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Variation within the serotonin (5-HT) 5-HT2C receptor system aligns with vulnerability to cocaine cue reactivity
Anastasio, N. C., Liu, S., Maili, L., Swinford, S., Lane, S. D., Fox, R. G., Hamon, S. C., Nielsen, D. A., Cunningham, K. A. & Moeller, F. G., 2014, In: Translational psychiatry. 4, e369.Research output: Contribution to journal › Article › peer-review
28 Scopus citations -
Translating pharmacology into therapeutics to fight the opioid crisis
Marek, G. J., Cunningham, K. A. & Rasmussen, K., 2019, In: Journal of Pharmacology and Experimental Therapeutics. 371, 2, p. 394-395 2 p.Research output: Contribution to journal › Editorial › peer-review
Open Access -
The 5-HT2A receptor (5-HT2AR) regulates impulsive action and cocaine cue reactivity in Male Sprague-Dawley rats
Sholler, D. J., Stutz, S. J., Fox, R. G., Boone, E. L., Wang, Q., Rice, K. C., Gerard Moeller, F., Anastasio, N. C. & Cunningham, K. A., Jan 2019, In: Journal of Pharmacology and Experimental Therapeutics. 368, 1, p. 41-49 9 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Targeting the 5-ht2c receptor in biological context and the current state of 5-ht2c receptor ligand development
Wold, E. A., Wild, C. T., Cunningham, K. A. & Zhou, J., 2019, In: Current topics in medicinal chemistry. 19, 16, p. 1381-1398 18 p.Research output: Contribution to journal › Review article › peer-review
13 Scopus citations -
Synthesis and evaluation of dimeric derivatives of 5-HT 2A receptor (5-HT 2AR) antagonist M-100907
Shashack, M. J., Cunningham, K. A., Seitz, P. K., McGinnis, A., Smith, T. D., Watson, C. S. & Gilbertson, S. R., Nov 16 2011, In: ACS chemical neuroscience. 2, 11, p. 640-644 5 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
Synergism between a serotonin 5-HT2A receptor (5-HT 2AR) antagonist and 5-HT2CR agonist suggests new pharmacotherapeutics for cocaine addiction
Cunningham, K. A., Anastasio, N. C., Fox, R. G., Stutz, S. J., Bubar, M. J., Swinford, S. E., Watson, C. S., Gilbertson, S. R., Rice, K. C., Rosenzweig-Lipson, S. & Moeller, F. G., Jan 16 2013, In: ACS chemical neuroscience. 4, 1, p. 110-121 12 p.Research output: Contribution to journal › Article › peer-review
66 Scopus citations -
Suppression of cocaine relapse-like behaviors upon pimavanserin and lorcaserin co-administration
Anastasio, N. C., Sholler, D. J., Fox, R. G., Stutz, S. J., Merritt, C. R., Bjork, J. M., Moeller, F. G. & Cunningham, K. A., May 15 2020, In: Neuropharmacology. 168, 108009.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Serotonin neurobiology in cocaine use disorder
Cunningham, K. A., Howell, L. L. & Anastasio, N. C., 2020, Handbook of Behavioral Neuroscience. Elsevier B.V., p. 745-802 58 p. (Handbook of Behavioral Neuroscience; vol. 31).Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Serotonin at the nexus of impulsivity and cue reactivity in cocaine addiction
Cunningham, K. A. & Anastasio, N. C., 2014, In: Neuropharmacology. 76, PART B, p. 460-478 19 p.Research output: Contribution to journal › Review article › peer-review
85 Scopus citations -
Serotonin 5-HT2C Receptor Cys23Ser Single Nucleotide Polymorphism Associates with Receptor Function and Localization In Vitro
Land, M. A., Chapman, H. L., Davis-Reyes, B. D., Felsing, D. E., Allen, J. A., Moeller, F. G., Elferink, L. A., Cunningham, K. A. & Anastasio, N. C., Dec 1 2019, In: Scientific reports. 9, 1, 16737.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Serotonin2C receptors in the ventral pallidum regulate motor function in rats
Graves, S. M., Viskniskki, A. A., Cunningham, K. A. & Celeste Napier, T., Aug 7 2013, In: NeuroReport. 24, 11, p. 605-608 4 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Serotonin (5-hydroxytryptamine) 5-HT2A receptor: Association with inherent and cocaine-evoked behavioral disinhibition in rats
Anastasio, N. C., Stoffel, E. C., Fox, R. G., Bubar, M. J., Rice, K. C., Moeller, F. G. & Cunningham, K. A., Jun 2011, In: Behavioural Pharmacology. 22, 3, p. 248-261 14 p.Research output: Contribution to journal › Article › peer-review
34 Scopus citations -
Selective serotonin 5-HT2C receptor activation suppresses the reinforcing efficacy of cocaine and sucrose but differentially affects the incentive-salience value of cocaine- vs. sucrose-associated cues
Cunningham, K. A., Fox, R. G., Anastasio, N. C., Bubar, M. J., Stutz, S. J., Moeller, F. G., Gilbertson, S. R. & Rosenzweig-Lipson, S., Sep 2011, In: Neuropharmacology. 61, 3, p. 513-523 11 p.Research output: Contribution to journal › Article › peer-review
77 Scopus citations -
Relationship between attentional bias to cocaine-related stimuli and impulsivity in cocaine-dependent subjects
Liu, S., Lane, S. D., Schmitz, J. M., Waters, A. J., Cunningham, K. A. & Moeller, F. G., Mar 2011, In: American Journal of Drug and Alcohol Abuse. 37, 2, p. 117-122 6 p.Research output: Contribution to journal › Article › peer-review
59 Scopus citations -
Quantitative changes in intracellular calcium and extracellular-regulated kinase activation measured in parallel in CHO cells stably expressing serotonin (5-HT) 5-HT 2A or 5-HT 2C receptors
Seitz, P. K., Bremer, N. M., McGinnis, A. G., Cunningham, K. A. & Watson, C. S., Mar 7 2012, In: BMC Neuroscience. 13, 1, 25.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
Positive-allosteric modulation of the 5-HT2C receptor: implications for neuropsychopharmacology and neurotherapeutics
Zhou, J. & Cunningham, K. A., Jan 1 2019, In: Neuropsychopharmacology. 44, 1, p. 230-231 2 p.Research output: Contribution to journal › Comment/debate › peer-review
6 Scopus citations -
Peptide inhibitors disrupt the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog to allosterically modulate cellular signaling and behavior
Anastasio, N. C., Gilbertson, S. R., Bubar, M. J., Agarkov, A., Stutz, S. J., Jeng, Y., Bremer, N. M., Smith, T. D., Fox, R. G., Swinford, S. E., Seitz, P. K., Charendoff, M. N., Craft, J. W., Laezza, F. M., Watson, C. S., Briggs, J. M. & Cunningham, K. A., Jan 23 2013, In: Journal of Neuroscience. 33, 4, p. 1615-1630 16 p.Research output: Contribution to journal › Article › peer-review
27 Scopus citations -
Multi-well plate immunoassays for measuring signaling protein activations/deactivations and membrane vs. intracellular receptor levels
Watson, C. S., Jeng, Y. J., Bulayeva, N. N., Finnerty, C. C., Koong, L. Y., Zivadinovic, D., Alyea, R. A., Midoro-Horiuti, T., Goldblum, R. M., Anastasio, N. C., Cunningham, K. A., Seitz, P. K. & Smith, T. D., 2014, In: Methods in Molecular Biology. 1204, p. 123-133 11 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Methylation Patterns of the HTR2A Associate With Relapse-Related Behaviors in Cocaine-Dependent Participants
Land, M. A., Ramesh, D., Miller, A. L., Pyles, R. B., Cunningham, K. A., Moeller, F. G. & Anastasio, N. C., Jun 10 2020, In: Frontiers in Psychiatry. 11, 532.Research output: Contribution to journal › Article › peer-review
Open Access -
Leave the Ordinary Elsewhere: Novel Serotonin Mechanisms to Address 21st Century Public Health Challenges
Sholler, D. J. & Cunningham, K. A., Jul 17 2019, In: ACS chemical neuroscience. 10, 7, p. 3045-3046 2 p.Research output: Contribution to journal › Editorial › peer-review
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In vivo and in vitro analyses of novel peptidomimetic disruptors for the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog (PTEN)
Soto, C., Du, H. C., Fox, R., Yang, T., Hooson, J., Anastasio, N. C., Gilbertson, S. R., Cunningham, K. A., Cunningham, K. A. & Gilbertson, S. R., 2019, In: Frontiers in Pharmacology. 10, JULY, 907.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Inherent Motor Impulsivity Associates with Specific Gene Targets in the Rat Medial Prefrontal Cortex
Sholler, D. J., Merritt, C. R., Davis-Reyes, B. D., Golovko, G., Anastasio, N. C. & Cunningham, K. A., May 21 2020, In: Neuroscience. 435, p. 161-173 13 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Influence of methamphetamine on genital herpes simplex virus type 2 infection in a mouse model
Valencia, F., Bubar, M. J., Milligan, G., Cunningham, K. A. & Bourne, N., Sep 2012, In: Sexually Transmitted Diseases. 39, 9, p. 720-725 6 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Increased intra-individual reaction time variability in cocaine-dependent subjects: Role of cocaine-related cues
Liu, S., Lane, S. D., Schmitz, J. M., Green, C. E., Cunningham, K. A. & Moeller, F. G., Feb 2012, In: Addictive Behaviors. 37, 2, p. 193-197 5 p.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
Functional status of the serotonin 5-HT 2C receptor (5-HT 2C R) drives interlocked phenotypes that precipitate relapse-like behaviors in cocaine dependence
Anastasio, N. C., Stutz, S. J., Fox, R. G., Sears, R. M., Emeson, R. B., Dileone, R. J., O'Neil, R. T., Fink, L. H., Li, D., Green, T. A., Gerard Moeller, F. & Cunningham, K. A., Jan 2014, In: Neuropsychopharmacology. 39, 2, p. 360-372 13 p.Research output: Contribution to journal › Article › peer-review
50 Scopus citations -
Frontiers of biomolecular exploration in brain disorders
Nilsson, C. L. & Cunningham, K. A., Jan 2014, In: Neuropsychopharmacology. 39, 1, p. 1-4 4 p.Research output: Contribution to journal › Review article › peer-review
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Forced abstinence from cocaine self-administration is associated with DNA methylation changes in myelin genes in the corpus callosum: A preliminary study
Nielsen, D. A., Huang, W., Hamon, S. C., Maili, L., Witkin, B. M., Fox, R. G., Cunningham, K. A. & Moeller, F. G., 2012, In: Frontiers in Psychiatry. 3, JUN, Article 60.Research output: Contribution to journal › Article › peer-review
27 Scopus citations -
Fentanyl self-administration impacts brain immune responses in male Sprague-Dawley rats
Ezeomah, C., Cunningham, K. A., Stutz, S. J., Fox, R. G., Bukreyeva, N., Dineley, K. T., Paessler, S. & Cisneros, I. E., Jul 2020, In: Brain, Behavior, and Immunity. 87, p. 725-738 14 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Exploration of synthetic approaches and pharmacological evaluation of PNU-69176E and its stereoisomer as 5-HT2C receptor allosteric modulators
Ding, C., Bremer, N. M., Smith, T. D., Seitz, P. K., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Jul 18 2012, In: ACS chemical neuroscience. 3, 7, p. 538-545 8 p.Research output: Contribution to journal › Article › peer-review
21 Scopus citations -
Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP Isoform 1
Yan, J., Mei, F. C., Cheng, H., Lao, D. H., Hu, Y., Wei, J., Patrikeev, I., Hao, D., Stutz, S. J., Dineley, K. T., Motamedi, M., Hommel, J. D., Cunningham, K. A., Chen, J. & Cheng, X., Mar 2013, In: Molecular and cellular biology. 33, 5, p. 918-926 9 p.Research output: Contribution to journal › Article › peer-review
59 Scopus citations -
Endogenous Serotonin 5-HT2A and 5-HT2C Receptors Associate in the Medial Prefrontal Cortex
Price, A. E., Sholler, D. J., Stutz, S. J., Anastasio, N. C. & Cunningham, K. A., Jul 17 2019, In: ACS chemical neuroscience. 10, 7, p. 3241-3248 8 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Elevated expression of serotonin 5-HT2A receptors in the rat ventral tegmental area enhances vulnerability to the behavioral effects of cocaine
Herin, D. V., Bubar, M. J., Seitz, P. K., Thomas, M. L., Hillman, G. R., Tarasenko, Y. I., Wu, P. & Cunningham, K. A., 2013, In: Frontiers in Psychiatry. 4, FEB, Article 2.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Effects of escitalopram on attentional bias to cocaine-related stimuli and inhibitory control in cocaine-dependent subjects
