Find Research outputs — UTMB Health Research Expert Profiles

A biosafety level-2 dose-dependent lethal mouse model of spotted fever rickettsiosis: Rickettsia parkeri Atlantic Rainforest-like isolate

Londoño, A. F., Mendell, N. L., Walker, D. H. & Bouyer, D. H., Dec 5 2018, In: Unknown Journal.

Research output: Contribution to journal › Article › peer-review

A biosafety level-2 dose-dependent lethal mouse model of spotted fever rickettsiosis: Rickettsia parkeri atlantic rainforest strain

Londoño, A. F., Mendell, N. L., Walker, D. H. & Bouyer, D. H., Jun 2019, In: PLoS neglected tropical diseases. 13, 6, e0007054.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

A cluster of cases of rocky mountain spotted fever in an area of Colombia not known to be endemic for this disease

Londoño, A. F., Arango-Ferreira, C., Acevedo-Gutiérrez, L. Y., Paternina, L. E., Montes, C., Ruiz, I., Labruna, M. B., Díaz, F. J., Walker, D. H. & Rodas, J. D., 2019, In: American Journal of Tropical Medicine and Hygiene. 101, 2, p. 336-342 7 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Activation of ASC Inflammasome Driven by Toll-Like Receptor 4 Contributes to Host Immunity against Rickettsial Infection

Rumfield, C., Hyseni, I., McBride, J. W., Walker, D. H. & Fang, R., Mar 23 2020, In: Infection and immunity. 88, 4

Research output: Contribution to journal › Article › peer-review

After malaria is controlled, what's next?

Walker, D. H., Jul 2014, In: American Journal of Tropical Medicine and Hygiene. 91, 1, p. 7-10 4 p.

Research output: Contribution to journal › Editorial › peer-review

1 Scopus citations

A Hematogenously Disseminated Orientia tsutsugamsushi-Infected Murine Model of Scrub Typhus

Shelite, T. R., Saito, T. B., Mendell, N. L., Gong, B., Xu, G., Soong, L., Valbuena, G., Bouyer, D. H. & Walker, D. H., Jul 2014, In: PLoS neglected tropical diseases. 8, 7, e2966.

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Analysis of health-Care charges in murine typhus: Need for improved clinical recognition and diagnostics for acute disease

Vohra, R. F., Walker, D. H. & Blanton, L. S., 2018, In: American Journal of Tropical Medicine and Hygiene. 98, 6, p. 1594-1598 5 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

An Intradermal Inoculation Mouse Model for Immunological Investigations of Acute Scrub Typhus and Persistent Infection

Soong, L., Mendell, N. L., Olano, J. P., Rockx-Brouwer, D., Xu, G., Goez-Rivillas, Y., Drom, C., Shelite, T. R., Valbuena, G., Walker, D. H. & Bouyer, D. H., Aug 1 2016, In: PLoS neglected tropical diseases. 10, 8, e0004884.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

A review of the global epidemiology of scrub typhus

Xu, G., Walker, D. H., Jupiter, D., Melby, P. C. & Arcari, C. M., Nov 3 2017, In: PLoS neglected tropical diseases. 11, 11, e0006062.

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

A single mutation (V64G) within the ring domain of Z attenuates junin virus

Hallam, S. J., Manning, J. T., Maruyama, J., Seregin, A., Huang, C., Walker, D. H., de la Torre, J. C. & Paessler, S., Sep 2020, In: PLoS neglected tropical diseases. 14, 9, p. 1-15 15 p., e0008555.

Research output: Contribution to journal › Article › peer-review

Open Access

Atg5 supports Rickettsia australis infection in macrophages in vitro and in vivo

Bechelli, J., Vergara, L., Smalley, C., Buzhdygan, T. P., Bender, S., Zhang, W., Liu, Y., Popov, V. L., Wang, J., Garg, N., Hwang, S., Walker, D. H. & Fang, R., Jan 1 2019, In: Infection and immunity. 87, 1, e00651.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Burkholderia pseudomallei ΔtonB Δhcp1 live attenuated vaccine strain elicits full protective immunity against aerosolized melioidosis infection

Khakhum, N., Bharaj, P., Myers, J. N., Tapia, D., Kilgore, P. B., Ross, B. N., Walker, D. H., Endsley, J. J. & Torresa, A. G., Jan 1 2019, In: mSphere. 4, 1, e00570-18.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

CD8⁺T cells provide immune protection against murine disseminated endotheliotropic Orientia tsutsugamushi infection

Xu, G., Mendell, N. L., Liang, Y., Shelite, T. R., Goez-Rivillas, Y., Soong, L., Bouyer, D. H. & Walker, D. H., Jul 19 2017, In: PLoS neglected tropical diseases. 11, 7, e0005763.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Chlamydial, Mycoplasmal, Rickettsial, and Ehrlichial Diseases

Walker, D. H., 2018, Pulmonary Pathology: A Volume in the Series: Foundations in Diagnostic Pathology. Elsevier Inc., p. 315-326 12 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Diseases Caused by Fungi

Walker, D. H. & McGinnis, M. R., Jan 1 2014, Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms. Elsevier Inc., p. 217-221 5 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Editorial: Changing dynamics of human-rickettsial interactions

Walker, D. H., Jan 2016, In: American Journal of Tropical Medicine and Hygiene. 94, 1, p. 3-4 2 p.

Research output: Contribution to journal › Editorial › peer-review

5 Scopus citations

Ehrlichia

Thirumalapura, N. R. & Walker, D., Nov 26 2014, Molecular Medical Microbiology: Second Edition. Elsevier Ltd, Vol. 3. p. 2011-2032 22 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Ehrlichia chaffeensis (Human Monocytotropic Ehrlichiosis), Anaplasma phagocytophilum (Human Granulocytotropic Anaplasmosis), and Other Anaplasmataceae

Dumler, J. S. & Walker, D. H., Aug 28 2014, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. Elsevier Inc., Vol. 2. p. 2227-2233.e3

Research output: Chapter in Book/Report/Conference proceeding › Chapter

9 Scopus citations

Ehrlichia chaffeensis and E. canis hypothetical protein immunoanalysis reveals small secreted immunodominant proteins and conformation-dependent antibody epitopes

Luo, T., Patel, J. G., Zhang, X., Walker, D. H. & McBride, J. W., Dec 1 2020, In: npj Vaccines. 5, 1, 85.

Research output: Contribution to journal › Article › peer-review

Open Access

Ehrlichia chaffeensis outer membrane protein 1-specific human antibody-mediated immunity is defined by intracellular TRIM21-dependent innate immune activation and extracellular neutralization

Velayutham, T. S., Kumar, S., Zhang, X., Kose, N., Walker, D. H., Winslow, G., Crowe, J. E. & McBride, J. W., Dec 1 2019, In: Infection and immunity. 87, 12, e00383-19.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Ehrlichioses: An important one health opportunity

Saito, T. B. & Walker, D. H., Sep 1 2016, In: Veterinary Sciences. 3, 3, 20.

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Endothelial Activation and Injury: The Mechanisms of Rickettsial Vasculiti

Sahni, A., Narra, H. P., Walker, D. H. & Sahni, S. K., Jan 1 2016, Vascular Responses to Pathogens. Elsevier Inc., p. 111-122 12 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

5 Scopus citations

Endothelial cell proteomic response to Rickettsia conorii infection reveals activation of the Janus Kinase (JAK)-signal transducer and activator of transcription (STAT)-inferferon stimulated gene (ISG)15 pathway and reprogramming plasma membrane integrin/cadherin signaling

Zhao, Y., Valbuena, G., Walker, D. H., Gazi, M., Hidalgo, M., DeSousa, R., Oteo, J. A., Goez, Y. & Brasier, A. R., Jan 2016, In: Molecular and Cellular Proteomics. 15, 1, p. 289-304 16 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Epidemiology, molecular biology, and pathogenic mechanisms of Ehrlichia infections

Yu, X. J. & Walker, D., Jan 1 2016, Rickettsiales: Biology, Molecular Biology, Epidemiology, and Vaccine Development. Springer International Publishing, p. 225-240 16 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Evaluation of Burkholderia mallei ΔtonB Δhcp1 (CLH001) as a live attenuated vaccine in murine models of glanders and melioidosis

Khakhum, N., Bharaj, P., Myers, J. N., Tapia, D., Walker, D. H., Endsley, J. J. & Torres, A. G., Jul 2019, In: PLoS neglected tropical diseases. 13, 7, e0007578.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Fatal monocytic ehrlichiosis in woman, Mexico, 2013

Sosa-Gutierrez, C. G., Solorzano-Santos, F., Walker, D. H., Torres, J., Serrano, C. A. & Gordillo-Perez, G., May 2016, In: Emerging infectious diseases. 22, 5, p. 871-874 4 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Fibroblast growth factor receptor-1 mediates internalization of pathogenic spotted fever rickettsiae into host endothelium

Sahni, A., Patel, J., Narra, H. P., Schroeder, C. L. C., Walker, D. H. & Sahni, S. K., Aug 2017, In: PloS one. 12, 8, e0183181.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Flea-Borne Rickettsioses and Rickettsiae

Blanton, L. S. & Walker, D. H., Jan 2017, In: American Journal of Tropical Medicine and Hygiene. 96, 1, p. 53-56 4 p.

Research output: Contribution to journal › Review article › peer-review

33 Scopus citations

Genotypic characterization of Orientia tsutsugamushi from patients in two geographical locations in Sri Lanka

Premaratna, R., Blanton, L. S., Samaraweera, D. N., de Silva, G. N. N., Chandrasena, N. T. G. A., Walker, D. H. & de Silva, H. J., Jan 13 2017, In: BMC Infectious Diseases. 17, 1, 67.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Human monocytic ehrlichiosis, Mexico City, Mexico

Alcántara-Rodríguez, V. E., Sánchez-Montes, S., Contreras, H., Colunga-Salas, P., Fierro-Flores, L., Avalos, S., Rodríguez-Rangel, F., Becker, I. & Walker, D. H., Dec 2020, In: Emerging infectious diseases. 26, 12, p. 3016-3019 4 p.

Research output: Contribution to journal › Article › peer-review

Human rickettsiosis caused by rickettsia parkeri strain Atlantic rainforest, Urabá, Colombia

Arboleda, M., Acevedo-Gutiérrez, L. Y., Ávila, A., Ospina, D., Díaz, F. J., Walker, D. H. & Rodas, J. D., Dec 2020, In: Emerging infectious diseases. 26, 12, p. 3048-3050 3 p.

Research output: Contribution to journal › Article › peer-review

Inactivation of sam-methyltransferase is the mechanism of attenuation of a historic louse borne typhus vaccine strain

Liu, Y., Wu, B., Weinstock, G., Walker, D. H. & Yu, X. J., Nov 20 2014, In: PloS one. 9, 11, e113285.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

11 Scopus citations

MyD88 mediates instructive signaling in dendritic cells and protective inflammatory response during rickettsial infection

Bechelli, J., Smalley, C., Zhao, X., Judy, B., Valdes, P., Walker, D. H. & Fang, R., Apr 1 2016, In: Infection and immunity. 84, 4, p. 883-893 11 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Omplete genome sequence of Ehrlichia muris strain AS145^T, a model monocytotropic Ehrlichia strain

Thirumalapura, N. R., Qin, X., Kuriakose, J. A. & Walker, D., 2014, In: Genome Announcements. 2, 1, e01234-13.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Opossums and cat fleas: New insights in the ecology of murine typhus in Galveston, Texas

Blanton, L. S., Idowu, B. M., Tatsch, T. N., Henderson, J. M., Bouyer, D. H. & Walker, D. H., Aug 2016, In: American Journal of Tropical Medicine and Hygiene. 95, 2, p. 457-461 5 p.

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Pathogenesis of Infectious Diseases and Mechanisms of Immunity

McBride, J. & Walker, D., Dec 9 2014, Vaccinology: An Essential Guide. Wiley Blackwell, p. 59-72 14 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Pathogenesis of Rickettsial Diseases: Pathogenic and Immune Mechanisms of an Endotheliotropic Infection

Sahni, A., Fang, R., Sahni, S. K. & Walker, D. H., 2019, In: Annual Review of Pathology: Mechanisms of Disease. 14, p. 127-152 26 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Perspective Piece: Ideal Criteria for Accurate Mouse Models of Vector-Borne Diseases with Emphasis on Scrub Typhus and Dengue

Sarathy, V. V. & Walker, D. H., Sep 2020, In: American Journal of Tropical Medicine and Hygiene. 103, 3, p. 970-975 6 p.

Research output: Contribution to journal › Review article › peer-review

Principles of Diagnosis of Infectious Diseases

Walker, D., Jan 1 2014, Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms. Elsevier Inc., p. 222-225 4 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Quantitative Proteomics of the Endothelial Secretome Identifies RC0497 as Diagnostic of Acute Rickettsial Spotted Fever Infections

Zhao, Y., Fang, R., Zhang, J., Zhang, Y., Bechelli, J., Smalley, C., Valbuena, G., Walker, D. H., Oteo, J. A. & Brasier, A. R., Feb 2020, In: American Journal of Pathology. 190, 2, p. 306-322 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Quantitative study of Rickettsia massiliae in Rhipicephalus sanguineus organs

Milhano, N., Popov, V., Vilhena, M., Bouyer, D. H., de Sousa, R. & Walker, D. H., Oct 1 2014, In: Ticks and Tick-borne Diseases. 5, 6, p. 709-714 6 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Recent research milestones in the pathogenesis of human rickettsioses and opportunities ahead

Narra, H. P., Sahni, A., Walker, D. H. & Sahni, S. K., Jun 2020, In: Future Microbiology. 15, 9, p. 753-765 13 p.

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Rickettsia

Walker, D., Oct 6 2016, International Encyclopedia of Public Health. Elsevier Inc., p. 370-377 8 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

"rickettsia amblyommii" Induces cross protection against lethal rocky mountain spotted fever in a guinea pig model

Blanton, L. S., Mendell, N. L., Walker, D. H. & Bouyer, D. H., Aug 1 2014, In: Vector-Borne and Zoonotic Diseases. 14, 8, p. 557-562 6 p.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Rickettsia australis activates inflammasome in human and murine macrophages

Smalley, C., Bechelli, J., Rockx-Brouwer, D., Saito, T., Azar, S. R., Ismail, N., Walker, D. H. & Fang, R., Jun 2016, In: PloS one. 11, 6, e0157231.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Rickettsiae and ehrlichiae within a city park: Is the urban dweller at risk?

Blanton, L. S., Walker, D. H. & Bouyer, D. H., Feb 1 2014, In: Vector-Borne and Zoonotic Diseases. 14, 2, p. 168-170 3 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Rickettsiae as Emerging Infectious Agents

Fang, R., Blanton, L. S. & Walker, D. H., Jun 2017, In: Clinics in Laboratory Medicine. 37, 2, p. 383-400 18 p.

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

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