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2′-O methylation of internal adenosine by flavivirus NS5 methyltransferase
Dong, H., Chang, D. C., Hua, M. H. C., Lim, S. P., Chionh, Y. H., Hia, F., Lee, Y. H., Kukkaro, P., Lok, S. M., Dedon, P. C. & Shi, P. Y., Apr 2012, In: PLoS pathogens. 8, 4, e1002642.Research output: Contribution to journal › Article › peer-review
85 Scopus citations -
A cDNA Clone-Launched Platform for High-Yield Production of Inactivated Zika Vaccine
Yang, Y., Shan, C., Zou, J., Muruato, A. E., Bruno, D. N., de Almeida Medeiros Daniele, B., Vasconcelos, P. F. C., Rossi, S. L., Weaver, S. C., Xie, X. & Shi, P. Y., Mar 1 2017, In: EBioMedicine. 17, p. 145-156 12 p.Research output: Contribution to journal › Article › peer-review
28 Scopus citations -
A cocrystal structure of dengue capsid protein in complex of inhibitor
Xia, H., Xie, X., Zou, J., Noble, C. G., Russell, W. K., Holthauzen, L. M. F., Choi, K. H., White, M. A. & Shi, P. Y., Jul 28 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 30, p. 17992-18001 10 p.Research output: Contribution to journal › Article › peer-review
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A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication
Zhao, Y., Soh, T. S., Zheng, J., Chan, K. W. K., Phoo, W. W., Lee, C. C., Tay, M. Y. F., Swaminathan, K., Cornvik, T. C., Lim, S. P., Shi, P. Y., Lescar, J., Vasudevan, S. G. & Luo, D., Mar 1 2015, In: PLoS pathogens. 11, 3, p. 1-27 27 p., e1004682.Research output: Contribution to journal › Article › peer-review
107 Scopus citations -
Activation of peripheral blood mononuclear cells by dengue virus infection depotentiates balapiravir
Chen, Y. L., Ghafar, N. A., Karuna, R., Fu, Y., Lim, S. P., Schul, W., Gu, F., Herve, M., Yokohama, F., Wang, G., Cerny, D., Fink, K., Blasco, F. & Shi, P. Y., Feb 2014, In: Journal of virology. 88, 3, p. 1740-1747 8 p.Research output: Contribution to journal › Article › peer-review
37 Scopus citations -
Adulthood Sequelae of Congenital Zika Virus Infection in Mice
Zou, J. & Shi, P. Y., Jun 2017, In: EBioMedicine. 20, p. 11-12 2 p.Research output: Contribution to journal › Comment/debate › peer-review
3 Scopus citations -
A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation
Muruato, A. E., Fontes-Garfias, C. R., Ren, P., Garcia-Blanco, M. A., Menachery, V. D., Xie, X. & Shi, P. Y., Dec 1 2020, In: Nature communications. 11, 1, 4059.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models
Shan, C., Muruato, A. E., Nunes, B. T. D., Luo, H., Xie, X., Medeiros, D. B. A., Wakamiya, M., Tesh, R. B., Barrett, A. D., Wang, T., Weaver, S. C., Vasconcelos, P. F. C., Rossi, S. L. & Shi, P. Y., Jun 1 2017, In: Nature Medicine. 23, 6, p. 763-767 5 p.Research output: Contribution to journal › Article › peer-review
159 Scopus citations -
A Multiplex Microsphere Immunoassay for Zika Virus Diagnosis
Wong, S. J., Furuya, A., Zou, J., Xie, X., Dupuis, A. P., Kramer, L. D. & Shi, P. Y., Feb 1 2017, In: EBioMedicine. 16, p. 136-140 5 p.Research output: Contribution to journal › Article › peer-review
58 Scopus citations -
A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19
Xie, X., Muruato, A. E., Zhang, X., Lokugamage, K. G., Fontes-Garfias, C. R., Zou, J., Liu, J., Ren, P., Balakrishnan, M., Cihlar, T., Tseng, C. T. K., Makino, S., Menachery, V. D., Bilello, J. P. & Shi, P. Y., Dec 1 2020, In: Nature communications. 11, 1, 5214.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
An Infectious cDNA Clone of SARS-CoV-2
Xie, X., Muruato, A., Lokugamage, K. G., Narayanan, K., Zhang, X., Zou, J., Liu, J., Schindewolf, C., Bopp, N. E., Aguilar, P. V., Plante, K. S., Weaver, S. C., Makino, S., LeDuc, J. W., Menachery, V. D. & Shi, P. Y., May 13 2020, In: Cell Host and Microbe. 27, 5, p. 841-848.e3Research output: Contribution to journal › Article › peer-review
Open Access62 Scopus citations -
A novel reporter system for neutralizing and enhancing antibody assay against dengue virus
Song, K. Y., Zhao, H., Jiang, Z. Y., Li, X. F., Deng, Y. Q., Jiang, T., Zhu, S. Y., Shi, P. Y., Zhang, B., Zhang, F. C., Qin, E. D. & Qin, C. F., Feb 18 2014, In: BMC Microbiology. 14, 1, 44.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
Antagonism of Type i Interferon by Severe Acute Respiratory Syndrome Coronavirus 2
Xia, H. & Shi, P. Y., Dec 2020, In: Journal of Interferon and Cytokine Research. 40, 12, p. 543-548 6 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Anti-dengue-virus activity and structure-activity relationship studies of lycorine derivatives
Wang, P., Li, L. F., Wang, Q. Y., Shang, L. Q., Shi, P. Y. & Yin, Z., Jul 2014, In: ChemMedChem. 9, 7, p. 1522-1533 12 p.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
A positively selected mutation in the WNV 2K peptide confers resistance to superinfection exclusion in vivo
Campbell, C. L., Smith, D. R., Sanchez-Vargas, I., Zhang, B., Shi, P. Y. & Ebel, G. D., Sep 2014, In: Virology. 464-465, 1, p. 228-232 5 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
A Rapid Zika Diagnostic Assay to Measure Neutralizing Antibodies in Patients
Shan, C., Xie, X., Ren, P., Loeffelholz, M. J., Yang, Y., Furuya, A., Dupuis, A. P., Kramer, L. D., Wong, S. J. & Shi, P. Y., Mar 1 2017, In: EBioMedicine. 17, p. 157-162 6 p.Research output: Contribution to journal › Article › peer-review
45 Scopus citations -
A replication-defective Japanese encephalitis virus (JEV) vaccine candidate with NS1 deletion confers dual protection against JEV and West Nile virus in mice
Li, N., Zhang, Z. R., Zhang, Y. N., Liu, J., Deng, C. L., Shi, P. Y., Yuan, Z. M., Ye, H. Q. & Zhang, B., Dec 1 2020, In: npj Vaccines. 5, 1, 73.Research output: Contribution to journal › Article › peer-review
Open Access -
A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage
Shan, C., Muruato, A. E., Jagger, B. W., Richner, J., Nunes, B. T. D., Medeiros, D. B. A., Xie, X., Nunes, J. G. C., Morabito, K. M., Kong, W. P., Pierson, T. C., Barrett, A. D., Weaver, S. C., Rossi, S. L., Vasconcelos, P. F. C., Graham, B. S., Diamond, M. S. & Shi, P. Y., Dec 1 2017, In: Nature communications. 8, 1, 676.Research output: Contribution to journal › Article › peer-review
80 Scopus citations -
A single mutation in the prM protein of Zika virus contributes to fetal microcephaly
Yuan, L., Huang, X. Y., Liu, Z. Y., Zhang, F., Zhu, X. L., Yu, J. Y., Ji, X., Xu, Y. P., Li, G., Li, C., Wang, H. J., Deng, Y. Q., Wu, M., Cheng, M. L., Ye, Q., Xie, D. Y., Li, X. F., Wang, X., Shi, W., Hu, B. & 3 others, , Nov 17 2017, In: Science. 358, 6365, p. 933-936 4 p.Research output: Contribution to journal › Article › peer-review
215 Scopus citations -
A Zika virus envelope mutation preceding the 2015 epidemic enhances virulence and fitness for transmission
