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• 2018

  Synthesis and activity of functionalizable derivatives of the serotonin (5-HT) 5-HT_2A receptor (5-HT_2AR) antagonist M100907

  Gilbertson, S. R., Chen, Y. C., Soto, C. A., Yang, Y., Rice, K. C., Cunningham, K. A. & Anastasio, N. C., May 1 2018, In: Bioorganic and Medicinal Chemistry Letters. 28, 8, p. 1381-1385 5 p.

  Research output: Contribution to journal › Article › peer-review

  • volinanserin
  • Serotonin 5-HT2 Receptor Antagonists
  • Receptor, Serotonin, 5-HT2A
  • Serotonin
  • Derivatives
  5 Scopus citations
• 2020

  Inherent Motor Impulsivity Associates with Specific Gene Targets in the Rat Medial Prefrontal Cortex

  Sholler, D. J., Merritt, C. R., Davis-Reyes, B. D., Golovko, G., Anastasio, N. C. & Cunningham, K. A., May 21 2020, In: Neuroscience. 435, p. 161-173 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Impulsive Behavior
  • Prefrontal Cortex
  • Genes
  • Calcium Channels
  • leucyl-cystinyl aminopeptidase
  1 Scopus citations

• Methylation Patterns of the HTR2A Associate With Relapse-Related Behaviors in Cocaine-Dependent Participants

  Land, M. A., Ramesh, D., Miller, A. L., Pyles, R. B., Cunningham, K. A., Moeller, F. G. & Anastasio, N. C., Jun 10 2020, In: Frontiers in Psychiatry. 11, 532.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cocaine
  • Methylation
  • Recurrence
  • Cues
  • Impulsive Behavior
• 2012

  Exploration of synthetic approaches and pharmacological evaluation of PNU-69176E and its stereoisomer as 5-HT_2C receptor allosteric modulators

  Ding, C., Bremer, N. M., Smith, T. D., Seitz, P. K., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Jul 18 2012, In: ACS chemical neuroscience. 3, 7, p. 538-545 8 p.

  Research output: Contribution to journal › Article › peer-review

  • L-threo-alpha-D-galacto-octopyranoside methyl-7-chloro-6,7,8-trideoxy-6-(((4-undecyl-2-piperidinyl)carbonyl)amino)-1-thiomonohydrochloride (2S-cis)
  • Receptor, Serotonin, 5-HT2C
  • Stereoisomerism
  • Modulators
  • Serotonin
  21 Scopus citations
• 2013

  Peptide inhibitors disrupt the serotonin 5-HT_2C receptor interaction with phosphatase and tensin homolog to allosterically modulate cellular signaling and behavior

  Anastasio, N. C., Gilbertson, S. R., Bubar, M. J., Agarkov, A., Stutz, S. J., Jeng, Y., Bremer, N. M., Smith, T. D., Fox, R. G., Swinford, S. E., Seitz, P. K., Charendoff, M. N., Craft, J. W., Laezza, F. M., Watson, C. S., Briggs, J. M. & Cunningham, K. A., Jan 23 2013, In: Journal of Neuroscience. 33, 4, p. 1615-1630 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Receptor, Serotonin, 5-HT2C
  • Tensins
  • Phosphoric Monoester Hydrolases
  • Peptides
  • Serotonin
  27 Scopus citations
• 2018

  Innovative Therapeutic Intervention for Opioid Use Disorder

  Moeller, F. G. & Cunningham, K. A., Jan 1 2018, In: Neuropsychopharmacology. 43, 1, p. 220-221 2 p.

  Research output: Contribution to journal › Short survey › peer-review
  5 Scopus citations

• Special Issue on Precision Medicine for Brain Cancer in ACS Chemical Neuroscience

  Nilsson, C. L. & Cunningham, K. A., Jan 17 2018, In: ACS chemical neuroscience. 9, 1, p. 5 1 p.

  Research output: Contribution to journal › Editorial › peer-review
  2 Scopus citations
• 2013

  Effects of escitalopram on attentional bias to cocaine-related stimuli and inhibitory control in cocaine-dependent subjects

  Liu, S., Lane, S. D., Schmitz, J. M., Cunningham, K. A., John, V. P. & Moeller, F. G., Sep 2013, In: Journal of Psychopharmacology. 27, 9, p. 801-807 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Attentional Bias
  • Citalopram
  • Cocaine
  • Cues
  • Short-Term Memory
  10 Scopus citations
• 2020

  Serotonin neurobiology in cocaine use disorder

  Cunningham, K. A., Howell, L. L. & Anastasio, N. C., 2020, Handbook of Behavioral Neuroscience. Elsevier B.V., p. 745-802 58 p. (Handbook of Behavioral Neuroscience; vol. 31).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Neurobiology
  • Cocaine
  • Serotonin
  • Serotonin Receptors
  • Brain Diseases
• 2012

  Forced abstinence from cocaine self-administration is associated with DNA methylation changes in myelin genes in the corpus callosum: A preliminary study

  Nielsen, D. A., Huang, W., Hamon, S. C., Maili, L., Witkin, B. M., Fox, R. G., Cunningham, K. A. & Moeller, F. G., 2012, In: Frontiers in Psychiatry. 3, JUN, Article 60.

  Research output: Contribution to journal › Article › peer-review

  • Self Administration
  • Corpus Callosum
  • Myelin Sheath
  • DNA Methylation
  • Cocaine
  27 Scopus citations
• 2016

  Is There a causal relation between maternal acetaminophen administration and ADHD?

  Saad, A., Hegde, S., Kechichian, T., Gamble, P., Rahman, M., Stutz, S. J., Anastasio, N. C., Alshehri, W., Lei, J., Mori, S., Kajs, B., Cunningham, K. A., Saade, G., Burd, I. & Costantine, M., Jun 2016, In: PloS one. 11, 6, e0157380.

  Research output: Contribution to journal › Article › peer-review

  • acetaminophen
  • Acetaminophen
  • Attention Deficit Disorder with Hyperactivity
  • Mothers
  • mice
  4 Scopus citations

• Incubation of cocaine cue reactivity associates with neuroadaptations in the cortical serotonin (5-HT) 5-HT_2C receptor (5-HT_2CR) system

  Swinford-Jackson, S. E., Anastasio, N. C., Fox, R. G., Stutz, S. J. & Cunningham, K. A., Jun 2 2016, In: Neuroscience. 324, p. 50-61 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Receptor, Serotonin, 5-HT2C
  • Cocaine
  • Cues
  • Serotonin
  • Self Administration
  24 Scopus citations
• 2020

  Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT_2CReceptor-Positive Allosteric Modulators with Enhanced Drug-like Properties

  Wold, E. A., Garcia, E. J., Wild, C. T., Miszkiel, J. M., Soto, C. A., Chen, J., Pazdrak, K., Fox, R. G., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Jul 23 2020, In: Journal of medicinal chemistry. 63, 14, p. 7529-7544 16 p.

  Research output: Contribution to journal › Article › peer-review

  • 4-phenylpiperidine
  • Receptor, Serotonin, 5-HT2C
  • Serotonin
  • Pharmaceutical Preparations
  • Serotonin 5-HT2 Receptor Agonists
  2 Scopus citations
• 2018

  PPARγ agonism attenuates cocaine cue reactivity

  Miller, W. R., Fox, R. G., Stutz, S. J., Lane, S. D., Denner, L., Cunningham, K. A. & Dineley, K. T., Jan 2018, In: Addiction Biology. 23, 1, p. 55-68 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Peroxisome Proliferator-Activated Receptors
  • Cocaine
  • Cues
  • 2-chloro-5-nitrobenzanilide
  • Craving
  12 Scopus citations

• Biophysical validation of serotonin 5-HT_2A and 5-HT_2C receptor interaction

  Felsing, D. E., Anastasio, N. C., Miszkiel, J. M., Gilbertson, S. R., Allen, J. A. & Cunningham, K. A., Aug 2018, In: PloS one. 13, 8, e0203137.

  Research output: Contribution to journal › Article › peer-review

  • Receptor, Serotonin, 5-HT2C
  • Receptor, Serotonin, 5-HT2A
  • serotonin
  • Serotonin
  • receptors
  11 Scopus citations
• 2013

  Synergism between a serotonin 5-HT_2A receptor (5-HT _2AR) antagonist and 5-HT_2CR agonist suggests new pharmacotherapeutics for cocaine addiction

  Cunningham, K. A., Anastasio, N. C., Fox, R. G., Stutz, S. J., Bubar, M. J., Swinford, S. E., Watson, C. S., Gilbertson, S. R., Rice, K. C., Rosenzweig-Lipson, S. & Moeller, F. G., Jan 16 2013, In: ACS chemical neuroscience. 4, 1, p. 110-121 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Serotonin 5-HT2 Receptor Antagonists
  • Cocaine-Related Disorders
  • Cocaine
  • Receptor, Serotonin, 5-HT2A
  • Cues
  66 Scopus citations
• 2020

  Suppression of cocaine relapse-like behaviors upon pimavanserin and lorcaserin co-administration

  Anastasio, N. C., Sholler, D. J., Fox, R. G., Stutz, S. J., Merritt, C. R., Bjork, J. M., Moeller, F. G. & Cunningham, K. A., May 15 2020, In: Neuropharmacology. 168, 108009.

  Research output: Contribution to journal › Article › peer-review

  • pimavanserin
  • lorcaserin
  • Cocaine
  • Recurrence
  • Self Administration
  4 Scopus citations
• 2016

  Gamma-Aminobutyric Acidergic Projections From the Dorsal Raphe to the Nucleus Accumbens Are Regulated by Neuromedin U

  Kasper, J. M., McCue, D. L., Milton, A. J., Szwed, A., Sampson, C. M., Huang, M., Carlton, S., Meltzer, H. Y., Cunningham, K. A. & Hommel, J. D., Dec 1 2016, In: Biological Psychiatry. 80, 11, p. 878-887 10 p.

  Research output: Contribution to journal › Article › peer-review

  • neuromedin U
  • Dorsal Raphe Nucleus
  • Nucleus Accumbens
  • Cocaine
  • neuromedin U receptor
  12 Scopus citations
• 2013

  Serotonin2C receptors in the ventral pallidum regulate motor function in rats

  Graves, S. M., Viskniskki, A. A., Cunningham, K. A. & Celeste Napier, T., Aug 7 2013, In: NeuroReport. 24, 11, p. 605-608 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Basal Forebrain
  • Receptor, Serotonin, 5-HT2C
  • 6-chloro-2-(1-piperazinyl)pyrazine
  • Serotonin 5-HT2 Receptor Agonists
  • Serotonergic Neurons
  6 Scopus citations
• 2018

  Altered anterior cingulate cortex to hippocampus effective connectivity in response to drug cues in men with cocaine use disorder

  Ma, L., Steinberg, J. L., Cunningham, K. A., Bjork, J. M., Lane, S. D., Schmitz, J. M., Burroughs, T., Narayana, P. A., Kosten, T. R., Bechara, A. & Moeller, F. G., Jan 30 2018, In: Psychiatry Research - Neuroimaging. 271, p. 59-66 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Gyrus Cinguli
  • Cocaine
  • Cues
  • Hippocampus
  • Attentional Bias
  5 Scopus citations
• 2016

  Suppression of Cocaine-Evoked Hyperactivity by Self-Adjuvanting and Multivalent Peptide Nanofiber Vaccines

  Rudra, J. S., Ding, Y., Neelakantan, H., Ding, C., Appavu, R., Stutz, S., Snook, J. D., Chen, H., Cunningham, K. A. & Zhou, J., May 18 2016, In: ACS chemical neuroscience. 7, 5, p. 546-552 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Nanofibers
  • Subunit Vaccines
  • Cocaine
  • Vaccines
  • Haptens
  23 Scopus citations
• 2020

  Fentanyl self-administration impacts brain immune responses in male Sprague-Dawley rats

  Ezeomah, C., Cunningham, K. A., Stutz, S. J., Fox, R. G., Bukreyeva, N., Dineley, K. T., Paessler, S. & Cisneros, I. E., Jul 2020, In: Brain, Behavior, and Immunity. 87, p. 725-738 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Self Administration
  • Fentanyl
  • Interferons
  • Sprague Dawley Rats
  • Brain
  1 Scopus citations
• 2018

  Cocaine evokes a profile of oxidative stress and impacts innate antiviral response pathways in astrocytes

  Cisneros, I. E., Erdenizmenli, M., Cunningham, K. A., Paessler, S. & Dineley, K. T., Jun 2018, In: Neuropharmacology. 135, p. 431-443 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Cocaine
  • Astrocytes
  • Antiviral Agents
  • Oxidative Stress
  • Zika Virus
  7 Scopus citations
• 2013

  Elevated expression of serotonin 5-HT_2A receptors in the rat ventral tegmental area enhances vulnerability to the behavioral effects of cocaine

  Herin, D. V., Bubar, M. J., Seitz, P. K., Thomas, M. L., Hillman, G. R., Tarasenko, Y. I., Wu, P. & Cunningham, K. A., May 17 2013, In: Frontiers in Psychiatry. 4, FEB, Article 2.

  Research output: Contribution to journal › Article › peer-review

  • Receptor, Serotonin, 5-HT2A
  • Ventral Tegmental Area
  • Cocaine
  • Locomotion
  • Parvovirus
  10 Scopus citations
• 2018

  Serotonin 5-HT_2C receptor activation suppresses binge intake and the reinforcing and motivational properties of high-fat food

  Price, A. E., Anastasio, N. C., Stutz, S. J., Hommel, J. D. & Cunningham, K. A., Jul 27 2018, In: Frontiers in Pharmacology. 9, JUL, 821.

  Research output: Contribution to journal › Article › peer-review

  • Receptor, Serotonin, 5-HT2C
  • 1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta(b)(1,4)diazepino(6,7,1hj)indole
  • Binge-Eating Disorder
  • Fats
  • Food
  10 Scopus citations

• A protocol for measuring cue reactivity in a rat model of cocaine use disorder

  Dimet, A. L., Cisneros, I. E., Fox, R. G., Stutz, S. J., Anastasio, N. C., Cunningham, K. A. & Dineley, K. T., Jun 20 2018, In: Journal of Visualized Experiments. 2018, 136, e55864.

  Research output: Contribution to journal › Article › peer-review

  • Rats
  • Cocaine
  • Cues
  • Drug therapy
  • Self Administration
  4 Scopus citations
• 2012

  Influence of methamphetamine on genital herpes simplex virus type 2 infection in a mouse model

  Valencia, F., Bubar, M. J., Milligan, G., Cunningham, K. A. & Bourne, N., Sep 2012, In: Sexually Transmitted Diseases. 39, 9, p. 720-725 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Herpes Genitalis
  • Methamphetamine
  • Herpes Simplex
  • Cytokines
  • Sexually Transmitted Diseases
  10 Scopus citations
• 2013

  Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP Isoform 1

  Yan, J., Mei, F. C., Cheng, H., Lao, D. H., Hu, Y., Wei, J., Patrikeev, I., Hao, D., Stutz, S. J., Dineley, K. T., Motamedi, M., Hommel, J. D., Cunningham, K. A., Chen, J. & Cheng, X., Mar 2013, In: Molecular and cellular biology. 33, 5, p. 918-926 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Adiposity
  • Leptin
  • Cyclic AMP
  • Protein Isoforms
  • Homeostasis
  59 Scopus citations
• 2020

  Discovery of Potent and Brain-Penetrant GPR52 Agonist that Suppresses Psychostimulant Behavior

  Wang, P., Felsing, D., Chen, H., Stutz, S. J., Murphy, R., Cunningham, K., Allen, J. & Zhou, J., Nov 25 2020, In: Journal of Medicinal Chemistry. 63, 22, p. 13951 13972 p.

  Research output: Contribution to journal › Article › peer-review

  • G-Protein-Coupled Receptors
  • Brain
  • Proof of Concept Study
  • Structure-Activity Relationship
  • Central Nervous System Diseases
• 2018

  Editors' Favorites of 2017

  Lindsley, C. W., Cunningham, K. A., Hooker, J. M. & Andrews, A. M., Jan 17 2018, In: ACS chemical neuroscience. 9, 1, p. 1-4 4 p.

  Research output: Contribution to journal › Review article › peer-review
  1 Scopus citations

• Novel Bivalent 5-HT _2A Receptor Antagonists Exhibit High Affinity and Potency in Vitro and Efficacy in Vivo

  Soto, C. A., Shashack, M. J., Fox, R. G., Bubar, M. J., Rice, K. C., Watson, C. S., Cunningham, K. A., Gilbertson, S. R. & Anastasio, N. C., Mar 21 2018, In: ACS chemical neuroscience. 9, 3, p. 514-521 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Receptor, Serotonin, 5-HT2A
  • Serotonin
  • In Vitro Techniques
  • volinanserin
  • Ligands
  8 Scopus citations
• 2012

  Quantitative changes in intracellular calcium and extracellular-regulated kinase activation measured in parallel in CHO cells stably expressing serotonin (5-HT) 5-HT _2A or 5-HT _2C receptors

  Seitz, P. K., Bremer, N. M., McGinnis, A. G., Cunningham, K. A. & Watson, C. S., Mar 7 2012, In: BMC Neuroscience. 13, 1, 25.

  Research output: Contribution to journal › Article › peer-review

  • Receptor, Serotonin, 5-HT2C
  • CHO Cells
  • Serotonin
  • Phosphotransferases
  • Calcium
  19 Scopus citations
• 2020

  Editorial: Contemporary Perspective on 5-HT_2C Receptor Function and Its Pharmacological Targeting

  De Deurwaerdère, P., Chagraoui, A. & Cunningham, K. A., Nov 23 2020, In: Frontiers in Pharmacology. 11, 606414.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access
• 2012

  Increased intra-individual reaction time variability in cocaine-dependent subjects: Role of cocaine-related cues

  Liu, S., Lane, S. D., Schmitz, J. M., Green, C. E., Cunningham, K. A. & Moeller, F. G., Feb 2012, In: Addictive Behaviors. 37, 2, p. 193-197 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Cocaine
  • Reaction Time
  • Cues
  • Stroop Test
  • Electronic Data Processing
  15 Scopus citations