Find Research Outputs — UTMB Health Research Expert Profiles

2015

Whole transcriptome analysis reveals a role for OGG1-initiated DNA repair signaling in airway remodeling

Aguilera-Aguirre, L., Hosoki, K., Bacsi, A., Radák, Z., Sur, S., Hegde, M. L., Tian, B., Saavedra-Molina, A., Brasier, A. R., Ba, X. & Boldogh, I., Dec 1 2015, In: Free Radical Biology and Medicine. 89, p. 20-33 14 p.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

2018

Excision release of 5?hydroxycytosine oxidatively induced DNA base lesions from the lung genome by cat dander extract challenge stimulates allergic airway inflammation

Hosoki, K., Jaruga, P., Itazawa, T., Aguilera-Aguirre, L., Coskun, E., Hazra, T. K., Boldogh, I., Dizdaroglu, M. & Sur, S., Dec 2018, In: Clinical and Experimental Allergy. 48, 12, p. 1676-1687 12 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

2012

Modulatory effects of low-dose hydrogen peroxide on the function of human plasmacytoid dendritic cells

Pazmandi, K., Magyarics, Z., Boldogh, I., Csillag, A., Rajnavolgyi, E. & Bacsi, A., Feb 1 2012, In: Free Radical Biology and Medicine. 52, 3, p. 635-645 11 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

2018

Effects of the stimuli-dependent enrichment of 8-oxoguanine DNA glycosylase1 on chromatinized DNA

Hao, W., Qi, T., Pan, L., Wang, R., Zhu, B., Aguilera-Aguirre, L., Radak, Z., Hazra, T. K., Vlahopoulos, S. A., Bacsi, A., Brasier, A. R., Ba, X. & Boldogh, I., Sep 2018, In: Redox Biology. 18, p. 43-53 11 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

2014

Eating habits modulate short term memory and epigenetical regulation of brain derived neurotrophic factor in hippocampus of low- and high running capacity rats

Torma, F., Bori, Z., Koltai, E., Felszeghy, K., Vacz, G., Koch, L., Britton, S., Boldogh, I. & Radak, Z., Aug 2014, In: Brain Research Bulletin. 107, p. 54-60 7 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

2017

Erratum: PARP1 promotes gene expression at the post-transcriptional level by modulating the RNA-binding protein HuR

Ke, Y., Han, Y., Guo, X., Wen, J., Wang, K., Jiang, X., Tian, X., Ba, X., Boldogh, I. & Zeng, X., Mar 31 2017, In: Nature communications. 8, p. 15191 1 p., 15191.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

2014

Histological evidence of oxidative stress and premature senescence in preterm premature rupture of the human fetal membranes recapitulated in vitro

Menon, R., Boldogh, I., Hawkins, H. K., Woodson, M., Polettini, J., Syed, T. A., Fortunato, S. J., Saade, G. R., Papaconstantinou, J. & Taylor, R. N., Jun 2014, In: American Journal of Pathology. 184, 6, p. 1740-1751 12 p.

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

The role of 8-oxoguanine DNA glycosylase-1 in inflammation

Ba, X., Aguilera-Aguirre, L., Rashid, Q. T. A. N., Bacsi, A., Radak, Z., Sur, S., Hosoki, K., Hegde, M. L. & Boldogh, I., Sep 23 2014, In: International journal of molecular sciences. 15, 9, p. 16975-16997 23 p.

Research output: Contribution to journal › Review article › peer-review

52 Scopus citations

2017

Innate mechanism of pollen- and cat dander–induced oxidative stress and DNA damage in the airways

Hosoki, K., Redding, D., Itazawa, T., Chakraborty, A., Tapryal, N., Qian, S., Qi, H., Aguilera-Aguirre, L., Brasier, A. R., Phani, V. S., Hazra, T. K., Boldogh, I. & Sur, S., Nov 2017, In: Journal of Allergy and Clinical Immunology. 140, 5, p. 1436-1439.e5

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

2014

Systems biology approaches to understanding epithelial mesenchymal transition (EMT) in mucosal remodeling and signaling in asthma

Ijaz, T., Pazdrak, K., Kalita, M., Konig, R., Choudhary, S., Tian, B., Boldogh, I. & Brasier, A. R., Jun 2 2014, In: World Allergy Organization Journal. 7, 1, 13.

Research output: Contribution to journal › Review article › peer-review

55 Scopus citations

2012

Hypolipidemic activity of eryngium carlinae on streptozotocin-induced diabetic rats

Noriega-Cisneros, R., Ortiz-Vila, O., Esquivel-Gutiérrez, E., Clemente-Guerrero, M., Manzo-Avalos, S., Salgado-Garciglia, R., Cortés-Rojo, C., Boldogh, I. & Saavedra-Molina, A., 2012, In: Biochemistry Research International. 603501.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

2015

BRG1 promotes the repair of DNA double-strand breaks by facilitating the replacement of RPA with RAD51

Qi, W., Wang, R., Chen, H., Wang, X., Xiao, T., Boldogh, I., Ba, X., Han, L. & Zeng, X., 2015, In: Journal of Cell Science. 128, 2, p. 317-330 14 p.

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

2012

Ragweed Subpollen Particles of Respirable Size Activate Human Dendritic Cells

Pazmandi, K., Kumar, B. V., Szabo, K., Boldogh, I., Szoor, A., Vereb, G., Veres, A., Lanyi, A., Rajnavolgyi, E. & Bacsi, A., Dec 14 2012, In: PloS one. 7, 12, e52085.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

2017

Pollen-induced oxidative DNA damage response regulates miRNAs controlling allergic inflammation

Aguilera-Aguirre, L., Hao, W., Pan, L., Li, X., Saavedra-Molina, A., Bacsi, A., Radak, Z., Sur, S., Brasier, A. R., Ba, X. & Boldogh, I., Dec 2017, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 313, 6, p. L1058-L1068

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

2020

Enzymatically inactive OGG1 binds to DNA and steers base excision repair toward gene transcription

Hao, W., Wang, J., Zhang, Y., Wang, C., Xia, L., Zhang, W., Zafar, M., Kang, J. Y., Wang, R., Ali Bohio, A., Pan, L., Zeng, X., Wei, M., Boldogh, I. & Ba, X., Jun 1 2020, In: FASEB Journal. 34, 6, p. 7427-7441 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2015

The C-terminal domain (CTD) of human DNA glycosylase NEIL1 is required for forming BERosome repair complex with DNA replication proteins at the replicating genome: Dominant negative function of the CTD

Hegde, P. M., Dutta, A., Sengupta, S., Mitra, J., Adhikari, S., Tomkinson, A. E., Li, G. M., Boldogh, I., Hazra, T. K., Mitra, S. & Hegde, M. L., Aug 21 2015, In: Journal of Biological Chemistry. 290, 34, p. 20919-20933 15 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

2014

Exposure to inhomogeneous static magnetic field beneficially affects allergic inflammation in a murine model

Csillag, A., Kumar, B. V., Szabó, K., Szilasi, M., Papp, Z., Szilasi, M. E., Pázmándi, K., Boldogh, I., Rajnavölgyi, É., Bácsi, A. & László, J. F., Jun 6 2014, In: Journal of the Royal Society Interface. 11, 95, 20140097.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

2017

OGG1-DNA interactions facilitate NF-k B binding to DNA targets

Pan, L., Hao, W., Zheng, X., Zeng, X., Ahmed Abbasi, A., Boldogh, I. & Ba, X., Mar 7 2017, In: Scientific reports. 7, 43297.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

2012

Enhancement of NEIL1 protein-initiated oxidized DNA base excision repair by heterogeneous nuclear ribonucleoprotein U (hnRNP-U) via direct interaction

Hegde, M. L., Banerjee, S., Hegde, P. M., Bellot, L. J., Hazra, T. K., Boldogh, I. & Mitra, S., Oct 5 2012, In: Journal of Biological Chemistry. 287, 41, p. 34202-34211 10 p.

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

2020

Exercise, redox system and neurodegenerative diseases

Quan, H., Koltai, E., Suzuki, K., Aguiar, A. S., Pinho, R., Boldogh, I., Berkes, I. & Radak, Z., Oct 1 2020, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1866, 10, 165778.

Research output: Contribution to journal › Review article › peer-review

Open Access

Poly(ADP-ribosyl)ation enhances HuR oligomerization and contributes to pro-inflammatory gene mRNA stabilization

Ke, Y., Lv, X., Fu, X., Zhang, J., Bohio, A. A., Zeng, X., Hao, W., Wang, R., Boldogh, I. & Ba, X., 2020, (Accepted/In press) In: Cellular and Molecular Life Sciences.

Research output: Contribution to journal › Article › peer-review

Open Access

2017

SIRT1 may play a crucial role in overload-induced hypertrophy of skeletal muscle

Koltai, E., Bori, Z., Chabert, C., Dubouchaud, H., Naito, H., Machida, S., Davies, K. J. A., Murlasits, Z., Fry, A. C., Boldogh, I. & Radak, Z., Jun 1 2017, In: Journal of Physiology. 595, 11, p. 3361-3376 16 p.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

2014

Exercise increases markers of spermatogenesis in rats selectively bred for low running capacity

Torma, F., Koltai, E., Nagy, E., Ziaaldini, M. M., Posa, A., Koch, L. G., Britton, S. L., Boldogh, I. & Radak, Z., Dec 10 2014, In: PloS one. 9, 12, e11407.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

2018

The roles of base excision repair enzyme OGG1 in gene expression

Wang, R., Hao, W., Pan, L., Boldogh, I. & Ba, X., Oct 1 2018, In: Cellular and Molecular Life Sciences. 75, 20, p. 3741-3750 10 p.

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

2014

Expression of 8-oxoguanine Glycosylase in Human Fetal Membranes

Menon, R., Polettini, J., Syed, T. A., Saade, G. R. & Boldogh, I., Jan 1 2014, In: American Journal of Reproductive Immunology. 72, 1, p. 75-84 10 p.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

2015

Neil2-null mice accumulate oxidized DNA bases in the transcriptionally active sequences of the genome and are susceptible to innate inflammation

Chakraborty, A., Wakamiya, M., Venkova-Canova, T., Pandita, R. K., Aguilera-Aguirre, L., Sarker, A. H., Singh, D. K., Hosoki, K., Wood, T. G., Sharma, G., Cardenas, V., Sarkar, P. S., Sur, S., Pandita, T. K., Boldogh, I. & Hazra, T. K., Oct 9 2015, In: Journal of Biological Chemistry. 290, 41, p. 24636-24648 13 p.

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

2012

Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2

Dey, S., Maiti, A. K., Hegde, M. L., Hegde, P. M., Boldogh, I., Sarkar, P. S., Abdel-Rahman, S. Z., Sarker, A. H., Hang, B., Xie, J., Tomkinson, A. E., Zhou, M., Shen, B., Wang, G., Wu, C., Yu, D., Lin, D., Cardenas, V. & Hazra, T. K., Jun 1 2012, In: DNA Repair. 11, 6, p. 570-578 9 p.

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

2015

17-beta estradiol inhibits oxidative stress-induced accumulation of AIF into nucleolus and PARP1-dependent cell death via estrogen receptor alpha

Batnasan, E., Wang, R., Wen, J., Ke, Y., Li, X., Bohio, A. A., Zeng, X., Huo, H., Han, L., Boldogh, I. & Ba, X., Jan 5 2015, In: Toxicology Letters. 232, 1, p. 1-9 9 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

2012

Alternaria-induced release of IL-18 from damaged airway epithelial cells: An NF-κB dependent mechanism of Th2 differentiation?

Murai, H., Qi, H., Choudhury, B., Wild, J., Dharajiya, N., Vaidya, S., Kalita, A., Bacsi, A., Corry, D., Kurosky, A., Brasier, A., Boldogh, I. & Sur, S., Feb 7 2012, In: PloS one. 7, 2, e30280.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

2015

Mitochondrial biogenesis-associated factors underlie the magnitude of response to aerobic endurance training in rats

Marton, O., Koltai, E., Takeda, M., Koch, L. G., Britton, S. L., Davies, K. J. A., Boldogh, I. & Radak, Z., Jan 1 2015, In: Pflugers Archiv European Journal of Physiology. 467, 4, p. 779-788 10 p.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

2017

Exercise, oxidants, and antioxidants change the shape of the bell-shaped hormesis curve

Radak, Z., Ishihara, K., Tekus, E., Varga, C., Posa, A., Balogh, L., Boldogh, I. & Koltai, E., Aug 1 2017, In: Redox Biology. 12, p. 285-290 6 p.

Research output: Contribution to journal › Short survey › peer-review

64 Scopus citations

2014

8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and α-smooth muscle actin polymerization

Luo, J., Hosoki, K., Bacsi, A., Radak, Z., Hegde, M. L., Sur, S., Hazra, T. K., Brasier, A. R., Ba, X. & Boldogh, I., Aug 2014, In: Free Radical Biology and Medicine. 73, p. 430-438 9 p.

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

2015

8-Oxoguanine DNA glycosylase-1-driven DNA base excision repair: Role in asthma pathogenesis

Ba, X., Aguilera-Aguirre, L., Sur, S. & Boldogh, I., Feb 13 2015, In: Current opinion in allergy and clinical immunology. 15, 1, p. 89-97 9 p.

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

2014

NEIL2 Protects against Oxidative DNA damage induced by sidestream smoke in human cells

Sarker, A. H., Chatterjee, A., Williams, M., Lin, S., Havel, C., Jacob, P., Boldogh, I., Hazra, T. K., Talbot, P. & Hang, B., Mar 3 2014, In: PloS one. 9, 3, e90261.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

2017

Regulation of type I interferon responses by mitochondria-derived reactive oxygen species in plasmacytoid dendritic cells

Agod, Z., Fekete, T., Budai, M. M., Varga, A., Szabo, A., Moon, H., Boldogh, I., Biro, T., Lanyi, A., Bacsi, A. & Pazmandi, K., Oct 2017, In: Redox Biology. 13, p. 633-645 13 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

2012

Human DNA glycosylase NEIL1's interactions with downstream repair proteins is critical for efficient repair of oxidized DNA base damage and enhanced cell survival

Hegde, M. L., Hegde, P. M., Arijit, D., Boldogh, I. & Mitra, S., Dec 2012, In: Biomolecules. 2, 4, p. 564-578 15 p.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

2014

Innate inflammation induced by the 8-oxoguanine DNA glycosylase-1-KRAS-NF-κB pathway

Aguilera-Aguirre, L., Bacsi, A., Radak, Z., Hazra, T. K., Mitra, S., Sur, S., Brasier, A. R., Ba, X. & Boldogh, I., Nov 1 2014, In: Journal of Immunology. 193, 9, p. 4643-4653 11 p.

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Oxidative modification enhances the immunostimulatory effects of extracellular mitochondrial DNA on plasmacytoid dendritic cells

Pazmandi, K., Agod, Z., Kumar, B. V., Szabo, A., Fekete, T., Sogor, V., Veres, A., Boldogh, I., Rajnavolgyi, E., Lanyi, A. & Bacsi, A., 2014, In: Free Radical Biology and Medicine. 77, p. 281-290 10 p.

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

2015

Analysis of a panel of 48 cytokines in BAL fluids specifically identifies IL-8 levels as the only cytokine that distinguishes controlled asthma from uncontrolled asthma, and correlates inversely with FEV₁

Hosoki, K., Ying, S., Corrigan, C., Qi, H., Kurosky, A., Jennings, K., Sun, Q., Boldogh, I. & Sur, S., May 2015, In: PloS one. 10, 5, e0126035.

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

2012

Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3′-phosphatase in maintenance of mitochondrial genome

Mandal, S. M., Hegde, M. L., Chatterjee, A., Hegde, P. M., Szczesny, B., Banerjee, D., Boldogh, I., Gao, R., Falkenberg, M., Gustafsson, C. M., Sarkar, P. S. & Hazra, T. K., Jan 20 2012, In: Journal of Biological Chemistry. 287, 4, p. 2819-2829 11 p.

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

2014

8-Oxoguanine DNA glycosylase-1 augments proinflammatory gene expression by facilitating the recruitment of site-specific transcription factors

Ba, X., Bacsi, A., Luo, J., Aguilera-Aguirre, L., Zeng, X., Radak, Z., Brasier, A. R. & Boldogh, I., Mar 1 2014, In: Journal of Immunology. 192, 5, p. 2384-2394 11 p.

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

2015

The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis

Chatterjee, A., Saha, S., Chakraborty, A., Silva-Fernandes, A., Mandal, S. M., Neves-Carvalho, A., Liu, Y., Pandita, R. K., Hegde, M. L., Hegde, P. M., Boldogh, I., Ashizawa, T., Koeppen, A. H., Pandita, T. K., Maciel, P., Sarkar, P. S. & Hazra, T. K., 2015, In: PLoS genetics. 11, 1, e1004749.

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

2012

Biochemical identification of a hydroperoxide derivative of the free 8-oxo-7,8-dihydroguanine base

Hajas, G., Bacsi, A., Aguilerra-Aguirre, L., German, P., Radak, Z., Sur, S., Hazra, T. K. & Boldogh, I., Feb 15 2012, In: Free Radical Biology and Medicine. 52, 4, p. 749-756 8 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

2014

New perspectives on oxidized genome damage and repair inhibition by pro-oxidant metals in neurological diseases

Mitra, J., Guerrero, E. N., Hegde, P. M., Wang, H., Boldogh, I., Rao, K. S., Mitra, S. & Hegde, M. L., Sep 1 2014, In: Biomolecules. 4, 3, p. 678-703 26 p.

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

2015

Genetic Evidence for XPC-KRAS Interactions During Lung Cancer Development

Zhang, X., He, N., Gu, D., Wickliffe, J., Salazar, J., Boldogh, I. & Xie, J., Oct 20 2015, In: Journal of Genetics and Genomics. 42, 10, p. 589-596 8 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Dynamic aberrant NF-κB spurs tumorigenesis: A new model encompassing the microenvironment

Vlahopoulos, S. A., Cen, O., Hengen, N., Agan, J., Moschovi, M., Critselis, E., Adamaki, M., Bacopoulou, F., Copland, J. A., Boldogh, I., Karin, M. & Chrousos, G. P., Aug 1 2015, In: Cytokine and Growth Factor Reviews. 26, 4, p. 389-403 15 p.

Research output: Contribution to journal › Review article › peer-review

57 Scopus citations

2018

OGG1-initiated base excision repair exacerbates oxidative stress-induced parthanatos

Wang, R., Li, C., Qiao, P., Xue, Y., Zheng, X., Chen, H., Zeng, X., Liu, W., Boldogh, I. & Ba, X., Jun 1 2018, In: Cell Death and Disease. 9, 6, 628.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

2014

Effects of diabetes on oxidative and nitrosative stress in kidney mitochondria from aged rats

Pérez-Gallardo, R. V., Noriega-Cisneros, R., Esquivel-Gutiérrez, E., Calderón-Cortés, E., Cortés-Rojo, C., Manzo-Avalos, S., Campos-García, J., Salgado-Garciglia, R., Montoya-Pérez, R., Boldogh, I. & Saavedra-Molina, A., Dec 9 2014, In: Journal of Bioenergetics and Biomembranes. 46, 6, p. 511-518 8 p.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

2017

8-Oxoguanine DNA glycosylase1–driven DNA repair—A paradoxical role in lung aging

German, P., Saenz, D., Szaniszlo, P., Aguilera-Aguirre, L., Pan, L., Hegde, M. L., Bacsi, A., Hajas, G., Radak, Z., Ba, X., Mitra, S., Papaconstantinou, J. & Boldogh, I., Jan 1 2017, In: Mechanisms of Ageing and Development. 161, p. 51-65 15 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

2012

The effects of aging, physical training, and a single bout of exercise on mitochondrial protein expression in human skeletal muscle

Bori, Z., Zhao, Z., Koltai, E., Fatouros, I. G., Jamurtas, A. Z., Douroudos, I. I., Terzis, G., Chatzinikolaou, A., Sovatzidis, A., Draganidis, D., Boldogh, I. & Radak, Z., Jun 2012, In: Experimental Gerontology. 47, 6, p. 417-424 8 p.

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

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