Shan, C., Xia, H., Haller, S. L., Azar, S. R., Liu, Y., Liu, J., Muruato, A. E., Chen, R., Rossi, S. L., Wakamiya, M., Vasilakis, N., Pei, R., Fontes-Garfias, C. R., Singh, S. K., Xie, X., Weaver, S. C. & Shi, P. Y., Aug 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 33, p. 20190-20197 8 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential
Xu, J., Shi, P. Y., Li, H. & Zhou, J., May 8 2020, In: ACS Infectious Diseases. 6, 5, p. 909-915 7 p.Research output: Contribution to journal › Review article › peer-review
Open Access71 Scopus citations -
Characterization of Dengue virus NS4A and NS4B protein interaction
Zou, J., Xie, X., Wang, Q. Y., Dong, H., Lee, M. Y., Kang, C., Yuan, Z. & Shi, P. Y., 2015, In: Journal of virology. 89, 7, p. 3455-3470 16 p.Research output: Contribution to journal › Article › peer-review
70 Scopus citations -
Combined treatment of adenosine nucleoside inhibitor NITD008 and histone deacetylase inhibitor vorinostat represents an immunotherapy strategy to ameliorate West Nile virus infection
Nelson, J., Roe, K., Orillo, B., Shi, P. Y. & Verma, S., Oct 1 2015, In: Antiviral research. 122, p. 39-45 7 p., 3668.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
Construction of stable reporter flaviviruses and their applications
Baker, C. & Shi, P. Y., Oct 2020, In: Viruses. 12, 10, 1082.Research output: Contribution to journal › Article › peer-review
Open Access -
COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses
Sahin, U., Muik, A., Derhovanessian, E., Vogler, I., Kranz, L. M., Vormehr, M., Baum, A., Pascal, K., Quandt, J., Maurus, D., Brachtendorf, S., Lörks, V., Sikorski, J., Hilker, R., Becker, D., Eller, A. K., Grützner, J., Boesler, C., Rosenbaum, C., Kühnle, M. C. & 22 others, , Oct 22 2020, In: Nature. 586, 7830, p. 594-599 6 p.Research output: Contribution to journal › Article › peer-review
Open Access50 Scopus citations -
Crystal structure of dengue virus methyltransferase without S-adenosyl-L-methionine
Noble, C. G., Li, S. H., Dong, H., Chew, S. H. & Shi, P. Y., Nov 2014, In: Antiviral research. 111, p. 78-81 4 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Dengue in China: not a passing problem
Qin, C. F. & Shi, P. Y., Dec 11 2014, In: Science China Life Sciences. 57, 12, p. 1230-1231 2 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Dengue subgenomic flaviviral RNA disrupts immunity in mosquito salivary glands to increase virus transmission
Pompon, J., Manuel, M., Ng, G. K., Wong, B., Shan, C., Manokaran, G., Soto-Acosta, R., Bradrick, S. S., Ooi, E. E., Missé, D., Shi, P. Y. & Garcia-Blanco, M. A., Jul 2017, In: PLoS pathogens. 13, 7, e1006535.Research output: Contribution to journal › Article › peer-review
47 Scopus citations -
Dengue Therapeutics, Chemoprophylaxis, and Allied Tools: State of the Art and Future Directions
Whitehorn, J., Yacoub, S., Anders, K. L., Macareo, L. R., Cassetti, M. C., Nguyen Van, V. C., Shi, P. Y., Wills, B. & Simmons, C. P., Aug 28 2014, In: PLoS neglected tropical diseases. 8, 8, e3025.Research output: Contribution to journal › Article › peer-review
47 Scopus citations -
Design, synthesis and biological evaluation of spiropyrazolopyridone derivatives as potent dengue virus inhibitors
Xu, J., Xie, X., Chen, H., Zou, J., Xue, Y., Ye, N., Shi, P. Y. & Zhou, J., Jun 1 2020, In: Bioorganic and Medicinal Chemistry Letters. 30, 11, 127162.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Determinants of dengue virus NS4A protein oligomerization
Lee, C. M., Xie, X., Zou, J., Li, S. H., Qi Lee, M. Y., Dong, H., Qin, C. F., Kang, C. & Shi, P. Y., 2015, In: Journal of virology. 89, 12, p. 6171-6183 13 p.Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
Development of a FACS-based assay for evaluating antiviral potency of compound in dengue infected peripheral blood mononuclear cells
Fu, Y., Chen, Y. L., Herve, M., Gu, F., Shi, P. Y. & Blasco, F., Feb 2014, In: Journal of Virological Methods. 196, p. 18-24 7 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Development of a Rapid Focus Reduction Neutralization Test Assay for Measuring SARS-CoV-2 Neutralizing Antibodies
Vanderheiden, A., Edara, V. V., Floyd, K., Kauffman, R. C., Mantus, G., Anderson, E., Rouphael, N., Edupuganti, S., Shi, P-Y., Menachery, V. D., Wrammert, J. & Suthar, M. S., Dec 2020, In: Current Protocols in Immunology. 131, 1, e116.Research output: Contribution to journal › Article › peer-review
Open Access -
Development of a stable Gaussia luciferase enterovirus 71 reporter virus
Xu, L. L., Shan, C., Deng, C. L., Li, X. D., Shang, B. D., Ye, H. Q., Liu, S. Q., Yuan, Z. M., Wang, Q. Y., Shi, P. Y. & Zhang, B., Jul 1 2015, In: Journal of Virological Methods. 219, p. 62-66 5 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Dimerization of flavivirus NS4B protein
Zou, J., Xie, X., Lee, L. T., Chandrasekaran, R., Reynaud, A., Yap, L., Wang, Q. Y., Dong, H., Kang, C., Yuan, Z., Lescar, J. & Shi, P. Y., Mar 2014, In: Journal of virology. 88, 6, p. 3379-3391 13 p.Research output: Contribution to journal › Article › peer-review
44 Scopus citations -
Discovery of dengue virus NS4B inhibitors
Wang, Q. Y., Dong, H., Zou, B., Karuna, R., Wan, K. F., Zou, J., Susila, A., Yip, A., Shan, C., Yeo, K. L., Xu, H., Ding, M., Chan, W. L., Gu, F., Seah, P. G., Liu, W., Lakshminarayana, S. B., Kang, C. B., Lescar, J., Blasco, F. & 2 others, , 2015, In: Journal of virology. 89, 16, p. 8233-8244 12 p.Research output: Contribution to journal › Article › peer-review
54 Scopus citations -
Drug discovery for the developing world: Progress at the Novartis Institute for Tropical Diseases
Jones, C. L., Yeung, B. K. S., Manjunatha, U., Shi, P. Y., Bodenreider, C. & Diagana, T. T., Jun 3 2015, In: Nature Reviews Drug Discovery. 14, 6, p. 442-444 3 p.Research output: Contribution to journal › Letter › peer-review
4 Scopus citations -
Dysregulation of Ephrin receptor and PPAR signaling pathways in neural progenitor cells infected by Zika virus
Thulasi Raman, S. N., Latreille, E., Gao, J., Zhang, W., Wu, J., Russell, M. S., Walrond, L., Cyr, T., Lavoie, J. R., Safronetz, D., Cao, J., Sauve, S., Farnsworth, A., Chen, W., Shi, P. Y., Wang, Y., Wang, L., Rosu-Myles, M. & Li, X., Jan 1 2020, In: Emerging Microbes and Infections. 9, 1, p. 2046-2060 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Enterovirus 71 VPg uridylation uses a two-molecular mechanism of 3D polymerase
Sun, Y., Wang, Y., Shan, C., Chen, C., Xu, P., Song, M., Zhou, H., Yang, C., Xu, W., Shi, P. Y., Zhang, B. & Lou, Z., Dec 2012, In: Journal of virology. 86, 24, p. 13662-13671 10 p.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
Envelope protein ubiquitination drives entry and pathogenesis of Zika virus
Giraldo, M. I., Xia, H., Aguilera-Aguirre, L., Hage, A., van Tol, S., Shan, C., Xie, X., Sturdevant, G. L., Robertson, S. J., McNally, K. L., Meade-White, K., Azar, S. R., Rossi, S. L., Maury, W., Woodson, M., Ramage, H., Johnson, J. R., Krogan, N. J., Morais, M. C., Best, S. M. & 2 others, , Sep 17 2020, In: Nature. 585, 7825, p. 414-419 6 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Erratum: Zika virus has oncolytic activity against glioblastoma stem cells [The Journal of Experimental Medicine, 214, 10, (2017)] DOI: 10.1084/jem.20171093
Zhu, Z., Gorman, M. J., McKenzie, L. D., Chai, J. N., Hubert, C. G., Prager, B. C., Fernandez, E., Richner, J. M., Zhang, R., Shan, C., Tycksen, E., Wang, X., Shi, P. Y., Diamond, M. S., Rich, J. N. & Chheda, M. G., 2017, In: Journal of Experimental Medicine. 214, 10, p. 3145 1 p.Research output: Contribution to journal › Comment/debate › peer-review
6 Scopus citations -
Evaluation of a novel reporter virus neutralization test for serological diagnosis of Zika and Dengue virus infection
Shan, C., Ortiz, D. A., Yang, Y., Wong, S. J., Kramer, L. D., Shi, P. Y., Loeffelholz, M. J. & Ren, P., Oct 2017, In: Journal of Clinical Microbiology. 55, 10, p. 3028-3036 9 p.Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
Evasion of Type I Interferon by SARS-CoV-2
Xia, H., Cao, Z., Xie, X., Zhang, X., Chen, J. Y. C., Wang, H., Menachery, V. D., Rajsbaum, R. & Shi, P. Y., Oct 6 2020, In: Cell Reports. 33, 1, 108234.Research output: Contribution to journal › Article › peer-review
Open Access24 Scopus citations -
Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes
Liu, Y., Liu, J., Du, S., Shan, C., Nie, K., Zhang, R., Li, X. F., Zhang, R., Wang, T., Qin, C. F., Wang, P., Shi, P. Y. & Cheng, G., May 25 2017, In: Nature. 545, 7655, p. 482-486 5 p.Research output: Contribution to journal › Article › peer-review
193 Scopus citations -
Flavivirus NS5 prevents the InSTATement of IFN
Shi, P. Y., Sep 10 2014, In: Cell Host and Microbe. 16, 3, p. 269-271 3 p.Research output: Contribution to journal › Short survey › peer-review
10 Scopus citations -
Flavivirus RNA methylation
Dong, H., Fink, K., Züst, R., Lim, S. P., Qin, C. F. & Shi, P. Y., 2014, In: Journal of General Virology. 95, PART 4, p. 763-778 16 p.Research output: Contribution to journal › Review article › peer-review
66 Scopus citations -
Flexibility of NS5 methyltransferase-polymerase linker region is essential for dengue virus replication
Zhao, Y., Soh, T. S., Chan, K. W. K., Fung, S. S. Y., Swaminathan, K., Lim, S. P., Shi, P. Y., Huber, T., Lescar, J., Luo, D. & Vasudevan, S. G., Jan 1 2015, In: Journal of virology. 89, 20, p. 10717-10721 5 p.Research output: Contribution to journal › Article › peer-review
28 Scopus citations -
Functional Analysis of Glycosylation of Zika Virus Envelope Protein
Fontes-Garfias, C. R., Shan, C., Luo, H., Muruato, A. E., Medeiros, D. B. A., Mays, E., Xie, X., Zou, J., Roundy, C. M., Wakamiya, M., Rossi, S. L., Wang, T., Weaver, S. C. & Shi, P. Y., Oct 31 2017, In: Cell Reports. 21, 5, p. 1180-1190 11 p.Research output: Contribution to journal › Article › peer-review
62 Scopus citations -
Generation and characterization of West Nile pseudo-infectious reporter virus for antiviral screening
Zhang, H. L., Ye, H. Q., Deng, C. L., Liu, S. Q., Shi, P. Y., Qin, C. F., Yuan, Z. M. & Zhang, B., May 1 2017, In: Antiviral research. 141, p. 38-47 10 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Genomic analysis and growth characteristic of dengue viruses from Makassar, Indonesia
Sasmono, R. T., Wahid, I., Trimarsanto, H., Yohan, B., Wahyuni, S., Hertanto, M., Yusuf, I., Mubin, H., Ganda, I. J., Latief, R., Bifani, P. J., Shi, P. Y. & Schreiber, M. J., Jun 1 2015, In: Infection, Genetics and Evolution. 32, p. 165-177 13 p.Research output: Contribution to journal › Article › peer-review
48 Scopus citations