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• AAV2-mediated GRP78 transfer alleviates retinal neuronal injury by downregulating ER stress and Tau oligomer formation

  Ha, Y., Liu, W., Liu, H., Zhu, S., Xia, F., Gerson, J. E., Azhar, N. A., Tilton, R. G., Motamedi, M., Kayed, R. & Zhang, W., Sep 2018, In: Investigative Ophthalmology and Visual Science. 59, 11, p. 4670-4682 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Nerve Crush
  • Retinal Ganglion Cells
  • Endoplasmic Reticulum Stress
  • Optic Nerve
  • Down-Regulation
  6 Scopus citations

• Accelerated neurodegeneration through chaperone-mediated oligomerization of tau

  Blair, L. J., Nordhues, B. A., Hill, S. E., Scaglione, K. M., O'Leary, J. C., Fontaine, S. N., Breydo, L., Zhang, B., Li, P., Wang, L., Cotman, C., Paulson, H. L., Muschol, M., Uversky, V. N., Klengel, T., Binder, E. B., Kayed, R., Golde, T. E., Berchtold, N. & Dickey, C. A., Oct 1 2013, In: Journal of Clinical Investigation. 123, 10, p. 4158-4169 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Alzheimer Disease
  • Tauopathies
  • Brain
  • Tacrolimus Binding Proteins
  • tau Proteins
  128 Scopus citations

• Amyloid oligomer interactions and polymorphisms: disease-relevant distinct assembly of α-synuclein and tau

  Sengupta, U. & Kayed, R., Jan 1 2019, In: Neuropsychopharmacology. 44, 1, p. 222-223 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review
  1 Scopus citations

• Amyloid-β annular protofibrils evade fibrillar fate in Alzheimer disease brain

  Lasagna-Reeves, C. A., Glabe, C. G. & Kayed, R., Jun 24 2011, In: Journal of Biological Chemistry. 286, 25, p. 22122-22130 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Amyloid
  • Brain
  • Alzheimer Disease
  • Toxicity
  • In Vitro Techniques
  101 Scopus citations

• ApoE4-driven accumulation of intraneuronal oligomerized Aß42 following activation of the amyloid cascade in vivo is mediated by a gain of function

  Zepa, L., Frenkel, M., Belinson, H., Kariv-Inbal, Z., Kayed, R., Masliah, E. & Michaelson, D. M., 2011, In: International Journal of Alzheimer's Disease. 792070.

  Research output: Contribution to journal › Article › peer-review

  • Apolipoprotein E4
  • Amyloid
  • Apolipoprotein E3
  • Apolipoproteins E
  • Neprilysin
  21 Scopus citations

• Astrocytes contain amyloid-β annular protofibrils in Alzheimer's disease brains

  Lasagna-Reeves, C. A. & Kayed, R., Oct 3 2011, In: FEBS Letters. 585, 19, p. 3052-3057 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Astrocytes
  • Amyloid
  • Brain
  • Alzheimer Disease
  • Conformations
  29 Scopus citations

• Azure C Targets and Modulates Toxic Tau Oligomers

  Lo Cascio, F. & Kayed, R., Jun 20 2018, In: ACS chemical neuroscience. 9, 6, p. 1317-1326 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Azure C
  • Oligomers
  • Poisons
  • Alzheimer Disease
  • Toxicity
  17 Scopus citations

• Binding and neurotoxicity mitigation of toxic tau oligomers by synthetic heparin like oligosaccharides

  Wang, P., Lo Cascio, F., Gao, J., Kayed, R. & Huang, X., 2018, In: Chemical Communications. 54, 72, p. 10120-10123 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Oligosaccharides
  • Heparin
  • Oligomers
  • Poisons
  • Cytotoxicity
  10 Scopus citations

• Design of metastable β-sheet oligomers from natively unstructured peptide

  Guerrero-Muñoz, M. J., Castillo-Carranza, D. L., Sengupta, U., White, M. A. & Kayed, R., Dec 18 2013, In: ACS chemical neuroscience. 4, 12, p. 1520-1523 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Oligomers
  • Prion Proteins
  • Amyloid
  • Peptides
  • Antibodies
  11 Scopus citations

• Dual role of p53 amyloid formation in cancer; loss of function and gain of toxicity

  Lasagna-Reeves, C. A., Clos, A. L., Castillo-Carranza, D., Sengupta, U., Guerrero-Muñoz, M., Kelly, B., Wagner, R. & Kayed, R., Jan 18 2013, In: Biochemical and Biophysical Research Communications. 430, 3, p. 963-968 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Toxicity
  • Amyloid
  • Oligomers
  • Conformations
  • Neoplasms
  54 Scopus citations

• Elevated phospholipase D isoform 1 in Alzheimer's disease patients’ hippocampus: Relevance to synaptic dysfunction and memory deficits

  Krishnan, B., Kayed, R. & Taglialatela, G., 2018, In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 4, p. 89-102 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Alzheimer disease type 1
  • Phospholipase D
  • Memory Disorders
  • Protein Isoforms
  • Hippocampus
  12 Scopus citations

• Evaluating Passive Immunotherapy using Aged Transgenic Animals of Tauopathy

  Al Lahham, R., Bittar, A., Montalbano, M., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Apr 2018, (Unpublished).

  Research output: Contribution to conference › Poster › peer-review

• Evaluating Tau Oligomers Passive Immunotherapy using Aged Transgenic Animals of Tauopathy

  Al Lahham, R., Bittar, A., Montalbano, M., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Jul 2018, In: Alzheimer's and Dementia. 14, 7, p. 1657

  Research output: Contribution to journal › Meeting Abstract › peer-review

• Formation and propagation of tau oligomeric seeds

  Gerson, J. E. & Kayed, R., 2013, In: Frontiers in Neurology. 4 JUL, Article 93.

  Research output: Contribution to journal › Review article › peer-review

  • Seeds
  • Tauopathies
  • Neurofibrillary Tangles
  • Poisons
  • Exocytosis
  68 Scopus citations

• Formation of immunoglobulin light chain amyloid oligomers in primary cutaneous nodular amyloidosis

  Clos, A. L., Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Jackson, G. R., Kelly, B., Beachkofsky, T. M. & Kayed, R., Dec 1 2011, In: British Journal of Dermatology. 165, 6, p. 1349-1354 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Primary Cutaneous Amyloidosis
  • Immunoglobulin Light Chains
  • Amyloid
  • Immunoglobulins
  • Keratinocytes
  12 Scopus citations

• Formation of Toxic Oligomeric Assemblies of RNA-binding Protein: Musashi in Alzheimer's disease

  Sengupta, U., Montalbano, M., McAllen, S., Minuesa, G., Kharas, M. & Kayed, R., Oct 26 2018, In: Acta Neuropathologica Communications. 6, 1, p. 113 1 p.

  Research output: Contribution to journal › Article › peer-review

  • RNA-Binding Proteins
  • Alzheimer Disease
  • Poisons
  • Brain
  • Proteins
  9 Scopus citations

• Immunotherapy Targeting Tau Oligomeric Strains in Aged Transgenic Animals of Tauopathy

  Al Lahham, R., Bittar, A., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Oct 2018, p. S64.

  Research output: Contribution to conference › Abstract › peer-review

  • Tauopathies
  • Genetically Modified Animals
  • Passive Immunization
  • Immunotherapy
  • Clone Cells

• Molecular mechanisms of amyloid oligomers toxicity

  Kayed, R. & Lasagna-Reeves, C. A., 2013, In: Journal of Alzheimer's Disease. 33, SUPPL. 1, p. S67-S78

  Research output: Contribution to journal › Review article › peer-review

  • Amyloid
  • Amyloid Plaques
  • Cell Death
  • Poisons
  • Memory
  212 Scopus citations

• Molecular mechanisms of amyloid oligomers toxicity

  Kayed, R. & Lasagna-Reeves, C. A., Feb 15 2013, Alzheimer's Disease: Advances for a New Century. IOS Press, p. 67-78 12 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Amyloid
  • Amyloid Plaques
  • Cell Death
  • Poisons
  • Memory
  2 Scopus citations

• Near Infrared Light Treatment Reduces Synaptic Levels of Toxic Tau Oligomers in Two Transgenic Mouse Models of Human Tauopathies

  Comerota, M. M., Tumurbaatar, B., Krishnan, B., Kayed, R. & Taglialatela, G., May 1 2019, In: Molecular Neurobiology. 56, 5, p. 3341-3355 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Tauopathies
  • Transgenic Mice
  • Poisons
  • Light
  • Synaptosomes
  5 Scopus citations

• NLRP3 inflammasome activation drives tau pathology

  Ising, C., Venegas, C., Zhang, S., Scheiblich, H., Schmidt, S. V., Vieira-Saecker, A., Schwartz, S., Albasset, S., McManus, R. M., Tejera, D., Griep, A., Santarelli, F., Brosseron, F., Opitz, S., Stunden, J., Merten, M., Kayed, R., Golenbock, D. T., Blum, D., Latz, E. & 2 others, Buée, L. & Heneka, M. T., Nov 28 2019, In: Nature. 575, 7784, p. 669-673 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Inflammasomes
  • Drive
  • Amyloid
  • Pathology
  • Neurofibrillary Tangles
  136 Scopus citations

• Preparation and characterization of tau oligomer strains

  Sengupta, U., Carretero-Murillo, M. & Kayed, R., 2018, Methods in Molecular Biology. Humana Press Inc., p. 113-146 34 p. (Methods in Molecular Biology; vol. 1779).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Prion Proteins
  • In Vitro Techniques
  6 Scopus citations

• Prospects for strain-specific immunotherapy in Alzheimer's disease and tauopathies

  Bittar, A., Sengupta, U. & Kayed, R., Dec 1 2018, In: npj Vaccines. 3, 1, 9.

  Research output: Contribution to journal › Article › peer-review

  • Tauopathies
  • Passive Immunization
  • Immunotherapy
  • Alzheimer Disease
  • Poisons
  25 Scopus citations

• Rapid accumulation of endogenous Tau oligomers in a rat model of traumatic brain injury: Possible link between traumatic brain injury and sporadic tauopathies

  Hawkins, B. E., Krishnamurthy, S., Castillo-Carranza, D. L., Sengupta, U., Prough, D. S., Jackson, G. R., DeWitt, D. S. & Kayed, R., Jun 7 2013, In: Journal of Biological Chemistry. 288, 23, p. 17042-17050 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Oligomers
  • Tauopathies
  • Rats
  • Traumatic Brain Injury
  • Brain
  91 Scopus citations

• Role of oligomers in the amyloidogenesis of primary cutaneous amyloidosis

  Clos, A. L., Lasagna-Reeves, C. A., Kelly, B., Wagner, R., Wilkerson, M., Jackson, G. R. & Kayed, R., Nov 2011, In: Journal of the American Academy of Dermatology. 65, 5, p. 1023-1031 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Primary Cutaneous Amyloidosis
  • Amyloid
  • Skin
  • antibiotic I-11
  • thioflavin T
  10 Scopus citations

• Small misfolded tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons

  Wu, J. W., Herman, M., Liu, L., Simoes, S., Acker, C. M., Figueroa, H., Steinberg, J. I., Margittai, M., Kayed, R., Zurzolo, C., Di Paolo, G. & Duff, K. E., Jan 18 2013, In: Journal of Biological Chemistry. 288, 3, p. 1856-1870 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Endocytosis
  • Neurons
  • Tauopathies
  • Conformations
  • Molecular weight
  282 Scopus citations

• Soluble tau aggregates, not large fibrils, are the toxic species that display seeding and cross-seeding behavior

  Ghag, G., Bhatt, N., Cantu, D. V., Guerrero-Munoz, M. J., Ellsworth, A., Sengupta, U. & Kayed, R., Nov 2018, In: Protein Science. 27, 11, p. 1901-1909 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Sonication
  • Poisons
  • Oligomers
  • Amyloidogenic Proteins
  • Prions
  26 Scopus citations

• Tau aggregates as immunotherapeutic targets

  Castillo-Carranza, D. L., Lasagna-Reeves, C. A. & Kayed, R., Jan 1 2013, In: Frontiers in Bioscience - Scholar. 5 S, 2, p. 426-438 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Oligomers
  • Neurofibrillary Tangles
  • Toxicity
  • Tauopathies
  • Neurodegenerative diseases
  30 Scopus citations

• Tau Immunotherapy for Alpha-Synucleinopathy

  Aguilar, C., Al Lahham, R., Sengupta, U., Carretero Murillo, M., Kayed, R. & Dineley, K., Jul 2018, In: Alzheimer's and Dementia. 14, 7, p. 1442

  Research output: Contribution to journal › Meeting Abstract › peer-review

• Tau Immunotherapy for Alpha-Synucleinopathy

  Aguilar, C., Al Lahham, R., Sengupta, U., Carretero Murillo, M., Kayed, R. & Dineley, K., Jul 2018, In: Alzheimer's and Dementia. 14, 7, p. 1412

  Research output: Contribution to journal › Article › peer-review

• Tau Interacts with the C-Terminal Region of α-Synuclein, Promoting Formation of Toxic Aggregates with Distinct Molecular Conformations

  Dasari, A. K. R., Kayed, R., Wi, S. & Lim, K. H., Jun 25 2019, In: Biochemistry. 58, 25, p. 2814-2821 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Molecular Conformation
  • Synucleins
  • Conformations
  • Poisons
  • Agglomeration
  10 Scopus citations

• Tau oligomers as potential targets for immunotherapy for alzheimer's disease and tauopathies

  Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Jackson, G. R. & Kayed, R., Sep 1 2011, In: Current Alzheimer Research. 8, 6, p. 659-665 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Tauopathies
  • Immunotherapy
  • Alzheimer Disease
  • Neurofibrillary Tangles
  • tau Proteins
  57 Scopus citations

• Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

  Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Clos, A. L., Jackson, G. R. & Kayed, R., 2011, In: Molecular Neurodegeneration. 6, 1, 39.

  Research output: Contribution to journal › Article › peer-review

  • Electron Transport Complex I
  • Tauopathies
  • human MAPT protein
  • Alzheimer Disease
  • Septins
  282 Scopus citations

• Tau oligomers mediate aggregation of RNA-binding proteins Musashi1 and Musashi2 inducing Lamin alteration

  Montalbano, M., McAllen, S., Sengupta, U., Puangmalai, N., Bhatt, N., Ellsworth, A. & Kayed, R., Dec 1 2019, In: Aging cell. 18, 6, e13035.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lamins
  • Tauopathies
  • RNA-Binding Proteins
  • Alzheimer Disease
  • Poisons
  8 Scopus citations

• Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy

  Gerson, J. E., Farmer, K. M., Henson, N., Castillo-Carranza, D. L., Carretero Murillo, M., Sengupta, U., Barrett, A. & Kayed, R., Mar 15 2018, In: Molecular Neurodegeneration. 13, 1, 13.

  Research output: Contribution to journal › Article › peer-review

  • Synucleins
  • Immunotherapy
  • Poisons
  • Monoclonal Antibodies
  • Lewy Bodies
  25 Scopus citations

• Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives

  Lo Cascio, F., Puangmalai, N., Ellsworth, A., Bucchieri, F., Pace, A., Palumbo Piccionello, A. & Kayed, R., Dec 1 2019, In: Scientific reports. 9, 1, 19011.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Curcumin
  • Neurodegenerative Diseases
  • Poisons
  • Tauopathies
  • Microtubule-Associated Proteins
  14 Scopus citations

• α-Synuclein Oligomers Induce a Unique Toxic Tau Strain

  Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Sengupta, U., Gerson, J. E. & Kayed, R., Oct 1 2018, In: Biological Psychiatry. 84, 7, p. 499-508 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Synucleins
  • Poisons
  • Parkinson Disease
  • Brain
  • Disease Progression
  29 Scopus citations