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5-HT2C receptor desensitization moderates anxiety in 5-HTT deficient mice: From behavioral to cellular evidence
Martin, C. B. P., Martin, V. S., Trigo, J. M., Chevarin, C., Maldonado, R., Fink, L. H., Cunningham, K. A., Hamon, M., Lanfumey, L. & Mongeau, R., 2015, In: International Journal of Neuropsychopharmacology. 18, 3Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
5-HT2c Receptors localize to dopamine and gaba neurons in the rat mesoaccumbens pathway
Bubar, M. J., Stutz, S. J. & Cunningham, K. A., 2011, In: PloS one. 6, 6, e20508.Research output: Contribution to journal › Article › peer-review
75 Scopus citations -
Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts
Wold, E. A., Chen, J., Cunningham, K. A. & Zhou, J., Oct 1 2019, In: Journal of medicinal chemistry. 62, 1, p. 88-127 40 p.Research output: Contribution to journal › Article › peer-review
28 Scopus citations -
Altered anterior cingulate cortex to hippocampus effective connectivity in response to drug cues in men with cocaine use disorder
Ma, L., Steinberg, J. L., Cunningham, K. A., Bjork, J. M., Lane, S. D., Schmitz, J. M., Burroughs, T., Narayana, P. A., Kosten, T. R., Bechara, A. & Moeller, F. G., Jan 30 2018, In: Psychiatry Research - Neuroimaging. 271, p. 59-66 8 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Anterior insula activity regulates the associated behaviors of high fat food binge intake and cue reactivity in male rats
Price, A. E., Stutz, S. J., Hommel, J. D., Anastasio, N. C. & Cunningham, K. A., Feb 1 2019, In: Appetite. 133, p. 231-239 9 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
A protocol for measuring cue reactivity in a rat model of cocaine use disorder
Dimet, A. L., Cisneros, I. E., Fox, R. G., Stutz, S. J., Anastasio, N. C., Cunningham, K. A. & Dineley, K. T., Jun 20 2018, In: Journal of Visualized Experiments. 2018, 136, e55864.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Biophysical validation of serotonin 5-HT2A and 5-HT2C receptor interaction
Felsing, D. E., Anastasio, N. C., Miszkiel, J. M., Gilbertson, S. R., Allen, J. A. & Cunningham, K. A., Aug 2018, In: PloS one. 13, 8, e0203137.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Chronic poly-drug administration damages adult mouse brain neural stem cells
McGrath, E. L., Schlagal, C. R., Cortez, I., Dunn, T. J., Gao, J., Fox, R. G., Stutz, S. J., Kuo, Y. F., Hommel, J. D., Dineley, K. T., Cunningham, K. A., Kaphalia, B. S. & Wu, P., Nov 15 2019, In: Brain Research. 1723, 146425.Research output: Contribution to journal › Article › peer-review
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Cingulo-hippocampal effective connectivity positively correlates with drug-cue attentional bias in opioid use disorder
Ma, L., Steinberg, J. L., Bjork, J. M., Taylor, B. A., Arias, A. J., Terplan, M., Anastasio, N. C., Zuniga, E. A., Lennon, M., Cunningham, K. A. & Moeller, F. G., Dec 30 2019, In: Psychiatry Research - Neuroimaging. 294, 110977.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Cocaine evokes a profile of oxidative stress and impacts innate antiviral response pathways in astrocytes
Cisneros, I. E., Erdenizmenli, M., Cunningham, K. A., Paessler, S. & Dineley, K. T., Jun 2018, In: Neuropharmacology. 135, p. 431-443 13 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Coevolution of Residues Provides Evidence of a Functional Heterodimer of 5-HT2AR and 5-HT2CR Involving Both Intracellular and Extracellular Domains
