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  • Mark Hellmich

3-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics

Abdollahi Govar, A., Törő, G., Szaniszlo, P., Pavlidou, A., Bibli, S. I., Thanki, K., Resto, V. A., Chao, C., Hellmich, M. R., Szabo, C., Papapetropoulos, A. & Módis, K., Feb 1 2020, In : British Journal of Pharmacology. 177, 4, p. 866-883 18 p.

Research output: Contribution to journalArticle

4 Scopus citations

Apigenin inhibits pancreatic stellate cell activity in pancreatitis

Mrazek, A. A., Porro, L. J., Bhatia, V., Falzon, M., Spratt, H., Zhou, J., Chao, C. & Hellmich, M. R., Jun 1 2015, In : Journal of Surgical Research. 196, 1, p. 8-16 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

BMP2 inhibits TGF-β-induced pancreatic stellate cell activation and extracellular matrix formation

Gao, X., Cao, Y., Yang, W., Duan, C., Aronson, J. F., Rastellini, C., Chao, C., Hellmich, M. R. & Ko, T. C., 2013, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 304, 9, p. G804-G813

Research output: Contribution to journalArticle

40 Scopus citations

Bone morphogenetic protein signaling protects against cerulein-induced pancreatic fibrosis

Gao, X., Cao, Y., Staloch, D. A., Gonzales, M. A., Aronson, J. F., Chao, C., Hellmich, M. R. & Ko, T. C., Feb 21 2014, In : PloS one. 9, 2, e89114.

Research output: Contribution to journalArticle

16 Scopus citations

CD133+ colon cancer cells are more interactive with the tumor microenvironment than CD133-cells

Chao, C., Carmical, J. R., Ives, K. L., Wood, T. G., Aronson, J. F., Gomez, G. A., Djukom, C. D. & Hellmich, M. R., Mar 2012, In : Laboratory Investigation. 92, 3, p. 420-436 17 p.

Research output: Contribution to journalArticle

32 Scopus citations

Colorectal cancer-associated fibroblasts are genotypically distinct

Mrazek, A. A., Carmical, J. R., Wood, T. G., Hellmich, M. R., Eltorky, M. & Chao, C., Jan 1 2014, In : Current Cancer Therapy Reviews. 10, 3, p. 97-218 122 p.

Research output: Contribution to journalArticle

10 Scopus citations

Cystathionine-β-synthase inhibition for colon cancer: Enhancement of the efficacy of aminooxyacetic acid via the prodrug approach

Chao, C., Zatarain, J. R., Ding, Y., Coletta, C., Mrazek, A. A., Druzhyna, N., Johnson, P., Chen, H., Hellmich, J. L., Asimakopoulou, A., Yanagi, K., Olah, G., Szoleczky, P., Törö, G., Bohanon, F. J., Cheema, M., Lewis, R., Eckelbarger, D., Ahmad, A., Módis, K. & 6 others, Untereiner, A., Szczesny, B., Papapetropoulos, A., Zhou, J., Hellmich, M. R. & Szabo, C., 2016, In : Molecular Medicine. 22, p. 361-379 19 p.

Research output: Contribution to journalArticle

23 Scopus citations

Design, synthesis, and characterization of novel apigenin analogues that suppress pancreatic stellate cell proliferation in vitro and associated pancreatic fibrosis in vivo

Chen, H., Mrazek, A. A., Wang, X., Ding, C., Ding, Y., Porro, L. J., Liu, H., Chao, C., Hellmich, M. R. & Zhou, J., Jul 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 13, p. 3393-3404 12 p.

Research output: Contribution to journalArticle

25 Scopus citations

Dual inhibition of PI3K and mTOR signaling pathways decreases human pancreatic neuroendocrine tumor metastatic progression

Djukom, C., Porro, L. J., Mrazek, A., Townsend, C. M., Hellmich, M. R. & Chao, C., Jan 2014, In : Pancreas. 43, 1, p. 88-92 5 p.

Research output: Contribution to journalArticle

13 Scopus citations
44 Scopus citations

Endogenously produced hydrogen sulfide supports tumor cell growth and proliferation

Szabo, C. & Hellmich, M. R., Sep 15 2013, In : Cell Cycle. 12, 18, p. 2915-2916 2 p.

Research output: Contribution to journalEditorial

27 Scopus citations

Gastrointestinal Peptides: Gastrin, Cholecystokinin, Somatostatin, and Ghrelin

Chao, C. & Hellmich, M. R., Dec 1 2012, Physiology of the Gastrointestinal Tract. Elsevier Inc., Vol. 1. p. 115-154 40 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Gremlin is a key pro-fibrogenic factor in chronic pancreatitis

Staloch, D., Gao, X., Liu, K., Xu, M., Feng, X., Aronson, J. F., Falzon, M., Greeley, G. H., Rastellini, C., Chao, C., Hellmich, M. R., Cao, Y. & Ko, T. C., Oct 3 2015, In : Journal of Molecular Medicine. 93, 10, p. 1085-1093 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

H2S-induced S-sulfhydration of lactate dehydrogenase a (LDHA) stimulates cellular bioenergetics in HCT116 colon cancer cells

Untereiner, A. A., Oláh, G., Módis, K., Hellmich, M. R. & Szabo, C., Jul 15 2017, In : Biochemical Pharmacology. 136, p. 86-98 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

Hydrogen sulfide and cancer

Hellmich, M. R. & Szabo, C., 2015, In : Handbook of Experimental Pharmacology. 230, p. 233-241 9 p.

Research output: Contribution to journalArticle

77 Scopus citations

Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics

Szczesny, B., Marcatti, M., Zatarain, J. R., Druzhyna, N., Wiktorowicz, J. E., Nagy, P., Hellmich, M. R. & Szabo, C., Nov 3 2016, In : Scientific reports. 6, 36125.

Research output: Contribution to journalArticle

39 Scopus citations

Isolation of CD 90+ fibroblast/myofibroblasts from human frozen gastrointestinal specimens

Johnson, P., Beswick, E. J., Chao, C., Powell, D. W., Hellmich, M. & Pinchuk, I., Jan 31 2016, In : Journal of Visualized Experiments. 2016, 107, e53691.

Research output: Contribution to journalArticle

8 Scopus citations

Noggin attenuates cerulein-induced acute pancreatitis and impaired autophagy

Cao, Y., Yang, W., Tyler, M. A., Gao, X., Duan, C., Kim, S. O., Aronson, J. F., Popov, V., Takahashi, H., Saito, H., Evers, B. M., Chao, C., Hellmich, M. R. & Ko, T. C., Mar 2013, In : Pancreas. 42, 2, p. 301-307 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Overexpression of Evi-1 oncoprotein represses TGF-β signaling in colorectal cancer

Deng, X., Cao, Y., Liu, Y., Li, F., Sambandam, K., Rajaraman, S., Perkins, A. S., Fields, A. P., Hellmich, M. R., Townsend, C. M., Thompson, E. A. & Ko, T. C., Apr 2013, In : Molecular Carcinogenesis. 52, 4, p. 255-264 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Patient-derived xenografts from colorectal carcinoma: A temporal and hierarchical study of murine stromal cell replacement

Chao, C., Widen, S. G., Wood, T. G., Zatarain, J. R., Johnson, P., Gajjar, A., Gomez, G., Qiu, S., Thompson, J., Spratt, H. & Hellmich, M. R., Jul 2017, In : Anticancer Research. 37, 7, p. 3405-3412 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Pharmacological inhibition and genetic knockdown of exchange protein directly activated by cAMP 1 reduce pancreatic cancer metastasis in vivos

