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  • Nigel Bourne

Activity and the metabolic activation pathway of the potent and selective hepatitis C virus pronucleotide inhibitor PSI-353661

Furman, P. A., Murakami, E., Niu, C., Lam, A. M., Espiritu, C., Bansal, S., Bao, H., Tolstykh, T., Micolochick Steuer, H., Keilman, M., Zennou, V., Bourne, N., Veselenak, R. L., Chang, W., Ross, B. S., Du, J., Otto, M. J. & Sofia, M. J., Aug 2011, In : Antiviral research. 91, 2, p. 120-132 13 p.

Research output: Contribution to journalArticle

32 Scopus citations

A dengue virus type 4 model of disseminated lethal infection in AG129 mice

Milligan, G. N., Sarathy, V. V., Infante, E., Li, L., Campbell, G. A., Beatty, P. R., Harris, E., Barrett, A. D. T. & Bourne, N., May 4 2015, In : PloS one. 10, 5, e0125476.

Research output: Contribution to journalArticle

32 Scopus citations

A lethal model of disseminated dengue virus type 1 infection in AG129 mice

Milligan, G. N., Sarathy, V. V., White, M. M., Greenberg, M. B., Campbell, G. A., Pyles, R. B., Barrett, A. D. T. & Bourne, N., Oct 2017, In : Journal of General Virology. 98, 10, p. 2507-2519 13 p., 000923.

Research output: Contribution to journalArticle

10 Scopus citations
43 Scopus citations

An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses

Li, G., Adam, A., Luo, H., Shan, C., Cao, Z., Fontes-Garfias, C. R., Sarathy, V. V., Teleki, C., Winkelmann, E. R., Liang, Y., Sun, J., Bourne, N., Barrett, A. D. T., Shi, P. Y. & Wang, T., Dec 1 2019, In : npj Vaccines. 4, 1, 48.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

An Infectious cDNA Clone of Zika Virus to Study Viral Virulence, Mosquito Transmission, and Antiviral Inhibitors

Shan, C., Xie, X., Muruato, A. E., Rossi, S. L., Roundy, C. M., Azar, S. R., Yang, Y., Tesh, R. B., Bourne, N., Barrett, A. D., Vasilakis, N., Weaver, S. C. & Shi, P. Y., Jun 8 2016, In : Cell Host and Microbe. 19, 6, p. 891-900 10 p.

Research output: Contribution to journalArticle

150 Scopus citations

Attenuation of zika virus by passage in human HeLa cells

Li, L., Collins, N. D., Widen, S. G., Davis, E. H., Kaiser, J. A., White, M. M., Greenberg, M. B., Barrett, A. D. T., Bourne, N. & Sarathy, V. V., Sep 2019, In : Vaccines. 7, 3, 93.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
16 Scopus citations

Control and Eradication of Human and Animal Diseases by Vaccination

Bourne, N. & Milligan, G., Dec 9 2014, Vaccinology: An Essential Guide. Wiley Blackwell, p. 43-58 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Cultivated human vaginal microbiome communities impact zika and herpes simplex virus replication in ex vivovaginal mucosal cultures

Amerson-Brown, M. H., Miller, A. L., Maxwell, C. A., White, M. M., Vincent, K. L., Bourne, N. & Pyles, R. B., 2019, In : Frontiers in Microbiology. 10, JAN, 3340.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Detection of herpes simplex virus type 2 (HSV-2) -specific cell-mediated immune responses in guinea pigs during latent HSV-2 genital infection

Perry, C. L., Banasik, B. N., Gorder, S. R., Xia, J., Auclair, S., Bourne, N. & Milligan, G., Dec 1 2016, In : Journal of Immunological Methods. 439, p. 1-7 7 p.

Research output: Contribution to journalArticle

2 Scopus citations
7 Scopus citations

Development of an anti-guinea pig CD4 monoclonal antibody for depletion of CD4+ T cells in vivo

Banasik, B. N., Perry, C. L., Keith, C. A., Bourne, N., Schäfer, H. & Milligan, G. N., Nov 2019, In : Journal of Immunological Methods. 474, 112654.

Research output: Contribution to journalArticle

Development of disease and immunity at the genital epithelium following intrarectal inoculation of male guinea pigs with herpes simplex virus type 2

Bourne, N., Banasik, B. N., Perry, C. L., Miller, A. L., White, M., Pyles, R. B. & Milligan, G. N., Jan 2 2019, In : Virology. 526, p. 180-188 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Distinct neutralizing antibody correlates of protection among related Zika virus vaccines identify a role for antibody quality

Maciejewski, S., Ruckwardt, T. J., Morabito, K. M., Foreman, B. M., Burgomaster, K. E., Gordon, D. N., Pelc, R. S., DeMaso, C. R., Ko, S. Y., Fisher, B. E., Yang, E. S., Nair, D., Foulds, K. E., Todd, J. P., Kong, W. P., Roy, V., Aleshnick, M., Speer, S. D., Bourne, N., Barrett, A. D. & 10 others, Nason, M. C., Roederer, M., Gaudinski, M. R., Chen, G. L., Dowd, K. A., Ledgerwood, J. E., Alter, G., Mascola, J. R., Graham, B. S. & Pierson, T. C., Jun 10 2020, In : Science Translational Medicine. 12, 547, eaaw9066.

Research output: Contribution to journalArticle

1 Scopus citations

Enhancing the utility of a prM/E-expressing chimeric vaccine for Japanese encephalitis by addition of the JEV NS1 gene

Ishikawa, T., Wang, G., Widman, D. G., Infante, E., Winkelmann, E. R., Bourne, N. & Mason, P. W., Oct 6 2011, In : Vaccine. 29, 43, p. 7444-7455 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Evolution of a cell culture-derived genotype 1a hepatitis C Virus (H77S.2) during persistent infection with chronic hepatitis in a Chimpanzee

Yi, M. K., Hu, F., Joyce, M., Saxena, V., Welsch, C., Chavez, D., Guerra, B., Yamane, D., Veselenak, R., Pyles, R., Walker, C. M., Tyrrell, L., Bourne, N., Lanford, R. E. & Lemon, S. M., Apr 2014, In : Journal of virology. 88, 7, p. 3678-3694 17 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Image-based noninvasive evaluation of colorectal mucosal injury in sheep after topical application of microbicides

Vincent, K. L., Vargas, G., Bourne, N., Galvan-Turner, V., Saada, J. I., Lee, G. H., Sbrana, E. & Motamedi, M., Nov 2013, In : Sexually Transmitted Diseases. 40, 11, p. 854-859 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Increased frequency of virus shedding by herpes simplex virus 2-infected Guinea pigs in the absence of CD4 T lymphocytes

Bourne, N., Perry, C. L., Banasik, B. N., Miller, A. L., White, M., Pyles, R. B., Schäfer, H. & Milligan, G. N., Feb 1 2019, In : Journal of virology. 93, 4, e0172118.

Research output: Contribution to journalArticle

6 Scopus citations

Inhibition of hepatitis C virus replicon RNA synthesis by PSI-352938, a cyclic phosphate prodrug of β-D-2′-deoxy-2′-α-fluoro- 2′-β-C-methylguanosine

Lam, A. M., Espiritu, C., Murakami, E., Zennou, V., Bansal, S., Micolochick Steuer, H. M., Niu, C., Keilman, M., Bao, H., Bourne, N., Veselenak, R. L., Reddy, P. G., Chang, W., Du, J., Nagarathnam, D., Sofia, M. J., Otto, M. J. & Furman, P. A., Jun 1 2011, In : Antimicrobial Agents and Chemotherapy. 55, 6, p. 2566-2575 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Investigating the efficacy of monovalent and tetravalent dengue vaccine formulations against DENV-4 challenge in AG129 mice

Fuchs, J., Chu, H., O'Day, P., Pyles, R., Bourne, N., Das, S. C., Milligan, G. N., Barrett, A. D. T., Partidos, C. D. & Osorio, J. E., Nov 12 2014, In : Vaccine. 32, 48, p. 6537-6543 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

In vivo evaluation of antiviral efficacy against genital herpes using mouse and guinea pig models

Valencia, F., Veselenak, R. L. & Bourne, N., Jul 18 2013, Antiviral Methods and Protocols. p. 315-326 12 p. (Methods in Molecular Biology; vol. 1030).

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Scopus citations
1 Scopus citations
10 Scopus citations

Mouse models of dengue virus infection for vaccine testing

Sarathy, V., Milligan, G., Bourne, N. & Barrett, A., Dec 10 2015, In : Vaccine. 33, 50, p. 7051-7060 10 p.

Research output: Contribution to journalArticle

31 Scopus citations
4 Scopus citations

Subcapsular sinus macrophages limit dissemination of West Nile virus particles after inoculation but are not essential for the development of West Nile virus-specific T cell responses

Winkelmann, E. R., Widman, D. G., Xia, J., Johnson, A. J., van Rooijen, N., Mason, P. W., Bourne, N. & Milligan, G. N., Feb 2014, In : Virology. 450-451, p. 278-289 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

The fibroblast growth factor 14·voltage-gated sodium channel complex is a new target of glycogen synthase kinase 3 (GSK3)

Shavkunov, A. S., Wildburger, N. C., Nenov, M. N., James, T. F., Buzhdygan, T. P., Panova-Elektronova, N. I., Green, T. A., Veselenak, R. L., Bourne, N. & Laezza, F., Jul 5 2013, In : Journal of Biological Chemistry. 288, 27, p. 19370-19385 16 p.

Research output: Contribution to journalArticle

57 Scopus citations
1 Scopus citations

Virus-specific immune memory at peripheral sites of Herpes Simplex Virus type 2 (HSV-2) infection in Guinea pigs

Xia, J., Veselenak, R. L., Gorder, S. R., Bourne, N. & Milligan, G. N., Dec 8 2014, In : PloS one. 9, 12, e114652.

Research output: Contribution to journalArticle

9 Scopus citations