlichioses; Q fever

Walker, D. & Yu, X. J., Jul 23 2012, Medical Microbiology: Eighteenth Edition. Elsevier Inc., p. 390-399 10 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

2016

Editorial: Changing dynamics of human-rickettsial interactions

Walker, D. H., Jan 2016, In: American Journal of Tropical Medicine and Hygiene. 94, 1, p. 3-4 2 p.

Research output: Contribution to journal › Editorial › peer-review

5 Scopus citations

2017

Time to Worry about Anthrax Again

Keim, P. S., Walker, D. H. & Zilinskas, R. A., Mar 14 2017, In: Scientific American. 316, 4, p. 70-75 6 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

2016

Ehrlichioses: An important one health opportunity

Saito, T. B. & Walker, D. H., Sep 1 2016, In: Veterinary Sciences. 3, 3, 20.

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

2020

The guinea pig model for tick-borne spotted fever rickettsioses: A second look

Stokes, J. V., Walker, D. H. & Varela-Stokes, A. S., Nov 2020, In: Ticks and Tick-borne Diseases. 11, 6, 101538.

Research output: Contribution to journal › Review article › peer-review

Open Access

2013

Approaches to vaccines against Orientia tsutsugamushi

Valbuena, G. & Walker, D. H., 2013, In: Frontiers in cellular and infection microbiology. 4, JAN, Article 170.

Research output: Contribution to journal › Article › peer-review

2012

Person-to-person transmission of severe fever with thrombocytopenia syndrome virus

Liu, Y., Li, Q., Hu, W., Wu, J., Weng, Y., Mei, L., Walker, D. H., Ren, J., Wang, Y. & Yu, X. J., Feb 1 2012, In: Vector-Borne and Zoonotic Diseases. 12, 2, p. 156-160 5 p.

Research output: Contribution to journal › Article › peer-review

154 Scopus citations

2013

Simple method to differentiate among Rickettsia species

Peniche-Lara, G., Zavala-Velazquez, J., Dzul-Rosado, K., Walker, D. H. & Zavala-Castro, J., Apr 1 2013, In: Journal of Molecular Microbiology and Biotechnology. 23, 3, p. 203-208 6 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

2017

A review of the global epidemiology of scrub typhus

Xu, G., Walker, D. H., Jupiter, D., Melby, P. C. & Arcari, C. M., Nov 3 2017, In: PLoS neglected tropical diseases. 11, 11, e0006062.

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

2016

An Intradermal Inoculation Mouse Model for Immunological Investigations of Acute Scrub Typhus and Persistent Infection

Soong, L., Mendell, N. L., Olano, J. P., Rockx-Brouwer, D., Xu, G., Goez-Rivillas, Y., Drom, C., Shelite, T. R., Valbuena, G., Walker, D. H. & Bouyer, D. H., Aug 1 2016, In: PLoS neglected tropical diseases. 10, 8, e0004884.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

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