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• A cDNA Clone-Launched Platform for High-Yield Production of Inactivated Zika Vaccine

  Yang, Y., Shan, C., Zou, J., Muruato, A. E., Bruno, D. N., de Almeida Medeiros Daniele, B., Vasconcelos, P. F. C., Rossi, S. L., Weaver, S. C., Xie, X. & Shi, P. Y., Mar 1 2017, In: EBioMedicine. 17, p. 145-156 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Inactivated Vaccines
  • Viruses
  • Zika Virus
  • Complementary DNA
  • Clone Cells
  27 Scopus citations

• A chimeric dengue virus vaccine using japanese encephalitis virus vaccine strain SA14-14-2 as backbone is immunogenic and protective against either parental virus in mice and nonhuman primates

  Li, X. F., Deng, Y. Q., Yang, H. Q., Zhao, H., Jiang, T., Yu, X. D., Li, S. H., Ye, Q., Zhu, S. Y., Wang, H. J., Zhang, Y., Ma, J., Yu, Y. X., Liu, Z. Y., Li, Y. H., Qin, E. D., Shi, P. Y. & Qin, C. F., Dec 2013, In: Journal of virology. 87, 24, p. 13694-13705 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Vaccines
  • Japanese encephalitis virus
  • Japanese Encephalitis Virus
  • Dengue virus
  • Dengue Virus
  43 Scopus citations

• A conserved pocket in the dengue virus polymerase identified through fragment-based screening

  Noble, C. G., Lim, S. P., Arora, R., Yokokawa, F., Nilar, S., Seh, C. C., Wright, S. K., Benson, T. E., Smith, P. W. & Shi, P. Y., Apr 15 2016, In: Journal of Biological Chemistry. 291, 16, p. 8541-8548 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • Viruses
  • Screening
  • Serogroup
  • Enzyme inhibition
  30 Scopus citations

• A crystal structure of the dengue virus non-structural protein 5 (NS5) polymerase delineates interdomain amino acid residues that enhance its thermostability and de novo initiation activities

  Lim, S. P., Koh, J. H. K., Seh, C. C., Liew, C. W., Davidson, A. D., Chua, L. S., Chandrasekaran, R., Cornvik, T. C., Shi, P. Y. & Lescar, J., Oct 25 2013, In: Journal of Biological Chemistry. 288, 43, p. 31105-31114 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Viral Structural Proteins
  • RNA Replicase
  • Crystal structure
  • Dengue Virus
  • Viruses
  55 Scopus citations

• A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication

  Zhao, Y., Soh, T. S., Zheng, J., Chan, K. W. K., Phoo, W. W., Lee, C. C., Tay, M. Y. F., Swaminathan, K., Cornvik, T. C., Lim, S. P., Shi, P. Y., Lescar, J., Vasudevan, S. G. & Luo, D., Mar 1 2015, In: PLoS pathogens. 11, 3, p. 1-27 27 p., e1004682.

  Research output: Contribution to journal › Article › peer-review

  • dengue virus NS5 protein
  • RNA Replicase
  • Virus Replication
  • Flavivirus
  • Methyltransferases
  106 Scopus citations

• Adenosine analog NITD008 is a potent inhibitor of zika virus

  Deng, Y. Q., Zhang, N. N., Li, C. F., Tian, M., Hao, J. N., Xie, X. P., Shi, P. Y. & Qin, C. F., Oct 1 2016, In: Open Forum Infectious Diseases. 3, 4

  Research output: Contribution to journal › Article › peer-review

  • NITD008
  • Zika Virus
  • Adenosine
  • Antiviral Agents
  • Viremia
  82 Scopus citations

• Adulthood Sequelae of Congenital Zika Virus Infection in Mice

  Zou, J. & Shi, P. Y., Jun 2017, In: EBioMedicine. 20, p. 11-12 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review
  3 Scopus citations

• A fluorescence-based alkaline phosphatase-coupled polymerase assay for identification of inhibitors of dengue virus RNA-Dependent RNA polymerase

  Niyomrattanakit, P., Abas, S. N., Lim, C. C., Beer, D., Shi, P. Y. & Chen, Y. L., Feb 2011, In: Journal of Biomolecular Screening. 16, 2, p. 201-210 10 p.

  Research output: Contribution to journal › Article › peer-review

  • RNA Replicase
  • Dengue Virus
  • Viruses
  • Assays
  • Fluorescence
  39 Scopus citations

• A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models

  Shan, C., Muruato, A. E., Nunes, B. T. D., Luo, H., Xie, X., Medeiros, D. B. A., Wakamiya, M., Tesh, R. B., Barrett, A. D., Wang, T., Weaver, S. C., Vasconcelos, P. F. C., Rossi, S. L. & Shi, P. Y., Jun 1 2017, In: Nature Medicine. 23, 6, p. 763-767 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Viruses
  • Immunity
  • Vaccines
  • Epidemics
  157 Scopus citations

• A multidimensional platform for the purification of non-coding RNA species

  Chionh, Y. H., Ho, C. H., Pruksakorn, D., Ramesh Babu, I., Ng, C. S., Hia, F., McBee, M. E., Su, D., Pang, Y. L. J., Gu, C., Dong, H., Prestwich, E. G., Shi, P. Y., Preiser, P. R., Alonso, S. & Dedon, P. C., Sep 2013, In: Nucleic acids research. 41, 17, p. e168

  Research output: Contribution to journal › Article › peer-review

  • Untranslated RNA
  • Ribonucleosides
  • Viral Genome
  • RNA
  • Plasmodium
  26 Scopus citations

• A Multiplex Microsphere Immunoassay for Zika Virus Diagnosis

  Wong, S. J., Furuya, A., Zou, J., Xie, X., Dupuis, A. P., Kramer, L. D. & Shi, P. Y., Feb 1 2017, In: EBioMedicine. 16, p. 136-140 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Microspheres
  • Viruses
  • Immunoassay
  • Zika Virus Infection
  57 Scopus citations

• An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction

  Xia, H., Luo, H., Shan, C., Muruato, A. E., Nunes, B. T. D., Medeiros, D. B. A., Zou, J., Xie, X., Giraldo, M. I., Vasconcelos, P. F. C., Weaver, S. C., Wang, T., Rajsbaum, R. & Shi, P. Y., Dec 1 2018, In: Nature communications. 9, 1, 414.

  Research output: Contribution to journal › Article › peer-review

  • interferon
  • Zika Virus
  • viruses
  • Viruses
  • mutations
  93 Scopus citations

• An Infectious cDNA Clone of Zika Virus to Study Viral Virulence, Mosquito Transmission, and Antiviral Inhibitors

  Shan, C., Xie, X., Muruato, A. E., Rossi, S. L., Roundy, C. M., Azar, S. R., Yang, Y., Tesh, R. B., Bourne, N., Barrett, A. D., Vasilakis, N., Weaver, S. C. & Shi, P. Y., Jun 8 2016, In: Cell Host and Microbe. 19, 6, p. 891-900 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Culicidae
  • Virulence
  • Antiviral Agents
  • Complementary DNA
  162 Scopus citations

• Anti-infectives: Can cellular screening deliver?

  Keller, T. H., Shi, P. Y. & Wang, Q. Y., Aug 1 2011, In: Current Opinion in Chemical Biology. 15, 4, p. 529-533 5 p.

  Research output: Contribution to journal › Review article › peer-review

  • Emerging Communicable Diseases
  • Drug Discovery
  • Diarylquinolines
  • Screening
  • Viruses
  22 Scopus citations

• A Rapid Zika Diagnostic Assay to Measure Neutralizing Antibodies in Patients

  Shan, C., Xie, X., Ren, P., Loeffelholz, M. J., Yang, Y., Furuya, A., Dupuis, A. P., Kramer, L. D., Wong, S. J. & Shi, P. Y., Mar 1 2017, In: EBioMedicine. 17, p. 157-162 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Viruses
  • Assays
  • Neutralizing Antibodies
  • Zika Virus Infection
  • Neutralization Tests
  44 Scopus citations

• A single amino acid in nonstructural protein NS4B Confers virulence to dengue virus in AG129 mice through enhancement of viral RNA synthesis

  Grant, D., Tan, G. K., Qing, M., Ng, J. K. W., Yip, A., Zou, G., Xie, X., Yuan, Z. Y., Schreiber, J., Schul, W., Shi, P. Y. & Alonso, S., Aug 2011, In: Journal of virology. 85, 15, p. 7775-7787 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus
  • dengue
  • Dengue Virus
  • Dengue
  • Viral RNA
  67 Scopus citations

• A Single Amino Acid Substitution in the Core Protein of West Nile Virus Increases Resistance to Acidotropic Compounds

  Martín-Acebes, M. A., Blázquez, A. B., de Oya, N. J., Escribano-Romero, E., Shi, P. Y. & Saiz, J. C., Jul 18 2013, In: PloS one. 8, 7, e69479.

  Research output: Contribution to journal › Article › peer-review

  • West Nile virus
  • Viruses
  • Amino Acid Substitution
  • amino acid substitution
  • Substitution reactions
  10 Scopus citations

• A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage

  Shan, C., Muruato, A. E., Jagger, B. W., Richner, J., Nunes, B. T. D., Medeiros, D. B. A., Xie, X., Nunes, J. G. C., Morabito, K. M., Kong, W. P., Pierson, T. C., Barrett, A. D., Weaver, S. C., Rossi, S. L., Vasconcelos, P. F. C., Graham, B. S., Diamond, M. S. & Shi, P. Y., Dec 1 2017, In: Nature communications. 8, 1, 676.

  Research output: Contribution to journal › Article › peer-review

  • vaccines
  • testes
  • pregnancy
  • Zika Virus
  • Attenuated Vaccines
  80 Scopus citations

• A Single-Dose Live-Attenuated Zika Virus Vaccine with Controlled Infection Rounds that Protects against Vertical Transmission

  Xie, X., Kum, D. B., Xia, H., Luo, H., Shan, C., Zou, J., Muruato, A. E., Medeiros, D. B. A., Nunes, B. T. D., Dallmeier, K., Rossi, S. L., Weaver, S. C., Neyts, J., Wang, T., Vasconcelos, P. F. C. & Shi, P. Y., Oct 10 2018, In: Cell Host and Microbe. 24, 4, p. 487-499.e5

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Vaccines
  • Infection
  • Attenuated Vaccines
  • Capsid Proteins
  22 Scopus citations

• A single-dose plasmid-launched live-attenuated Zika vaccine induces protective immunity

  Zou, J., Xie, X., Luo, H., Shan, C., Muruato, A. E., Weaver, S. C., Wang, T. & Shi, P. Y., Oct 2018, In: EBioMedicine. 36, p. 92-102 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Attenuated Vaccines
  • Immunity
  • Plasmids
  • Vaccines
  • DNA
  21 Scopus citations

• A single mutation in the prM protein of Zika virus contributes to fetal microcephaly

  Yuan, L., Huang, X. Y., Liu, Z. Y., Zhang, F., Zhu, X. L., Yu, J. Y., Ji, X., Xu, Y. P., Li, G., Li, C., Wang, H. J., Deng, Y. Q., Wu, M., Cheng, M. L., Ye, Q., Xie, D. Y., Li, X. F., Wang, X., Shi, W., Hu, B. & 3 others, Shi, P. Y., Xu, Z. & Qin, C. F., Nov 17 2017, In: Science. 358, 6365, p. 933-936 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Microcephaly
  • Mutation
  • Epidemics
  • Polynesia
  211 Scopus citations

• A single residue in the αb helix of the e protein is critical for Zika virus thermostability correspondence

  Xie, D. Y., Liu, Z. Y., Nian, Q. G., Zhu, L., Wang, N., Deng, Y. Q., Zhao, H., Ji, X., Li, X. F., Wang, X., Shi, P. Y. & Qin, C. F., Dec 1 2018, In: Emerging Microbes and Infections. 7, 1, 0006.

  Research output: Contribution to journal › Letter › peer-review
  3 Scopus citations

• A translation inhibitor that suppresses dengue virus in vitro and in vivo

  Wang, Q. Y., Kondreddi, R. R., Xie, X., Rao, R., Nilar, S., Xu, H. Y., Qing, M., Chang, D., Dong, H., Yokokawa, F., Lakshminarayana, S. B., Goh, A., Schul, W., Kramer, L., Keller, T. H. & Shi, P. Y., Sep 2011, In: Antimicrobial agents and chemotherapy. 55, 9, p. 4072-4080 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • Benzomorphans
  • Viral RNA
  • In Vitro Techniques
  • Pharmacokinetics
  39 Scopus citations

• A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein

  Li, A., Yu, J., Lu, M., Ma, Y., Attia, Z., Shan, C., Xue, M., Liang, X., Craig, K., Makadiya, N., He, J. J., Jennings, R., Shi, P. Y., Peeples, M. E., Liu, S. L., Boyaka, P. N. & Li, J., Dec 1 2018, In: Nature communications. 9, 1, 3067.

  Research output: Contribution to journal › Article › peer-review

  • vaccines
  • Zika Virus
  • Polyproteins
  • viruses
  • Viruses
  24 Scopus citations

• Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

  Qian, X., Nguyen, H. N., Song, M. M., Hadiono, C., Ogden, S. C., Hammack, C., Yao, B., Hamersky, G. R., Jacob, F., Zhong, C., Yoon, K. J., Jeang, W., Lin, L., Li, Y., Thakor, J., Berg, D. A., Zhang, C., Kang, E., Chickering, M., Nauen, D. & 10 others, Ho, C. Y., Wen, Z., Christian, K. M., Shi, P. Y., Maher, B. J., Wu, H., Jin, P., Tang, H., Song, H. & Ming, G. L., May 19 2016, In: Cell. 165, 5, p. 1238-1254 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Organoids
  • Bioreactors
  • Viruses
  • Brain
  766 Scopus citations

• Characterization of a 2016 Clinical Isolate of Zika Virus in Non-human Primates

  Li, X. F., Dong, H. L., Huang, X. Y., Qiu, Y. F., Wang, H. J., Deng, Y. Q., Zhang, N. N., Ye, Q., Zhao, H., Liu, Z. Y., Fan, H., An, X. P., Sun, S. H., Gao, B., Fa, Y. Z., Tong, Y. G., Zhang, F. C., Gao, G. F., Cao, W. C., Shi, P. Y. & 1 others, Qin, C. F., Oct 1 2016, In: EBioMedicine. 12, p. 170-177 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Viruses
  • Primates
  • Animals
  • Spleen
  86 Scopus citations

• Characterization of a candidate tetravalent vaccine based on 2’-O-methyltransferase mutants

  Züst, R., Li, S. H., Xie, X., Velumani, S., Chng, M., Toh, Y. X., Zou, J., Dong, H., Shan, C., Pang, J., Qin, C. F., Newell, E. W., Shi, P. Y. & Fink, K., Jan 2018, In: PloS one. 13, 1, e0189262.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus
  • Dengue Virus
  • Viruses
  • Methyltransferases
  • methyltransferases
  4 Scopus citations

• Characterization of Dengue virus NS4A and NS4B protein interaction

  Zou, J., Xie, X., Wang, Q. Y., Dong, H., Lee, M. Y., Kang, C., Yuan, Z. & Shi, P. Y., 2015, In: Journal of virology. 89, 7, p. 3455-3470 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus NS4A protein
  • Dengue virus NS4B protein
  • Dengue virus
  • virus replication
  • Amino Acids
  69 Scopus citations

• Combination of α-glucosidase inhibitor and ribavirin for the treatment of dengue virus infection in vitro and in vivo

  Chang, J., Schul, W., Butters, T. D., Yip, A., Liu, B., Goh, A., Lakshminarayana, S. B., Alonzi, D., Reinkensmeier, G., Pan, X., Qu, X., Weidner, J. M., Wang, L., Yu, W., Borune, N., Kinch, M. A., Rayahin, J. E., Moriarty, R., Xu, X., Shi, P. Y. & 2 others, Guo, J. T. & Block, T. M., Jan 2011, In: Antiviral research. 89, 1, p. 26-34 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Glucosidases
  • Dengue Virus
  • Ribavirin
  • 4-nitrophenyl-alpha-glucosidase
  • glucosidase I
  67 Scopus citations

• Combined treatment of adenosine nucleoside inhibitor NITD008 and histone deacetylase inhibitor vorinostat represents an immunotherapy strategy to ameliorate West Nile virus infection

  Nelson, J., Roe, K., Orillo, B., Shi, P. Y. & Verma, S., Oct 1 2015, In: Antiviral research. 122, p. 39-45 7 p., 3668.

  Research output: Contribution to journal › Article › peer-review

  • NITD008
  • West Nile Fever
  • Vorinostat
  • Histone Deacetylase Inhibitors
  • West Nile virus
  17 Scopus citations

• Conformational flexibility of the dengue virus RNA-Dependent RNA polymerase revealed by a complex with an inhibitor

  Noble, C. G., Lim, S. P., Chen, Y. L., Liew, C. W., Yap, L., Lescar, J. & Shi, P. Y., May 2013, In: Journal of virology. 87, 9, p. 5291-5295 5 p.

  Research output: Contribution to journal › Article › peer-review

  • RNA Replicase
  • Dengue virus
  • RNA-directed RNA polymerase
  • Dengue Virus
  • Serogroup
  70 Scopus citations

• Corrigendum to "Population variation of West Nile virus confers a host-specific fitness benefit in mosquitoes" [Virology 404 (2010) 89-95]

  Fitzpatrick, K. A., Deardorff, E. R., Pesko, K., Brackney, D. E., Zhang, B., Bedrick, E., Shi, P. Y. & Ebel, G. D., Feb 20 2011, In: Virology. 410, 2, p. 437 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

• Crystal structure of enterovirus 71 RNA-dependent RNA polymerase complexed with its protein primer VPg: Implication for a trans mechanism of VPg uridylylation

  Chen, C., Wang, Y., Shan, C., Sun, Y., Xu, P., Zhou, H., Yang, C., Shi, P. Y., Rao, Z., Zhang, B. & Lou, Z., May 1 2013, In: Journal of virology. 87, 10, p. 5755-5768 14 p.

  Research output: Contribution to journal › Article › peer-review

  • RNA Replicase
  • RNA-directed RNA polymerase
  • Enterovirus
  • crystal structure
  • Picornaviridae
  45 Scopus citations

• Dengue drug discovery

  Shi, P. Y., Yin, Z., Nilar, S. & Keller, T. H., Oct 31 2011, Third World Diseases. Elliot, R. (ed.). p. 243-276 34 p. (Topics in Medicinal Chemistry; vol. 7).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Dengue
  • Drug Discovery
  • Antiviral Agents
  • Dengue Vaccines
  • Serogroup
  4 Scopus citations

• Dengue subgenomic flaviviral RNA disrupts immunity in mosquito salivary glands to increase virus transmission

  Pompon, J., Manuel, M., Ng, G. K., Wong, B., Shan, C., Manokaran, G., Soto-Acosta, R., Bradrick, S. S., Ooi, E. E., Missé, D., Shi, P. Y. & Garcia-Blanco, M. A., Jul 2017, In: PLoS pathogens. 13, 7, e1006535.

  Research output: Contribution to journal › Article › peer-review

  • Dengue
  • Culicidae
  • Salivary Glands
  • Immunity
  • RNA
  47 Scopus citations

• Detection and quantification of flavivirus NS5 methyl-transferase activities

  Lim, S. P., Bodenreider, C. & Shi, P. Y., Jul 18 2013, Antiviral Methods and Protocols. p. 249-268 20 p. (Methods in Molecular Biology; vol. 1030).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Flavivirus
  • Thin Layer Chromatography
  • Transferases
  • mRNA guanylyltransferase
  • Fluorescence Polarization
  5 Scopus citations

• Determinants of dengue virus NS4A protein oligomerization

  Lee, C. M., Xie, X., Zou, J., Li, S. H., Qi Lee, M. Y., Dong, H., Qin, C. F., Kang, C. & Shi, P. Y., 2015, In: Journal of virology. 89, 12, p. 6171-6183 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus NS4A protein
  • Dengue virus
  • Flavivirus
  • oligomerization
  • Amino Acids
  24 Scopus citations

• Development and characterization of a stable eGFP enterovirus 71 for antiviral screening

  Shang, B., Deng, C., Ye, H., Xu, W., Yuan, Z., Shi, P. Y. & Zhang, B., Feb 2013, In: Antiviral research. 97, 2, p. 198-205 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Enterovirus
  • Antiviral Agents
  • Viruses
  • Vero Cells
  • Complementary DNA
  32 Scopus citations

• Development and characterization of a stable luciferase dengue virus for high-throughput screening

  Zou, G., Xu, H. Y., Qing, M., Wang, Q. Y. & Shi, P. Y., Jul 1 2011, In: Antiviral research. 91, 1, p. 11-19 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • Luciferases
  • Viruses
  • Complementary DNA
  • Renilla Luciferases
  83 Scopus citations

• Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone

  Li, X. F., Dong, H. L., Wang, H. J., Huang, X. Y., Qiu, Y. F., Ji, X., Ye, Q., Li, C., Liu, Y., Deng, Y. Q., Jiang, T., Cheng, G., Zhang, F. C., Davidson, A. D., Song, Y. J., Shi, P. Y. & Qin, C. F., Dec 1 2018, In: Nature communications. 9, 1, 673.

  Research output: Contribution to journal › Article › peer-review

  • vaccines
  • Zika Virus
  • Flavivirus
  • Attenuated Vaccines
  • viruses
  45 Scopus citations

• Development of a stable Gaussia luciferase enterovirus 71 reporter virus

  Xu, L. L., Shan, C., Deng, C. L., Li, X. D., Shang, B. D., Ye, H. Q., Liu, S. Q., Yuan, Z. M., Wang, Q. Y., Shi, P. Y. & Zhang, B., Jul 1 2015, In: Journal of Virological Methods. 219, p. 62-66 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Enterovirus
  • Luciferases
  • Viruses
  • Vero Cells
  • Drug Discovery
  8 Scopus citations

• Did Zika Virus Mutate to Cause Severe Outbreaks?

  Rossi, S. L., Ebel, G. D., Shan, C., Shi, P. Y. & Vasilakis, N., Oct 2018, In: Trends in Microbiology. 26, 10, p. 877-885 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Zika Virus
  • Disease Outbreaks
  • Venezuelan Equine Encephalitis Viruses
  • Chikungunya virus
  • Arboviruses
  11 Scopus citations

• Difficulties and advancements in developing drugs for the treatment of dengue fever

  Noble, C. G. & Shi, P. Y., Jan 1 2013, In: Expert Opinion on Orphan Drugs. 1, 12, p. 947-949 3 p.

  Research output: Contribution to journal › Review article › peer-review

  • Dengue
  • Dengue Virus
  • Antiviral Agents
  • Pharmaceutical Preparations
  • Culicidae
  1 Scopus citations

• Discovery of dengue virus NS4B inhibitors

  Wang, Q. Y., Dong, H., Zou, B., Karuna, R., Wan, K. F., Zou, J., Susila, A., Yip, A., Shan, C., Yeo, K. L., Xu, H., Ding, M., Chan, W. L., Gu, F., Seah, P. G., Liu, W., Lakshminarayana, S. B., Kang, C. B., Lescar, J., Blasco, F. & 2 others, Smith, P. W. & Shi, P. Y., 2015, In: Journal of virology. 89, 16, p. 8233-8244 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus
  • Dengue Virus
  • Inhibition (Psychology)
  • Amino Acids
  • Pharmaceutical Chemistry
  53 Scopus citations

• Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design

  Yokokawa, F., Nilar, S., Noble, C. G., Lim, S. P., Rao, R., Tania, S., Wang, G., Lee, G., Hunziker, J., Karuna, R., Manjunatha, U., Shi, P-Y. & Smith, P. W., Apr 28 2016, In: Journal of Medicinal Chemistry. 59, 8, p. 3935-3952 18 p.

  Research output: Contribution to journal › Article › peer-review

  • RNA Replicase
  • Drug Design
  • Dengue
  • Viral RNA
  • Serogroup
  46 Scopus citations

• Discovery of potent non-nucleoside inhibitors of dengue viral RNA-dependent rna polymerase from fragment screening and structure-guided design

  Lim, S. P., Noble, C. G., Nilar, S., Shi, P. Y. & Yokokawa, F., 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 187-198 12 p. (Advances in Experimental Medicine and Biology; vol. 1062).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • RNA Replicase
  • Viruses
  • Dengue
  • DNA-Directed RNA Polymerases
  • Viral RNA
  4 Scopus citations

• Drug discovery for the developing world: Progress at the Novartis Institute for Tropical Diseases

  Jones, C. L., Yeung, B. K. S., Manjunatha, U., Shi, P-Y., Bodenreider, C. & Diagana, T. T., Jun 3 2015, In: Nature Reviews Drug Discovery. 14, 6, p. 442-444 3 p.

  Research output: Contribution to journal › Letter › peer-review
  4 Scopus citations

• Erratum: Zika virus has oncolytic activity against glioblastoma stem cells [The Journal of Experimental Medicine, 214, 10, (2017)] DOI: 10.1084/jem.20171093

  Zhu, Z., Gorman, M. J., McKenzie, L. D., Chai, J. N., Hubert, C. G., Prager, B. C., Fernandez, E., Richner, J. M., Zhang, R., Shan, C., Tycksen, E., Wang, X., Shi, P. Y., Diamond, M. S., Rich, J. N. & Chheda, M. G., 2017, In: Journal of Experimental Medicine. 214, 10, p. 3145 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  • Zika Virus
  • Biomedical Research
  • Glioblastoma
  • Emotions
  • Stem Cells
  6 Scopus citations

• Erratum to: Targeting vesicle size (Nature Materials, (2018), 17, 11, (955-956), 10.1038/s41563-018-0200-8)

  Fei, Z. & Shi, P. Y., Dec 1 2018, In: Nature Materials. 17, 12, p. 1164 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  • news

• Evaluation of a novel reporter virus neutralization test for serological diagnosis of Zika and Dengue virus infection

  Shan, C., Ortiz, D. A., Yang, Y., Wong, S. J., Kramer, L. D., Shi, P. Y., Loeffelholz, M. J. & Ren, P., Oct 2017, In: Journal of Clinical Microbiology. 55, 10, p. 3028-3036 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus Infection
  • Zika Virus
  • Neutralization Tests
  • Dengue Virus
  • Viruses
  23 Scopus citations