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Zika Virus Vaccine: Progress and Challenges
Shan, C., Xie, X. & Shi, P. Y., Jul 11 2018, In: Cell Host and Microbe. 24, 1, p. 12-17 6 p.Research output: Contribution to journal › Review article › peer-review
34 Scopus citations -
Zika virus infects human Sertoli cells and modulates the integrity of the in vitro blood-testis barrier model
Siemann, D. N., Strange, D. P., Maharaj, P. N., Shi, P. Y. & Verma, S., Nov 1 2017, In: Journal of virology. 91, 22, e00623-17.Research output: Contribution to journal › Article › peer-review
44 Scopus citations -
Zika virus infection elicits auto-antibodies to C1q
Koma, T., Veljkovic, V., Anderson, D. E., Wang, L. F., Rossi, S. L., Shan, C., Shi, P. Y., Beasley, D. W., Bukreyeva, N., Smith, J. N., Hallam, S., Huang, C., Von Messling, V. & Paessler, S., Dec 1 2018, In: Scientific reports. 8, 1, 1882.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Zika virus has oncolytic activity against glioblastoma stem cells
Zhu, Z., Gorman, M. J., McKenzie, L. D., Chai, J. N., Hubert, C. G., Prager, B. C., Fernandez, E., Richner, J. M., Zhang, R., Shan, C., Tycksen, E., Wang, X., Shi, P. Y., Diamond, M. S., Rich, J. N. & Chheda, M. G., 2017, In: Journal of Experimental Medicine. 214, 10, p. 2843-2857 15 p.Research output: Contribution to journal › Article › peer-review
75 Scopus citations -
Zika structural genes determine the virulence of African and Asian lineages
Nunes, B. T. D., Fontes-Garfias, C. R., Shan, C., Muruato, A. E., Nunes, J. G. C., Burbano, R. M. R., Vasconcelos, P. F. C., Shi, P. Y. & Medeiros, D. B. A., Jan 1 2020, In: Emerging Microbes and Infections. 9, 1, p. 1023-1033 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Zika in the Americas, year 2: What have we learned? What gaps remain? A report from the Global Virus Network
Aliota, M. T., Bassit, L., Bradrick, S. S., Cox, B., Garcia-Blanco, M. A., Gavegnano, C., Friedrich, T. C., Golos, T. G., Griffin, D. E., Haddow, A. D., Kallas, E. G., Kitron, U., Lecuit, M., Magnani, D. M., Marrs, C., Mercer, N., McSweegan, E., Ng, L. F. P., O'Connor, D. H., Osorio, J. E. & 11 others, , Aug 2017, In: Antiviral research. 144, p. 223-246 24 p.Research output: Contribution to journal › Review article › peer-review
66 Scopus citations -
West Nile virus NS1 antagonizes interferon beta production by targeting RIG-I and MDA5
Zhang, H. L., Ye, H. Q., Liu, S. Q., Deng, C. L., Li, X. D., Shi, P. Y. & Zhang, B., Sep 1 2017, In: Journal of virology. 91, 18, e02396-16.Research output: Contribution to journal › Article › peer-review
28 Scopus citations -
West nile virus experimental evolution in vivo and the trade-off hypothesis
Deardorff, E. R., Fitzpatrick, K. A., Jerzak, G. V. S., Shi, P. Y., Kramer, L. D. & Ebel, G. D., Nov 2011, In: PLoS pathogens. 7, 11, e1002335.Research output: Contribution to journal › Article › peer-review
70 Scopus citations -
West Nile virus drug discovery
Lim, S. P. & Shi, P. Y., Dec 3 2013, In: Viruses. 5, 12, p. 2977-3006 30 p.Research output: Contribution to journal › Review article › peer-review
27 Scopus citations -
Vesicular stomatitis virus and DNA vaccines expressing zika virus nonstructural protein 1 induce substantial but not sterilizing protection against zika virus infection
Li, A., Xue, M., Attia, Z., Yu, J., Lu, M., Shan, C., Liang, X., Gao, T. Z., Shi, P. Y., Peeples, M. E., Boyaka, P. N., Liu, S. L. & Li, J., Sep 2020, In: Journal of virology. 94, 17, e00048-20.Research output: Contribution to journal › Article › peer-review
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Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease
Richner, J. M., Jagger, B. W., Shan, C., Fontes, C. R., Dowd, K. A., Cao, B., Himansu, S., Caine, E. A., Nunes, B. T. D., Medeiros, D. B. A., Muruato, A. E., Foreman, B. M., Luo, H., Wang, T., Barrett, A. D., Weaver, S. C., Vasconcelos, P. F. C., Rossi, S. L., Ciaramella, G., Mysorekar, I. U. & 3 others, , Jul 13 2017, In: Cell. 170, 2, p. 273-283.e12Research output: Contribution to journal › Article › peer-review
119 Scopus citations -
Using recombination-dependent lethal mutations to stabilize reporter flaviviruses for rapid serodiagnosis and drug discovery
Baker, C., Xie, X., Zou, J., Muruato, A., Fink, K. & Shi, P. Y., Jul 2020, In: EBioMedicine. 57, 102838.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Using next generation sequencing to study the genetic diversity of candidate live attenuated zika vaccines
Collins, N. D., Shan, C., Nunes, B. T. D., Widen, S. G., Shi, P. Y., Barrett, A. D. T. & Sarathy, V. V., Apr 2020, In: Vaccines. 8, 2, 161.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Using a virion assembly-defective dengue virus as a vaccine approach
Shan, C., Xie, X., Zou, J., Züst, R., Zhang, B., Ambrose, R., Mackenzie, J., Fink, K. & Shi, P. Y., Nov 1 2018, In: Journal of virology. 92, 21, e01002.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Understanding zika virus stability and developing a chimeric vaccine through functional analysis
Xie, X., Yang, Y., Muruato, A. E., Zou, J., Shan, C., Nunes, B. T. D., Medeiros, D. B. A., Vasconcelos, P. F. C., Weaver, S. C., Rossi, S. L. & Shi, P. Y., Jan 1 2017, In: mBio. 8, 1, e02134-16.Research output: Contribution to journal › Article › peer-review
62 Scopus citations -
U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication
Poh, M. K., Shui, G., Xie, X., Shi, P. Y., Wenk, M. R. & Gu, F., Jan 2012, In: Antiviral research. 93, 1, p. 191-198 8 p.Research output: Contribution to journal › Article › peer-review
72 Scopus citations -
Type I and Type III interferons restrict SARS-CoV-2 infection of human airway epithelial cultures
Vanderheiden, A., Ralfs, P., Chirkova, T., Upadhyay, A. A., Zimmerman, M. G., Bedoya, S., Aoued, H., Tharp, G. M., Pellegrini, K. L., Manfredi, C., Sorscher, E., Mainou, B., Lobby, J. L., Kohlmeier, J. E., Lowen, A. C., Shi, P. Y., Menachery, V. D., Anderson, L. J., Grakoui, A., Bosinger, S. E. & 1 others, , Oct 2020, In: Journal of virology. 94, 19, e00985-20.Research output: Contribution to journal › Review article › peer-review
Open Access12 Scopus citations -
Two RNA Tunnel Inhibitors Bind in Highly Conserved Sites in Dengue Virus NS5 Polymerase: Structural and Functional Studies
Arora, R., Liew, C. W., Soh, T. S., Otoo, D. A., Seh, C. C., Yue, K., Nilar, S., Wang, G., Yokokawa, F., Noble, C. G., Chen, Y. L., Shi, P. Y., Lescar, J., Smith, T. M., Benson, T. E. & Lim, S. P., Dec 2020, In: Journal of virology. 94, 24, e01130-20.Research output: Contribution to journal › Article › peer-review
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Two distinct sets of NS2A molecules are responsible for dengue virus RNA synthesis and virion assembly
Xie, X., Zou, J., Puttikhunt, C., Yuan, Z. & Shi, P. Y., 2015, In: Journal of virology. 89, 2, p. 1298-1313 16 p.Research output: Contribution to journal › Article › peer-review
53 Scopus citations -
Treatment of human glioblastoma with a live attenuated Zika virus vaccine candidate
Chen, Q., Wu, J., Ye, Q., Ma, F., Zhu, Q., Wu, Y., Shan, C., Xie, X., Li, D., Zhan, X., Li, C., Li, X. F., Qin, X., Zhao, T., Wu, H., Shi, P. Y., Man, J. & Qin, C. F., Sep 1 2018, In: mBio. 9, 5, e01683-18.Research output: Contribution to journal › Article › peer-review
30 Scopus citations -
Topoisomerase III-β is required for efficient replication of positive-sense RNA viruses
Prasanth, K. R., Hirano, M., Fagg, W. S., McAnarney, E. T., Shan, C., Xie, X., Hage, A., Pietzsch, C. A., Bukreyev, A., Rajsbaum, R., Shi, P. Y., Bedford, M. T., Bradrick, S. S., Menachery, V. & Garcia-Blanco, M. A., Oct 2020, In: Antiviral research. 182, 104874.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Topoisomerase III-ß is required for efficient replication of positive-sense RNA viruses
Kambham, R., Hirano, M., Fagg, W. S., McAnarney, E. T., Shan, C., Xie, X., Hage, A., Pietzsch, C. A., Bukreyev, A., Rajsbaum Gorodezky, R., Shi, P. Y., Bedford, M. T., Bradrick, S., Menachery, V. & Garcia-Blanco, M. A., Mar 27 2020, In: Unknown Journal.Research output: Contribution to journal › Article › peer-review
Open Access -
The structural basis for serotype-specific neutralization of dengue virus by a human antibody
Teoh, E. P., Kukkaro, P., Teo, E. W., Lim, A. P. C., Tan, T. T., Yip, A., Schul, W., Aung, M., Kostyuchenko, V. A., Leo, Y. S., Chan, S. H., Smith, K. G. C., Chan, A. H. Y., Zou, G., Ooi, E. E., Kemeny, D. M., Tan, G. K., Ng, J. K. W., Ng, M. L., Alonso, S. & 5 others, , Jun 20 2012, In: Science Translational Medicine. 4, 139, 139ra83.Research output: Contribution to journal › Article › peer-review
165 Scopus citations -
The stem region of premembrane protein plays an important role in the virus surface protein rearrangement during dengue maturation
Zhang, Q., Hunke, C., Yau, Y. H., Seow, V., Lee, S., Tanner, L. B., Guan, X. L., Wenk, M. R., Fibriansah, G., Chew, P. L., Kukkaro, P., Biuković, G., Shi, P. Y., Shochat, S. G., Grüber, G. & Lok, S. M., Nov 23 2012, In: Journal of Biological Chemistry. 287, 48, p. 40525-40534 10 p.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
The search for nucleoside/nucleotide analog inhibitors of dengue virus
Chen, Y. L., Yokokawa, F. & Shi, P. Y., Aug 10 2015, In: Antiviral research. 122, p. 12-19 8 p., 3670.Research output: Contribution to journal › Review article › peer-review
43 Scopus citations -
Therapeutics for Neglected Infectious Diseases: Progress and Challenge
Shi, P. Y., Smith, P. W. & Diagana, T. T., Jan 8 2015, In: ACS Infectious Diseases. 1, 1, p. 76-78 3 p.Research output: Contribution to journal › Short survey › peer-review
7 Scopus citations -
Therapeutics for Dengue: Recommendations for Design and Conduct of Early-Phase Clinical Trials
Simmons, C. P., Wolbers, M., Nguyen, M. N., Whitehorn, J., Shi, P. Y., Young, P., Petric, R., Nguyen, V. V. C., Farrar, J. & Wills, B., Sep 2012, In: PLoS neglected tropical diseases. 6, 9, e1752.Research output: Contribution to journal › Article › peer-review
25 Scopus citations -
The helical domains of the stem region of dengue virus envelope protein are involved in both virus assembly and entry
Lin, S. R., Zou, G., Hsieh, S. C., Qing, M., Tsai, W. Y., Shi, P. Y. & Wang, W. K., May 2011, In: Journal of virology. 85, 10, p. 5159-5171 13 p.Research output: Contribution to journal › Article › peer-review
34 Scopus citations -
The dengue virus NS5 protein as a target for drug discovery
Lim, S. P., Noble, C. G. & Shi, P-Y., Jul 1 2015, In: Antiviral Research. 119, p. 57-67 11 p.Research output: Contribution to journal › Article › peer-review
101 Scopus citations -
The C-terminal helical domain of dengue virus precursor membrane protein is involved in virus assembly and entry
Hsieh, S. C., Zou, G., Tsai, W. Y., Qing, M., Chang, G. J., Shi, P. Y. & Wang, W. K., Feb 5 2011, In: Virology. 410, 1, p. 170-180 11 p.Research output: Contribution to journal › Article › peer-review
26 Scopus citations -
The 5′ and 3′ downstream AUG region elements are required for mosquito-borne flavivirus RNA replication