Fongang, B., Cunningham, K. A., Rowicka, M. & Kudlicki, A., Aug 1 2019, In: Neuroscience. 412, p. 48-59 12 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Convergent neural connectivity in motor impulsivity and high-fat food binge-like eating in male Sprague-Dawley rats
Anastasio, N. C., Stutz, S. J., Price, A. E., Davis-Reyes, B. D., Sholler, D. J., Ferguson, S. M., Neumaier, J. F., Moeller, F. G., Hommel, J. D. & Cunningham, K. A., Sep 1 2019, In: Neuropsychopharmacology. 44, 10, p. 1752-1761 10 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT 2C Receptor
Wild, C. T., Miszkiel, J. M., Wold, E. A., Soto, C. A., Ding, C., Hartley, R. M., White, M. A., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Oct 1 2019, In: Journal of medicinal chemistry. 62, 1, p. 288-305 18 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT2CReceptor-Positive Allosteric Modulators with Enhanced Drug-like Properties
Wold, E. A., Garcia, E. J., Wild, C. T., Miszkiel, J. M., Soto, C. A., Chen, J., Pazdrak, K., Fox, R. G., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Jul 23 2020, In: Journal of medicinal chemistry. 63, 14, p. 7529-7544 16 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Discovery of Potent and Brain-Penetrant GPR52 Agonist that Suppresses Psychostimulant Behavior
Wang, P., Felsing, D., Chen, H., Stutz, S. J., Murphy, R., Cunningham, K., Allen, J. & Zhou, J., Nov 25 2020, In: Journal of Medicinal Chemistry. 63, 22, p. 13951 13972 p.Research output: Contribution to journal › Article › peer-review
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Editorial: Contemporary Perspective on 5-HT2C Receptor Function and Its Pharmacological Targeting
De Deurwaerdère, P., Chagraoui, A. & Cunningham, K. A., Nov 23 2020, In: Frontiers in Pharmacology. 11, 606414.Research output: Contribution to journal › Editorial › peer-review
Open Access -
Editors' Favorites of 2017
Lindsley, C. W., Cunningham, K. A., Hooker, J. M. & Andrews, A. M., Jan 17 2018, In: ACS chemical neuroscience. 9, 1, p. 1-4 4 p.Research output: Contribution to journal › Review article › peer-review
1 Scopus citations -
Effects of escitalopram on attentional bias to cocaine-related stimuli and inhibitory control in cocaine-dependent subjects
Liu, S., Lane, S. D., Schmitz, J. M., Cunningham, K. A., John, V. P. & Moeller, F. G., Sep 1 2013, In: Journal of Psychopharmacology. 27, 9, p. 801-807 7 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Elevated expression of serotonin 5-HT2A receptors in the rat ventral tegmental area enhances vulnerability to the behavioral effects of cocaine
Herin, D. V., Bubar, M. J., Seitz, P. K., Thomas, M. L., Hillman, G. R., Tarasenko, Y. I., Wu, P. & Cunningham, K. A., May 17 2013, In: Frontiers in Psychiatry. 4, FEB, Article 2.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Endogenous Serotonin 5-HT2A and 5-HT2C Receptors Associate in the Medial Prefrontal Cortex
Price, A. E., Sholler, D. J., Stutz, S. J., Anastasio, N. C. & Cunningham, K. A., Jul 17 2019, In: ACS chemical neuroscience. 10, 7, p. 3241-3248 8 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP Isoform 1
Yan, J., Mei, F. C., Cheng, H., Lao, D. H., Hu, Y., Wei, J., Patrikeev, I., Hao, D., Stutz, S. J., Dineley, K. T., Motamedi, M., Hommel, J. D., Cunningham, K. A., Chen, J. & Cheng, X., Mar 2013, In: Molecular and cellular biology. 33, 5, p. 918-926 9 p.Research output: Contribution to journal › Article › peer-review
59 Scopus citations -
Evaluation of the dopamine β-hydroxylase (DβH) inhibitor nepicastat in participants who meet criteria for cocaine use disorder
De La Garza, R., Bubar, M. J., Carbone, C. L., Moeller, F. G., Newton, T. F., Anastasio, N. C., Harper, T. A., Ware, D. L., Fuller, M. A., Holstein, G. J., Jayroe, J. B., Bandak, S. I., Reiman, K. Z., Neale, A. C., Pickford, L. B. & Cunningham, K. A., Jun 3 2015, In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 59, p. 40-48 9 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Exploration of synthetic approaches and pharmacological evaluation of PNU-69176E and its stereoisomer as 5-HT2C receptor allosteric modulators
Ding, C., Bremer, N. M., Smith, T. D., Seitz, P. K., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Jul 18 2012, In: ACS chemical neuroscience. 3, 7, p. 538-545 8 p.Research output: Contribution to journal › Article › peer-review
20 Scopus citations -
Fentanyl self-administration impacts brain immune responses in male Sprague-Dawley rats
Ezeomah, C., Cunningham, K. A., Stutz, S. J., Fox, R. G., Bukreyeva, N., Dineley, K. T., Paessler, S. & Cisneros, I. E., Jul 2020, In: Brain, Behavior, and Immunity. 87, p. 725-738 14 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Forced abstinence from cocaine self-administration is associated with DNA methylation changes in myelin genes in the corpus callosum: A preliminary study
Nielsen, D. A., Huang, W., Hamon, S. C., Maili, L., Witkin, B. M., Fox, R. G., Cunningham, K. A. & Moeller, F. G., 2012, In: Frontiers in Psychiatry. 3, JUN, Article 60.Research output: Contribution to journal › Article › peer-review
28 Scopus citations -
Increased intra-individual reaction time variability in cocaine-dependent subjects: Role of cocaine-related cues
Liu, S., Lane, S. D., Schmitz, J. M., Green, C. E., Cunningham, K. A. & Moeller, F. G., Feb 2012, In: Addictive Behaviors. 37, 2, p. 193-197 5 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
Individual differences in impulsive action reflect variation in the cortical serotonin 5-HT 2A receptor system
Fink, L. H., Anastasio, N. C., Fox, R. G., Rice, K. C., Moeller, F. G. & Cunningham, K. A., Jul 13 2015, In: Neuropsychopharmacology. 40, 8, p. 1957-1968 12 p.Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
Influence of methamphetamine on genital herpes simplex virus type 2 infection in a mouse model
Valencia, F., Bubar, M. J., Milligan, G., Cunningham, K. A. & Bourne, N., Sep 2012, In: Sexually Transmitted Diseases. 39, 9, p. 720-725 6 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Inherent Motor Impulsivity Associates with Specific Gene Targets in the Rat Medial Prefrontal Cortex
Sholler, D. J., Merritt, C. R., Davis-Reyes, B. D., Golovko, G., Anastasio, N. C. & Cunningham, K. A., May 21 2020, In: Neuroscience. 435, p. 161-173 13 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Inhibitory behavioral control: a stochastic dynamic causal modeling study using network discovery analysis
Ma, L., Steinberg, J. L., Cunningham, K., Lane, S. D., Kramer, L. A., Narayana, P. A., Kosten, T. R., Bechara, A. & Moeller, F. G., Apr 1 2015, In: Brain Connectivity. 5, 3, p. 177-186 10 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Inhibitory behavioral control: A stochastic dynamic causal modeling study comparing cocaine dependent subjects and controls
Ma, L., Steinberg, J. L., Cunningham, K. A., Lane, S. D., Bjork, J. M., Neelakantan, H., Price, A. E., Narayana, P. A., Kosten, T. R., Bechara, A. & Moeller, F. G., 2015, In: NeuroImage: Clinical. 7, p. 837-847 11 p.Research output: Contribution to journal › Article › peer-review
23 Scopus citations -
Innovative Therapeutic Intervention for Opioid Use Disorder
Moeller, F. G. & Cunningham, K. A., Jan 1 2018, In: Neuropsychopharmacology. 43, 1, p. 220-221 2 p.Research output: Contribution to journal › Short survey › peer-review
5 Scopus citations -
In vivo and in vitro analyses of novel peptidomimetic disruptors for the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog (PTEN)
Soto, C., Du, H. C., Fox, R., Yang, T., Hooson, J., Anastasio, N. C., Gilbertson, S. R., Cunningham, K. A., Cunningham, K. A. & Gilbertson, S. R., 2019, In: Frontiers in Pharmacology. 10, JULY, 907.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Leave the Ordinary Elsewhere: Novel Serotonin Mechanisms to Address 21st Century Public Health Challenges
Sholler, D. J. & Cunningham, K. A., Jul 17 2019, In: ACS chemical neuroscience. 10, 7, p. 3045-3046 2 p.Research output: Contribution to journal › Editorial › peer-review
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Methylation Patterns of the HTR2A Associate With Relapse-Related Behaviors in Cocaine-Dependent Participants
Land, M. A., Ramesh, D., Miller, A. L., Pyles, R. B., Cunningham, K. A., Moeller, F. G. & Anastasio, N. C., Jun 10 2020, In: Frontiers in Psychiatry. 11, 532.Research output: Contribution to journal › Article › peer-review
Open Access -
Novel Bivalent 5-HT 2A Receptor Antagonists Exhibit High Affinity and Potency in Vitro and Efficacy in Vivo
Soto, C. A., Shashack, M. J., Fox, R. G., Bubar, M. J., Rice, K. C., Watson, C. S., Cunningham, K. A., Gilbertson, S. R. & Anastasio, N. C., Mar 21 2018, In: ACS chemical neuroscience. 9, 3, p. 514-521 8 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Peptide inhibitors disrupt the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog to allosterically modulate cellular signaling and behavior
Anastasio, N. C., Gilbertson, S. R., Bubar, M. J., Agarkov, A., Stutz, S. J., Jeng, Y., Bremer, N. M., Smith, T. D., Fox, R. G., Swinford, S. E., Seitz, P. K., Charendoff, M. N., Craft, J. W., Laezza, F. M., Watson, C. S., Briggs, J. M. & Cunningham, K. A., Jan 23 2013, In: Journal of Neuroscience. 33, 4, p. 1615-1630 16 p.Research output: Contribution to journal › Article › peer-review
25 Scopus citations -
Positive-allosteric modulation of the 5-HT2C receptor: implications for neuropsychopharmacology and neurotherapeutics
Zhou, J. & Cunningham, K. A., Jan 1 2019, In: Neuropsychopharmacology. 44, 1, p. 230-231 2 p.Research output: Contribution to journal › Comment/debate › peer-review
6 Scopus citations -
PPARγ agonism attenuates cocaine cue reactivity
Miller, W. R., Fox, R. G., Stutz, S. J., Lane, S. D., Denner, L., Cunningham, K. A. & Dineley, K. T., Jan 2018, In: Addiction Biology. 23, 1, p. 55-68 14 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
Prevalence of Food Addiction among Low-Income Reproductive-Aged Women
Berenson, A. B., Laz, T. H., Pohlmeier, A. M., Rahman, M. & Cunningham, K. A., Sep 1 2015, In: Journal of Women's Health. 24, 9, p. 740-744 5 p.Research output: Contribution to journal › Article › peer-review
23 Scopus citations -
Quantitative changes in intracellular calcium and extracellular-regulated kinase activation measured in parallel in CHO cells stably expressing serotonin (5-HT) 5-HT 2A or 5-HT 2C receptors
Seitz, P. K., Bremer, N. M., McGinnis, A. G., Cunningham, K. A. & Watson, C. S., Mar 7 2012, In: BMC Neuroscience. 13, 1, 25.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
Rapid-response impulsivity: Definitions, measurement issues, and clinical implications
Hamilton, K. R., Littlefield, A. K., Anastasio, N. C., Cunningham, K. A., Fink, L. H. L., Wing, V. C., Mathias, C. W., Lane, S. D., Schütz, C. G., Swann, A. C., Lejuez, C. W., Clark, L., Moeller, F. G. & Potenza, M. N., Apr 1 2015, In: Personality Disorders: Theory, Research, and Treatment. 6, 2, p. 168-181 14 p.Research output: Contribution to journal › Article › peer-review
69 Scopus citations -
Relationship between attentional bias to cocaine-related stimuli and impulsivity in cocaine-dependent subjects
Liu, S., Lane, S. D., Schmitz, J. M., Waters, A. J., Cunningham, K. A. & Moeller, F. G., Mar 2011, In: American Journal of Drug and Alcohol Abuse. 37, 2, p. 117-122 6 p.Research output: Contribution to journal › Article › peer-review
56 Scopus citations -
Selective serotonin 5-HT2C receptor activation suppresses the reinforcing efficacy of cocaine and sucrose but differentially affects the incentive-salience value of cocaine- vs. sucrose-associated cues
Cunningham, K. A., Fox, R. G., Anastasio, N. C., Bubar, M. J., Stutz, S. J., Moeller, F. G., Gilbertson, S. R. & Rosenzweig-Lipson, S., Sep 2011, In: Neuropharmacology. 61, 3, p. 513-523 11 p.Research output: Contribution to journal › Article › peer-review
76 Scopus citations -
Serotonin (5-HT) 5-HT2A Receptor (5-HT2AR):5-HT2CR Imbalance in Medial Prefrontal Cortex Associates with Motor Impulsivity
Anastasio, N. C., Stutz, S. J., Fink, L. H. L., Swinford-Jackson, S. E., Sears, R. M., Dileone, R. J., Rice, K. C., Moeller, F. G. & Cunningham, K. A., Jul 15 2015, In: ACS chemical neuroscience. 6, 7, p. 1248-1258 11 p.Research output: Contribution to journal › Article › peer-review
45 Scopus citations -
Serotonin (5-hydroxytryptamine) 5-HT2A receptor: Association with inherent and cocaine-evoked behavioral disinhibition in rats
Anastasio, N. C., Stoffel, E. C., Fox, R. G., Bubar, M. J., Rice, K. C., Moeller, F. G. & Cunningham, K. A., Jun 2011, In: Behavioural Pharmacology. 22, 3, p. 248-261 14 p.Research output: Contribution to journal › Article › peer-review
34 Scopus citations -
Serotonin2C receptors in the ventral pallidum regulate motor function in rats
Graves, S. M., Viskniskki, A. A., Cunningham, K. A. & Celeste Napier, T., Aug 7 2013, In: NeuroReport. 24, 11, p. 605-608 4 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Serotonin 5-HT2C receptor activation suppresses binge intake and the reinforcing and motivational properties of high-fat food
Price, A. E., Anastasio, N. C., Stutz, S. J., Hommel, J. D. & Cunningham, K. A., Jul 27 2018, In: Frontiers in Pharmacology. 9, JUL, 821.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Serotonin 5-HT2C Receptor Cys23Ser Single Nucleotide Polymorphism Associates with Receptor Function and Localization In Vitro
Land, M. A., Chapman, H. L., Davis-Reyes, B. D., Felsing, D. E., Allen, J. A., Moeller, F. G., Elferink, L. A., Cunningham, K. A. & Anastasio, N. C., Dec 1 2019, In: Scientific reports. 9, 1, 16737.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Serotonin 5-HT2 receptor interactions with dopamine function: implications for therapeutics in cocaine use disorder
Howell, L. L. & Cunningham, K. A., 2015, In: Pharmacological reviews. 67, 1, p. 176-197 22 p.Research output: Contribution to journal › Review article › peer-review
111 Scopus citations