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  • Elena Volpi

Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin

Gundermann, D. M., Walker, D. K., Reidy, P. T., Borack, M. S., Dickinson, J. M., Volpi, E. & Rasmussen, B. B., May 15 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 306, 10, p. E1198-E1204

Research output: Contribution to journalArticle

48 Scopus citations

Addition of carbohydrate or alanine to an essential amino acid mixture does not enhance human skeletal muscle protein anabolism1-3

Glynn, E. L., Fry, C. S., Timmerman, K. L., Drummond, M. J., Volpi, E. & Rasmussen, B. B., Mar 2013, In : Journal of Nutrition. 143, 3, p. 307-314 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

Aging differentially affects human skeletal muscle amino acid transporter expression when essential amino acids are ingested after exercise

Dickinson, J. M., Drummond, M. J., Coben, J. R., Volpi, E. & Rasmussen, B. B., Apr 2013, In : Clinical Nutrition. 32, 2, p. 273-280 8 p.

Research output: Contribution to journalArticle

47 Scopus citations

AGS and NIA Bench-to Bedside Conference Summary: Osteoporosis and Soft Tissue (Muscle and Fat) Disorders

Colón-Emeric, C., Whitson, H. E., Berry, S. D., Fielding, R. A., Houston, D. K., Kiel, D. P., Rosen, C. J., Seldeen, K. L., Volpi, E., White, J. P. & Troen, B. R., Jan 1 2019, (Accepted/In press) In : Journal of the American Geriatrics Society.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

A moderate acute increase in physical activity enhances nutritive flow and the muscle protein anabolic response to mixed nutrient intake in older adults

Timmerman, K. L., Dhanani, S., Glynn, E. L., Fry, C. S., Drummond, M. J., Jennings, K., Rasmussen, B. B. & Volpi, E., Jun 1 2012, In : American Journal of Clinical Nutrition. 95, 6, p. 1403-1412 10 p.

Research output: Contribution to journalArticle

82 Scopus citations

Androgen Therapy and Rehospitalization in Older Men with Testosterone Deficiency

Baillargeon, J., Deer, R. R., Kuo, Y. F., Zhang, D., Goodwin, J. S. & Volpi, E., May 1 2016, In : Mayo Clinic Proceedings. 91, 5, p. 587-595 9 p.

Research output: Contribution to journalArticle

4 Scopus citations
Open Access
4 Scopus citations
10 Scopus citations

A randomized trial of a multifactorial strategy to prevent serious fall injuries

Bhasin, S., Gill, T. M., Reuben, D. B., Latham, N. K., Ganz, D. A., Greene, E. J., Dziura, J., Basaria, S., Gurwitz, J. H., Dykes, P. C., McMahon, S., Storer, T. W., Gazarian, P., Miller, M. E., Travison, T. G., Esserman, D., Carnie, M. B., Goehring, L., Fagan, M., Greenspan, S. L. & 27 others, Alexander, N., Wiggins, J., Ko, F., Siu, A. L., Volpi, E., Wu, A. W., Rich, J., Waring, S. C., Wallace, R. B., Casteel, C., Resnick, N. M., Magaziner, J., Charpentier, P., Lu, C., Araujo, K., Rajeevan, H., Meng, C., Allore, H., Brawley, B. F., Eder, R., McGloin, J. M., Skokos, E. A., Duncan, P. W., Baker, D., Boult, C., Correa-De-Araujo, R. & Peduzzi, P., Jul 9 2020, In : New England Journal of Medicine. 383, 2, p. 129-140 12 p.

Research output: Contribution to journalArticle

A soy, whey and caseinate blend extends postprandial skeletal muscle protein synthesis in rats

Butteiger, D. N., Cope, M., Liu, P., Mukherjea, R., Volpi, E., Rasmussen, B. B. & Krul, E. S., Aug 2013, In : Clinical Nutrition. 32, 4, p. 585-591 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults

Drummond, M. J., Dickinson, J. M., Fry, C. S., Walker, D. K., Gundermann, D. M., Reidy, P. T., Timmerman, K. L., Markofski, M. M., Paddon-Jones, D., Rasmussen, B. B. & Volpi, E., May 1 2012, In : American Journal of Physiology - Endocrinology and Metabolism. 302, 9, p. E1113-E1122

Research output: Contribution to journalArticle

115 Scopus citations

Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans

Chondronikola, M., Volpi, E., Børsheim, E., Porter, C., Saraf, M. K., Annamalai, P., Yfanti, C., Chao, T., Wong, D., Shinoda, K., Labbe, S. M., Hurren, N. M., Cesani, F., Kajimura, S. & Sidossis, L. S., Jun 14 2016, In : Cell Metabolism. 23, 6, p. 1200-1206 7 p.

Research output: Contribution to journalArticle

122 Scopus citations

Brown adipose tissue improves whole-body glucose homeostasis and insulin sensitivity in humans

Chondronikola, M., Volpi, E., Børsheim, E., Porter, C., Annamalai, P., Enerbäck, S., Lidell, M. E., Saraf, M. K., Labbe, S. M., Hurren, N. M., Yfanti, C., Chao, T., Andersen, C. R., Cesani, F., Hawkins, H. & Sidossis, L. S., Dec 1 2014, In : Diabetes. 63, 12, p. 4089-4099 11 p.

Research output: Contribution to journalArticle

Open Access
356 Scopus citations

Brown adipose tissue is linked to a distinct thermoregulatory response to mild cold in people

Chondronikola, M., Volpi, E., Børsheim, E., Chao, T., Porter, C., Annamalai, P., Yfanti, C., Labbe, S. M., Hurren, N. M., Malagaris, I., Cesani, F. & Sidossis, L. S., Apr 19 2016, In : Frontiers in Physiology. 7, APR, 129.

Research output: Contribution to journalArticle

22 Scopus citations

Deficiency in Repair of the Mitochondrial Genome Sensitizes Proliferating Myoblasts to Oxidative Damage

Szczesny, B., Olah, G., Walker, D. K., Volpi, E., Rasmussen, B. B., Szabo, C. & Mitra, S., Sep 16 2013, In : PloS one. 8, 9, e75201.

Research output: Contribution to journalArticle

27 Scopus citations
1 Scopus citations

Effect of aerobic exercise training and essential amino acid supplementation for 24 weeks on physical function, body composition, and muscle metabolism in healthy, independent older adults: A randomized clinical trial

Markofski, M. M., Jennings, K., Timmerman, K. L., Dickinson, J. M., Fry, C. S., Borack, M. S., Reidy, P. T., Deer, R. R., Randolph, A., Rasmussen, B. B. & Volpi, E., Oct 1 2019, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 74, 10, p. 1598-1604 7 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Effect of essential amino acid supplementation and aerobic exercise on insulin sensitivity in healthy older adults: A randomized clinical trial

Randolph, A. C., Markofski, M. M., Rasmussen, B. B. & Volpi, E., May 2020, In : Clinical Nutrition. 39, 5, p. 1371-1378 8 p.

Research output: Contribution to journalArticle

Effect of high-fat diet on peripheral blood mononuclear cells and adipose tissue in early stages of diet-induced weight gain

Lowry, J. E., Tumurbaatar, B., D'agostino, C., Main, E., Wright, T. J., Dillon, E. L., Saito, T. B., Porter, C., Andersen, C. R., Brining, D. L., Endsley, J. J., Sheffield-Moore, M., Volpi, E., Fang, R., Abate, N. & Tuvdendorj, D. R., Dec 28 2019, In : British Journal of Nutrition. 122, 12, p. 1359-1367 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Efficacy and safety of leucine supplementation in the elderly

Borack, M. S. & Volpi, E., Dec 1 2016, In : Journal of Nutrition. 146, 12, p. 2625S-2629S

Research output: Contribution to journalArticle

23 Scopus citations

Endothelial function and the regulation of muscle protein anabolism in older adults

Timmerman, K. L. & Volpi, E., 2013, In : Nutrition, Metabolism and Cardiovascular Diseases. 23, SUPPL1, p. S44eS50

Research output: Contribution to journalReview article

27 Scopus citations
6 Scopus citations

Evidence-based recommendations for optimal dietary protein intake in older people: A position paper from the prot-age study group

Bauer, J., Biolo, G., Cederholm, T., Cesari, M., Cruz-Jentoft, A. J., Morley, J. E., Phillips, S., Sieber, C., Stehle, P., Teta, D., Visvanathan, R., Volpi, E. & Boirie, Y., Aug 2013, In : Journal of the American Medical Directors Association. 14, 8, p. 542-559 18 p.

Research output: Contribution to journalArticle

844 Scopus citations

Exercise and nutrition to target protein synthesis impairments in aging skeletal muscle

Dickinson, J. M., Volpi, E. & Rasmussen, B. B., Oct 1 2013, In : Exercise and Sport Sciences Reviews. 41, 4, p. 216-223 8 p.

Research output: Contribution to journalArticle

66 Scopus citations

Functional Improvements Utilizing the Short Physical Performance Battery (SPPB) in the Elderly after Epidural Steroid Injections

Przkora, R., Kinsky, M. P., Fisher, S. R., Babl, C., Heyde, C. E., Vasilopoulos, T., Kaye, A. D. & Volpi, E., Feb 1 2019, In : Current Pain and Headache Reports. 23, 2, 14.

Research output: Contribution to journalReview article

1 Scopus citations
10 Scopus citations

Insulin increases mRNA abundance of the amino acid transporter SLC7A5/LAT1 via an mTORC1-dependent mechanism in skeletal muscle cells

Walker, D. K., Drummond, M. J., Dickinson, J. M., Borack, M. S., Jennings, K., Volpi, E. & Rasmussen, B. B., 2014, In : Physiological reports. 2, 3, e00238.

Research output: Contribution to journalArticle

20 Scopus citations

Is leucine content in dietary protein the key to muscle preservation in older women?

Volpi, E., Feb 1 2018, In : The American journal of clinical nutrition. 107, 2, p. 143-144 2 p.

Research output: Contribution to journalEditorial

Is the optimal level of protein intake for older adults greater than the recommended dietary allowance?

Volpi, E., Campbell, W. W., Dwyer, J. T., Johnson, M. A., Jensen, G. L., Morley, J. E. & Wolfe, R. R., Jun 2013, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 68, 6, p. 677-681 5 p.

Research output: Contribution to journalArticle

193 Scopus citations

Kyphoplasty for vertebral augmentation in the elderly with osteoporotic vertebral compression fractures: Scenarios and review of recent studies

Bednar, T., Heyde, C. E., Bednar, G., Nguyen, D., Volpi, E. & Przkora, R., Nov 2013, In : Clinical Therapeutics. 35, 11, p. 1721-1727 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Leucine-enriched Amino acid ingestion after resistance exercise prolongs myofibrillar protein synthesis and amino acid transporter expression in older men

Dickinson, J. M., Gundermann, D. M., Walker, D. K., Reidy, P. T., Borack, M. S., Drummond, M. J., Arora, M., Volpi, E. & Rasmussen, B. B., 2014, In : Journal of Nutrition. 144, 11, p. 1694-1702 9 p.

Research output: Contribution to journalArticle

56 Scopus citations

Low skeletal muscle capillarization limits muscle adaptation to resistance exercise training in older adults

Moro, T., Brightwell, C. R., Phalen, D. E., McKenna, C. F., Lane, S. J., Porter, C., Volpi, E., Rasmussen, B. B. & Fry, C., Nov 2019, In : Experimental Gerontology. 127, 110723.

Research output: Contribution to journalArticle

7 Scopus citations

Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise

the Molecular Transducers of Physical Activity Consortium, Jun 25 2020, In : Cell. 181, 7, p. 1464-1474 11 p.

Research output: Contribution to journalReview article

Open Access
2 Scopus citations

Muscle Biology and mTORC1 Signaling in Aging

Rasmussen, B. B. & Volpi, E., 2012, Sarcopenia. Cruz-Jentoft, A. J. & Morley, J. E. (eds.). 1st ed. Wiley-Blackwell, p. 20-40

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Muscle Biology and mTORC1 Signaling in Aging

Rasmussen, B. B. & Volpi, E., Jul 27 2012, Sarcopenia. John Wiley and Sons, p. 20-40 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Muscle protein anabolic resistance to essential amino acids does not occur in healthy older adults before or after resistance exercise training

Moro, T., Brightwell, C. R., Deer, R. R., Graber, T. G., Galvan, E., Fry, C. S., Volpi, E. & Rasmussen, B. B., Jun 1 2018, In : Journal of Nutrition. 148, 6, p. 900-909 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Palmitoyl-carnitine production by blood cells associates with the concentration of circulating acyl-carnitines in healthy overweight women

Chondronikola, M., Asghar, R., Zhang, X., Dillon, E. L., Durham, W. J., Wu, Z., Porter, C., Camacho-Hughes, M., Zhao, Y., Brasier, A. R., Volpi, E., Sheffield-Moore, M., Abate, N., Sidossis, L. & Tuvdendorj, D., Oct 2017, In : Clinical Nutrition. 36, 5, p. 1310-1319 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

PAX7+ satellite cells in young and older adults following resistance exercise

Walker, D. K., Fry, C. S., Drummond, M. J., Dickinson, J. M., Timmerman, K. L., Gundermann, D. M., Jennings, K., Volpi, E. & Rasmussen, B. B., Jul 2012, In : Muscle and Nerve. 46, 1, p. 51-59 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Post-absorptive muscle protein turnover affects resistance training hypertrophy

Reidy, P. T., Borack, M. S., Markofski, M. M., Dickinson, J. M., Fry, C. S., Deer, R. R., Volpi, E. & Rasmussen, B. B., May 1 2017, In : European Journal of Applied Physiology. 117, 5, p. 853-866 14 p.

Research output: Contribution to journalArticle

15 Scopus citations

Protein blend ingestion following resistance exercise promotes human muscle protein synthesis

Reidy, P. T., Walker, D. K., Dickinson, J. M., Gundermann, D. M., Drummond, M. J., Timmerman, K. L., Fry, C. S., Borack, M. S., Cope, M. B., Mukherjea, R., Jennings, K., Volpi, E. & Rasmussen, B. B., Apr 1 2013, In : Journal of Nutrition. 143, 4, p. 410-416 7 p.

Research output: Contribution to journalArticle

81 Scopus citations

Protein requirements in critically ill older adults

Deer, R. R. & Volpi, E., Mar 20 2018, In : Nutrients. 10, 3, 378.

Research output: Contribution to journalReview article

8 Scopus citations

Protein supplementation does not affect myogenic adaptations to resistance training

Reidy, P. T., Fry, C. S., Igbinigie, S., Deer, R. R., Jennings, K., Cope, M. B., Mukherjea, R., Volpi, E. & Rasmussen, B. B., 2017, In : Medicine and Science in Sports and Exercise. 49, 6, p. 1197-1208 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Protein supplementation has minimal effects on muscle adaptations during resistance exercise training in young men: A double-blind randomized clinical trial

Reidy, P. T., Borack, M. S., Markofski, M. M., Dickinson, J. M., Deer, R. R., Husaini, S. H., Walker, D. K., Igbinigie, S., Robertson, S. M., Cope, M. B., Mukherjea, R., Hall-Porter, J. M., Jennings, K., Volpi, E. & Rasmussen, B. B., 2016, In : Journal of Nutrition. 146, 9, p. 1660-1669 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Protocol for serious fall injury adjudication in the Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE) study

Ganz, D. A., Siu, A. L., Magaziner, J., Latham, N. K., Travison, T. G., Lorenze, N. P., Lu, C., Wang, R., Greene, E. J., Stowe, C. L., Harvin, L. N., Araujo, K. L. B., Gurwitz, J. H., Agrawal, Y., Correa-De-Araujo, R., Peduzzi, P., Gill, T. M., Bhasin, S., Gill, T. M., Reuben, D. B. & 149 others, McMahon, S., Latham, N. K., Basaria, S., Brawley, B., Eder, R., Larson, A., Goehring, L., Lukas, M., Margolis, S., Storer, T. W., Carnie, M. B., Gazarian, P., Fagan, M., Peduzzi, P., Dziura, J., Esserman, D., Greene, E. J., Hawthorne-Jones, G., Allore, H., Doyle, M., Funaro, B., Lorenze, N., Mignosa, B., Miller, M. E., Travison, T. G., Charpentier, P., Araujo, K., Baker, D., McGloin, J. M., Lu, C., Rajeevan, H., Katsovich, L., Wang, R., Shelton, A., Skokos, E., Tang, S., Abella, M., Gordon, C., Pennestri, T., Bianco, L., Castro, R., Rubeck, S., Rando, K., Foster, B., Wu, K., Nock, D., Collins, C., Sherman, L., Waring, S. C., Chopskie, E., Larsen, H., Taran, A., Bianco, J., Hoberg, M., Rich, J., Chavez, V., Moore, C., Howe, J., Garcia, R., Nunez, J., Ho, S., Chen, Y., Wu, A. W., Walston, J. D., Agrawal, Y., Ephraim, P., Campbell, T., Albert, M., Ashar, B., Birnbaum, B., Chaudry, S., Edwards, L. T., Feeser, S., Hussain, N., Joseph, A., Larsen, K., Lee, A., Okuwobi, O., Scheck, T., Wallace, R., Casteel, C., Shanahan, A., Weldon, J., Leveke, A., Keller, C., Reist, J., Alexander, N., Wiggins, J., Burek, K., Ledesma, T., Nyquist, L. V., Gallagher, N., Hanson, C., Ko, F., Siu, A. L., Leipzig, R. M., Espino, C., Ramaswamy, R., West, D., Matza, D., Dykes, P., Stenvig, H., Florgomes, K., Christiansen, T., Salazar, A., Frain, L., Orkaby, A., Bean, J., Wells, Y., Foskett, C., Gurwitz, J. H., Richards, A., Amroze, A., Garber, L., Preusse, P., McDonald, A., Greenspan, S. L., Ferchak, M. A., Rigatti, M., Madia, J., Volpi, E., Hirst, R., Martinez, E., Raji, M., Magaziner, J., Ganz, D. A., Duncan, P. W., Boult, C., Goodwin, J., Manini, T., High, K. P., Harvin, L., Stowe, C., Romashkan, S., Correa-De-Araujo, R., Joseph, L., Salive, M., Hadley, E. C., Clauser, S. B., Buchner, D., Fulmer, T., Ellenberg, S., Beattie, B. L., King, A. C., Brown, C. J., Rubenstein, L., Sterling, M. A., Prohaska, T. & Friedman, L., Apr 15 2019, In : Injury Epidemiology. 6, 1, 14.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Pulsatile portal vein insulin delivery enhances hepatic insulin action and signaling

Matveyenko, A. V., Liuwantara, D., Gurlo, T., Kirakossian, D., Dalla Man, C., Cobelli, C., White, M. F., Copps, K. D., Volpi, E., Fujita, S. & Butler, P. C., Sep 2012, In : Diabetes. 61, 9, p. 2269-2279 11 p.

Research output: Contribution to journalArticle

79 Scopus citations

Quantification of muscle triglyceride synthesis rate requires an adjustment for total triglyceride content

Asghar, R., Chondronikola, M., Dillon, E. L., Durham, W. J., Porter, C., Wu, Z., Camacho-Hughes, M., Andersen, C. R., Spratt, H., Volpi, E., Sheffield-Moore, M., Sidossis, L., Wolfe, R. R., Abate, N. & Tuvdendorj, D. R., 2018, In : Journal of Lipid Research. 59, 10, p. 2018-2024 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Rapamycin does not affect post-absorptive protein metabolism in human skeletal muscle

Dickinson, J. M., Drummond, M. J., Fry, C. S., Gundermann, D. M., Walker, D. K., Timmerman, K. L., Volpi, E. & Rasmussen, B. B., Jan 2013, In : Metabolism: Clinical and Experimental. 62, 1, p. 144-151 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Reactive hyperemia is not responsible for stimulating muscle protein synthesis following blood flow restriction exercise

Gundermann, D. M., Fry, C. S., Dickinson, J. M., Walker, D. K., Timmerman, K. L., Drummond, M. J., Volpi, E. & Rasmussen, B. B., May 1 2012, In : Journal of Applied Physiology. 112, 9, p. 1520-1528 9 p.

Research output: Contribution to journalArticle

55 Scopus citations

Resistance exercise training promotes fiber type-specific myonuclear adaptations in older adults

Moro, T., Brightwell, C. R., Volpi, E., Rasmussen, B. B. & Fry, C., Jan 1 2020, In : Journal of Applied Physiology. 128, 4, p. 795-804 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Sex-dependent difference in the relationship between adipose-tissue cholesterol efflux and estradiol concentrations in young healthy humans

Iqbal, F., Durham, W. J., Melhem, A., Raslan, S., Tran, T. T., Wright, T. J., Asghar, R., Fujise, K., Volpi, E., Sidossis, L., Abate, N., Sheffield-Moore, M. & Tuvdendorj, D., Feb 2018, In : International Journal of Developmental Neuroscience. 64, p. 59-62 4 p.

Research output: Contribution to journalArticle

1 Scopus citations