Friebe, P., Shi, P. Y. & Harris, E., Feb 2011, In: Journal of virology. 85, 4, p. 1900-1905 6 p.Research output: Contribution to journal › Article › peer-review
54 Scopus citations -
Testing Antiviral Compounds in a Dengue Mouse Model
Schul, W., Yip, A. & Shi, P. Y., Jul 18 2013, Antiviral Methods and Protocols. p. 269-281 13 p. (Methods in Molecular Biology; vol. 1030).Research output: Chapter in Book/Report/Conference proceeding › Chapter
3 Scopus citations -
Ten years of dengue drug discovery: Progress and prospects
Lim, S. P., Wang, Q. Y., Noble, C. G., Chen, Y. L., Dong, H., Zou, B., Yokokawa, F., Nilar, S., Smith, P., Beer, D., Lescar, J. & Shi, P. Y., Oct 21 2013, In: Antiviral research. 100, 2, p. 500-519 20 p.Research output: Contribution to journal › Review article › peer-review
239 Scopus citations -
Targeting vesicle size
Zou, J. & Shi, P. Y., Nov 1 2018, In: Nature Materials. 17, 11, p. 955-956 2 p.Research output: Contribution to journal › Comment/debate › peer-review
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Targeting dengue virus NS4B protein for drug discovery
Xie, X., Zou, J., Wang, Q. Y. & Shi, P. Y., Jun 2015, In: Antiviral research. 118, p. 39-45 7 p., 3603.Research output: Contribution to journal › Review article › peer-review
44 Scopus citations -
Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides
Tichý, M., Pohl, R., Xu, H. Y., Chen, Y. L., Yokokawa, F., Shi, P. Y. & Hocek, M., Oct 15 2012, In: Bioorganic and Medicinal Chemistry. 20, 20, p. 6123-6133 11 p.Research output: Contribution to journal › Article › peer-review
37 Scopus citations -
Synergistic suppression of dengue virus replication using a combination of nucleoside analogs and nucleoside synthesis inhibitors
Yeo, K. L., Chen, Y. L., Xu, H. Y., Dong, H., Wang, Q. Y., Yokokawa, F. & Shi, P. Y., Apr 1 2015, In: Antimicrobial agents and chemotherapy. 59, 4, p. 2086-2093 8 p.Research output: Contribution to journal › Article › peer-review
39 Scopus citations -
Structure-activity relationship of uridine-based nucleoside phosphoramidate prodrugs for inhibition of dengue virus RNA-dependent RNA polymerase
Wang, G., Lim, S. P., Chen, Y. L., Hunziker, J., Rao, R., Gu, F., Seh, C. C., Ghafar, N. A., Xu, H., Chan, K., Lin, X., Saunders, O. L., Fenaux, M., Zhong, W., Shi, P-Y. & Yokokawa, F., Jan 1 2018, (Accepted/In press) In: Bioorganic and Medicinal Chemistry Letters.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Structural biology of dengue virus enzymes: Towards rational design of therapeutics
Noble, C. G. & Shi, P. Y., Nov 1 2012, In: Antiviral research. 96, 2, p. 115-126 12 p.Research output: Contribution to journal › Review article › peer-review
78 Scopus citations -
Stabilization of dengue virus polymerase in de novo initiation assay provides advantages for compound screening
Niyomrattanakit, P., Wan, K. F., Chung, K. Y., Abas, S. N., Seh, C. C., Dong, H., Lim, C. C., Chao, A. T., Lee, C. B., Nilar, S., Lescar, J., Shi, P. Y., Beer, D. & Lim, S. P., Jul 1 2015, In: Antiviral research. 119, p. 36-46 11 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility
Plante, J. A., Liu, Y., Liu, J., Xia, H., Johnson, B. A., Lokugamage, K. G., Zhang, X., Muruato, A. E., Zou, J., Fontes-Garfias, C. R., Mirchandani, D., Scharton, D., Bilello, J. P., Ku, Z., An, Z., Kalveram, B., Freiberg, A. N., Menachery, V., Xie, X., Plante, K. S. & 2 others, , Sep 2 2020, In: Unknown Journal.Research output: Contribution to journal › Article › peer-review
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Spike mutation D614G alters SARS-CoV-2 fitness
