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• 2′-O methylation of internal adenosine by flavivirus NS5 methyltransferase

  Dong, H., Chang, D. C., Hua, M. H. C., Lim, S. P., Chionh, Y. H., Hia, F., Lee, Y. H., Kukkaro, P., Lok, S. M., Dedon, P. C. & Shi, P. Y., Apr 2012, In: PLoS pathogens. 8, 4, e1002642.

  Research output: Contribution to journal › Article › peer-review

  • Flavivirus
  • Methyltransferases
  • Adenosine
  • Methylation
  • 2'-O-methyladenosine
  84 Scopus citations

• A chimeric dengue virus vaccine using japanese encephalitis virus vaccine strain SA14-14-2 as backbone is immunogenic and protective against either parental virus in mice and nonhuman primates

  Li, X. F., Deng, Y. Q., Yang, H. Q., Zhao, H., Jiang, T., Yu, X. D., Li, S. H., Ye, Q., Zhu, S. Y., Wang, H. J., Zhang, Y., Ma, J., Yu, Y. X., Liu, Z. Y., Li, Y. H., Qin, E. D., Shi, P. Y. & Qin, C. F., Dec 2013, In: Journal of virology. 87, 24, p. 13694-13705 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Vaccines
  • Japanese encephalitis virus
  • Japanese Encephalitis Virus
  • Dengue virus
  • Dengue Virus
  43 Scopus citations

• A cocrystal structure of dengue capsid protein in complex of inhibitor

  Xia, H., Xie, X., Zou, J., Noble, C. G., Russell, W. K., Holthauzen, L. M. F., Choi, K. H., White, M. A. & Shi, P. Y., Jul 28 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 30, p. 17992-18001 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • Dengue
  • Capsid Proteins
  • Capsid
  • Serogroup

• A crystal structure of the dengue virus non-structural protein 5 (NS5) polymerase delineates interdomain amino acid residues that enhance its thermostability and de novo initiation activities

  Lim, S. P., Koh, J. H. K., Seh, C. C., Liew, C. W., Davidson, A. D., Chua, L. S., Chandrasekaran, R., Cornvik, T. C., Shi, P. Y. & Lescar, J., Oct 25 2013, In: Journal of Biological Chemistry. 288, 43, p. 31105-31114 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Viral Structural Proteins
  • RNA Replicase
  • Crystal structure
  • Dengue Virus
  • Viruses
  55 Scopus citations

• A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication

  Zhao, Y., Soh, T. S., Zheng, J., Chan, K. W. K., Phoo, W. W., Lee, C. C., Tay, M. Y. F., Swaminathan, K., Cornvik, T. C., Lim, S. P., Shi, P. Y., Lescar, J., Vasudevan, S. G. & Luo, D., Mar 1 2015, In: PLoS pathogens. 11, 3, p. 1-27 27 p., e1004682.

  Research output: Contribution to journal › Article › peer-review

  • dengue virus NS5 protein
  • RNA Replicase
  • Virus Replication
  • Flavivirus
  • Methyltransferases
  106 Scopus citations

• Activation of peripheral blood mononuclear cells by dengue virus infection depotentiates balapiravir

  Chen, Y. L., Ghafar, N. A., Karuna, R., Fu, Y., Lim, S. P., Schul, W., Gu, F., Herve, M., Yokohama, F., Wang, G., Cerny, D., Fink, K., Blasco, F. & Shi, P. Y., Feb 2014, In: Journal of virology. 88, 3, p. 1740-1747 8 p.

  Research output: Contribution to journal › Article › peer-review

  • balapiravir
  • 4'-azidocytidine
  • Dengue virus
  • Dengue Virus
  • mononuclear leukocytes
  37 Scopus citations

• A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation

  Muruato, A. E., Fontes-Garfias, C. R., Ren, P., Garcia-Blanco, M. A., Menachery, V. D., Xie, X. & Shi, P. Y., Dec 1 2020, In: Nature communications. 11, 1, 4059.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • vaccines
  • SARS Virus
  • antibodies
  • Assays
  • Neutralizing Antibodies
  18 Scopus citations

• A multidimensional platform for the purification of non-coding RNA species

  Chionh, Y. H., Ho, C. H., Pruksakorn, D., Ramesh Babu, I., Ng, C. S., Hia, F., McBee, M. E., Su, D., Pang, Y. L. J., Gu, C., Dong, H., Prestwich, E. G., Shi, P. Y., Preiser, P. R., Alonso, S. & Dedon, P. C., Sep 2013, In: Nucleic acids research. 41, 17, p. e168

  Research output: Contribution to journal › Article › peer-review

  • Untranslated RNA
  • Ribonucleosides
  • Viral Genome
  • RNA
  • Plasmodium
  26 Scopus citations

• A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19

  Xie, X., Muruato, A. E., Zhang, X., Lokugamage, K. G., Fontes-Garfias, C. R., Zou, J., Liu, J., Ren, P., Balakrishnan, M., Cihlar, T., Tseng, C. T. K., Makino, S., Menachery, V. D., Bilello, J. P. & Shi, P. Y., Dec 1 2020, In: Nature communications. 11, 1, 5214.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • SARS Virus
  • Coronavirus
  • drugs
  • Screening
  • screening
  2 Scopus citations

• An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction

  Xia, H., Luo, H., Shan, C., Muruato, A. E., Nunes, B. T. D., Medeiros, D. B. A., Zou, J., Xie, X., Giraldo, M. I., Vasconcelos, P. F. C., Weaver, S. C., Wang, T., Rajsbaum, R. & Shi, P. Y., Dec 1 2018, In: Nature communications. 9, 1, 414.

  Research output: Contribution to journal › Article › peer-review

  • interferon
  • Zika Virus
  • viruses
  • Viruses
  • mutations
  93 Scopus citations

• An Infectious cDNA Clone of SARS-CoV-2

  Xie, X., Muruato, A., Lokugamage, K. G., Narayanan, K., Zhang, X., Zou, J., Liu, J., Schindewolf, C., Bopp, N. E., Aguilar, P. V., Plante, K. S., Weaver, S. C., Makino, S., LeDuc, J. W., Menachery, V. D. & Shi, P. Y., May 13 2020, In: Cell Host and Microbe. 27, 5, p. 841-848.e3

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Severe Acute Respiratory Syndrome
  • Coronavirus
  • Clone Cells
  • SARS Virus
  • DNA
  53 Scopus citations

• A novel reporter system for neutralizing and enhancing antibody assay against dengue virus

  Song, K. Y., Zhao, H., Jiang, Z. Y., Li, X. F., Deng, Y. Q., Jiang, T., Zhu, S. Y., Shi, P. Y., Zhang, B., Zhang, F. C., Qin, E. D. & Qin, C. F., Feb 18 2014, In: BMC Microbiology. 14, 1, 44.

  Research output: Contribution to journal › Article › peer-review

  • Blocking Antibodies
  • Dengue Virus
  • Neutralizing Antibodies
  • Antibody-Dependent Enhancement
  • Virus Diseases
  12 Scopus citations

• Antagonism of Type i Interferon by Severe Acute Respiratory Syndrome Coronavirus 2

  Xia, H. & Shi, P. Y., Dec 2020, In: Journal of Interferon and Cytokine Research. 40, 12, p. 543-548 6 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Severe Acute Respiratory Syndrome
  • Coronavirus
  • Interferons
  • Coronavirus Infections
  • Interferon Type I

• Anti-dengue-virus activity and structure-activity relationship studies of lycorine derivatives

  Wang, P., Li, L. F., Wang, Q. Y., Shang, L. Q., Shi, P. Y. & Yin, Z., Jul 2014, In: ChemMedChem. 9, 7, p. 1522-1533 12 p.

  Research output: Contribution to journal › Article › peer-review

  • lycorine
  • Viral Structures
  • Dengue Virus
  • Structure-Activity Relationship
  • Viruses
  31 Scopus citations

• A positively selected mutation in the WNV 2K peptide confers resistance to superinfection exclusion in vivo

  Campbell, C. L., Smith, D. R., Sanchez-Vargas, I., Zhang, B., Shi, P. Y. & Ebel, G. D., Sep 2014, In: Virology. 464-465, 1, p. 228-232 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Superinfection
  • Culicidae
  • Flaviviridae
  • Culex
  • Viruses
  12 Scopus citations

• A replication-defective Japanese encephalitis virus (JEV) vaccine candidate with NS1 deletion confers dual protection against JEV and West Nile virus in mice

  Li, N., Zhang, Z. R., Zhang, Y. N., Liu, J., Deng, C. L., Shi, P. Y., Yuan, Z. M., Ye, H. Q. & Zhang, B., Dec 1 2020, In: npj Vaccines. 5, 1, 73.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Japanese Encephalitis Virus
  • West Nile virus
  • Vaccines
  • Flavivirus
  • West Nile Virus Vaccines

• A Single Amino Acid Substitution in the Core Protein of West Nile Virus Increases Resistance to Acidotropic Compounds

  Martín-Acebes, M. A., Blázquez, A. B., de Oya, N. J., Escribano-Romero, E., Shi, P. Y. & Saiz, J. C., Jul 18 2013, In: PloS one. 8, 7, e69479.

  Research output: Contribution to journal › Article › peer-review

  • West Nile virus
  • Viruses
  • Amino Acid Substitution
  • amino acid substitution
  • Substitution reactions
  10 Scopus citations

• A Single-Dose Live-Attenuated Zika Virus Vaccine with Controlled Infection Rounds that Protects against Vertical Transmission

  Xie, X., Kum, D. B., Xia, H., Luo, H., Shan, C., Zou, J., Muruato, A. E., Medeiros, D. B. A., Nunes, B. T. D., Dallmeier, K., Rossi, S. L., Weaver, S. C., Neyts, J., Wang, T., Vasconcelos, P. F. C. & Shi, P. Y., Oct 10 2018, In: Cell Host and Microbe. 24, 4, p. 487-499.e5

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Vaccines
  • Infection
  • Attenuated Vaccines
  • Capsid Proteins
  22 Scopus citations

• A single-dose plasmid-launched live-attenuated Zika vaccine induces protective immunity

  Zou, J., Xie, X., Luo, H., Shan, C., Muruato, A. E., Weaver, S. C., Wang, T. & Shi, P. Y., Oct 2018, In: EBioMedicine. 36, p. 92-102 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Attenuated Vaccines
  • Immunity
  • Plasmids
  • Vaccines
  • DNA
  21 Scopus citations

• A single residue in the αb helix of the e protein is critical for Zika virus thermostability correspondence

  Xie, D. Y., Liu, Z. Y., Nian, Q. G., Zhu, L., Wang, N., Deng, Y. Q., Zhao, H., Ji, X., Li, X. F., Wang, X., Shi, P. Y. & Qin, C. F., Dec 1 2018, In: Emerging Microbes and Infections. 7, 1, 0006.

  Research output: Contribution to journal › Letter › peer-review
  3 Scopus citations

• A Zika virus envelope mutation preceding the 2015 epidemic enhances virulence and fitness for transmission

  Shan, C., Xia, H., Haller, S. L., Azar, S. R., Liu, Y., Liu, J., Muruato, A. E., Chen, R., Rossi, S. L., Wakamiya, M., Vasilakis, N., Pei, R., Fontes-Garfias, C. R., Singh, S. K., Xie, X., Weaver, S. C. & Shi, P. Y., Aug 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 33, p. 20190-20197 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Viremia
  • Virulence
  • Epidemics
  • Mutation
  6 Scopus citations

• A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein

  Li, A., Yu, J., Lu, M., Ma, Y., Attia, Z., Shan, C., Xue, M., Liang, X., Craig, K., Makadiya, N., He, J. J., Jennings, R., Shi, P. Y., Peeples, M. E., Liu, S. L., Boyaka, P. N. & Li, J., Dec 1 2018, In: Nature communications. 9, 1, 3067.

  Research output: Contribution to journal › Article › peer-review

  • vaccines
  • Zika Virus
  • Polyproteins
  • viruses
  • Viruses
  24 Scopus citations

• Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential

  Xu, J., Shi, P. Y., Li, H. & Zhou, J., May 8 2020, In: ACS Infectious Diseases. 6, 5, p. 909-915 7 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Niclosamide
  • Coronavirus
  • Antiviral Agents
  • Middle East Respiratory Syndrome Coronavirus
  • SARS Virus
  65 Scopus citations

• Characterization of a candidate tetravalent vaccine based on 2’-O-methyltransferase mutants

  Züst, R., Li, S. H., Xie, X., Velumani, S., Chng, M., Toh, Y. X., Zou, J., Dong, H., Shan, C., Pang, J., Qin, C. F., Newell, E. W., Shi, P. Y. & Fink, K., Jan 2018, In: PloS one. 13, 1, e0189262.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus
  • Dengue Virus
  • Viruses
  • Methyltransferases
  • methyltransferases
  4 Scopus citations

• Characterization of Dengue virus NS4A and NS4B protein interaction

  Zou, J., Xie, X., Wang, Q. Y., Dong, H., Lee, M. Y., Kang, C., Yuan, Z. & Shi, P. Y., 2015, In: Journal of virology. 89, 7, p. 3455-3470 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus NS4A protein
  • Dengue virus NS4B protein
  • Dengue virus
  • virus replication
  • Amino Acids
  69 Scopus citations

• Combined treatment of adenosine nucleoside inhibitor NITD008 and histone deacetylase inhibitor vorinostat represents an immunotherapy strategy to ameliorate West Nile virus infection

  Nelson, J., Roe, K., Orillo, B., Shi, P. Y. & Verma, S., Oct 1 2015, In: Antiviral research. 122, p. 39-45 7 p., 3668.

  Research output: Contribution to journal › Article › peer-review

  • NITD008
  • West Nile Fever
  • Vorinostat
  • Histone Deacetylase Inhibitors
  • West Nile virus
  17 Scopus citations

• Conformational flexibility of the dengue virus RNA-Dependent RNA polymerase revealed by a complex with an inhibitor

  Noble, C. G., Lim, S. P., Chen, Y. L., Liew, C. W., Yap, L., Lescar, J. & Shi, P. Y., May 2013, In: Journal of virology. 87, 9, p. 5291-5295 5 p.

  Research output: Contribution to journal › Article › peer-review

  • RNA Replicase
  • Dengue virus
  • RNA-directed RNA polymerase
  • Dengue Virus
  • Serogroup
  70 Scopus citations

• Construction of stable reporter flaviviruses and their applications

  Baker, C. & Shi, P. Y., Oct 2020, In: Viruses. 12, 10, 1082.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Flavivirus
  • Epidemics
  • Antiviral Agents
  • Vaccines
  • Viruses

• COVID-19 vaccine BNT162b1 elicits human antibody and T_H1 T cell responses

  Sahin, U., Muik, A., Derhovanessian, E., Vogler, I., Kranz, L. M., Vormehr, M., Baum, A., Pascal, K., Quandt, J., Maurus, D., Brachtendorf, S., Lörks, V., Sikorski, J., Hilker, R., Becker, D., Eller, A. K., Grützner, J., Boesler, C., Rosenbaum, C., Kühnle, M. C. & 22 others, Luxemburger, U., Kemmer-Brück, A., Langer, D., Bexon, M., Bolte, S., Karikó, K., Palanche, T., Fischer, B., Schultz, A., Shi, P. Y., Fontes-Garfias, C., Perez, J. L., Swanson, K. A., Loschko, J., Scully, I. L., Cutler, M., Kalina, W., Kyratsous, C. A., Cooper, D., Dormitzer, P. R., Jansen, K. U. & Türeci, Ö., Oct 22 2020, In: Nature. 586, 7830, p. 594-599 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Coronavirus
  • Th1 Cells
  • Vaccines
  • Severe Acute Respiratory Syndrome
  • Antibodies
  40 Scopus citations

• Crystal structure of dengue virus methyltransferase without S-adenosyl-L-methionine

  Noble, C. G., Li, S. H., Dong, H., Chew, S. H. & Shi, P. Y., Nov 2014, In: Antiviral research. 111, p. 78-81 4 p.

  Research output: Contribution to journal › Article › peer-review

  • S-Adenosylmethionine
  • Dengue Virus
  • Methyltransferases
  • Enzymes
  • Flavivirus
  11 Scopus citations

• Crystal structure of enterovirus 71 RNA-dependent RNA polymerase complexed with its protein primer VPg: Implication for a trans mechanism of VPg uridylylation

  Chen, C., Wang, Y., Shan, C., Sun, Y., Xu, P., Zhou, H., Yang, C., Shi, P. Y., Rao, Z., Zhang, B. & Lou, Z., May 1 2013, In: Journal of virology. 87, 10, p. 5755-5768 14 p.

  Research output: Contribution to journal › Article › peer-review

  • RNA Replicase
  • RNA-directed RNA polymerase
  • Enterovirus
  • crystal structure
  • Picornaviridae
  45 Scopus citations

• Dengue in China: not a passing problem

  Qin, C. F. & Shi, P. Y., Dec 11 2014, In: Science China Life Sciences. 57, 12, p. 1230-1231 2 p.

  Research output: Contribution to journal › Article › peer-review
  13 Scopus citations

• Dengue Therapeutics, Chemoprophylaxis, and Allied Tools: State of the Art and Future Directions

  Whitehorn, J., Yacoub, S., Anders, K. L., Macareo, L. R., Cassetti, M. C., Nguyen Van, V. C., Shi, P. Y., Wills, B. & Simmons, C. P., Aug 28 2014, In: PLoS neglected tropical diseases. 8, 8, e3025.

  Research output: Contribution to journal › Article › peer-review

  • Dengue
  • Chemoprevention
  • Direction compound
  • Drug Discovery
  • Dengue Virus
  47 Scopus citations

• Design, synthesis and biological evaluation of spiropyrazolopyridone derivatives as potent dengue virus inhibitors

  Xu, J., Xie, X., Chen, H., Zou, J., Xue, Y., Ye, N., Shi, P. Y. & Zhou, J., Jun 1 2020, In: Bioorganic and Medicinal Chemistry Letters. 30, 11, 127162.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • Viruses
  • Substitution reactions
  • Nitrogen
  • Derivatives

• Detection and quantification of flavivirus NS5 methyl-transferase activities

  Lim, S. P., Bodenreider, C. & Shi, P. Y., Jul 18 2013, Antiviral Methods and Protocols. p. 249-268 20 p. (Methods in Molecular Biology; vol. 1030).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Flavivirus
  • Thin Layer Chromatography
  • Transferases
  • mRNA guanylyltransferase
  • Fluorescence Polarization
  5 Scopus citations

• Determinants of dengue virus NS4A protein oligomerization

  Lee, C. M., Xie, X., Zou, J., Li, S. H., Qi Lee, M. Y., Dong, H., Qin, C. F., Kang, C. & Shi, P. Y., 2015, In: Journal of virology. 89, 12, p. 6171-6183 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus NS4A protein
  • Dengue virus
  • Flavivirus
  • oligomerization
  • Amino Acids
  24 Scopus citations

• Development and characterization of a stable eGFP enterovirus 71 for antiviral screening

  Shang, B., Deng, C., Ye, H., Xu, W., Yuan, Z., Shi, P. Y. & Zhang, B., Feb 2013, In: Antiviral research. 97, 2, p. 198-205 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Enterovirus
  • Antiviral Agents
  • Viruses
  • Vero Cells
  • Complementary DNA
  32 Scopus citations

• Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone

  Li, X. F., Dong, H. L., Wang, H. J., Huang, X. Y., Qiu, Y. F., Ji, X., Ye, Q., Li, C., Liu, Y., Deng, Y. Q., Jiang, T., Cheng, G., Zhang, F. C., Davidson, A. D., Song, Y. J., Shi, P. Y. & Qin, C. F., Dec 1 2018, In: Nature communications. 9, 1, 673.

  Research output: Contribution to journal › Article › peer-review

  • vaccines
  • Zika Virus
  • Flavivirus
  • Attenuated Vaccines
  • viruses
  45 Scopus citations

• Development of a FACS-based assay for evaluating antiviral potency of compound in dengue infected peripheral blood mononuclear cells

  Fu, Y., Chen, Y. L., Herve, M., Gu, F., Shi, P. Y. & Blasco, F., Feb 2014, In: Journal of Virological Methods. 196, p. 18-24 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • Dengue
  • Antiviral Agents
  • Blood Cells
  • Virus Diseases
  4 Scopus citations

• Development of a stable Gaussia luciferase enterovirus 71 reporter virus

  Xu, L. L., Shan, C., Deng, C. L., Li, X. D., Shang, B. D., Ye, H. Q., Liu, S. Q., Yuan, Z. M., Wang, Q. Y., Shi, P. Y. & Zhang, B., Jul 1 2015, In: Journal of Virological Methods. 219, p. 62-66 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Enterovirus
  • Luciferases
  • Viruses
  • Vero Cells
  • Drug Discovery
  8 Scopus citations

• Did Zika Virus Mutate to Cause Severe Outbreaks?

  Rossi, S. L., Ebel, G. D., Shan, C., Shi, P. Y. & Vasilakis, N., Oct 2018, In: Trends in Microbiology. 26, 10, p. 877-885 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Zika Virus
  • Disease Outbreaks
  • Venezuelan Equine Encephalitis Viruses
  • Chikungunya virus
  • Arboviruses
  11 Scopus citations

• Difficulties and advancements in developing drugs for the treatment of dengue fever

  Noble, C. G. & Shi, P. Y., Jan 1 2013, In: Expert Opinion on Orphan Drugs. 1, 12, p. 947-949 3 p.

  Research output: Contribution to journal › Review article › peer-review

  • Dengue
  • Dengue Virus
  • Antiviral Agents
  • Pharmaceutical Preparations
  • Culicidae
  1 Scopus citations

• Dimerization of flavivirus NS4B protein

  Zou, J., Xie, X., Lee, L. T., Chandrasekaran, R., Reynaud, A., Yap, L., Wang, Q. Y., Dong, H., Kang, C., Yuan, Z., Lescar, J. & Shi, P. Y., Mar 2014, In: Journal of virology. 88, 6, p. 3379-3391 13 p.

  Research output: Contribution to journal › Article › peer-review

  • flavivirus NS4B protein
  • Flavivirus
  • dimerization
  • Dimerization
  • Dengue virus
  43 Scopus citations

• Discovery of dengue virus NS4B inhibitors

  Wang, Q. Y., Dong, H., Zou, B., Karuna, R., Wan, K. F., Zou, J., Susila, A., Yip, A., Shan, C., Yeo, K. L., Xu, H., Ding, M., Chan, W. L., Gu, F., Seah, P. G., Liu, W., Lakshminarayana, S. B., Kang, C. B., Lescar, J., Blasco, F. & 2 others, Smith, P. W. & Shi, P. Y., 2015, In: Journal of virology. 89, 16, p. 8233-8244 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus
  • Dengue Virus
  • Inhibition (Psychology)
  • Amino Acids
  • Pharmaceutical Chemistry
  53 Scopus citations

• Discovery of potent non-nucleoside inhibitors of dengue viral RNA-dependent rna polymerase from fragment screening and structure-guided design

  Lim, S. P., Noble, C. G., Nilar, S., Shi, P. Y. & Yokokawa, F., 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 187-198 12 p. (Advances in Experimental Medicine and Biology; vol. 1062).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • RNA Replicase
  • Viruses
  • Dengue
  • DNA-Directed RNA Polymerases
  • Viral RNA
  4 Scopus citations

• Drug discovery for the developing world: Progress at the Novartis Institute for Tropical Diseases

  Jones, C. L., Yeung, B. K. S., Manjunatha, U., Shi, P-Y., Bodenreider, C. & Diagana, T. T., Jun 3 2015, In: Nature Reviews Drug Discovery. 14, 6, p. 442-444 3 p.

  Research output: Contribution to journal › Letter › peer-review
  4 Scopus citations

• Dysregulation of Ephrin receptor and PPAR signaling pathways in neural progenitor cells infected by Zika virus

  Thulasi Raman, S. N., Latreille, E., Gao, J., Zhang, W., Wu, J., Russell, M. S., Walrond, L., Cyr, T., Lavoie, J. R., Safronetz, D., Cao, J., Sauve, S., Farnsworth, A., Chen, W., Shi, P. Y., Wang, Y., Wang, L., Rosu-Myles, M. & Li, X., Jan 1 2020, In: Emerging Microbes and Infections. 9, 1, p. 2046-2060 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Eph Family Receptors
  • Zika Virus
  • Neural Pathways
  • Microcephaly
  • Peroxisome Proliferator-Activated Receptors

• Enterovirus 71 VPg uridylation uses a two-molecular mechanism of 3D polymerase

  Sun, Y., Wang, Y., Shan, C., Chen, C., Xu, P., Song, M., Zhou, H., Yang, C., Xu, W., Shi, P. Y., Zhang, B. & Lou, Z., Dec 2012, In: Journal of virology. 86, 24, p. 13662-13671 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Enterovirus
  • Picornaviridae
  • RNA
  • mutation
  • Mutation
  32 Scopus citations

• Envelope protein ubiquitination drives entry and pathogenesis of Zika virus

  Giraldo, M. I., Xia, H., Aguilera-Aguirre, L., Hage, A., van Tol, S., Shan, C., Xie, X., Sturdevant, G. L., Robertson, S. J., McNally, K. L., Meade-White, K., Azar, S. R., Rossi, S. L., Maury, W., Woodson, M., Ramage, H., Johnson, J. R., Krogan, N. J., Morais, M. C., Best, S. M. & 2 others, Shi, P. Y. & Rajsbaum, R., Sep 17 2020, In: Nature. 585, 7825, p. 414-419 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Ubiquitination
  • Virus Internalization
  • Polyubiquitin
  • Proteins
  6 Scopus citations

• Erratum to: Targeting vesicle size (Nature Materials, (2018), 17, 11, (955-956), 10.1038/s41563-018-0200-8)

  Fei, Z. & Shi, P. Y., Dec 1 2018, In: Nature Materials. 17, 12, p. 1164 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  • news