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2′-O methylation of internal adenosine by flavivirus NS5 methyltransferase
Dong, H., Chang, D. C., Hua, M. H. C., Lim, S. P., Chionh, Y. H., Hia, F., Lee, Y. H., Kukkaro, P., Lok, S. M., Dedon, P. C. & Shi, P. Y., Apr 2012, In: PLoS pathogens. 8, 4, e1002642.Research output: Contribution to journal › Article › peer-review
83 Scopus citations -
A cDNA Clone-Launched Platform for High-Yield Production of Inactivated Zika Vaccine
Yang, Y., Shan, C., Zou, J., Muruato, A. E., Bruno, D. N., de Almeida Medeiros Daniele, B., Vasconcelos, P. F. C., Rossi, S. L., Weaver, S. C., Xie, X. & Shi, P. Y., Mar 1 2017, In: EBioMedicine. 17, p. 145-156 12 p.Research output: Contribution to journal › Article › peer-review
26 Scopus citations -
A chimeric dengue virus vaccine using japanese encephalitis virus vaccine strain SA14-14-2 as backbone is immunogenic and protective against either parental virus in mice and nonhuman primates
Li, X. F., Deng, Y. Q., Yang, H. Q., Zhao, H., Jiang, T., Yu, X. D., Li, S. H., Ye, Q., Zhu, S. Y., Wang, H. J., Zhang, Y., Ma, J., Yu, Y. X., Liu, Z. Y., Li, Y. H., Qin, E. D., Shi, P. Y. & Qin, C. F., Dec 2013, In: Journal of virology. 87, 24, p. 13694-13705 12 p.Research output: Contribution to journal › Article › peer-review
43 Scopus citations -
A cocrystal structure of dengue capsid protein in complex of inhibitor
Xia, H., Xie, X., Zou, J., Noble, C. G., Russell, W. K., Holthauzen, L. M. F., Choi, K. H., White, M. A. & Shi, P. Y., Jul 28 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 30, p. 17992-18001 10 p.Research output: Contribution to journal › Article › peer-review
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A conserved pocket in the dengue virus polymerase identified through fragment-based screening
Noble, C. G., Lim, S. P., Arora, R., Yokokawa, F., Nilar, S., Seh, C. C., Wright, S. K., Benson, T. E., Smith, P. W. & Shi, P. Y., Apr 15 2016, In: Journal of Biological Chemistry. 291, 16, p. 8541-8548 8 p.Research output: Contribution to journal › Article › peer-review
30 Scopus citations -
A crystal structure of the dengue virus non-structural protein 5 (NS5) polymerase delineates interdomain amino acid residues that enhance its thermostability and de novo initiation activities
Lim, S. P., Koh, J. H. K., Seh, C. C., Liew, C. W., Davidson, A. D., Chua, L. S., Chandrasekaran, R., Cornvik, T. C., Shi, P. Y. & Lescar, J., Oct 25 2013, In: Journal of Biological Chemistry. 288, 43, p. 31105-31114 10 p.Research output: Contribution to journal › Article › peer-review
54 Scopus citations -
A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication
Zhao, Y., Soh, T. S., Zheng, J., Chan, K. W. K., Phoo, W. W., Lee, C. C., Tay, M. Y. F., Swaminathan, K., Cornvik, T. C., Lim, S. P., Shi, P. Y., Lescar, J., Vasudevan, S. G. & Luo, D., Mar 1 2015, In: PLoS pathogens. 11, 3, p. 1-27 27 p., e1004682.Research output: Contribution to journal › Article › peer-review
106 Scopus citations -
Adenosine analog NITD008 is a potent inhibitor of zika virus
Deng, Y. Q., Zhang, N. N., Li, C. F., Tian, M., Hao, J. N., Xie, X. P., Shi, P. Y. & Qin, C. F., 2016, In: Open Forum Infectious Diseases. 3, 4Research output: Contribution to journal › Article › peer-review
80 Scopus citations -
Adulthood Sequelae of Congenital Zika Virus Infection in Mice
