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  • Jia Zhou

Selective Antagonists of the Bronchiolar Epithelial NF-κB-Bromodomain-Containing Protein 4 Pathway in Viral-Induced Airway Inflammation

Tian, B., Liu, Z., Yang, J., Sun, H., Zhao, Y., Wakamiya, M., Chen, H., Rytting, E., Zhou, J. & Brasier, A. R., Apr 24 2018, In : Cell Reports. 23, 4, p. 1138-1151 14 p.

Research output: Contribution to journalArticle

16 Scopus citations

Selective BCL-X L inhibition promotes apoptosis in combination with MLN8237 in medulloblastoma and pediatric glioblastoma cells

Levesley, J., Steele, L., Brüning-Richardson, A., Davison, A., Zhou, J., Ding, C., Lawler, S. & Short, S. C., Jan 22 2018, In : Neuro-Oncology. 20, 2, p. 203-214 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Small Molecule Neuromedin U Receptor 2 Agonists Suppress Food Intake and Decrease Visceral Fat in Animal Models.

Sampson, C. M., Kasper, J., Felsing, D., Raval, S., Ye, N., P, W., Rytting, E., Zhou, J., Allen, J. & Hommel, J., Aug 23 2018, In : Pharmacology Research and Perspectives. 6, (5):e00425. , doi: 10.1002/prp2.425.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

STAT3 inhibition suppresses hepatic stellate cell fibrogenesis: HJC0123, a potential therapeutic agent for liver fibrosis

Lopez, O. N., Bohanon, F. J., Wang, X., Ye, N., Corsello, T., Rojas-Khalil, Y., Chen, H., Chen, H., Zhou, J. & Radhakrishnan, R. S., 2016, In : RSC Advances. 6, 102, p. 100652-100663 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Structure-activity relationship studies on Bax activator SMBA1 for the treatment of ER-positive and triple-negative breast cancer

Liu, G., Yin, T., Kim, H., Ding, C., Yu, Z., Wang, H., Chen, H., Yan, R., Wold, E. A., Zou, H., Liu, X., Ding, Y., Shen, Q. & Zhou, J., Sep 15 2019, In : European journal of medicinal chemistry. 178, p. 589-605 17 p.

Research output: Contribution to journalArticle

Structure-Activity Relationship Studies on Diversified Salicylamide Derivatives as Potent Inhibitors of Human Adenovirus Infection

Xu, J., Berastegui-Cabrera, J., Chen, H., Pachón, J., Zhou, J. & Sánchez-Céspedes, J., Mar 26 2020, In : Journal of Medicinal Chemistry. 63, 6, p. 3142-3160 19 p.

Research output: Contribution to journalArticle

1 Scopus citations

Structure-guided drug design identifies a BRD4-selective small molecule that suppresses HIV

Niu, Q., Liu, Z., Alamer, E., Fan, X., Chen, H., Endsley, J., Gelman, B. B., Tian, B., Kim, J. H., Michael, N. L., Robb, M. L., Ananworanich, J., Zhou, J. & Hu, H., Aug 1 2019, In : Journal of Clinical Investigation. 129, 8, p. 3361-3373 13 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Suppression of Cocaine-Evoked Hyperactivity by Self-Adjuvanting and Multivalent Peptide Nanofiber Vaccines

Rudra, J. S., Ding, Y., Neelakantan, H., Ding, C., Appavu, R., Stutz, S., Snook, J. D., Chen, H., Cunningham, K. A. & Zhou, J., May 18 2016, In : ACS Chemical Neuroscience. 7, 5, p. 546-552 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Synthesis and Biochemical Evaluation of Noncyclic Nucleotide Exchange Proteins Directly Activated by cAMP 1 (EPAC1) Regulators

Wang, P., Luchowska-Stańska, U., Van Basten, B., Chen, H., Liu, Z., Wiejak, J., Whelan, P., Morgan, D., Lochhead, E., Barker, G., Rehmann, H., Yarwood, S. J. & Zhou, J., May 28 2020, In : Journal of medicinal chemistry. 63, 10, p. 5159-5184 26 p.

Research output: Contribution to journalArticle

Synthesis and pharmacological evaluation of non-catechol G protein biased and unbiased dopamine D1 receptor agonists

Wang, P., Felsing, D., Chen, H., Raval, S., Allen, J. & Zhou, J., May 9 2019, In : ACS Medicinal Chemistry Letters. 10.1021/acsmedchemlett.9b00050, p. 792-799 8 p., 10.1021/acsmedchemlett.9b00050.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Synthesis and structure–activity relationship studies of MI-2 analogues as MALT1 inhibitors

Wu, G., Wang, H., Zhou, W., Zeng, B., Mo, W., Zhu, K., Liu, R., Zhou, J., Chen, C. & Chen, H., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journalArticle

6 Scopus citations

Targeting the 5-ht2c receptor in biological context and the current state of 5-ht2c receptor ligand development

Wold, E. A., Wild, C. T., Cunningham, K. A. & Zhou, J., 2019, In : Current topics in medicinal chemistry. 19, 16, p. 1381-1398 18 p.

Research output: Contribution to journalReview article

7 Scopus citations

Targeting the NRF-2/RHOA/ROCK signaling pathway with a novel aziridonin, YD0514, to suppress breast cancer progression and lung metastasis

Li, D., Wang, H., Ding, Y., Zhang, Z., Zheng, Z., Dong, J., Kim, H., Meng, X., Zhou, Q., Zhou, J., Fang, L. & Shen, Q., Jun 28 2018, In : Cancer Letters. 424, p. 97-108 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Targeting XBP1-mediated β-catenin expression associated with bladder cancer with newly synthetic Oridonin analogues

Chen, W., Zhou, J., Wu, K., Huang, J., Ding, Y., Yun, E. J., Wang, B., Ding, C., Hernandez, E., Santoyo, J., Chen, H., Lin, H., Sagalowsky, A., He, D., Zhou, J. & Hsieh, J. T., 2016, In : Oncotarget. 7, 35, p. 56842-56854 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

Therapeutic potential of oridonin and its analogs: From anticancer and antiinflammation to neuroprotection

Xu, J., Wold, E. A., Ding, Y., Shen, Q. & Zhou, J., 2018, In : Molecules. 23, 2, 474.

Research output: Contribution to journalReview article

31 Scopus citations

Therapeutic potential of spirooxindoles as antiviral agents

Ye, N., Chen, H., Wold, E. A., Shi, P. Y. & Zhou, J., Jun 10 2016, In : ACS Infectious Diseases. 2, 6, p. 382-392 11 p.

Research output: Contribution to journalReview article

163 Scopus citations

Validation of the epigenetic reader bromodomain-containing protein 4 (BRD4) as a therapeutic target for treatment of airway remodeling

Brasier, A. R. & Zhou, J., Jan 2020, In : Drug Discovery Today. 25, 1, p. 126-132 7 p.

Research output: Contribution to journalReview article

3 Scopus citations