Liu, S., Lane, S. D., Schmitz, J. M., Cunningham, K. A., John, V. P. & Moeller, F. G., Sep 2013, In: Journal of Psychopharmacology. 27, 9, p. 801-807 7 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Editorial: Contemporary Perspective on 5-HT2C Receptor Function and Its Pharmacological Targeting
De Deurwaerdère, P., Chagraoui, A. & Cunningham, K. A., Nov 23 2020, In: Frontiers in Pharmacology. 11, 606414.Research output: Contribution to journal › Editorial › peer-review
Open Access -
Discovery of Potent and Brain-Penetrant GPR52 Agonist that Suppresses Psychostimulant Behavior
Wang, P., Felsing, D., Chen, H., Stutz, S. J., Murphy, R., Cunningham, K., Allen, J. & Zhou, J., Nov 25 2020, In: Journal of Medicinal Chemistry. 63, 22, p. 13951 13972 p.Research output: Contribution to journal › Article › peer-review
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Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT2CReceptor-Positive Allosteric Modulators with Enhanced Drug-like Properties
Wold, E. A., Garcia, E. J., Wild, C. T., Miszkiel, J. M., Soto, C. A., Chen, J., Pazdrak, K., Fox, R. G., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Jul 23 2020, In: Journal of medicinal chemistry. 63, 14, p. 7529-7544 16 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT 2C Receptor
Wild, C. T., Miszkiel, J. M., Wold, E. A., Soto, C. A., Ding, C., Hartley, R. M., White, M. A., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Oct 1 2019, In: Journal of medicinal chemistry. 62, 1, p. 288-305 18 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Convergent neural connectivity in motor impulsivity and high-fat food binge-like eating in male Sprague-Dawley rats
Anastasio, N. C., Stutz, S. J., Price, A. E., Davis-Reyes, B. D., Sholler, D. J., Ferguson, S. M., Neumaier, J. F., Moeller, F. G., Hommel, J. D. & Cunningham, K. A., Sep 1 2019, In: Neuropsychopharmacology. 44, 10, p. 1752-1761 10 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Coevolution of Residues Provides Evidence of a Functional Heterodimer of 5-HT2AR and 5-HT2CR Involving Both Intracellular and Extracellular Domains
Fongang, B., Cunningham, K. A., Rowicka, M. & Kudlicki, A., Aug 1 2019, In: Neuroscience. 412, p. 48-59 12 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Cingulo-hippocampal effective connectivity positively correlates with drug-cue attentional bias in opioid use disorder
Ma, L., Steinberg, J. L., Bjork, J. M., Taylor, B. A., Arias, A. J., Terplan, M., Anastasio, N. C., Zuniga, E. A., Lennon, M., Cunningham, K. A. & Moeller, F. G., Dec 30 2019, In: Psychiatry Research - Neuroimaging. 294, 110977.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Chronic poly-drug administration damages adult mouse brain neural stem cells
McGrath, E. L., Schlagal, C. R., Cortez, I., Dunn, T. J., Gao, J., Fox, R. G., Stutz, S. J., Kuo, Y. F., Hommel, J. D., Dineley, K. T., Cunningham, K. A., Kaphalia, B. S. & Wu, P., Nov 15 2019, In: Brain Research. 1723, 146425.Research output: Contribution to journal › Article › peer-review
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Anterior insula activity regulates the associated behaviors of high fat food binge intake and cue reactivity in male rats
Price, A. E., Stutz, S. J., Hommel, J. D., Anastasio, N. C. & Cunningham, K. A., Feb 1 2019, In: Appetite. 133, p. 231-239 9 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts
Wold, E. A., Chen, J., Cunningham, K. A. & Zhou, J., Oct 1 2019, In: Journal of medicinal chemistry. 62, 1, p. 88-127 40 p.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
5-HT2c Receptors localize to dopamine and gaba neurons in the rat mesoaccumbens pathway
Bubar, M. J., Stutz, S. J. & Cunningham, K. A., 2011, In: PloS one. 6, 6, e20508.Research output: Contribution to journal › Article › peer-review
77 Scopus citations