Almahariq, M., Chao, C., Mei, F. C., Hellmich, M. R., Patrikeev, I., Motamedi, M. & Cheng, X., Feb 1 2015, In : Molecular pharmacology. 87, 2, p. 142-149 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

PTHrP is a novel mediator for TGF-β-induced apoptosis

Cao, Y., Zhang, W., Gao, X., Zhang, G., Falzon, M., Townsend, C. M., Hellmich, M. R. & Ko, T. C., Jun 1 2013, In : Regulatory Peptides. 184, p. 40-46 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Raf-1 kinase inhibitory protein (RKIP) mediates ethanol-induced sensitization of secretagogue signaling in pancreatic acinar cells

Kim, S. O., Ives, K. L., Wang, X., Davey, R. A., Chao, C. & Hellmich, M. R., Sep 28 2012, In : Journal of Biological Chemistry. 287, 40, p. 33377-33388 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Regulation of bombesin-stimulated cyclooxygenase-2 expression in prostate cancer cells

Wen, X., Chao, C., Ives, K. & Hellmich, M. R., Jul 11 2011, In : BMC Molecular Biology. 12, 29.

Research output: Contribution to journalArticle

8 Scopus citations

Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part II Pathophysiological and therapeutic aspects

Módis, K., Bos, E. M., Calzia, E., Van Goor, H., Coletta, C., Papapetropoulos, A., Hellmich, M. R., Radermacher, P., Bouillaud, F. & Szabo, C., Apr 2014, In : British Journal of Pharmacology. 171, 8, p. 2123-2146 24 p.

Research output: Contribution to journalReview article

76 Scopus citations
15 Scopus citations

Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon cancer

Druzhyna, N., Szczesny, B., Olah, G., Módis, K., Asimakopoulou, A., Pavlidou, A., Szoleczky, P., Gerö, D., Yanagi, K., Törö, G., López-García, I., Myrianthopoulos, V., Mikros, E., Zatarain, J. R., Chao, C., Papapetropoulos, A., Hellmich, M. R. & Szabo, C., Nov 1 2016, In : Pharmacological Research. 113, p. 18-37 20 p.

Research output: Contribution to journalArticle

25 Scopus citations

The Multidisciplinary Translational Team (MTT) Model for Training and Development of Translational Research Investigators

Ameredes, B. T., Hellmich, M. R., Cestone, C. M., Wooten, K. C., Ottenbacher, K. J., Chonmaitree, T., Anderson, K. E. & Brasier, A. R., Oct 2015, In : Clinical and translational science. 8, 5, p. 533-541 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

The therapeutic potential of cystathionine β-Synthetase/hydrogen sulfide inhibition in cancer

Hellmich, M. R., Coletta, C., Chao, C. & Szabo, C., Feb 10 2015, In : Antioxidants and Redox Signaling. 22, 5, p. 424-448 25 p.

Research output: Contribution to journalReview article

110 Scopus citations

Translational Research Track for Medical Students: Developing Interprofessional Collaborative Competencies for Translational Research

Aronson, J. F., Valbuena, G. A., Hellmich, M. R. & Asimakis, G., Apr 1 2011, In : Medical Science Educator. 21, 1, p. 63-66 4 p.

Research output: Contribution to journalArticle

1 Scopus citations
303 Scopus citations

Upregulation of cystathionine-β-synthase in colonic epithelia reprograms metabolism and promotes carcinogenesis

Phillips, CN. M., Zatarain, J. R., Nicholls, M. E., Porter, C., Widen, S. G., Thanki, K., Johnson, P., Jawad, M. U., Moyer, M. P., Randall, J. W., Hellmich, J. L., Maskey, M., Qiu, S., Wood, T. G., Druzhyna, N., Szczesny, B., Módis, K., Szabo, C., Chao, C. & Hellmich, M. R., Nov 1 2017, In : Cancer Research. 77, 21, p. 5741-5754 14 p.

Research output: Contribution to journalArticle

23 Scopus citations