Zou, J. & Shi, P. Y., Jun 2017, In: EBioMedicine. 20, p. 11-12 2 p.Research output: Contribution to journal › Comment/debate › peer-review
3 Scopus citations -
A fluorescence-based alkaline phosphatase-coupled polymerase assay for identification of inhibitors of dengue virus RNA-Dependent RNA polymerase
Niyomrattanakit, P., Abas, S. N., Lim, C. C., Beer, D., Shi, P. Y. & Chen, Y. L., Feb 2011, In: Journal of Biomolecular Screening. 16, 2, p. 201-210 10 p.Research output: Contribution to journal › Article › peer-review
39 Scopus citations -
A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation
Muruato, A. E., Fontes-Garfias, C. R., Ren, P., Garcia-Blanco, M. A., Menachery, V. D., Xie, X. & Shi, P. Y., Dec 1 2020, In: Nature communications. 11, 1, 4059.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models
Shan, C., Muruato, A. E., Nunes, B. T. D., Luo, H., Xie, X., Medeiros, D. B. A., Wakamiya, M., Tesh, R. B., Barrett, A. D., Wang, T., Weaver, S. C., Vasconcelos, P. F. C., Rossi, S. L. & Shi, P. Y., Jun 1 2017, In: Nature Medicine. 23, 6, p. 763-767 5 p.Research output: Contribution to journal › Article › peer-review
153 Scopus citations -
A multidimensional platform for the purification of non-coding RNA species
Chionh, Y. H., Ho, C. H., Pruksakorn, D., Ramesh Babu, I., Ng, C. S., Hia, F., McBee, M. E., Su, D., Pang, Y. L. J., Gu, C., Dong, H., Prestwich, E. G., Shi, P. Y., Preiser, P. R., Alonso, S. & Dedon, P. C., Sep 2013, In: Nucleic acids research. 41, 17, p. e168Research output: Contribution to journal › Article › peer-review
26 Scopus citations -
A Multiplex Microsphere Immunoassay for Zika Virus Diagnosis
Wong, S. J., Furuya, A., Zou, J., Xie, X., Dupuis, A. P., Kramer, L. D. & Shi, P. Y., Feb 1 2017, In: EBioMedicine. 16, p. 136-140 5 p.Research output: Contribution to journal › Article › peer-review
56 Scopus citations -
A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19
Xie, X., Muruato, A. E., Zhang, X., Lokugamage, K. G., Fontes-Garfias, C. R., Zou, J., Liu, J., Ren, P., Balakrishnan, M., Cihlar, T., Tseng, C. T. K., Makino, S., Menachery, V. D., Bilello, J. P. & Shi, P. Y., Dec 1 2020, In: Nature communications. 11, 1, 5214.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
An Infectious cDNA Clone of SARS-CoV-2
Xie, X., Muruato, A., Lokugamage, K. G., Narayanan, K., Zhang, X., Zou, J., Liu, J., Schindewolf, C., Bopp, N. E., Aguilar, P. V., Plante, K. S., Weaver, S. C., Makino, S., LeDuc, J. W., Menachery, V. D. & Shi, P. Y., May 13 2020, In: Cell Host and Microbe. 27, 5, p. 841-848.e3Research output: Contribution to journal › Article › peer-review
Open Access42 Scopus citations -
An Infectious cDNA Clone of Zika Virus to Study Viral Virulence, Mosquito Transmission, and Antiviral Inhibitors
Shan, C., Xie, X., Muruato, A. E., Rossi, S. L., Roundy, C. M., Azar, S. R., Yang, Y., Tesh, R. B., Bourne, N., Barrett, A. D., Vasilakis, N., Weaver, S. C. & Shi, P. Y., Jun 8 2016, In: Cell Host and Microbe. 19, 6, p. 891-900 10 p.Research output: Contribution to journal › Article › peer-review
158 Scopus citations -
Antagonism of Type i Interferon by Severe Acute Respiratory Syndrome Coronavirus 2
Xia, H. & Shi, P. Y., Dec 2020, In: Journal of Interferon and Cytokine Research. 40, 12, p. 543-548 6 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Anti-infectives: Can cellular screening deliver?
Keller, T. H., Shi, P. Y. & Wang, Q. Y., Aug 1 2011, In: Current Opinion in Chemical Biology. 15, 4, p. 529-533 5 p.Research output: Contribution to journal › Review article › peer-review
22 Scopus citations -
A Rapid Zika Diagnostic Assay to Measure Neutralizing Antibodies in Patients
Shan, C., Xie, X., Ren, P., Loeffelholz, M. J., Yang, Y., Furuya, A., Dupuis, A. P., Kramer, L. D., Wong, S. J. & Shi, P. Y., Mar 1 2017, In: EBioMedicine. 17, p. 157-162 6 p.Research output: Contribution to journal › Article › peer-review
43 Scopus citations -
A replication-defective Japanese encephalitis virus (JEV) vaccine candidate with NS1 deletion confers dual protection against JEV and West Nile virus in mice
Li, N., Zhang, Z. R., Zhang, Y. N., Liu, J., Deng, C. L., Shi, P. Y., Yuan, Z. M., Ye, H. Q. & Zhang, B., Dec 1 2020, In: npj Vaccines. 5, 1, 73.Research output: Contribution to journal › Article › peer-review
Open Access -
A single amino acid in nonstructural protein NS4B Confers virulence to dengue virus in AG129 mice through enhancement of viral RNA synthesis
Grant, D., Tan, G. K., Qing, M., Ng, J. K. W., Yip, A., Zou, G., Xie, X., Yuan, Z. Y., Schreiber, J., Schul, W., Shi, P. Y. & Alonso, S., Aug 2011, In: Journal of virology. 85, 15, p. 7775-7787 13 p.Research output: Contribution to journal › Article › peer-review
66 Scopus citations -
A Single Amino Acid Substitution in the Core Protein of West Nile Virus Increases Resistance to Acidotropic Compounds
Martín-Acebes, M. A., Blázquez, A. B., de Oya, N. J., Escribano-Romero, E., Shi, P. Y. & Saiz, J. C., Jul 18 2013, In: PloS one. 8, 7, e69479.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage
Shan, C., Muruato, A. E., Jagger, B. W., Richner, J., Nunes, B. T. D., Medeiros, D. B. A., Xie, X., Nunes, J. G. C., Morabito, K. M., Kong, W. P., Pierson, T. C., Barrett, A. D., Weaver, S. C., Rossi, S. L., Vasconcelos, P. F. C., Graham, B. S., Diamond, M. S. & Shi, P. Y., Dec 1 2017, In: Nature communications. 8, 1, 676.Research output: Contribution to journal › Article › peer-review
79 Scopus citations -
A single mutation in the prM protein of Zika virus contributes to fetal microcephaly
Yuan, L., Huang, X. Y., Liu, Z. Y., Zhang, F., Zhu, X. L., Yu, J. Y., Ji, X., Xu, Y. P., Li, G., Li, C., Wang, H. J., Deng, Y. Q., Wu, M., Cheng, M. L., Ye, Q., Xie, D. Y., Li, X. F., Wang, X., Shi, W., Hu, B. & 3 others, , Nov 17 2017, In: Science. 358, 6365, p. 933-936 4 p.Research output: Contribution to journal › Article › peer-review
211 Scopus citations -
A translation inhibitor that suppresses dengue virus in vitro and in vivo
Wang, Q. Y., Kondreddi, R. R., Xie, X., Rao, R., Nilar, S., Xu, H. Y., Qing, M., Chang, D., Dong, H., Yokokawa, F., Lakshminarayana, S. B., Goh, A., Schul, W., Kramer, L., Keller, T. H. & Shi, P. Y., Sep 2011, In: Antimicrobial agents and chemotherapy. 55, 9, p. 4072-4080 9 p.Research output: Contribution to journal › Article › peer-review
38 Scopus citations -
A Zika virus envelope mutation preceding the 2015 epidemic enhances virulence and fitness for transmission
Shan, C., Xia, H., Haller, S. L., Azar, S. R., Liu, Y., Liu, J., Muruato, A. E., Chen, R., Rossi, S. L., Wakamiya, M., Vasilakis, N., Pei, R., Fontes-Garfias, C. R., Singh, S. K., Xie, X., Weaver, S. C. & Shi, P. Y., Aug 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 33, p. 20190-20197 8 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure
Qian, X., Nguyen, H. N., Song, M. M., Hadiono, C., Ogden, S. C., Hammack, C., Yao, B., Hamersky, G. R., Jacob, F., Zhong, C., Yoon, K. J., Jeang, W., Lin, L., Li, Y., Thakor, J., Berg, D. A., Zhang, C., Kang, E., Chickering, M., Nauen, D. & 10 others, , May 19 2016, In: Cell. 165, 5, p. 1238-1254 17 p.Research output: Contribution to journal › Article › peer-review
747 Scopus citations -
Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential
Xu, J., Shi, P. Y., Li, H. & Zhou, J., May 8 2020, In: ACS Infectious Diseases. 6, 5, p. 909-915 7 p.Research output: Contribution to journal › Review article › peer-review
Open Access58 Scopus citations -
Characterization of a 2016 Clinical Isolate of Zika Virus in Non-human Primates
Li, X. F., Dong, H. L., Huang, X. Y., Qiu, Y. F., Wang, H. J., Deng, Y. Q., Zhang, N. N., Ye, Q., Zhao, H., Liu, Z. Y., Fan, H., An, X. P., Sun, S. H., Gao, B., Fa, Y. Z., Tong, Y. G., Zhang, F. C., Gao, G. F., Cao, W. C., Shi, P. Y. & 1 others, , Oct 1 2016, In: EBioMedicine. 12, p. 170-177 8 p.Research output: Contribution to journal › Article › peer-review
84 Scopus citations -
Characterization of Dengue virus NS4A and NS4B protein interaction
Zou, J., Xie, X., Wang, Q. Y., Dong, H., Lee, M. Y., Kang, C., Yuan, Z. & Shi, P. Y., 2015, In: Journal of virology. 89, 7, p. 3455-3470 16 p.Research output: Contribution to journal › Article › peer-review
66 Scopus citations -
Combination of α-glucosidase inhibitor and ribavirin for the treatment of dengue virus infection in vitro and in vivo
Chang, J., Schul, W., Butters, T. D., Yip, A., Liu, B., Goh, A., Lakshminarayana, S. B., Alonzi, D., Reinkensmeier, G., Pan, X., Qu, X., Weidner, J. M., Wang, L., Yu, W., Borune, N., Kinch, M. A., Rayahin, J. E., Moriarty, R., Xu, X., Shi, P. Y. & 2 others, , Jan 2011, In: Antiviral research. 89, 1, p. 26-34 9 p.Research output: Contribution to journal › Article › peer-review
67 Scopus citations -
Combined treatment of adenosine nucleoside inhibitor NITD008 and histone deacetylase inhibitor vorinostat represents an immunotherapy strategy to ameliorate West Nile virus infection
Nelson, J., Roe, K., Orillo, B., Shi, P. Y. & Verma, S., Oct 1 2015, In: Antiviral research. 122, p. 39-45 7 p., 3668.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
Conformational flexibility of the dengue virus RNA-Dependent RNA polymerase revealed by a complex with an inhibitor
Noble, C. G., Lim, S. P., Chen, Y. L., Liew, C. W., Yap, L., Lescar, J. & Shi, P. Y., May 2013, In: Journal of virology. 87, 9, p. 5291-5295 5 p.Research output: Contribution to journal › Article › peer-review
70 Scopus citations -
Construction of stable reporter flaviviruses and their applications
Baker, C. & Shi, P. Y., Oct 2020, In: Viruses. 12, 10, 1082.Research output: Contribution to journal › Article › peer-review
Open Access -
Corrigendum to "Population variation of West Nile virus confers a host-specific fitness benefit in mosquitoes" [Virology 404 (2010) 89-95]
Fitzpatrick, K. A., Deardorff, E. R., Pesko, K., Brackney, D. E., Zhang, B., Bedrick, E., Shi, P. Y. & Ebel, G. D., Feb 20 2011, In: Virology. 410, 2, p. 437 1 p.Research output: Contribution to journal › Comment/debate › peer-review
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COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses
Sahin, U., Muik, A., Derhovanessian, E., Vogler, I., Kranz, L. M., Vormehr, M., Baum, A., Pascal, K., Quandt, J., Maurus, D., Brachtendorf, S., Lörks, V., Sikorski, J., Hilker, R., Becker, D., Eller, A. K., Grützner, J., Boesler, C., Rosenbaum, C., Kühnle, M. C. & 22 others, , Oct 22 2020, In: Nature. 586, 7830, p. 594-599 6 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Crystal structure of enterovirus 71 RNA-dependent RNA polymerase complexed with its protein primer VPg: Implication for a trans mechanism of VPg uridylylation
Chen, C., Wang, Y., Shan, C., Sun, Y., Xu, P., Zhou, H., Yang, C., Shi, P. Y., Rao, Z., Zhang, B. & Lou, Z., May 1 2013, In: Journal of virology. 87, 10, p. 5755-5768 14 p.Research output: Contribution to journal › Article › peer-review
44 Scopus citations -
Dengue drug discovery
Shi, P. Y., Yin, Z., Nilar, S. & Keller, T. H., Oct 31 2011, Third World Diseases. Elliot, R. (ed.). p. 243-276 34 p. (Topics in Medicinal Chemistry; vol. 7).Research output: Chapter in Book/Report/Conference proceeding › Chapter
4 Scopus citations -
Dengue subgenomic flaviviral RNA disrupts immunity in mosquito salivary glands to increase virus transmission
Pompon, J., Manuel, M., Ng, G. K., Wong, B., Shan, C., Manokaran, G., Soto-Acosta, R., Bradrick, S. S., Ooi, E. E., Missé, D., Shi, P. Y. & Garcia-Blanco, M. A., Jul 2017, In: PLoS pathogens. 13, 7, e1006535.Research output: Contribution to journal › Article › peer-review
46 Scopus citations -
Design, synthesis and biological evaluation of spiropyrazolopyridone derivatives as potent dengue virus inhibitors
Xu, J., Xie, X., Chen, H., Zou, J., Xue, Y., Ye, N., Shi, P. Y. & Zhou, J., Jun 1 2020, In: Bioorganic and Medicinal Chemistry Letters. 30, 11, 127162.Research output: Contribution to journal › Article › peer-review
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Detection and quantification of flavivirus NS5 methyl-transferase activities
Lim, S. P., Bodenreider, C. & Shi, P. Y., Jul 18 2013, Antiviral Methods and Protocols. p. 249-268 20 p. (Methods in Molecular Biology; vol. 1030).Research output: Chapter in Book/Report/Conference proceeding › Chapter
5 Scopus citations -
Determinants of dengue virus NS4A protein oligomerization
Lee, C. M., Xie, X., Zou, J., Li, S. H., Qi Lee, M. Y., Dong, H., Qin, C. F., Kang, C. & Shi, P. Y., 2015, In: Journal of virology. 89, 12, p. 6171-6183 13 p.Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
Development and characterization of a stable eGFP enterovirus 71 for antiviral screening
Shang, B., Deng, C., Ye, H., Xu, W., Yuan, Z., Shi, P. Y. & Zhang, B., Feb 2013, In: Antiviral research. 97, 2, p. 198-205 8 p.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
Development and characterization of a stable luciferase dengue virus for high-throughput screening
Zou, G., Xu, H. Y., Qing, M., Wang, Q. Y. & Shi, P. Y., Jul 1 2011, In: Antiviral research. 91, 1, p. 11-19 9 p.Research output: Contribution to journal › Article › peer-review
81 Scopus citations -
Development of a stable Gaussia luciferase enterovirus 71 reporter virus
Xu, L. L., Shan, C., Deng, C. L., Li, X. D., Shang, B. D., Ye, H. Q., Liu, S. Q., Yuan, Z. M., Wang, Q. Y., Shi, P. Y. & Zhang, B., Jul 1 2015, In: Journal of Virological Methods. 219, p. 62-66 5 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Difficulties and advancements in developing drugs for the treatment of dengue fever
Noble, C. G. & Shi, P. Y., Jan 1 2013, In: Expert Opinion on Orphan Drugs. 1, 12, p. 947-949 3 p.Research output: Contribution to journal › Review article › peer-review
1 Scopus citations -
Discovery of dengue virus NS4B inhibitors
Wang, Q. Y., Dong, H., Zou, B., Karuna, R., Wan, K. F., Zou, J., Susila, A., Yip, A., Shan, C., Yeo, K. L., Xu, H., Ding, M., Chan, W. L., Gu, F., Seah, P. G., Liu, W., Lakshminarayana, S. B., Kang, C. B., Lescar, J., Blasco, F. & 2 others, , 2015, In: Journal of virology. 89, 16, p. 8233-8244 12 p.Research output: Contribution to journal › Article › peer-review
52 Scopus citations -
Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design
Yokokawa, F., Nilar, S., Noble, C. G., Lim, S. P., Rao, R., Tania, S., Wang, G., Lee, G., Hunziker, J., Karuna, R., Manjunatha, U., Shi, P-Y. & Smith, P. W., Apr 28 2016, In: Journal of Medicinal Chemistry. 59, 8, p. 3935-3952 18 p.Research output: Contribution to journal › Article › peer-review
45 Scopus citations -
Drug discovery for the developing world: Progress at the Novartis Institute for Tropical Diseases
Jones, C. L., Yeung, B. K. S., Manjunatha, U., Shi, P-Y., Bodenreider, C. & Diagana, T. T., Jun 3 2015, In: Nature Reviews Drug Discovery. 14, 6, p. 442-444 3 p.Research output: Contribution to journal › Letter › peer-review
4 Scopus citations