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Zika Virus Vaccine: Progress and Challenges
Shan, C., Xie, X. & Shi, P. Y., Jul 11 2018, In: Cell Host and Microbe. 24, 1, p. 12-17 6 p.Research output: Contribution to journal › Review article › peer-review
36 Scopus citations -
Zika virus infects human Sertoli cells and modulates the integrity of the in vitro blood-testis barrier model
Siemann, D. N., Strange, D. P., Maharaj, P. N., Shi, P. Y. & Verma, S., Nov 1 2017, In: Journal of virology. 91, 22, e00623-17.Research output: Contribution to journal › Article › peer-review
46 Scopus citations -
Zika virus infection elicits auto-antibodies to C1q
Koma, T., Veljkovic, V., Anderson, D. E., Wang, L. F., Rossi, S. L., Shan, C., Shi, P. Y., Beasley, D. W., Bukreyeva, N., Smith, J. N., Hallam, S., Huang, C., Von Messling, V. & Paessler, S., Dec 1 2018, In: Scientific reports. 8, 1, 1882.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Zika virus has oncolytic activity against glioblastoma stem cells
Zhu, Z., Gorman, M. J., McKenzie, L. D., Chai, J. N., Hubert, C. G., Prager, B. C., Fernandez, E., Richner, J. M., Zhang, R., Shan, C., Tycksen, E., Wang, X., Shi, P. Y., Diamond, M. S., Rich, J. N. & Chheda, M. G., 2017, In: Journal of Experimental Medicine. 214, 10, p. 2843-2857 15 p.Research output: Contribution to journal › Article › peer-review
77 Scopus citations -
Zika structural genes determine the virulence of African and Asian lineages
Nunes, B. T. D., Fontes-Garfias, C. R., Shan, C., Muruato, A. E., Nunes, J. G. C., Burbano, R. M. R., Vasconcelos, P. F. C., Shi, P. Y. & Medeiros, D. B. A., Jan 1 2020, In: Emerging Microbes and Infections. 9, 1, p. 1023-1033 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
West Nile virus NS1 antagonizes interferon beta production by targeting RIG-I and MDA5
Zhang, H. L., Ye, H. Q., Liu, S. Q., Deng, C. L., Li, X. D., Shi, P. Y. & Zhang, B., Sep 1 2017, In: Journal of virology. 91, 18, e02396-16.Research output: Contribution to journal › Article › peer-review
29 Scopus citations -
West nile virus experimental evolution in vivo and the trade-off hypothesis
Deardorff, E. R., Fitzpatrick, K. A., Jerzak, G. V. S., Shi, P. Y., Kramer, L. D. & Ebel, G. D., Nov 2011, In: PLoS pathogens. 7, 11, e1002335.Research output: Contribution to journal › Article › peer-review
70 Scopus citations -
West Nile virus drug discovery
Lim, S. P. & Shi, P. Y., Dec 3 2013, In: Viruses. 5, 12, p. 2977-3006 30 p.Research output: Contribution to journal › Review article › peer-review
27 Scopus citations -
Vesicular stomatitis virus and DNA vaccines expressing zika virus nonstructural protein 1 induce substantial but not sterilizing protection against zika virus infection
Li, A., Xue, M., Attia, Z., Yu, J., Lu, M., Shan, C., Liang, X., Gao, T. Z., Shi, P. Y., Peeples, M. E., Boyaka, P. N., Liu, S. L. & Li, J., Sep 2020, In: Journal of virology. 94, 17, e00048-20.Research output: Contribution to journal › Article › peer-review
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Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease
Richner, J. M., Jagger, B. W., Shan, C., Fontes, C. R., Dowd, K. A., Cao, B., Himansu, S., Caine, E. A., Nunes, B. T. D., Medeiros, D. B. A., Muruato, A. E., Foreman, B. M., Luo, H., Wang, T., Barrett, A. D., Weaver, S. C., Vasconcelos, P. F. C., Rossi, S. L., Ciaramella, G., Mysorekar, I. U. & 3 others, , Jul 13 2017, In: Cell. 170, 2, p. 273-283.e12Research output: Contribution to journal › Article › peer-review
124 Scopus citations -
Using recombination-dependent lethal mutations to stabilize reporter flaviviruses for rapid serodiagnosis and drug discovery
Baker, C., Xie, X., Zou, J., Muruato, A., Fink, K. & Shi, P. Y., Jul 2020, In: EBioMedicine. 57, 102838.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Using next generation sequencing to study the genetic diversity of candidate live attenuated zika vaccines
Collins, N. D., Shan, C., Nunes, B. T. D., Widen, S. G., Shi, P. Y., Barrett, A. D. T. & Sarathy, V. V., Apr 2020, In: Vaccines. 8, 2, 161.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Using a virion assembly-defective dengue virus as a vaccine approach
Shan, C., Xie, X., Zou, J., Züst, R., Zhang, B., Ambrose, R., Mackenzie, J., Fink, K. & Shi, P. Y., Nov 1 2018, In: Journal of virology. 92, 21, e01002.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Unraveling a flavivirus enigma
Shi, P. Y., Jan 1 2014, In: Science. 343, 6173, p. 849-850 2 p.Research output: Contribution to journal › Short survey › peer-review
9 Scopus citations -
Understanding zika virus stability and developing a chimeric vaccine through functional analysis
Xie, X., Yang, Y., Muruato, A. E., Zou, J., Shan, C., Nunes, B. T. D., Medeiros, D. B. A., Vasconcelos, P. F. C., Weaver, S. C., Rossi, S. L. & Shi, P. Y., Jan 1 2017, In: mBio. 8, 1, e02134-16.Research output: Contribution to journal › Article › peer-review
62 Scopus citations -
Type I interferon signals in macrophages and dendritic cells control dengue virus infection: Implications for a new mouse model to test dengue vaccines
Züst, R., Toh, Y. X., Valdés, I., Cerny, D., Heinrich, J., Hermida, L., Marcos, E., Guillén, G., Kalinke, U., Shi, P. Y. & Fink, K., 2014, In: Journal of virology. 88, 13, p. 7276-7285 10 p.Research output: Contribution to journal › Article › peer-review
52 Scopus citations -
Type I and Type III interferons restrict SARS-CoV-2 infection of human airway epithelial cultures
Vanderheiden, A., Ralfs, P., Chirkova, T., Upadhyay, A. A., Zimmerman, M. G., Bedoya, S., Aoued, H., Tharp, G. M., Pellegrini, K. L., Manfredi, C., Sorscher, E., Mainou, B., Lobby, J. L., Kohlmeier, J. E., Lowen, A. C., Shi, P. Y., Menachery, V. D., Anderson, L. J., Grakoui, A., Bosinger, S. E. & 1 others, , Oct 2020, In: Journal of virology. 94, 19, e00985-20.Research output: Contribution to journal › Review article › peer-review
Open Access19 Scopus citations -
Two RNA Tunnel Inhibitors Bind in Highly Conserved Sites in Dengue Virus NS5 Polymerase: Structural and Functional Studies
Arora, R., Liew, C. W., Soh, T. S., Otoo, D. A., Seh, C. C., Yue, K., Nilar, S., Wang, G., Yokokawa, F., Noble, C. G., Chen, Y. L., Shi, P. Y., Lescar, J., Smith, T. M., Benson, T. E. & Lim, S. P., Dec 2020, In: Journal of virology. 94, 24, e01130-20.Research output: Contribution to journal › Article › peer-review
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Treatment of human glioblastoma with a live attenuated Zika virus vaccine candidate
Chen, Q., Wu, J., Ye, Q., Ma, F., Zhu, Q., Wu, Y., Shan, C., Xie, X., Li, D., Zhan, X., Li, C., Li, X. F., Qin, X., Zhao, T., Wu, H., Shi, P. Y., Man, J. & Qin, C. F., Sep 1 2018, In: mBio. 9, 5, e01683-18.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
Topoisomerase III-β is required for efficient replication of positive-sense RNA viruses
Prasanth, K. R., Hirano, M., Fagg, W. S., McAnarney, E. T., Shan, C., Xie, X., Hage, A., Pietzsch, C. A., Bukreyev, A., Rajsbaum, R., Shi, P. Y., Bedford, M. T., Bradrick, S. S., Menachery, V. & Garcia-Blanco, M. A., Oct 2020, In: Antiviral research. 182, 104874.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus Replication
Li, X. D., Shan, C., Deng, C. L., Ye, H. Q., Shi, P. Y., Yuan, Z. M., Gong, P. & Zhang, B., May 2014, In: PLoS neglected tropical diseases. 8, 5, e2891.Research output: Contribution to journal › Article › peer-review
28 Scopus citations -
The helical domains of the stem region of dengue virus envelope protein are involved in both virus assembly and entry
Lin, S. R., Zou, G., Hsieh, S. C., Qing, M., Tsai, W. Y., Shi, P. Y. & Wang, W. K., May 2011, In: Journal of virology. 85, 10, p. 5159-5171 13 p.Research output: Contribution to journal › Article › peer-review
34 Scopus citations -
The C-terminal helical domain of dengue virus precursor membrane protein is involved in virus assembly and entry
Hsieh, S. C., Zou, G., Tsai, W. Y., Qing, M., Chang, G. J., Shi, P. Y. & Wang, W. K., Feb 5 2011, In: Virology. 410, 1, p. 170-180 11 p.Research output: Contribution to journal › Article › peer-review
26 Scopus citations -
The 5′ and 3′ downstream AUG region elements are required for mosquito-borne flavivirus RNA replication
Friebe, P., Shi, P. Y. & Harris, E., Feb 2011, In: Journal of virology. 85, 4, p. 1900-1905 6 p.Research output: Contribution to journal › Article › peer-review
54 Scopus citations -
Testing Antiviral Compounds in a Dengue Mouse Model
Schul, W., Yip, A. & Shi, P. Y., Jul 18 2013, Antiviral Methods and Protocols. p. 269-281 13 p. (Methods in Molecular Biology; vol. 1030).Research output: Chapter in Book/Report/Conference proceeding › Chapter
3 Scopus citations -
Ten years of dengue drug discovery: Progress and prospects
Lim, S. P., Wang, Q. Y., Noble, C. G., Chen, Y. L., Dong, H., Zou, B., Yokokawa, F., Nilar, S., Smith, P., Beer, D., Lescar, J. & Shi, P. Y., 2013, In: Antiviral research. 100, 2, p. 500-519 20 p.Research output: Contribution to journal › Review article › peer-review
241 Scopus citations -
Targeting vesicle size
Zou, J. & Shi, P. Y., Nov 1 2018, In: Nature Materials. 17, 11, p. 955-956 2 p.Research output: Contribution to journal › Comment/debate › peer-review
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Structure-activity relationship of uridine-based nucleoside phosphoramidate prodrugs for inhibition of dengue virus RNA-dependent RNA polymerase
Wang, G., Lim, S. P., Chen, Y. L., Hunziker, J., Rao, R., Gu, F., Seh, C. C., Ghafar, N. A., Xu, H., Chan, K., Lin, X., Saunders, O. L., Fenaux, M., Zhong, W., Shi, P. Y. & Yokokawa, F., Jul 15 2018, In: Bioorganic and Medicinal Chemistry Letters. 28, 13, p. 2324-2327 4 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
35 Scopus citations
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Spike mutation D614G alters SARS-CoV-2 fitness
Plante, J. A., Liu, Y., Liu, J., Xia, H., Johnson, B. A., Lokugamage, K. G., Zhang, X., Muruato, A. E., Zou, J., Fontes-Garfias, C. R., Mirchandani, D., Scharton, D., Bilello, J. P., Ku, Z., An, Z., Kalveram, B., Freiberg, A. N., Menachery, V. D., Xie, X., Plante, K. S. & 2 others, , 2020, (Accepted/In press) In: Nature.Research output: Contribution to journal › Article › peer-review
35 Scopus citations -
Small Molecules and Antibodies for Zika Therapy
Xie, X., Zou, J., Shan, C. & Shi, P. Y., 2017, In: Journal of Infectious Diseases. 216, p. S945-S950Research output: Contribution to journal › Review article › peer-review
15 Scopus citations -
Small molecule inhibitors that selectively block dengue virus methyltransferase
Lim, S. P., Sonntag, L. S., Noble, C., Nilar, S. H., Ng, R. H., Zou, G., Monaghan, P., Chung, K. Y., Dong, H., Liu, B., Bodenreider, C., Lee, G., Ding, M., Chan, W. L., Wang, G., Jian, Y. L., Chao, A. T., Lescar, J., Yin, Z., Vedananda, T. R. & 2 others, , Feb 25 2011, In: Journal of Biological Chemistry. 286, 8, p. 6233-6240 8 p.Research output: Contribution to journal › Article › peer-review
108 Scopus citations -
Short Direct Repeats in the 3' Untranslated Region Are Involved in Subgenomic Flaviviral RNA Production
Zhang, Q. Y., Li, X. F., Niu, X., Li, N., Wang, H. J., Deng, C. L., Ye, H. Q., Huang, X. Y., Chen, Q., Xu, Y. P., Dong, H. L., Li, X. D., Zhao, H., Shi, P. Y., Yuan, Z. M., Gong, P., Fang, X., Qin, C. F. & Zhang, B., Feb 28 2020, In: Journal of virology. 94, 6Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Safety and immunogenicity of two RNA-based covid-19 vaccine candidates
Walsh, E. E., Frenck, R. W., Falsey, A. R., Kitchin, N., Absalon, J., Gurtman, A., Lockhart, S., Neuzil, K., Mulligan, M. J., Bailey, R., Swanson, K. A., Li, P., Koury, K., Kalina, W., Cooper, D., Fontes-Garfias, C., Shi, P. Y., Türeci, Ö., Tompkins, K. R., Lyke, K. E. & 5 others, , Dec 17 2020, In: New England Journal of Medicine. 383, 25, p. 2439-2450 12 p.Research output: Contribution to journal › Article › peer-review
Open Access73 Scopus citations -
RPLP1 and RPLP2 are essential flavivirus host factors that promote early viral protein accumulation
Campos, R. K., Wong, B., Xie, X., Lu, Y. F., Shi, P. Y., Pompon, J., Garcia-Blanco, M. A. & Bradrick, S. S., 2017, In: Journal of virology. 91, 4, e01706-16.Research output: Contribution to journal › Article › peer-review
29 Scopus citations -
Role of microglia in the dissemination of zika virus from mother to fetal brain
Xu, P., Shan, C., Dunn, T. J., Xie, X., Xia, H., Gao, J., Labastida, J. A., Zou, J., Villarreal, P. P., Schlagal, C. R., Yu, Y., Vargas, G., Rossi, S. L., Vasilakis, N., Shi, P. Y., Weaver, S. C. & Wu, P., Jul 2020, In: PLoS neglected tropical diseases. 14, 7, p. 1-21 21 p., e0008413.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Reserve genetic approaches for the development of Zika vaccines and therapeutics
Fontes-Garfias, C. R., Baker, C. K. & Shi, P. Y., Oct 2020, In: Current Opinion in Virology. 44, p. 7-15 9 p.Research output: Contribution to journal › Review article › peer-review
2 Scopus citations -
Report of the fifth symposium on emerging viral diseases
Zhang, B. & Shi, P. Y., Apr 2013, In: Virologica Sinica. 28, 2, p. 63-64 2 p.Research output: Contribution to journal › Editorial › peer-review
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Recovery of a chemically synthesized Japanese encephalitis virus reveals two critical adaptive mutations in NS2B and NS4A
Li, X. D., Li, X. F., Ye, H. Q., Deng, C. L., Ye, Q., Shan, C., Shang, B. D., Xu, L. L., Li, S. H., Cao, S. B., Yuan, Z. M., Shi, P. Y., Qin, C. F. & Zhang, B., 2014, In: Journal of General Virology. 95, PART 4, p. 806-815 10 p.Research output: Contribution to journal › Article › peer-review
27 Scopus citations -
Rational Design of a Live Attenuated Dengue Vaccine: 2′-O-Methyltransferase Mutants Are Highly Attenuated and Immunogenic in Mice and Macaques
Züst, R., Dong, H., Li, X. F., Chang, D. C., Zhang, B., Balakrishnan, T., Toh, Y. X., Jiang, T., Li, S. H., Deng, Y. Q., Ellis, B. R., Ellis, E. M., Poidinger, M., Zolezzi, F., Qin, C. F., Shi, P. Y. & Fink, K., Aug 2013, In: PLoS pathogens. 9, 8, e1003521.Research output: Contribution to journal › Article › peer-review
79 Scopus citations -
Rational design of a flavivirus vaccine by abolishing viral RNA 2′-O methylation
Li, S. H., Dong, H., Li, X. F., Xie, X., Zhao, H., Deng, Y. Q., Wang, X. Y., Ye, Q., Zhu, S. Y., Wang, H. J., Zhang, B., Leng, Q. B., Zuest, R., Qin, E. D., Qin, C. F. & Shi, P. Y., May 2013, In: Journal of virology. 87, 10, p. 5812-5819 8 p.Research output: Contribution to journal › Article › peer-review
67 Scopus citations -
Quantitative SARS-CoV-2 Serology in Children With Multisystem Inflammatory Syndrome (MIS-C)
Rostad, C. A., Chahroudi, A., Mantus, G., Lapp, S. A., Teherani, M., Macoy, L., Tarquinio, K. M., Basu, R. K., Kao, C., Linam, W. M., Zimmerman, M. G., Shi, P-Y., Menachery, V. D., Oster, M. E., Edupuganti, S., Anderson, E. J., Suthar, M. S., Wrammert, J. & Jaggi, P., Dec 1 2020, In: Pediatrics. 146, 6Research output: Contribution to journal › Article › peer-review
Open Access -
Potential Mechanisms for Enhanced Zika Epidemic and Disease
Xia, H., Xie, X., Shan, C. & Shi, P. Y., May 11 2018, In: ACS Infectious Diseases. 4, 5, p. 656-659 4 p.Research output: Contribution to journal › Review article › peer-review
5 Scopus citations -
Polymerases of hepatitis C viruses and flaviviruses: Structural and mechanistic insights and drug development
Caillet-Saguy, C., Lim, S. P., Shi, P. Y., Lescar, J. & Bressanelli, S., May 2014, In: Antiviral research. 105, 1, p. 8-16 9 p.Research output: Contribution to journal › Review article › peer-review
38 Scopus citations -
Peli1 signaling blockade attenuates congenital zika syndrome
Luo, H., Li, G., Wang, B., Tian, B., Gao, J., Zou, J., Shi, S., Zhu, S., Peng, B. H., Adam, A., Martinez, A., Hein, K., Winkelmann, E. R., Mahmoud, Y., Zhou, X., Shan, C., Rossi, S., Weaver, S., Barrett, A. D. T., Sun, S. C. & 4 others, , Jun 2020, In: PLoS pathogens. 16, 6, e1008538.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection
Luo, H., Winkelmann, E. R., Zhu, S., Ru, W., Mays, E., Silvas, J. A., Vollmer, L. L., Gao, J., Peng, B. H., Bopp, N. E., Cromer, C., Shan, C., Xie, G., Li, G., Tesh, R., Popov, V. L., Shi, P. Y., Sun, S. C., Wu, P., Klein, R. S. & 4 others, , Nov 1 2018, In: Journal of Clinical Investigation. 128, 11, p. 4980-4991 12 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Overlapping and distinct molecular determinants dictating the antiviral activities of TRIM56 against flaviviruses and coronavirus
Liu, B., Li, N. L., Wang, J., Shi, P. Y., Wang, T., Miller, M. A. & Li, K., 2014, In: Journal of virology. 88, 23, p. 13821-13835 15 p.Research output: Contribution to journal › Article › peer-review
40 Scopus citations -
NS5 from dengue virus serotype 2 can adopt a conformation analogous to that of its zika virus and Japanese encephalitis virus homologues
El Sahili, A., Soh, T. S., Schiltz, J., Gharbi-Ayachi, A., Seh, C. C., Shi, P. Y., Lim, S. P. & Lescar, J., Jan 1 2020, In: Journal of virology. 94, 1, e01294-19.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Noninvasive bioluminescence imaging of dengue virus infection in the brain of A129 mice
Li, X. F., Deng, Y. Q., Zhao, H., Ye, Q., Wang, H. J., Li, S. H., Zhu, S. Y., Shi, P. Y., Qin, E. D., Zhang, B. & Qin, C. F., May 1 2013, In: Applied Microbiology and Biotechnology. 97, 10, p. 4589-4596 8 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Nonconsensus west nile virus genomes arising during mosquito infection suppress pathogenesis and modulate virus fitness in vivo
Ebel, G. D., Fitzpatrick, K. A., Lim, P. Y., Bennett, C. J., Deardorff, E. R., Kramer, G. V. S. J., Zhou, Y., Shi, P. Y. & Bernard, K. A., Dec 2011, In: Journal of virology. 85, 23, p. 12605-12613 9 p.Research output: Contribution to journal › Article › peer-review
19 Scopus citations