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Small Molecules and Antibodies for Zika Therapy
Xie, X., Zou, J., Shan, C. & Shi, P. Y., 2017, In: Journal of Infectious Diseases. 216, p. S945-S950Research output: Contribution to journal › Review article › peer-review
15 Scopus citations -
Short Direct Repeats in the 3' Untranslated Region Are Involved in Subgenomic Flaviviral RNA Production
Zhang, Q. Y., Li, X. F., Niu, X., Li, N., Wang, H. J., Deng, C. L., Ye, H. Q., Huang, X. Y., Chen, Q., Xu, Y. P., Dong, H. L., Li, X. D., Zhao, H., Shi, P. Y., Yuan, Z. M., Gong, P., Fang, X., Qin, C. F. & Zhang, B., Feb 28 2020, In: Journal of virology. 94, 6Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Secondary Structure and Membrane Topology of the Full-Length Dengue Virus NS4B in Micelles
Li, Y., Wong, Y. L., Lee, M. Y., Li, Q., Wang, Q. Y., Lescar, J., Shi, P. Y. & Kang, C. B., Sep 19 2016, In: Angewandte Chemie - International Edition. 55, 39, p. 12068-12072 5 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
Secondary structure and membrane topology of dengue virus NS4B N-terminal 125 amino acids
Li, Y., Kim, Y. M., Zou, J., Wang, Q. Y., Gayen, S., Wong, Y. L., Lee, L. T., Xie, X., Huang, Q., Lescar, J., Shi, P. Y. & Kang, C., Dec 1 2015, In: Biochimica et Biophysica Acta - Biomembranes. 1848, 12, p. 3150-3157 8 p.Research output: Contribution to journal › Article › peer-review
21 Scopus citations -
Safety and immunogenicity of two RNA-based covid-19 vaccine candidates
Walsh, E. E., Frenck, R. W., Falsey, A. R., Kitchin, N., Absalon, J., Gurtman, A., Lockhart, S., Neuzil, K., Mulligan, M. J., Bailey, R., Swanson, K. A., Li, P., Koury, K., Kalina, W., Cooper, D., Fontes-Garfias, C., Shi, P. Y., Türeci, Ö., Tompkins, K. R., Lyke, K. E. & 5 others, , Dec 17 2020, In: New England Journal of Medicine. 383, 25, p. 2439-2450 12 p.Research output: Contribution to journal › Article › peer-review
Open Access42 Scopus citations -
RPLP1 and RPLP2 are essential flavivirus host factors that promote early viral protein accumulation
Campos, R. K., Wong, B., Xie, X., Lu, Y. F., Shi, P. Y., Pompon, J., Garcia-Blanco, M. A. & Bradrick, S. S., 2017, In: Journal of virology. 91, 4, e01706-16.Research output: Contribution to journal › Article › peer-review
29 Scopus citations -
Role of microglia in the dissemination of zika virus from mother to fetal brain
Xu, P., Shan, C., Dunn, T. J., Xie, X., Xia, H., Gao, J., Labastida, J. A., Zou, J., Villarreal, P. P., Schlagal, C. R., Yu, Y., Vargas, G., Rossi, S. L., Vasilakis, N., Shi, P. Y., Weaver, S. C. & Wu, P., Jul 2020, In: PLoS neglected tropical diseases. 14, 7, p. 1-21 21 p., e0008413.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Reverse genetics of Zika virus
Shan, C., Xie, X. & Shi, P-Y., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1602. p. 47-58 12 p. (Methods in Molecular Biology; vol. 1602).Research output: Chapter in Book/Report/Conference proceeding › Chapter
4 Scopus citations -
Restriction of Zika Virus by Host Innate Immunity
Xie, X., Shan, C. & Shi, P. Y., May 11 2016, In: Cell Host and Microbe. 19, 5, p. 566-567 2 p.Research output: Contribution to journal › Short survey › peer-review
20 Scopus citations -
Resistance analysis of an antibody that selectively inhibits dengue virus serotype-1
Zou, G., Kukkaro, P., Lok, S. M., Ng, J. K. W., Tan, G. K., Hanson, B. J., Alonso, S., MacAry, P. A. & Shi, P. Y., Sep 1 2012, In: Antiviral research. 95, 3, p. 216-223 8 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Reserve genetic approaches for the development of Zika vaccines and therapeutics
Fontes-Garfias, C. R., Baker, C. K. & Shi, P. Y., Oct 2020, In: Current Opinion in Virology. 44, p. 7-15 9 p.Research output: Contribution to journal › Review article › peer-review
2 Scopus citations -
Repurposing an HIV Drug for Zika Virus Therapy
Xie, X. & Shi, P. Y., Dec 4 2019, In: Molecular Therapy. 27, 12, p. 2064-2066 3 p.Research output: Contribution to journal › Short survey › peer-review
1 Scopus citations -
Report of the fifth symposium on emerging viral diseases
Zhang, B. & Shi, P. Y., Apr 2013, In: Virologica Sinica. 28, 2, p. 63-64 2 p.Research output: Contribution to journal › Editorial › peer-review
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Replication-defective West Nile virus with NS1 deletion as a new vaccine platform for flavivirus
Li, N., Zhang, Y. N., Deng, C. L., Shi, P. Y., Yuan, Z. M. & Zhang, B., Sep 1 2019, In: Journal of virology. 93, 17, e00720-19.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Rational Design of a Live Attenuated Dengue Vaccine: 2′-O-Methyltransferase Mutants Are Highly Attenuated and Immunogenic in Mice and Macaques
Züst, R., Dong, H., Li, X. F., Chang, D. C., Zhang, B., Balakrishnan, T., Toh, Y. X., Jiang, T., Li, S. H., Deng, Y. Q., Ellis, B. R., Ellis, E. M., Poidinger, M., Zolezzi, F., Qin, C. F., Shi, P. Y. & Fink, K., Aug 2013, In: PLoS pathogens. 9, 8, e1003521.Research output: Contribution to journal › Article › peer-review
79 Scopus citations -
Rational design of a flavivirus vaccine by abolishing viral RNA 2′-O methylation
Li, S. H., Dong, H., Li, X. F., Xie, X., Zhao, H., Deng, Y. Q., Wang, X. Y., Ye, Q., Zhu, S. Y., Wang, H. J., Zhang, B., Leng, Q. B., Zuest, R., Qin, E. D., Qin, C. F. & Shi, P. Y., May 2013, In: Journal of virology. 87, 10, p. 5812-5819 8 p.Research output: Contribution to journal › Article › peer-review
67 Scopus citations -
Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA
Wang, J., Alvin Chew, B. L., Lai, Y., Dong, H., Xu, L., Balamkundu, S., Cai, W. M., Cui, L., Liu, C. F., Fu, X. Y., Lin, Z., Shi, P. Y., Lu, T. K., Luo, D., Jaffrey, S. R. & Dedon, P. C., Nov 18 2019, In: Nucleic acids research. 47, 20, p. e130Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
Potential Mechanisms for Enhanced Zika Epidemic and Disease
Xia, H., Xie, X., Shan, C. & Shi, P. Y., May 11 2018, In: ACS Infectious Diseases. 4, 5, p. 656-659 4 p.Research output: Contribution to journal › Review article › peer-review
5 Scopus citations -
Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling
Lim, S. P., Noble, C. G., Seh, C. C., Soh, T. S., El Sahili, A., Chan, G. K. Y., Lescar, J., Arora, R., Benson, T., Nilar, S., Manjunatha, U., Wan, K. F., Dong, H., Xie, X., Shi, P. Y. & Yokokawa, F., Aug 2016, In: PLoS pathogens. 12, 8, e1005737.Research output: Contribution to journal › Article › peer-review
64 Scopus citations -
Point mutations in the West Nile virus (Flaviviridae; Flavivirus) RNA-dependent RNA polymerase alter viral fitness in a host-dependent manner in vitro and in vivo
Van Slyke, G. A., Ciota, A. T., Willsey, G. G., Jaeger, J., Shi, P. Y. & Kramer, L. D., May 25 2012, In: Virology. 427, 1, p. 18-24 7 p.Research output: Contribution to journal › Article › peer-review
21 Scopus citations -
Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults
Mulligan, M. J., Lyke, K. E., Kitchin, N., Absalon, J., Gurtman, A., Lockhart, S., Neuzil, K., Raabe, V., Bailey, R., Swanson, K. A., Li, P., Koury, K., Kalina, W., Cooper, D., Fontes-Garfias, C., Shi, P. Y., Türeci, Ö., Tompkins, K. R., Walsh, E. E., Frenck, R. & 5 others, , Oct 22 2020, In: Nature. 586, 7830, p. 589-593 5 p.Research output: Contribution to journal › Article › peer-review
73 Scopus citations -
Peli1 signaling blockade attenuates congenital zika syndrome
Luo, H., Li, G., Wang, B., Tian, B., Gao, J., Zou, J., Shi, S., Zhu, S., Peng, B. H., Adam, A., Martinez, A., Hein, K., Winkelmann, E. R., Mahmoud, Y., Zhou, X., Shan, C., Rossi, S., Weaver, S., Barrett, A. D. T., Sun, S. C. & 4 others, , Jun 2020, In: PLoS pathogens. 16, 6, e1008538.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection
Luo, H., Winkelmann, E. R., Zhu, S., Ru, W., Mays, E., Silvas, J. A., Vollmer, L. L., Gao, J., Peng, B. H., Bopp, N. E., Cromer, C., Shan, C., Xie, G., Li, G., Tesh, R., Popov, V. L., Shi, P. Y., Sun, S. C., Wu, P., Klein, R. S. & 4 others, , Nov 1 2018, In: Journal of Clinical Investigation. 128, 11, p. 4980-4991 12 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
NS5 from dengue virus serotype 2 can adopt a conformation analogous to that of its zika virus and Japanese encephalitis virus homologues
El Sahili, A., Soh, T. S., Schiltz, J., Gharbi-Ayachi, A., Seh, C. C., Shi, P. Y., Lim, S. P. & Lescar, J., Jan 1 2020, In: Journal of virology. 94, 1, e01294-19.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Noninvasive bioluminescence imaging of dengue virus infection in the brain of A129 mice
Li, X. F., Deng, Y. Q., Zhao, H., Ye, Q., Wang, H. J., Li, S. H., Zhu, S. Y., Shi, P. Y., Qin, E. D., Zhang, B. & Qin, C. F., May 1 2013, In: Applied Microbiology and Biotechnology. 97, 10, p. 4589-4596 8 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
NMR analysis of a novel enzymatically active unlinked dengue NS2B-NS3 protease complex
Kim, Y. M., Gayen, S., Kang, C. B., Joy, J., Huang, Q., Chen, A. S., Wee, J. L. K., Ang, M. J. Y., Lim, H. A., Hung, A. W., Li, R., Noble, C. G., Lee, L. T., Yip, A., Wang, Q. Y., Chia, C. S. B., Hill, J., Shi, P. Y. & Keller, T. H., May 3 2013, In: Journal of Biological Chemistry. 288, 18, p. 12891-12900 10 p.Research output: Contribution to journal › Article › peer-review
69 Scopus citations -
Molecular signatures associated with ZIKV exposure in human cortical neural progenitors
Zhang, F., Hammack, C., Ogden, S. C., Cheng, Y., Lee, E. M., Wen, Z., Qian, X., Nguyen, H. N., Li, Y., Yao, B., Xu, M., Xu, T., Chen, L., Wang, Z., Feng, H., Huang, W. K., Yoon, K. J., Shan, C., Huang, L., Qin, Z. & 10 others, , Oct 14 2016, In: Nucleic acids research. 44, 18, p. 8610-8620 11 p.Research output: Contribution to journal › Article › peer-review
91 Scopus citations -
Molecular basis of dengue virus serotype 2 morphological switch from 29°C to 37°C
Lim, X. N., Shan, C., Marzinek, J. K., Dong, H., Ng, T. S., Ooi, J. S. G., Fibriansah, G., Wang, J., Verma, C. S., Bond, P. J., Shi, P. Y. & Lok, S. M., 2019, In: PLoS pathogens. 15, 9, e1007996.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Molecular basis for specific viral RNA recognition and 2'-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)
Zhao, Y., Soh, T. S., Lim, S. P., Chung, K. Y., Swaminathan, K., Vasudevan, S. G., Shi, P. Y., Lescar, J. & Luo, D., Dec 1 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 48, p. 14834-14839 6 p.Research output: Contribution to journal › Article › peer-review
39 Scopus citations -
Membrane topology and function of dengue virus NS2A protein
Xie, X., Gayen, S., Kang, C. B., Yuan, Z. & Shi, P. Y., Apr 2013, In: Journal of virology. 87, 8, p. 4609-4622 14 p.Research output: Contribution to journal › Article › peer-review
116 Scopus citations -
Maternal vaccination and protective immunity against Zika virus vertical transmission