Plante, J. A., Liu, Y., Liu, J., Xia, H., Johnson, B. A., Lokugamage, K. G., Zhang, X., Muruato, A. E., Zou, J., Fontes-Garfias, C. R., Mirchandani, D., Scharton, D., Bilello, J. P., Ku, Z., An, Z., Kalveram, B., Freiberg, A. N., Menachery, V. D., Xie, X., Plante, K. S. & 2 others, , 2020, (Accepted/In press) In: Nature.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Small Molecules and Antibodies for Zika Therapy
Xie, X., Zou, J., Shan, C. & Shi, P. Y., 2017, In: Journal of Infectious Diseases. 216, p. S945-S950Research output: Contribution to journal › Review article › peer-review
15 Scopus citations -
Small molecule inhibitors that selectively block dengue virus methyltransferase
Lim, S. P., Sonntag, L. S., Noble, C., Nilar, S. H., Ng, R. H., Zou, G., Monaghan, P., Chung, K. Y., Dong, H., Liu, B., Bodenreider, C., Lee, G., Ding, M., Chan, W. L., Wang, G., Jian, Y. L., Chao, A. T., Lescar, J., Yin, Z., Vedananda, T. R. & 2 others, , Feb 25 2011, In: Journal of Biological Chemistry. 286, 8, p. 6233-6240 8 p.Research output: Contribution to journal › Article › peer-review
108 Scopus citations -
Short Direct Repeats in the 3' Untranslated Region Are Involved in Subgenomic Flaviviral RNA Production
Zhang, Q. Y., Li, X. F., Niu, X., Li, N., Wang, H. J., Deng, C. L., Ye, H. Q., Huang, X. Y., Chen, Q., Xu, Y. P., Dong, H. L., Li, X. D., Zhao, H., Shi, P. Y., Yuan, Z. M., Gong, P., Fang, X., Qin, C. F. & Zhang, B., Feb 28 2020, In: Journal of virology. 94, 6Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Serology in Children with Multisystem Inflammatory Syndrome (MIS-C) associated with COVID-19
Rostad, C. A., Chahroudi, A., Mantus, G., Lapp, S. A., Teherani, M., Macoy, L., Rostad, B. S., Milla, S. S., Tarquinio, K. M., Basu, R. K., Kao, C., Linam, W. M., Zimmerman, M. G., Shi, P. Y., Menachery, V., Oster, M. E., Edupuganti, S., Anderson, E. J., Suthar, M., Wrammert, J. & 1 others, , Jul 11 2020, In: Unknown Journal.Research output: Contribution to journal › Article › peer-review
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Secondary structure and membrane topology of dengue virus NS4B N-terminal 125 amino acids
Li, Y., Kim, Y. M., Zou, J., Wang, Q. Y., Gayen, S., Wong, Y. L., Lee, L. T., Xie, X., Huang, Q., Lescar, J., Shi, P. Y. & Kang, C., Dec 1 2015, In: Biochimica et Biophysica Acta - Biomembranes. 1848, 12, p. 3150-3157 8 p.Research output: Contribution to journal › Article › peer-review
21 Scopus citations -
Safety and immunogenicity of two RNA-based covid-19 vaccine candidates
Walsh, E. E., Frenck, R. W., Falsey, A. R., Kitchin, N., Absalon, J., Gurtman, A., Lockhart, S., Neuzil, K., Mulligan, M. J., Bailey, R., Swanson, K. A., Li, P., Koury, K., Kalina, W., Cooper, D., Fontes-Garfias, C., Shi, P. Y., Türeci, Ö., Tompkins, K. R., Lyke, K. E. & 5 others, , Dec 17 2020, In: New England Journal of Medicine. 383, 25, p. 2439-2450 12 p.Research output: Contribution to journal › Article › peer-review
Open Access42 Scopus citations -
RPLP1 and RPLP2 are essential flavivirus host factors that promote early viral protein accumulation
Campos, R. K., Wong, B., Xie, X., Lu, Y. F., Shi, P. Y., Pompon, J., Garcia-Blanco, M. A. & Bradrick, S. S., 2017, In: Journal of virology. 91, 4, e01706-16.Research output: Contribution to journal › Article › peer-review
29 Scopus citations -
Role of microglia in the dissemination of zika virus from mother to fetal brain
Xu, P., Shan, C., Dunn, T. J., Xie, X., Xia, H., Gao, J., Labastida, J. A., Zou, J., Villarreal, P. P., Schlagal, C. R., Yu, Y., Vargas, G., Rossi, S. L., Vasilakis, N., Shi, P. Y., Weaver, S. C. & Wu, P., Jul 2020, In: PLoS neglected tropical diseases. 14, 7, p. 1-21 21 p., e0008413.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations