Find Research outputs

Search results

• A high-throughput drop microfluidic system for virus culture and analysis

  Fischer, A. E., Wu, S. K., Proescher, J. B. G., Rotem, A., Chang, C. B., Zhang, H., Tao, Y., Mehoke, T. S., Thielen, P. M., Kolawole, A. O., Smith, T. J., Wobus, C. E., Weitz, D. A., Lin, J. S., Feldman, A. B. & Wolfe, J. T., Mar 1 2015, In: Journal of Virological Methods. 213, p. 111-117 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Microfluidics
  • Virion
  • Viruses
  • RNA Viruses
  • Antibodies
  16 Scopus citations

• A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis

  Bailey, J., Powell, L., Sinanan, L., Neal, J., Li, M., Smith, T. & Bell, E., Sep 2011, In: FEBS Journal. 278, 17, p. 3140-3151 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Glutamate Dehydrogenase
  • Catalysis
  • Zinc
  • Inhibition (Psychology)
  • Europium
  7 Scopus citations

• Atomic structure of salutaridine reductase from the opium poppy (Papaver somniferum)

  Higashi, Y., Kutchan, T. M. & Smith, T. J., Feb 25 2011, In: Journal of Biological Chemistry. 286, 8, p. 6532-6541 10 p.

  Research output: Contribution to journal › Article › peer-review

  • salutaridine
  • Papaver
  • Short Chain Dehydrogenase-Reductases
  • Opium
  • Oxidoreductases
  10 Scopus citations

• Editorial overview: Theory and simulation: Macromolecular machines

  Hopfner, K. P. & Smith, T. J., Apr 2014, In: Current Opinion in Structural Biology. 25, p. 6-8 3 p.

  Research output: Contribution to journal › Editorial › peer-review

• Flexibility in surface-exposed loops in a virus capsid mediates escape from antibody neutralization

  Kolawole, A. O., Li, M., Xia, C., Fischer, A. E., Giacobbi, N. S., Rippinger, C. M., Proescher, J. B. G., Wu, S. K., Bessling, S. L., Gamez, M., Yu, C., Zhang, R., Mehoke, T. S., Pipas, J. M., Wolfe, J. T., Lin, J. S., Feldman, A. B., Smith, T. J. & Wobus, C. E., Apr 2014, In: Journal of virology. 88, 8, p. 4543-4557 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Norovirus
  • capsid
  • Capsid
  • neutralization
  • Viruses
  24 Scopus citations

• Glutamate dehydrogenase: Structure, regulation, and its role in insulin homeostasis

  Smith, T. J., Apr 4 2012, Monogenic Hyperinsulinemic Hypoglycemia Disorders. Charles, S. & Diva, D. L. (eds.). p. 87-99 13 p. (Frontiers in Diabetes; vol. 21).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Glutamate Dehydrogenase
  • Allosteric Regulation
  • Homeostasis
  • Insulin
  • Naphazoline

• Glutamate dehydrogenase: Structure, allosteric regulation, and role in insulin homeostasis

  Li, M., Li, C., Allen, A., Stanley, C. A. & Smith, T. J., Mar 2014, In: Neurochemical Research. 39, 3, p. 433-445 13 p.

  Research output: Contribution to journal › Review article › peer-review

  • Allosteric Regulation
  • Glutamate Dehydrogenase
  • Homeostasis
  • Insulin
  • Guanosine Triphosphate
  28 Scopus citations

• Glutamate dehydrogenase

  Smith, T. J. & Stanley, C. A., Nov 24 2011, Amino Acids in Human Nutrition and Health. CABI Publishing, p. 1-23 23 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Glutamate Dehydrogenase
  • glutamate dehydrogenase
  • Animals
  • Enzymes
  • enzymes

• Green tea polyphenols control dysregulated glutamate dehydrogenase in transgenic mice by hijacking the ADP activation site

  Li, C., Li, M., Chen, P., Narayan, S., Matschinsky, F. M., Bennett, M. J., Stanley, C. A. & Smith, T. J., Oct 30 2011, In: Journal of Biological Chemistry. 286, 39, p. 34164-34174 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Tea
  • Glutamate Dehydrogenase
  • Hyperinsulinemic hypoglycemia, familial, 6
  • Polyphenols
  • epigallocatechin gallate
  48 Scopus citations

• Green tea polyphenols in drug discovery: A success or failure?

  Smith, T. J., Jun 2011, In: Expert Opinion on Drug Discovery. 6, 6, p. 589-595 7 p.

  Research output: Contribution to journal › Review article › peer-review

  • Polyphenols
  • Tea
  • Drug Discovery
  • Camellia sinensis
  • Food Supply
  24 Scopus citations

• Identification of a Novel Activator of Mammalian Glutamate Dehydrogenase

  Smith, H. Q. & Smith, T., Nov 29 2016, In: Biochemistry. 55, 47, p. 6568-6576 9 p.

  Research output: Contribution to journal › Article › peer-review

  • N1-(4-(2-aminopyrimidin-4-yl)phenyl)-3-(trifluoromethyl)benzene-1-sulfonamide
  • Glutamate Dehydrogenase
  • Adenosine Diphosphate
  • Guanosine Triphosphate
  • Hyperinsulinemic hypoglycemia, familial, 6
  8 Scopus citations

• Multidomain carbohydrate-binding proteins involved in Bacteroides thetaiotaomicron starch metabolism

  Cameron, E. A., Maynard, M. A., Smith, C. J., Smith, T. J., Koropatkin, N. M. & Martens, E. C., Oct 5 2012, In: Journal of Biological Chemistry. 287, 41, p. 34614-34625 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Bacteroides thetaiotaomicron
  • saccharide-binding proteins
  • Metabolism
  • Starch
  • Carbohydrates
  59 Scopus citations

• Newly isolated mAbs broaden the neutralizing epitope in murine norovirus

  Kolawole, A. O., Xia, C., Li, M., Gamez, M., Yu, C., Rippinger, C. M., Yucha, R. E., Smith, T. J. & Wobus, C. E., Sep 2014, In: Journal of General Virology. 95, PART 9, p. 1958-1968 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Norovirus
  • Epitopes
  • Antibodies
  • Immunoglobulin A
  • Viruses
  9 Scopus citations

• Protruding domain of capsid protein is necessary and sufficient to determine murine norovirus replication and pathogenesis in vivo

  Strong, D. W., Thackray, L. B., Smith, T. J. & Virgin, H. W., Mar 2012, In: Journal of virology. 86, 6, p. 2950-2958 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Norovirus
  • Capsid Proteins
  • coat proteins
  • pathogenesis
  • mice
  55 Scopus citations

• Structural basis for broad detection of genogroup II noroviruses by a monoclonal antibody that binds to a site occluded in the viral particle

  Hansman, G. S., Taylor, D. W., McLellan, J. S., Smith, T. J., Georgiev, I., Tame, J. R. H., Park, S. Y., Yamazaki, M., Gondaira, F., Miki, M., Katayama, K., Murata, K. & Kwong, P. D., Apr 2012, In: Journal of virology. 86, 7, p. 3635-3646 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Norovirus
  • virus-like particles
  • virion
  • Virion
  • monoclonal antibodies
  50 Scopus citations

• Structural studies on antibody recognition and neutralization of viruses

  Smith, T. J., Aug 2011, In: Current Opinion in Virology. 1, 2, p. 150-156 7 p.

  Research output: Contribution to journal › Review article › peer-review

  • Viruses
  • Antibodies
  • Cucumovirus
  • Ross River virus
  • Aphids
  6 Scopus citations

• Structure-activity determinants in antifungal plant defensins msdef1 and mtdef4 with different modes of action against fusarium graminearum

  Sagaram, U. S., Pandurangi, R., Kaur, J., Smith, T. J. & Shah, D. M., 2011, In: PloS one. 6, 4, e18550.

  Research output: Contribution to journal › Article › peer-review

  • Defensins
  • Fusarium
  • Fusarium graminearum
  • mechanism of action
  • antifungal properties
  104 Scopus citations

• The structure and allosteric regulation of glutamate dehydrogenase

  Li, M., Li, C., Allen, A., Stanley, C. A. & Smith, T. J., Sep 2011, In: Neurochemistry International. 59, 4, p. 445-455 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • Allosteric Regulation
  • Glutamate Dehydrogenase
  • Insulin
  • Animals
  • Housekeeping
  30 Scopus citations

• The structure and allosteric regulation of mammalian glutamate dehydrogenase

  Li, M., Li, C., Allen, A., Stanley, C. A. & Smith, T. J., Mar 15 2012, In: Archives of Biochemistry and Biophysics. 519, 2, p. 69-80 12 p.

  Research output: Contribution to journal › Review article › peer-review

  • Allosteric Regulation
  • Glutamate Dehydrogenase
  • Guanosine Triphosphate
  • Hyperinsulinemic hypoglycemia, familial, 6
  • Animals
  78 Scopus citations

• Transgenic maize plants expressing the Totivirus antifungal protein, KP4, are highly resistant to corn smut

  Allen, A., Islamovic, E., Kaur, J., Gold, S., Shah, D. & Smith, T. J., Oct 2011, In: Plant Biotechnology Journal. 9, 8, p. 857-864 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Totivirus
  • Genetically Modified Plants
  • antifungal proteins
  • Zea mays
  • Ustilago zeae
  23 Scopus citations