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• Disclosures Undisclosed

  Janney, C. F., Shazadeh Safavi, K., Schneider, G. J., Jupiter, D. C. & Panchbhavi, V. K., Jun 5 2019, In: Journal of Bone and Joint Surgery - American Volume. 101, 11, e50.

  Research output: Contribution to journal › Article › peer-review

  • Disclosure
  • Conflict of Interest
  • Authorship
  • Physicians
  • Databases
  4 Scopus citations

• Discontinuous propagation: an hypothesis based on known cardiac structural complexities

  Spach, M. S., Dolber, P. C. & Sommer, J. R., Feb 1985, In: International Journal of Cardiology. 7, 2, p. 167-174 8 p.

  Research output: Contribution to journal › Comment/debate › peer-review
  17 Scopus citations

• Discontinuous transcription generates heterogeneity at the leader fusion sites of coronavirus mRNAs

  Makino, S., Soe, L. H., Shieh, C. K. & Lai, M. M. C., 1988, In: Journal of virology. 62, 10, p. 3870-3873 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Coronavirinae
  • Coronavirus
  • transcription (genetics)
  • RNA
  • Messenger RNA
  43 Scopus citations

• Discordant bilateral bronchoalveolar lavage findings in a patient with acute eosinophilic pneumonia associated with counterfeit tetrahydrocannabinol oil vaping

  Puebla Neira, D., Tambra, S., Bhasin, V., Nawgiri, R. & Duarte, A. G., 2020, In: Respiratory Medicine Case Reports. 29, 101015.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Vaping
  • Pulmonary Eosinophilia
  • Dronabinol
  • Bronchoalveolar Lavage
  • Oils
  2 Scopus citations

• Discordant effects of guanidines on renal structure and function and on regional vascular dysfunction and collagen changes in diabetic rats

  Nyengaard, J. R., Chang, K., Berhorst, S., Reiser, K. M., Williamson, J. R. & Tilton, R. G., Jan 1997, In: Diabetes. 46, 1, p. 94-106 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Guanidines
  • Collagen
  • pimagedine
  • Blood Vessels
  • Albumins
  44 Scopus citations

• Discordant effects of nisoldipine on coronary vascular resistance and permeability changes during reflow after ischemia in isolated rabbit hearts

  Tilton, R. G., Watts, J. A., Land, M. P., Larson, K. B., Sutera, S. P. & Williamson, J. R., Jul 1991, In: Journal of Molecular and Cellular Cardiology. 23, 7, p. 861-872 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Nisoldipine
  • Capillary Permeability
  • Ischemia
  • Rabbits
  • Heart
  5 Scopus citations

• Discordant effects of the aldose resuctase inhibitor, sorbinil, on vascular structure and function in chronically diabetic and galactosemic rats

  Tilton, R. G., Pugliese, G., LaRose, L. S., Faller, A. M., Chang, K., Province, M. A. & Williamson, J. R., 1991, In: Journal of Diabetic Complications. 5, 4, p. 230-237 8 p.

  Research output: Contribution to journal › Article › peer-review

  • sorbinil
  • Blood Vessels
  • Galactose
  • Albumins
  • Galactosemias
  25 Scopus citations

• Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma

  Decarvalho, A. C., Kim, H., Poisson, L. M., Winn, M. E., Mueller, C., Cherba, D., Koeman, J., Seth, S., Protopopov, A., Felicella, M., Zheng, S., Multani, A., Jiang, Y., Zhang, J., Nam, D. H., Petricoin, E. F., Chin, L., Mikkelsen, T. & Verhaak, R. G. W., May 1 2018, In: Nature Genetics. 50, 5, p. 708-717 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Extrachromosomal Inheritance
  • Glioblastoma
  • DNA
  • Inheritance Patterns
  • Heterologous Transplantation
  72 Scopus citations

• Discovering hidden relationships between renal diseases and regulated genes through 3D network visualizations

  Bhavnani, S. K., Ganesan, A., Hall, T., Maslowski, E., Eichinger, F., Martini, S., Saxman, P., Bellala, G. & Kretzler, M., 2010, In: BMC Research Notes. 3, 296.

  Research output: Contribution to journal › Article › peer-review

  • Genes
  • Visualization
  • Kidney
  • Gene expression
  • Chronic Renal Insufficiency
  9 Scopus citations

• Discovery and characterization of a novel CCND1/MRCK gene fusion in mantle cell lymphoma

  Masamha, C. P., Albrecht, T. R. & Wagner, E. J., 2016, In: Journal of Hematology and Oncology. 9, 1, 30.

  Research output: Contribution to journal › Article › peer-review

  • Mantle-Cell Lymphoma
  • Myotonic Dystrophy
  • Gene Fusion
  • Cyclin D1
  • Phosphotransferases
  6 Scopus citations

• Discovery and Characterization of Human Amniochorionic Membrane Microfractures

  Richardson, L. S., Vargas, G., Brown, T., Ochoa, L., Sheller-Miller, S., Saade, G. R., Taylor, R. N. & Menon, R., Dec 2017, In: American Journal of Pathology. 187, 12, p. 2821-2830 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Stress Fractures
  • Membranes
  • Preterm Premature Rupture of the Membranes
  • Oxidative Stress
  • Premature Birth
  25 Scopus citations

• Discovery and development of natural product oridonin-inspired anticancer agents

  Ding, Y., Ding, C., Ye, N., Liu, Z., Wold, E. A., Chen, H., Wild, C., Shen, Q. & Zhou, J., 2016, In: European journal of medicinal chemistry. 122, p. 102-117 16 p.

  Research output: Contribution to journal › Review article › peer-review

  • oridonin
  • Biological Products
  • Antineoplastic Agents
  • HAO472
  • Pharmaceutical Chemistry
  87 Scopus citations

• Discovery and Pharmacological Evaluation of STEAP4 as a Novel Target for HER2 Overexpressing Breast Cancer

  Orfanou, I. M., Argyros, O., Papapetropoulos, A., Tseleni-Balafouta, S., Vougas, K. & Tamvakopoulos, C., Mar 26 2021, In: Frontiers in Oncology. 11, 608201.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pharmacology
  • Breast Neoplasms
  • Lapatinib
  • Proteomics
  • Breast

• Discovery and Verification of Extracellular miRNA Biomarkers for Non-invasive Prediction of Pre-eclampsia in Asymptomatic Women

  The PAPR Study Consortium, May 19 2020, In: Cell Reports Medicine. 1, 2, 100013.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Biomarkers
  • Pre-Eclampsia
  • MicroRNAs
  • Mothers
  • Serum
  3 Scopus citations

• Discovery of 2,4-diarylaminopyrimidine SOMCL-12-81 as a potent inhibitor targeting both wild and mutant ALK kinases

  Song, Z., Ai, J., Liu, Z., Peng, X., Chen, Y., Ding, J., Geng, M. & Zhang, A., 2013.

  Research output: Contribution to conference › Abstract

• Discovery of 4-benzoyl-1-[(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2-(R) -methylpiperazine (BMS-378806): A novel HIV-1 attachment inhibitor that interferes with CD4-gp120 interactions

  Wang, T., Zhang, Z., Wallace, O. B., Deshpande, M., Fang, H., Yang, Z., Zadjura, L. M., Tweedie, D. L., Huang, S., Zhao, F., Ranadive, S., Robinson, B. S., Gong, Y. F., Ricarrdi, K., Spicer, T. P., Deminie, C., Rose, R., Wang, H. G. H., Blair, W. S., Shi, P. Y. & 3 others, Lin, P. F., Colonno, R. J. & Meanwell, N. A., Sep 25 2003, In: Journal of Medicinal Chemistry. 46, 20, p. 4236-4239 4 p.

  Research output: Contribution to journal › Article › peer-review

  • BMS-378806
  • 7-azaindole dimer
  • Human Immunodeficiency Virus Proteins
  • indole
  • CD4 Antigens
  189 Scopus citations

• Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT_2CReceptor-Positive Allosteric Modulators with Enhanced Drug-like Properties

  Wold, E. A., Garcia, E. J., Wild, C. T., Miszkiel, J. M., Soto, C. A., Chen, J., Pazdrak, K., Fox, R. G., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Jul 23 2020, In: Journal of medicinal chemistry. 63, 14, p. 7529-7544 16 p.

  Research output: Contribution to journal › Article › peer-review

  • 4-phenylpiperidine
  • Receptor, Serotonin, 5-HT2C
  • Serotonin
  • Pharmaceutical Preparations
  • Serotonin 5-HT2 Receptor Agonists
  2 Scopus citations

• Discovery of Adamantane Carboxamides as Ebola Virus Cell Entry and Glycoprotein Inhibitors

  Plewe, M. B., Sokolova, N. V., Gantla, V. R., Brown, E. R., Naik, S., Fetsko, A., Lorimer, D. D., Lorimer, D. D., Dranow, D. M., Dranow, D. M., Smutney, H., Smutney, H., Bullen, J., Bullen, J., Sidhu, R., Sidhu, R., Master, A., Master, A., Wang, J., Wang, J. & 6 others, Kallel, E. A., Zhang, L., Kalveram, B., Freiberg, A. N., Henkel, G. & McCormack, K., Jun 11 2020, In: ACS Medicinal Chemistry Letters. 11, 6, p. 1160-1167 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Adamantane
  • Ebolavirus
  • Virus Internalization
  • Viruses
  • Glycoproteins
  2 Scopus citations

• Discovery of an antibody for pan-ebolavirus therapy

  Furuyama, W., Marzi, A., Nanbo, A., Haddock, E., Maruyama, J., Miyamoto, H., Igarashi, M., Yoshida, R., Noyori, O., Feldmann, H. & Takada, A., Feb 10 2016, In: Scientific reports. 6, 20514.

  Research output: Contribution to journal › Article › peer-review

  • Ebolavirus
  • Antibodies
  • Neutralizing Antibodies
  • Monoclonal Antibodies
  • Western Africa
  64 Scopus citations

• Discovery of a novel B-raf fusion protein related to c-met drug resistance

  Dillon, R., Nilsson, C. L., Shi, S. D. H., Lee, N. V., Krastins, B. & Greig, M. J., Nov 4 2011, In: Journal of Proteome Research. 10, 11, p. 5084-5094 11 p.

  Research output: Contribution to journal › Article › peer-review

  • 2-(4-(3-quinolin-6-ylmethyl-3H-(1,2,3)triazolo(4,5-b)pyrazin-5-yl)pyrazol-1-yl)ethanol
  • Mass spectrometry
  • Drug Resistance
  • Mass Spectrometry
  • Fusion reactions
  14 Scopus citations

• Discovery of a novel dopamine transporter inhibitor, 4-hydroxy-1-methyl- 4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone, as a potential cocaine antagonist through 3D-database pharmacophore searching. Molecular modeling, structure - Activity relationships, and behavioral pharmacological studies

  Wang, S., Sakamuri, S., Enyedy, I. J., Kozikowski, A. P., Deschaux, O., Bandyopadhyay, B. C., Tella, S. R., Zaman, W. A. & Johnson, K. M., Feb 10 2000, In: Journal of medicinal chemistry. 43, 3, p. 351-360 10 p.

  Research output: Contribution to journal › Article › peer-review

  • 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone
  • Molecular modeling
  • Dopamine Plasma Membrane Transport Proteins
  • Molecular Structure
  • Structure-Activity Relationship
  70 Scopus citations

• Discovery of a novel highly potent broad-spectrum heterocyclic chemical series of arenavirus cell entry inhibitors

  Plewe, M. B., Gantla, V. R., Sokolova, N. V., Shin, Y. J., Naik, S., Brown, E. R., Fetsko, A., Zhang, L., Kalveram, B., Freiberg, A. N., Henkel, G. & McCormack, K., Jun 1 2021, In: Bioorganic and Medicinal Chemistry Letters. 41, 127983.

  Research output: Contribution to journal › Article › peer-review

  • imidazo(1,2-a)pyridine
  • Lead compounds
  • Arenavirus
  • Old World Arenaviruses
  • benzotriazole

• Discovery of a Protective Rickettsia prowazekii Antigen Recognized by CD8⁺ T Cells, RP884, Using an In Vivo Screening Platform

  Gazi, M., Caro-Gomez, E., Goez, Y., Cespedes, M. A., Hidalgo, M., Correa, P. & Valbuena, G., Oct 16 2013, In: PloS one. 8, 10, e76253.

  Research output: Contribution to journal › Article › peer-review

  • Rickettsia prowazekii
  • T-cells
  • CD8 Antigens
  • Epidemic Louse-Borne Typhus
  • typhus
  7 Scopus citations

• Discovery of a small molecule inhibitor of human adenovirus capable of preventing escape from the endosome

  Xu, J., Berastegui-Cabrera, J., Carretero-Ledesma, M., Chen, H., Xue, Y., Wold, E. A., Pachón, J., Zhou, J. & Sánchez-Céspedes, J., Feb 2 2021, In: International journal of molecular sciences. 22, 4, p. 1-21 21 p., 1617.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • adenoviruses
  • Human Adenovirus Infections
  • Niclosamide
  • Human Adenoviruses
  • Viruses

• Discovery of candidate biomarkers

  Wiktorowicz, J. E. & Soman, K. V., 2016, Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 919. p. 443-462 20 p. (Advances in Experimental Medicine and Biology; vol. 919).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Biomarkers
  • Proteomics
  • Assays
  • Medicine
  • Design of experiments
  5 Scopus citations

• Discovery of COVID-19 Inhibitors Targeting the SARS-CoV-2 Nsp13 Helicase

  White, M. A., Lin, W. & Cheng, X., 2020, (Accepted/In press) In: Journal of Physical Chemistry Letters. p. 9144-9151 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Adenosinetriphosphate
  • inhibitors
  • drugs
  • Binding sites
  • adenosine triphosphate
  7 Scopus citations

• Discovery of dengue virus NS4B inhibitors

  Wang, Q. Y., Dong, H., Zou, B., Karuna, R., Wan, K. F., Zou, J., Susila, A., Yip, A., Shan, C., Yeo, K. L., Xu, H., Ding, M., Chan, W. L., Gu, F., Seah, P. G., Liu, W., Lakshminarayana, S. B., Kang, C. B., Lescar, J., Blasco, F. & 2 others, Smith, P. W. & Shi, P. Y., 2015, In: Journal of virology. 89, 16, p. 8233-8244 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus
  • Dengue Virus
  • Inhibition (Psychology)
  • Amino Acids
  • Pharmaceutical Chemistry
  55 Scopus citations

• Discovery of Exosomes From Tick Saliva and Salivary Glands Reveals Therapeutic Roles for CXCL12 and IL-8 in Wound Healing at the Tick–Human Skin Interface

  Zhou, W., Tahir, F., Wang, J. C. Y., Woodson, M., Sherman, M. B., Karim, S., Neelakanta, G. & Sultana, H., Jul 16 2020, In: Frontiers in Cell and Developmental Biology. 8, 554.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chemokine CXCL12
  • Exosomes
  • Ticks
  • Salivary Glands
  • Saliva
  8 Scopus citations

• Discovery of functional genomic motifs in viruses with ViReMa-a virus recombination mapper-for analysis of next-generation sequencing data

  Routh, A. & Johnson, J. E., Jan 1 2014, In: Nucleic acids research. 42, 2, e11.

  Research output: Contribution to journal › Article › peer-review

  • Genetic Recombination
  • Viruses
  • Nucleotides
  • Viral Genome
  • Genome
  26 Scopus citations

• Discovery of genes related to steroidal alkaloid biosynthesis in Fritillaria cirrhosa by generating and mining a dataset of expressed sequence tags (ESTs)

  Sun, C., Sun, Y., Song, J., Li, C., Li, X., Zhang, X., Li, Y., Hu, S., Luo, H., Zhu, Y. & Chen, S., Oct 9 2011, In: Journal of Medicinal Plant Research. 5, 21, p. 5307-5314 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Fritillaria cirrhosa
  • Fritillaria
  • Expressed Sequence Tags
  • Alkaloids
  • Genetic Association Studies
  14 Scopus citations

• Discovery of genome of an immunodeficiency-associated virus-like virus from pig feces in Japan

  Oba, M., Katayama, Y., Tsuchiaka, S., Omatsu, T., Murata, Y., Ohya, K., Makino, S., Nagai, M. & Mizutani, T., 2018, In: Japanese Journal of Veterinary Research. 66, 1, p. 53-56 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Satellite Viruses
  • immunosuppression
  • Feces
  • Japan
  • feces
  1 Scopus citations

• Discovery of insect and human dengue virus host factors

  Sessions, O. M., Barrows, N. J., Souza-Neto, J. A., Robinson, T. J., Hershey, C. L., Rodgers, M. A., Ramirez, J. L., Dimopoulos, G., Yang, P. L., Pearson, J. L. & Garcia-Blanco, M. A., Apr 23 2009, In: Nature. 458, 7241, p. 1047-1050 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • Insecta
  • Flavivirus
  • Dengue
  • Insect Vectors
  290 Scopus citations

• Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach

  Yin, Z., Whittell, L. R., Wang, Y., Jergic, S., Liu, M., Harry, E. J., Dixon, N. E., Beck, J. L., Kelso, M. J. & Oakley, A. J., Mar 27 2014, In: Journal of medicinal chemistry. 57, 6, p. 2799-2806 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Lead
  • DNA Replication
  • DNA Polymerase III
  • Escherichia coli
  • X Ray Crystallography
  32 Scopus citations

• Discovery of Marburg virus neutralizing antibodies from virus-naïve human antibody repertoires using large-scale structural predictions

  Bozhanova, N. G., Sangha, A. K., Sevy, A. M., Gilchuk, P., Huang, K., Nargi, R. S., Reidy, J. X., Trivette, A., Carnahan, R. H., Bukreyev, A., Crowe, J. E. & Meiler, J., Dec 8 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 49, p. 31142-31148 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Marburgvirus
  • Neutralizing Antibodies
  • Viruses
  • Antibodies
  • Glycoproteins

• Discovery of markers of exposure specific to bites of Lutzomyia longipalpis, the vector of Leishmania infantum chagasiin Latin America

  Teixeira, C., Gomes, R., Collin, N., Reynoso, D., Jochim, R., Oliveira, F., Seitz, A., Elnaiem, D. E., Caldas, A., De Souza, A. P., Brodskyn, C. I., De Oliveira, C. I., Mendonca, I., Costa, C. H. N., Volf, P., Barral, A., Kamhawi, S. & Valenzuela, J. G., Mar 2010, In: PLoS neglected tropical diseases. 4, 3, e638.

  Research output: Contribution to journal › Article › peer-review

  • Psychodidae
  • Leishmania infantum
  • Latin America
  • Bites and Stings
  • Dogs
  85 Scopus citations

• Discovery of Mosquito Saliva MicroRNAs during CHIKV Infection

  Maharaj, P. D., Widen, S. G., Huang, J., Wood, T. G. & Thangamani, S., 2015, In: PLoS neglected tropical diseases. 9, 1

  Research output: Contribution to journal › Article › peer-review

  • Chikungunya Fever
  • Culicidae
  • Saliva
  • MicroRNAs
  • Salivary Proteins and Peptides
  35 Scopus citations

• Discovery of natural variant strain of HIV1 in env gene C2-V3 encoded PND of membrane protein

  Wang, B., Fu, J., Wu, H., Liu, C. X., Qian, D. M. & Fang, R., Sep 2001, In: Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology. 15, 3, p. 245-247 3 p.

  Research output: Contribution to journal › Article › peer-review

  • env Genes
  • Membrane Proteins
  • DNA
  • Genome
  • Restriction Mapping

• Discovery of niclosamide and its O-alkylamino-tethered derivatives as potent antibacterial agents against carbapenemase-producing and/or colistin resistant Enterobacteriaceae isolates

  Xu, J., Pachón-Ibáñez, M. E., Cebrero-Cangueiro, T., Chen, H., Sánchez-Céspedes, J. & Zhou, J., Jun 1 2019, In: Bioorganic and Medicinal Chemistry Letters. 29, 11, p. 1399-1402 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Niclosamide
  • carbapenemase
  • Colistin
  • Enterobacteriaceae
  • Derivatives
  8 Scopus citations

• Discovery of novel 2,4-diarylaminopyrimidine analogues (DAAPalogues) showing potent inhibitory activities against both wild-type and mutant ALK kinases

  Song, Z., Yang, Y., Liu, Z., Peng, X., Guo, J., Yang, X., Wu, K., Ai, J., Ding, J., Geng, M. & Zhang, A., Jan 8 2015, In: Journal of Medicinal Chemistry. 58, 1, p. 197-211 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Anaplastic Lymphoma Kinase
  • Enzyme Assays
  • Inhibitory Concentration 50
  • Heterografts
  • Amino Acids
  36 Scopus citations

• Discovery of novel antituberculosis agents among 3-phenyl-5-(1-phenyl-1H-[1,2,3]triazol-4-yl)-[1,2,4]oxadiazole derivatives targeting aminoacyl-tRNA synthetases

  Rybak, M. Y., Balanda, A. O., Yatsyshyna, A. P., Kotey, I. M., Starosyla, S. A., Bdzhola, V. G., Lukash, L. L., Yarmoluk, S. M., Tukalo, M. A. & Volynets, G. P., Dec 2021, In: Scientific reports. 11, 1, 7162.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Methionine-tRNA Ligase
  • Oxadiazoles
  • Amino Acyl-tRNA Synthetases
  • Mycobacterium tuberculosis
  • Tuberculosis

• Discovery of novel conformationally constrained tropane-based biaryl and arylacetylene ligands as potent and selective norepinephrine transporter inhibitors and potential antidepressants

  Zhou, J., Kläß, T., Johnson, K. M., Giberson, K. M. & Kozikowski, A. P., May 16 2005, In: Bioorganic and Medicinal Chemistry Letters. 15, 10, p. 2461-2465 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Tropanes
  • Norepinephrine Plasma Membrane Transport Proteins
  • Antidepressive Agents
  • Ligands
  • Structure-Activity Relationship
  4 Scopus citations

• Discovery of novel cross-protective Rickettsia prowazekii T-cell antigens using a combined reverse vaccinology and in vivo screening approach

  Caro-Gomez, E., Gazi, M., Goez, Y. & Valbuena, G., Sep 3 2014, In: Vaccine. 32, 39, p. 4968-4976 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Rickettsia prowazekii
  • Vaccinology
  • vaccine development
  • T-lymphocytes
  • Rickettsia
  30 Scopus citations

• Discovery of Novel Macrocyclic Hedgehog Pathway Inhibitors Acting by Suppressing the Gli-Mediated Transcription

  Liu, G., Huang, W., Wang, J., Liu, X., Yang, J., Zhang, Y., Geng, Y., Tan, W. & Zhang, A., Oct 12 2017, In: Journal of medicinal chemistry. 60, 19, p. 8218-8245 28 p.

  Research output: Contribution to journal › Article › peer-review

  • Hedgehogs
  • Medulloblastoma
  • Walking
  • Cyclization
  • Pharmaceutical Chemistry
  11 Scopus citations

• Discovery of novel mifepristone derivatives via suppressing KLF5 expression for the treatment of triple-negative breast cancer

  Lin, Y., Liu, R., Zhao, P., Ye, J., Zheng, Z., Huang, J., Zhang, Y., Gao, Y., Chen, H., Liu, S., Zhou, J., Chen, C. & Chen, H., Feb 25 2018, In: European journal of medicinal chemistry. 146, p. 354-367 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Mifepristone
  • Triple Negative Breast Neoplasms
  • Derivatives
  • compound 17
  • Cell proliferation
  9 Scopus citations

• Discovery of Novel Rhabdoviruses in the Blood of Healthy Individuals from West Africa

  Stremlau, M. H., Andersen, K. G., Folarin, O. A., Grove, J. N., Odia, I., Ehiane, P. E., Omoniwa, O., Omoregie, O., Jiang, P. P., Yozwiak, N. L., Matranga, C. B., Yang, X., Gire, S. K., Winnicki, S., Tariyal, R., Schaffner, S. F., Okokhere, P. O., Okogbenin, S., Akpede, G. O., Asogun, D. A. & 7 others, Agbonlahor, D. E., Walker, P. J., Tesh, R. B., Levin, J. Z., Garry, R. F., Sabeti, P. C. & Happi, C. T., Mar 17 2015, In: PLoS neglected tropical diseases. 9, 3, e0003631.

  Research output: Contribution to journal › Article › peer-review

  • Rhabdoviridae
  • Western Africa
  • Viruses
  • Fever
  • Nucleic Acids
  31 Scopus citations

• Discovery of Novel Substituted N-(4-Amino-2-chlorophenyl)-5-chloro-2-hydroxybenzamide Analogues as Potent Human Adenovirus Inhibitors

  Xu, J., Berastegui-Cabrera, J., Ye, N., Carretero-Ledesma, M., Pachón-Díaz, J., Chen, H., Pachón-Ibáñez, M. E., Sánchez-Céspedes, J. & Zhou, J., Nov 12 2020, In: Journal of medicinal chemistry. 63, 21, p. 12830-12852 23 p.

  Research output: Contribution to journal › Article › peer-review

  • 5-chloro-2-hydroxybenzamide
  • Human Adenoviruses
  • Human Adenovirus Infections
  • Niclosamide
  • Maximum Tolerated Dose
  2 Scopus citations

• Discovery of O-alkylamino-tethered niclosamide derivatives as potent and orally bioavailable anticancer agents

  Chen, H., Yang, Z., Ding, C., Chu, L., Zhang, Y., Terry, K., Liu, H., Shen, Q. & Zhou, J., Feb 14 2013, In: ACS Medicinal Chemistry Letters. 4, 2, p. 180-185 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Niclosamide
  • Antineoplastic Agents
  • Derivatives
  • Biological Availability
  • Solubility
  93 Scopus citations

• Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation

  Liu, Z., Chen, H., Wang, P., Li, Y., Wold, E. A., Leonard, P. G., Joseph, S., Brasier, A. R., Tian, B., Tian, B., Zhou, J., Zhou, J. & Zhou, J., May 28 2020, In: Journal of medicinal chemistry. 63, 10, p. 5242-5256 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Chromones
  • Pharmacology
  • human BRD4 protein
  • Proteins
  • Toll-Like Receptors
  11 Scopus citations

• Discovery of phenanthridine analogues as novel chemical probes disrupting the binding of DNA to ΔFosB homodimers and ΔFosB/JunD heterodimers

  Li, Y., Liu, Z., Aglyamova, G., Chen, J., Chen, H., Bhandari, M., White, M. A., Rudenko, G. & Zhou, J., Aug 15 2020, In: Bioorganic and Medicinal Chemistry Letters. 30, 16, 127300.

  Research output: Contribution to journal › Article › peer-review

  • Phenanthridines
  • Levodopa
  • Dyskinesias
  • Street Drugs
  • Substance-Related Disorders

• Discovery of Potent and Brain-Penetrant GPR52 Agonist that Suppresses Psychostimulant Behavior

  Wang, P., Felsing, D., Chen, H., Stutz, S. J., Murphy, R., Cunningham, K., Allen, J. & Zhou, J., Nov 25 2020, In: Journal of Medicinal Chemistry. 63, 22, p. 13951 13972 p.

  Research output: Contribution to journal › Article › peer-review

  • G-Protein-Coupled Receptors
  • Brain
  • Proof of Concept Study
  • Structure-Activity Relationship
  • Central Nervous System Diseases