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  • Krishna Rajarathnam

Characterizing protein–glycosaminoglycan interactions using solution NMR spectroscopy

Joseph, P. R. B., Poluri, K. M., Sepuru, K. M. & Rajarathnam, K., 2015, In : Methods in Molecular Biology. 1229, p. 325-333 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Chemokine CXCL1 dimer is a potent agonist for the CXCR2 receptor

Ravindran, A., Sawant, K. V., Sarmiento, J., Navarro, J. & Rajarathnam, K., Apr 26 2013, In : Journal of Biological Chemistry. 288, 17, p. 12244-12252 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Chemokine CXCL1 mediated neutrophil recruitment: Role of glycosaminoglycan interactions

Sawant, K. V., Poluri, K. M., Dutta, A. K., Sepuru, K. M., Troshkina, A., Garofalo, R. P. & Rajarathnam, K., Sep 14 2016, In : Scientific reports. 6, 33123.

Research output: Contribution to journalArticle

70 Scopus citations

Chemokine CXCL1-Mediated Neutrophil Trafficking in the Lung: Role of CXCR2 Activation

Sawant, K. V., Xu, R., Cox, R., Hawkins, H., Sbrana, E., Kolli, D., Garofalo, R. P. & Rajarathnam, K., Oct 16 2015, In : Journal of Innate Immunity. 7, 6, p. 647-658 12 p.

Research output: Contribution to journalArticle

40 Scopus citations
30 Scopus citations

Direct detection of lysine side chain NH3+ in protein-heparin complexes using NMR spectroscopy

Sepuru, K. M., Iwahara, J. & Rajarathnam, K., Feb 7 2018, In : Analyst. 143, 3, p. 635-638 4 p.

Research output: Contribution to journalArticle

7 Scopus citations
2 Scopus citations

Diverging mechanisms of activation of chemokine receptors revealed by novel chemokine agonists

Sarmiento, J., Shumate, C., Suetomi, K., Ravindran, A., Villegas, L., Rajarathnam, K. & Navarro, J., Dec 9 2011, In : PloS one. 6, 12, e27967.

Research output: Contribution to journalArticle

12 Scopus citations

Dynamic conformational switching in the chemokine ligand is essential for G-protein-coupled receptor activation

Joseph, P. R. B., Sawant, K. V., Isley, A., Pedroza, M., Garofalo, R. P., Richardson, R. M. & Rajarathnam, K., Dec 1 2013, In : Biochemical Journal. 456, 2, p. 241-251 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Dynamics-derived insights into complex formation between the CXCL8 monomer and CXCR1 N-terminal domain: An NMR study

Joseph, P. R. B., Spyracopoulos, L. & Rajarathnam, K., Oct 31 2018, In : Molecules. 23, 11

Research output: Contribution to journalArticle

3 Scopus citations

Ehrlichia chaffeensis TRP120 nucleomodulin binds DNA with disordered tandem repeat domain

Klema, V. J., Sepuru, K. M., Füllbrunn, N., Farris, T. R., Dunphy, P. S., McBride, J. W., Rajarathnam, K. & Choi, K. H., Apr 2018, In : PloS one. 13, 4, e0194891.

Research output: Contribution to journalArticle

3 Scopus citations

Flexible Linker Modulates Glycosaminoglycan Affinity of Decorin Binding Protein A

Morgan, A., Sepuru, K. M., Feng, W., Rajarathnam, K. & Wang, X., Jul 30 2015, In : Biochemistry. 54, 32, p. 5113-5119 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Glycosaminoglycan Interactions Fine-Tune Chemokine-Mediated Neutrophil Trafficking: Structural Insights and Molecular Mechanisms

Rajarathnam, K., Sepuru, K. M., Joseph, P. R. B., Sawant, K. V. & Brown, A. J., Apr 1 2018, In : Journal of Histochemistry and Cytochemistry. 66, 4, p. 229-239 11 p.

Research output: Contribution to journalReview article

11 Scopus citations

Interleukin-8 mediates neutrophil-endothelial interactions in pig-to-human xenogeneic models

French, B. M., Sendil, S., Sepuru, K. M., Ranek, J., Burdorf, L., Harris, D., Redding, E., Cheng, X., Laird, C. T., Zhao, Y., Cerel, B., Rajarathnam, K., Pierson, R. N. & Azimzadeh, A. M., Jan 1 2018, (Accepted/In press) In : Xenotransplantation.

Research output: Contribution to journalArticle

4 Scopus citations

Isothermal titration calorimetry of membrane proteins - Progress and challenges

Rajarathnam, K. & Rösgen, J., 2014, In : Biochimica et Biophysica Acta - Biomembranes. 1838, 1 PARTA, p. 69-77 9 p.

Research output: Contribution to journalReview article

51 Scopus citations

Lysines and Arginines play non-redundant roles in mediating chemokine-glycosaminoglycan interactions

Joseph, P. R. B., Sawant, K. V., Iwahara, J., Garofalo, R. P., Desai, U. R. & Rajarathnam, K., Dec 1 2018, In : Scientific reports. 8, 1, 12289.

Research output: Contribution to journalArticle

3 Scopus citations

Molecular basis of chemokine CXCL5-glycosaminoglycan interactions

Sepuru, K. M., Nagarajan, B., Desai, U. R. & Rajarathnam, K., Sep 23 2016, In : Journal of Biological Chemistry. 291, 39, p. 20539-20550 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Molecular basis of glycosaminoglycan heparin binding to the chemokine CXCL1 dimer

Poluri, K. M., Joseph, P. R. B., Sawant, K. V. & Rajarathnam, K., Aug 30 2013, In : Journal of Biological Chemistry. 288, 35, p. 25143-25153 11 p.

Research output: Contribution to journalArticle

42 Scopus citations

Neutrophil recruitment by chemokines Cxcl1/KC and Cxcl2/MIP2: Role of Cxcr2 activation and glycosaminoglycan interactions

Sawant, K. V., Sepuru, K. M., Lowry, E., Penaranda, B., Frevert, C. W., Garofalo, R. P. & Rajarathnam, K., 2020, (Accepted/In press) In : Journal of Leukocyte Biology.

Research output: Contribution to journalArticle

Organization and dynamics of the N-terminal domain of chemokine receptor CXCR1 in reverse micelles: Effect of graded hydration

Chaudhuri, A., Basu, P., Haldar, S., Kombrabail, M., Krishnamoorthy, G., Rajarathnam, K. & Chattopadhyay, A., Feb 7 2013, In : Journal of Physical Chemistry B. 117, 5, p. 1225-1233 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Proline substitution of dimer interface β-strand residues as a strategy for the design of functional monomeric proteins

Joseph, P. R. B., Poluri, K. M., Gangavarapu, P., Rajagopalan, L., Raghuwanshi, S., Richardson, R. M., Garofalo, R. P. & Rajarathnam, K., Sep 17 2013, In : Biophysical journal. 105, 6, p. 1491-1501 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Real-time kinetics of high-mobility group box 1 (HMGB1) oxidation in extracellular fluids studied by in situ protein NMR spectroscopy

Zandarashvili, L., Sahu, D., Lee, K., Lee, Y. S., Singh, P., Rajarathnam, K. & Iwahara, J., Apr 26 2013, In : Journal of Biological Chemistry. 288, 17, p. 11621-11627 7 p.

Research output: Contribution to journalArticle

35 Scopus citations

Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: Structural plasticity mediates differential binding interactions

Joseph, P. R. B., Mosier, P. D., Desai, U. R. & Rajarathnam, K., Nov 15 2015, In : Biochemical Journal. 472, 1, p. 121-133 13 p.

Research output: Contribution to journalArticle

52 Scopus citations

Solution NMR characterization of WT CXCL8 monomer and dimer binding to CXCR1 N-terminal domain

Joseph, P. R. B. & Rajarathnam, K., Jan 1 2015, In : Protein Science. 24, 1, p. 81-92 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

Solution structure of CXCL5 - A novel chemokine and adipokine implicated in inflammation and obesity

Sepuru, K. M., Poluri, K. M. & Rajarathnam, K., Apr 2 2014, In : PloS one. 9, 4, e93228.

Research output: Contribution to journalArticle

17 Scopus citations

Structural basis, stoichiometry, and thermodynamics of binding of the chemokines KC and MIP2 to the glycosaminoglycan heparin

Sepuru, K. M., Nagarajan, B., Desai, U. R. & Rajarathnam, K., Nov 16 2018, In : Journal of Biological Chemistry. 293, 46, p. 17817-17828 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Structural Insights Into How Proteoglycans Determine Chemokine-CXCR1/CXCR2 Interactions: Progress and Challenges

Rajarathnam, K. & Desai, U. R., Apr 24 2020, In : Frontiers in immunology. 11, 660.

Research output: Contribution to journalReview article

Open Access
3 Scopus citations

The monomer-dimer equilibrium and glycosaminoglycan interactions of chemokine CXCL8 regulate tissue-specific neutrophil recruitment

Gangavarapu, P., Rajagopalan, L., Kolli, D., Guerrero-Plata, A., Garofalo, R. P. & Rajarathnam, K., Feb 2012, In : Journal of Leukocyte Biology. 91, 2, p. 259-265 7 p.

Research output: Contribution to journalArticle

59 Scopus citations

Using isothermal titration calorimetry to determine thermodynamic parameters of protein–glycosaminoglycan interactions

Dutta, A. K., Rösgen, J. & Rajarathnam, K., 2015, In : Methods in Molecular Biology. 1229, p. 315-324 10 p.

Research output: Contribution to journalArticle

24 Scopus citations