Shan, C., Xie, X., Luo, H., Muruato, A. E., Liu, Y., Wakamiya, M., La, J. H., Chung, J. M., Weaver, S. C., Wang, T. & Shi, P. Y., Dec 1 2019, In: Nature communications. 10, 1, 5677.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Mapping the interactions between the NS4B and NS3 proteins of dengue virus
Zou, J., Lee, L. T., Wang, Q. Y., Xie, X., Lu, S., Yau, Y. H., Yuan, Z., Shochat, S. G., Kang, C., Lescar, J. & Shi, P. Y., Jan 1 2015, In: Journal of virology. 89, 7, p. 3471-3483 13 p.Research output: Contribution to journal › Article › peer-review
48 Scopus citations -
Ligand-bound structures of the dengue virus protease reveal the active conformation
Noble, C. G., Seh, C. C., Chao, A. T. & Shi, P. Y., Jan 2012, In: Journal of virology. 86, 1, p. 438-446 9 p.Research output: Contribution to journal › Article › peer-review
166 Scopus citations -
Lead optimization of spiropyrazolopyridones: A new and potent class of dengue virus inhibitors
Zou, B., Chan, W. L., Ding, M., Leong, S. Y., Nilar, S., Seah, P. G., Liu, W., Karuna, R., Blasco, F., Yip, A., Chao, A., Susila, A., Dong, H., Wang, Q. Y., Xu, H. Y., Chan, K., Wan, K. F., Gu, F., Diagana, T. T., Wagner, T. & 3 others, , Mar 12 2015, In: ACS Medicinal Chemistry Letters. 6, 3, p. 344-348 5 p.Research output: Contribution to journal › Article › peer-review
35 Scopus citations -
K48-linked polyubiquitination of dengue virus NS1 protein inhibits its interaction with the viral partner NS4B
Giraldo, M. I., Vargas-Cuartas, O., Gallego-Gomez, J. C., Shi, P. Y., Padilla-Sanabria, L., Castaño-Osorio, J. C. & Rajsbaum, R., Feb 15 2018, In: Virus Research. 246, p. 1-11 11 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
In vivo antiviral host transcriptional response to SARS-CoV-2 by viral load, sex, and age
Lieberman, N. A. P., Peddu, V., Xie, H., Shrestha, L., Huang, M. L., Mears, M. C., Cajimat, M. N., Bente, D. A., Shi, P. Y., Bovier, F., Roychoudhury, P., Jerome, K. R., Moscona, A., Porotto, M. & Greninger, A. L., Sep 2020, In: PLoS Biology. 18, 9, e3000849.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses
Lo, M. K., Shi, P. Y., Chen, Y. L., Flint, M. & Spiropoulou, C. F., Jun 1 2016, In: Antiviral research. 130, p. 46-49 4 p.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
Internally deleted WNV genomes isolated from exotic birds in New Mexico: Function in cells, mosquitoes, and mice
Pesko, K. N., Fitzpatrick, K. A., Ryan, E. M., Shi, P. Y., Zhang, B., Lennon, N. J., Newman, R. M., Henn, M. R. & Ebel, G. D., May 25 2012, In: Virology. 427, 1, p. 10-17 8 p.Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
Inter- and intra-lineage genetic diversity of wild-type Zika viruses reveals both common and distinctive nucleotide variants and clusters of genomic diversity
Collins, N. D., Widen, S. G., Li, L., Swetnam, D. M., Shi, P. Y., Tesh, R. B. & Sarathy, V. V., Jan 1 2019, In: Emerging Microbes and Infections. 8, 1, p. 1126-1138 13 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Inhibitors of HIV-1 attachment. Part 8: The effect of C7-heteroaryl substitution on the potency, and in vitro and in vivo profiles of indole-based inhibitors
Yeung, K. S., Qiu, Z., Yin, Z., Trehan, A., Fang, H., Pearce, B., Yang, Z., Zadjura, L., D'Arienzo, C. J., Riccardi, K., Shi, P. Y., Spicer, T. P., Gong, Y. F., Browning, M. R., Hansel, S., Santone, K., Barker, J., Coulter, T., Lin, P. F., Meanwell, N. A. & 1 others, , Jan 1 2013, In: Bioorganic and Medicinal Chemistry Letters. 23, 1, p. 203-208 6 p.Research output: Contribution to journal › Article › peer-review
29 Scopus citations -
Inhibitors of HIV-1 attachment. Part 7: Indole-7-carboxamides as potent and orally bioavailable antiviral agents
Yeung, K. S., Qiu, Z., Xue, Q., Fang, H., Yang, Z., Zadjura, L., D'Arienzo, C. J., Eggers, B. J., Riccardi, K., Shi, P. Y., Gong, Y. F., Browning, M. R., Gao, Q., Hansel, S., Santone, K., Lin, P. F., Meanwell, N. A. & Kadow, J. F., Jan 1 2013, In: Bioorganic and Medicinal Chemistry Letters. 23, 1, p. 198-202 5 p.Research output: Contribution to journal › Article › peer-review
37 Scopus citations -
Inhibition of coronavirus entry in vitro and ex vivo by a lipid-conjugated peptide derived from the sars-cov-2 spike glycoprotein hrc domain
Outlaw, V. K., Bovier, F. T., Mears, M. C., Cajimat, M. N., Zhu, Y., Lin, M. J., Addetia, A., Lieberman, N. A. P., Peddu, V., Xie, X., Shi, P. Y., Greninger, A. L., Gellman, S. H., Bente, D. A., Moscona, A. & Porotto, M., Sep 1 2020, In: mBio. 11, 5, p. 1-14 14 p., e01935-20.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Identifying optimal capsid duplication length for the stability of reporter flaviviruses
Baker, C., Liu, Y., Zou, J., Muruato, A., Xie, X. & Shi, P. Y., Jan 1 2020, In: Emerging Microbes and Infections. 9, 1, p. 2256-2265 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Identifying initiation and elongation inhibitors of dengue virus RNA polymerase in a high-throughput lead-finding campaign
Smith, T. M., Lim, S. P., Yue, K., Busby, S. A., Arora, R., Seh, C. C., Kirk Wright, S., Nutiu, R., Niyomrattanakit, P., Wan, K. F., Beer, D., Shi, P. Y. & Benson, T. E., Jan 30 2015, In: Journal of Biomolecular Screening. 20, 1, p. 153-163 11 p.Research output: Contribution to journal › Article › peer-review
20 Scopus citations -
Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability
Johnson, B., VanBlargan, L. A., Xu, W., White, J. P., Shan, C., Shi, P. Y., Zhang, R., Adhikari, J., Gross, M. L., Leung, D. W., Diamond, M. S. & Amarasinghe, G. K., Mar 20 2018, In: Immunity. 48, 3, p. 487-499.e5Research output: Contribution to journal › Article › peer-review
30 Scopus citations -
High-Throughput Fitness Profiling of Zika Virus E Protein Reveals Different Roles for Glycosylation during Infection of Mammalian and Mosquito Cells
Gong, D., Zhang, T. H., Zhao, D., Du, Y., Chapa, T. J., Shi, Y., Wang, L., Contreras, D., Zeng, G., Shi, P. Y., Wu, T. T., Arumugaswami, V. & Sun, R., Mar 23 2018, In: iScience. 1, p. 97-111 15 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Genomic analysis and growth characteristic of dengue viruses from Makassar, Indonesia
Sasmono, R. T., Wahid, I., Trimarsanto, H., Yohan, B., Wahyuni, S., Hertanto, M., Yusuf, I., Mubin, H., Ganda, I. J., Latief, R., Bifani, P. J., Shi, P. Y. & Schreiber, M. J., Jun 1 2015, In: Infection, Genetics and Evolution. 32, p. 165-177 13 p.Research output: Contribution to journal › Article › peer-review
47 Scopus citations -
Genetic stability of live-attenuated Zika vaccine candidates
Muruato, A. E., Shan, C., Fontes-Garfias, C. R., Liu, Y., Cao, Z., Gao, Q., Weaver, S. C. & Shi, P. Y., Nov 2019, In: Antiviral research. 171, 104596.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Genetic interaction between NS4A and NS4B for replication of Japanese encephalitis virus
Li, X. D., Ye, H. Q., Deng, C. L., Liu, S. Q., Zhang, H. L., Shang, B. D., Shi, P. Y., Yuan, Z. M. & Zhang, B., 2015, In: Journal of General Virology. 96, p. 1264-1275 12 p.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
Genetic and biochemical characterizations of Zika virus NS2A protein
Zhang, X., Xie, X., Zou, J., Xia, H., Shan, C., Chen, X. & Shi, P. Y., Jan 1 2019, In: Emerging Microbes and Infections. 8, 1, p. 585-602 18 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations