Search concepts
|
Selected Filters |
- 1 - 50 out of 67 results
- Export search results
Search results
-
α-Synuclein Oligomers Induce a Unique Toxic Tau Strain
Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Sengupta, U., Gerson, J. E. & Kayed, R., Oct 1 2018, In: Biological Psychiatry. 84, 7, p. 499-508 10 p.Research output: Contribution to journal › Article › peer-review
28 Scopus citations -
Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives
Lo Cascio, F., Puangmalai, N., Ellsworth, A., Bucchieri, F., Pace, A., Palumbo Piccionello, A. & Kayed, R., Dec 1 2019, In: Scientific reports. 9, 1, 19011.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy
Sengupta, U., Nilson, A. N. & Kayed, R., Apr 1 2016, In: EBioMedicine. 6, p. 42-49 8 p.Research output: Contribution to journal › Review article › peer-review
252 Scopus citations -
Therapeutic approaches targeting pathological tau aggregates
Gerson, J. & Kayed, R., Jul 1 2016, In: Current Pharmaceutical Design. 22, 26, p. 4028-4039 12 p.Research output: Contribution to journal › Review article › peer-review
9 Scopus citations -
The Potential of Small Molecules in Preventing Tau Oligomer Formation and Toxicity
Gerson, J. E., Lo Cascio, F. & Kayed, R., Jan 20 2017, Neuroprotection in Alzheimer's Disease. Elsevier Inc., p. 97-121 25 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
1 Scopus citations -
TDP-43 and Tau Oligomers in Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia
Montalbano, M., McAllen, S., Cascio, F. L., Sengupta, U., Garcia, S., Bhatt, N., Ellsworth, A., Heidelman, E. A., Johnson, O. D., Doskocil, S. & Kayed, R., Dec 2020, In: Neurobiology of Disease. 146, 105130.Research output: Contribution to journal › Article › peer-review
Open Access -
Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy
Gerson, J. E., Farmer, K. M., Henson, N., Castillo-Carranza, D. L., Carretero Murillo, M., Sengupta, U., Barrett, A. & Kayed, R., Mar 15 2018, In: Molecular Neurodegeneration. 13, 1, 13.Research output: Contribution to journal › Article › peer-review
21 Scopus citations -
Tau oligomers mediate aggregation of RNA-binding proteins Musashi1 and Musashi2 inducing Lamin alteration
Montalbano, M., McAllen, S., Sengupta, U., Puangmalai, N., Bhatt, N., Ellsworth, A. & Kayed, R., Dec 1 2019, In: Aging cell. 18, 6, e13035.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Tau Oligomers in Sera of Patients with Alzheimer's Disease and Aged Controls
Kolarova, M., Sengupta, U., Bartos, A., Ricny, J. & Kayed, R., 2017, In: Journal of Alzheimer's Disease. 58, 2, p. 471-478 8 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice
Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Clos, A. L., Jackson, G. R. & Kayed, R., 2011, In: Molecular Neurodegeneration. 6, 1, 39.Research output: Contribution to journal › Article › peer-review
270 Scopus citations -
Tau Oligomers Derived from Traumatic Brain Injury Cause Cognitive Impairment and Accelerate Onset of Pathology in Htau Mice
Gerson, J., Castillo-Carranza, D. L., Sengupta, U., Bodani, R., Prough, D. S., DeWitt, D. S., Hawkins, B. E. & Kayed, R., Nov 15 2016, In: Journal of neurotrauma. 33, 22, p. 2034-2043 10 p.Research output: Contribution to journal › Article › peer-review
39 Scopus citations -
Tau oligomers associate with inflammation in the brain and retina of tauopathy mice and in neurodegenerative diseases
Nilson, A. N., English, K. C., Gerson, J. E., Barton Whittle, T., Nicolas Crain, C., Xue, J., Sengupta, U., Castillo-Carranza, D. L., Zhang, W., Gupta, P. & Kayed, R., 2017, In: Journal of Alzheimer's Disease. 55, 3, p. 1083-1099 17 p.Research output: Contribution to journal › Article › peer-review
45 Scopus citations -
Tau oligomers as potential targets for immunotherapy for alzheimer's disease and tauopathies
Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Jackson, G. R. & Kayed, R., Sep 1 2011, In: Current Alzheimer Research. 8, 6, p. 659-665 7 p.Research output: Contribution to journal › Article › peer-review
57 Scopus citations -
Tau oligomers as pathogenic seeds: Preparation and propagation in vitro and in vivo
Gerson, J. E., Sengupta, U. & Kayed, R., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1523. p. 141-157 17 p. (Methods in Molecular Biology; vol. 1523).Research output: Chapter in Book/Report/Conference proceeding › Chapter
15 Scopus citations -
Tau Interacts with the C-Terminal Region of α-Synuclein, Promoting Formation of Toxic Aggregates with Distinct Molecular Conformations
Dasari, A. K. R., Kayed, R., Wi, S. & Lim, K. H., Jun 25 2019, In: Biochemistry. 58, 25, p. 2814-2821 8 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Tau Immunotherapy for Alpha-Synucleinopathy
Aguilar, C., Al Lahham, R., Sengupta, U., Carretero Murillo, M., Kayed, R. & Dineley, K., Jul 2018, In: Alzheimer's and Dementia. 14, 7, p. 1442Research output: Contribution to journal › Meeting Abstract › peer-review
-
Tau Immunotherapy for Alpha-Synucleinopathy
Aguilar, C., Al Lahham, R., Sengupta, U., Carretero Murillo, M., Kayed, R. & Dineley, K., Jul 2018, In: Alzheimer's and Dementia. 14, 7, p. 1412Research output: Contribution to journal › Article › peer-review
-
Tau aggregates as immunotherapeutic targets
Castillo-Carranza, D. L., Lasagna-Reeves, C. A. & Kayed, R., Jan 1 2013, In: Frontiers in Bioscience - Scholar. 5 S, 2, p. 426-438 13 p.Research output: Contribution to journal › Article › peer-review
30 Scopus citations -
Soluble tau aggregates, not large fibrils, are the toxic species that display seeding and cross-seeding behavior
Ghag, G., Bhatt, N., Cantu, D. V., Guerrero-Munoz, M. J., Ellsworth, A., Sengupta, U. & Kayed, R., Nov 2018, In: Protein Science. 27, 11, p. 1901-1909 9 p.Research output: Contribution to journal › Article › peer-review
21 Scopus citations -
Soluble endogenous oligomeric α-synuclein species in neurodegenerative diseases: Expression, spreading, and cross-talk
Kayed, R., Dettmer, U. & Lesné, S. E., 2020, In: Journal of Parkinson's Disease. 10, 3, p. 791-818 28 p.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
Small misfolded tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons
Wu, J. W., Herman, M., Liu, L., Simoes, S., Acker, C. M., Figueroa, H., Steinberg, J. I., Margittai, M., Kayed, R., Zurzolo, C., Di Paolo, G. & Duff, K. E., Jan 18 2013, In: Journal of Biological Chemistry. 288, 3, p. 1856-1870 15 p.Research output: Contribution to journal › Article › peer-review
273 Scopus citations -
Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits
Larson, M. E., Greimel, S. J., Amar, F., LaCroix, M., Boyle, G., Sherman, M. A., Schley, H., Miel, C., Schneider, J. A., Kayed, R., Benfenati, F., Lee, M. K., Bennett, D. A. & Lesné, S. E., Jun 6 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 23, p. E4648-E4657Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
Role of oligomers in the amyloidogenesis of primary cutaneous amyloidosis
Clos, A. L., Lasagna-Reeves, C. A., Kelly, B., Wagner, R., Wilkerson, M., Jackson, G. R. & Kayed, R., Nov 1 2011, In: Journal of the American Academy of Dermatology. 65, 5, p. 1023-1031 9 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction
Montalbano, M., McAllen, S., Puangmalai, N., Sengupta, U., Bhatt, N., Johnson, O. D., Kharas, M. G. & Kayed, R., Dec 1 2020, In: Nature communications. 11, 1, 4305.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective
Derry, P. J., Hegde, M. L., Jackson, G. R., Kayed, R., Tour, J. M., Tsai, A. L. & Kent, T. A., Jan 2020, In: Progress in Neurobiology. 184, 101716.Research output: Contribution to journal › Review article › peer-review
Open Access11 Scopus citations -
Rapid accumulation of endogenous Tau oligomers in a rat model of traumatic brain injury: Possible link between traumatic brain injury and sporadic tauopathies
Hawkins, B. E., Krishnamurthy, S., Castillo-Carranza, D. L., Sengupta, U., Prough, D. S., Jackson, G. R., DeWitt, D. S. & Kayed, R., Jun 7 2013, In: Journal of Biological Chemistry. 288, 23, p. 17042-17050 9 p.Research output: Contribution to journal › Article › peer-review
90 Scopus citations -
Prospects for strain-specific immunotherapy in Alzheimer's disease and tauopathies
Bittar, A., Sengupta, U. & Kayed, R., Dec 1 2018, In: npj Vaccines. 3, 1, 9.Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
Preparation and characterization of tau oligomer strains
Sengupta, U., Carretero-Murillo, M. & Kayed, R., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 113-146 34 p. (Methods in Molecular Biology; vol. 1779).Research output: Chapter in Book/Report/Conference proceeding › Chapter
6 Scopus citations -
Pre-amyloid oligomers budding: A metastatic mechanism of proteotoxicity
Bernini, F., Malferrari, D., Pignataro, M., Bortolotti, C. A., Di Rocco, G., Lancellotti, L., Brigatti, M. F., Kayed, R., Borsari, M., Del Monte, F. & Castellini, E., Oct 24 2016, In: Scientific reports. 6, 35865.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Potential mechanisms and implications for the formation of tau oligomeric strains
Gerson, J. E., Mudher, A. & Kayed, R., Nov 1 2016, In: Critical Reviews in Biochemistry and Molecular Biology. 51, 6, p. 482-496 15 p.Research output: Contribution to journal › Review article › peer-review
25 Scopus citations -
Polymorphic α-Synuclein Strains Modified by Dopamine and Docosahexaenoic Acid Interact Differentially with Tau Protein
Sengupta, U., Puangmalai, N., Bhatt, N., Garcia, S., Zhao, Y. & Kayed, R., Jun 1 2020, In: Molecular Neurobiology. 57, 6, p. 2741-2765 25 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer's disease
Farmer, K. M., Ghag, G., Puangmalai, N., Montalbano, M., Bhatt, N. & Kayed, R., Aug 10 2020, In: Acta Neuropathologica Communications. 8, 1, 132.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Oligomeric tau-targeted immunotherapy in Tg4510 mice
Schroeder, S., Joly-Amado, A., Soliman, A., Sengupta, U., Kayed, R., Gordon, M. N. & Morgan, D., Jun 27 2017, In: Alzheimer's Research and Therapy. 9, 1, 46.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Oligomer Formation and Cross-Seeding: The New Frontier
Farmer, K., Gerson, J. E. & Kayed, R., 2016, (Accepted/In press) In: Israel Journal of Chemistry.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
NLRP3 inflammasome activation drives tau pathology
Ising, C., Venegas, C., Zhang, S., Scheiblich, H., Schmidt, S. V., Vieira-Saecker, A., Schwartz, S., Albasset, S., McManus, R. M., Tejera, D., Griep, A., Santarelli, F., Brosseron, F., Opitz, S., Stunden, J., Merten, M., Kayed, R., Golenbock, D. T., Blum, D., Latz, E. & 2 others, , Nov 28 2019, In: Nature. 575, 7784, p. 669-673 5 p.Research output: Contribution to journal › Article › peer-review
109 Scopus citations -
Near Infrared Light Treatment Reduces Synaptic Levels of Toxic Tau Oligomers in Two Transgenic Mouse Models of Human Tauopathies
Comerota, M. M., Tumurbaatar, B., Krishnan, B., Kayed, R. & Taglialatela, G., May 1 2019, In: Molecular Neurobiology. 56, 5, p. 3341-3355 15 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Molecular mechanisms of amyloid oligomers toxicity
Kayed, R. & Lasagna-Reeves, C. A., Feb 15 2013, Alzheimer's Disease: Advances for a New Century. IOS Press, p. 67-78 12 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
2 Scopus citations -
Molecular mechanisms of amyloid oligomers toxicity
Kayed, R. & Lasagna-Reeves, C. A., 2013, In: Journal of Alzheimer's Disease. 33, SUPPL. 1, p. S67-S78Research output: Contribution to journal › Review article › peer-review
210 Scopus citations -
Modulating disease-relevant tau oligomeric strains by small molecules
Cascio, F. L., Garcia, S., Montalbano, M., Puangmalai, N., McAllen, S., Pace, A., Piccionello, A. P. & Kayed, R., Oct 30 2020, In: Journal of Biological Chemistry. 295, 44, p. 14807-14825 19 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases
Abud, E. M., Ramirez, R. N., Martinez, E. S., Healy, L. M., Nguyen, C. H. H., Newman, S. A., Yeromin, A. V., Scarfone, V. M., Marsh, S. E., Fimbres, C., Caraway, C. A., Fote, G. M., Madany, A. M., Agrawal, A., Kayed, R., Gylys, K. H., Cahalan, M. D., Cummings, B. J., Antel, J. P., Mortazavi, A. & 3 others, , Apr 19 2017, In: Neuron. 94, 2, p. 278-293.e9Research output: Contribution to journal › Article › peer-review
248 Scopus citations -
Internalization mechanisms of brain-derived tau oligomers from patients with Alzheimer’s disease, progressive supranuclear palsy and dementia with Lewy bodies
Puangmalai, N., Bhatt, N., Montalbano, M., Sengupta, U., Gaikwad, S., Ventura, F., McAllen, S., Ellsworth, A., Garcia, S. & Kayed, R., May 1 2020, In: Cell Death and Disease. 11, 5, 314.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Immunotherapy Targeting Tau Oligomeric Strains in Aged Transgenic Animals of Tauopathy
Al Lahham, R., Bittar, A., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Oct 2018, p. S64.Research output: Contribution to conference › Abstract › peer-review
-
Functional Integrity of Synapses in the Central Nervous System of Cognitively Intact Individuals with High Alzheimer's Disease Neuropathology Is Associated with Absence of Synaptic Tau Oligomers
Singh, A., Allen, D., Fracassi, A., Tumurbaatar, B., Natarajan, C., Scaduto, P., Woltjer, R., Kayed, R., Limon, A., Krishnan, B., Taglialatela, G. & Abisambra, J., 2020, In: Journal of Alzheimer's Disease. 78, 4, p. 1661-1678 18 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Formation of Toxic Oligomeric Assemblies of RNA-binding Protein: Musashi in Alzheimer's disease
Sengupta, U., Montalbano, M., McAllen, S., Minuesa, G., Kharas, M. & Kayed, R., Oct 26 2018, In: Acta Neuropathologica Communications. 6, 1, p. 113 1 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Formation of immunoglobulin light chain amyloid oligomers in primary cutaneous nodular amyloidosis
Clos, A. L., Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Jackson, G. R., Kelly, B., Beachkofsky, T. M. & Kayed, R., Dec 1 2011, In: British Journal of Dermatology. 165, 6, p. 1349-1354 6 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
Formation and propagation of tau oligomeric seeds
Gerson, J. E. & Kayed, R., Sep 11 2013, In: Frontiers in Neurology. 4 JUL, Article 93.Research output: Contribution to journal › Review article › peer-review
66 Scopus citations -
Evaluating Tau Oligomers Passive Immunotherapy using Aged Transgenic Animals of Tauopathy
Al Lahham, R., Bittar, A., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Dec 2017, (Unpublished).Research output: Contribution to conference › Poster
-
Evaluating Tau Oligomers Passive Immunotherapy using Aged Transgenic Animals of Tauopathy
Al Lahham, R., Bittar, A., Montalbano, M., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Jul 2018, In: Alzheimer's and Dementia. 14, 7, p. 1657Research output: Contribution to journal › Meeting Abstract › peer-review
-
Evaluating Passive Immunotherapy using Aged Transgenic Animals of Tauopathy
Al Lahham, R., Bittar, A., Montalbano, M., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Apr 2018, (Unpublished).Research output: Contribution to conference › Poster › peer-review
-
Elevated phospholipase D isoform 1 in Alzheimer's disease patients’ hippocampus: Relevance to synaptic dysfunction and memory deficits
Krishnan, B., Kayed, R. & Taglialatela, G., 2018, In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 4, p. 89-102 14 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations