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• A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis

  Bailey, J., Powell, L., Sinanan, L., Neal, J., Li, M., Smith, T. & Bell, E., Sep 2011, In: FEBS Journal. 278, 17, p. 3140-3151 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Glutamate Dehydrogenase
  • Catalysis
  • Zinc
  • Inhibition (Psychology)
  • Europium
  8 Scopus citations

• Antibody-induced uncoating of human rhinovirus B14

  Dong, Y., Liu, Y., Jiang, W., Smith, T. J., Xu, Z. & Rossmann, M. G., Jul 25 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 30, p. 8017-8022 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Rhinovirus
  • Capsid
  • Antibodies
  • Virus Uncoating
  • Cryoelectron Microscopy
  28 Scopus citations

• A severe case of hyperinsulinism due to hemizygous activating mutation of glutamate dehydrogenase

  Barrosse-Antle, M., Su, C., Chen, P., Boodhansingh, K. E., Smith, T. J., Stanley, C. A., De León, D. D. & Li, C., Dec 2017, In: Pediatric Diabetes. 18, 8, p. 911-916 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Glutamate Dehydrogenase
  • Hyperinsulinism
  • Guanosine Triphosphate
  • Mutation
  • Heterozygote
  9 Scopus citations

• Atomic structure of salutaridine reductase from the opium poppy (Papaver somniferum)

  Higashi, Y., Kutchan, T. M. & Smith, T. J., Feb 25 2011, In: Journal of Biological Chemistry. 286, 8, p. 6532-6541 10 p.

  Research output: Contribution to journal › Article › peer-review

  • salutaridine
  • Papaver
  • Short Chain Dehydrogenase-Reductases
  • Opium
  • Oxidoreductases
  11 Scopus citations

• Glutamate dehydrogenase

  Smith, T. J. & Stanley, C. A., Nov 24 2011, Amino Acids in Human Nutrition and Health. CABI Publishing, p. 1-23 23 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Glutamate Dehydrogenase
  • glutamate dehydrogenase
  • Animals
  • Enzymes
  • enzymes

• Glutamate dehydrogenase: Structure, regulation, and its role in insulin homeostasis

  Smith, T. J., Apr 4 2012, Monogenic Hyperinsulinemic Hypoglycemia Disorders. Charles, S. & Diva, D. L. (eds.). p. 87-99 13 p. (Frontiers in Diabetes; vol. 21).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Glutamate Dehydrogenase
  • Allosteric Regulation
  • Homeostasis
  • Insulin
  • Naphazoline

• Green tea polyphenols control dysregulated glutamate dehydrogenase in transgenic mice by hijacking the ADP activation site

  Li, C., Li, M., Chen, P., Narayan, S., Matschinsky, F. M., Bennett, M. J., Stanley, C. A. & Smith, T. J., Oct 30 2011, In: Journal of Biological Chemistry. 286, 39, p. 34164-34174 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Tea
  • Glutamate Dehydrogenase
  • Hyperinsulinemic hypoglycemia, familial, 6
  • Polyphenols
  • epigallocatechin gallate
  48 Scopus citations

• Green tea polyphenols in drug discovery: A success or failure?

  Smith, T. J., Jun 2011, In: Expert Opinion on Drug Discovery. 6, 6, p. 589-595 7 p.

  Research output: Contribution to journal › Review article › peer-review

  • Polyphenols
  • Tea
  • Drug Discovery
  • Camellia sinensis
  • Food Supply
  24 Scopus citations

• Identification of a Novel Activator of Mammalian Glutamate Dehydrogenase

  Smith, H. Q. & Smith, T. J., Nov 29 2016, In: Biochemistry. 55, 47, p. 6568-6576 9 p.

  Research output: Contribution to journal › Article › peer-review

  • N1-(4-(2-aminopyrimidin-4-yl)phenyl)-3-(trifluoromethyl)benzene-1-sulfonamide
  • Glutamate Dehydrogenase
  • Adenosine Diphosphate
  • Guanosine Triphosphate
  • Hyperinsulinemic hypoglycemia, familial, 6
  8 Scopus citations

• Multidomain carbohydrate-binding proteins involved in Bacteroides thetaiotaomicron starch metabolism

  Cameron, E. A., Maynard, M. A., Smith, C. J., Smith, T. J., Koropatkin, N. M. & Martens, E. C., Oct 5 2012, In: Journal of Biological Chemistry. 287, 41, p. 34614-34625 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Bacteroides thetaiotaomicron
  • saccharide-binding proteins
  • Metabolism
  • Starch
  • Carbohydrates
  60 Scopus citations

• Norovirus escape from broadly neutralizing antibodies is limited to allostery-like mechanisms

  Kolawole, A. O., Smith, H. Q., Svoboda, S. A., Lewis, M. S., Sherman, M. B., Lynch, G. C., Pettitt, B. M., Smith, T. J. & Wobus, C. E., Sep 1 2017, In: mSphere. 2, 5, e00334-17.

  Research output: Contribution to journal › Article › peer-review

  • Norovirus
  • Neutralizing Antibodies
  • Antibodies
  • Mutation
  • Vaccines
  18 Scopus citations

• Protruding domain of capsid protein is necessary and sufficient to determine murine norovirus replication and pathogenesis in vivo

  Strong, D. W., Thackray, L. B., Smith, T. J. & Virgin, H. W., Mar 2012, In: Journal of virology. 86, 6, p. 2950-2958 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Norovirus
  • Capsid Proteins
  • coat proteins
  • pathogenesis
  • mice
  56 Scopus citations

• Stability of cucumber necrosis virus at the quasi-6-fold axis affects zoospore transmission

  Sherman, M. B., Kakani, K., Rochon, DA., Jiang, W., Voss, N. R. & Smith, T. J., Oct 1 2017, In: Journal of virology. 91, 19, e01030-17.

  Research output: Contribution to journal › Article › peer-review

  • Cucumber necrosis virus
  • zoospores
  • Zinc
  • Tombusvirus
  • capsid
  2 Scopus citations

• Structural basis for broad detection of genogroup II noroviruses by a monoclonal antibody that binds to a site occluded in the viral particle

  Hansman, G. S., Taylor, D. W., McLellan, J. S., Smith, T. J., Georgiev, I., Tame, J. R. H., Park, S. Y., Yamazaki, M., Gondaira, F., Miki, M., Katayama, K., Murata, K. & Kwong, P. D., Apr 2012, In: Journal of virology. 86, 7, p. 3635-3646 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Norovirus
  • virus-like particles
  • virion
  • Virion
  • monoclonal antibodies
  51 Scopus citations

• Structural studies on antibody recognition and neutralization of viruses

  Smith, T. J., Aug 2011, In: Current Opinion in Virology. 1, 2, p. 150-156 7 p.

  Research output: Contribution to journal › Review article › peer-review

  • Viruses
  • Antibodies
  • Cucumovirus
  • Ross River virus
  • Aphids
  6 Scopus citations

• Structure-activity determinants in antifungal plant defensins msdef1 and mtdef4 with different modes of action against fusarium graminearum

  Sagaram, U. S., Pandurangi, R., Kaur, J., Smith, T. J. & Shah, D. M., 2011, In: PloS one. 6, 4, e18550.

  Research output: Contribution to journal › Article › peer-review

  • Defensins
  • Fusarium
  • Fusarium graminearum
  • mechanism of action
  • antifungal properties
  106 Scopus citations

• The dynamic life of virus capsids

  Sherman, M. B., Smith, H. Q. & Smith, T. J., Jun 2020, In: Viruses. 12, 6, 618.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Capsid
  • Viruses
  • Rhinovirus
  • Norovirus
  • Immune System

• The structure and allosteric regulation of glutamate dehydrogenase

  Li, M., Li, C., Allen, A., Stanley, C. A. & Smith, T. J., Sep 2011, In: Neurochemistry International. 59, 4, p. 445-455 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • Allosteric Regulation
  • Glutamate Dehydrogenase
  • Insulin
  • Animals
  • Housekeeping
  31 Scopus citations

• The structure and allosteric regulation of mammalian glutamate dehydrogenase

  Li, M., Li, C., Allen, A., Stanley, C. A. & Smith, T. J., Mar 15 2012, In: Archives of Biochemistry and Biophysics. 519, 2, p. 69-80 12 p.

  Research output: Contribution to journal › Review article › peer-review

  • Allosteric Regulation
  • Glutamate Dehydrogenase
  • Guanosine Triphosphate
  • Hyperinsulinemic hypoglycemia, familial, 6
  • Animals
  79 Scopus citations

• Transgenic maize plants expressing the Totivirus antifungal protein, KP4, are highly resistant to corn smut

  Allen, A., Islamovic, E., Kaur, J., Gold, S., Shah, D. & Smith, T. J., Oct 2011, In: Plant Biotechnology Journal. 9, 8, p. 857-864 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Totivirus
  • Genetically Modified Plants
  • antifungal proteins
  • Zea mays
  • Ustilago zeae
  23 Scopus citations