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  • Jia Zhou

Discovery of novel mifepristone derivatives via suppressing KLF5 expression for the treatment of triple-negative breast cancer

Lin, Y., Liu, R., Zhao, P., Ye, J., Zheng, Z., Huang, J., Zhang, Y., Gao, Y., Chen, H., Liu, S., Zhou, J., Chen, C. & Chen, H., Feb 25 2018, In : European Journal of Medicinal Chemistry. 146, p. 354-367 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Discovery of niclosamide and its O-alkylamino-tethered derivatives as potent antibacterial agents against carbapenemase-producing and/or colistin resistant Enterobacteriaceae isolates

Xu, J., Pachón-Ibáñez, M. E., Cebrero-Cangueiro, T., Chen, H., Sánchez-Céspedes, J. & Zhou, J., Jun 1 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 11, p. 1399-1402 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT2CReceptor-Positive Allosteric Modulators with Enhanced Drug-like Properties

Wold, E. A., Garcia, E. J., Wild, C. T., Miszkiel, J. M., Soto, C. A., Chen, J., Pazdrak, K., Fox, R. G., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Jul 23 2020, In : Journal of medicinal chemistry. 63, 14, p. 7529-7544 16 p.

Research output: Contribution to journalArticle

Discovery and development of natural product oridonin-inspired anticancer agents

Ding, Y., Ding, C., Ye, N., Liu, Z., Wold, E. A., Chen, H., Wild, C., Shen, Q. & Zhou, J., 2016, In : European journal of medicinal chemistry. 122, p. 102-117 16 p.

Research output: Contribution to journalReview article

78 Scopus citations

Direct Activation of Bax Protein for Cancer Therapy

Liu, Z., Ding, Y., Ye, N., Wild, C., Chen, H. & Zhou, J., Mar 1 2016, In : Medicinal Research Reviews. 36, 2, p. 313-341 29 p.

Research output: Contribution to journalArticle

58 Scopus citations

Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT 2C Receptor

Wild, C. T., Miszkiel, J. M., Wold, E. A., Soto, C. A., Ding, C., Hartley, R. M., White, M. A., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Oct 1 2019, In : Journal of medicinal chemistry. 62, 1, p. 288-305 18 p.

Research output: Contribution to journalArticle

11 Scopus citations
5 Scopus citations

Cystathionine-β-synthase inhibition for colon cancer: Enhancement of the efficacy of aminooxyacetic acid via the prodrug approach

Chao, C., Zatarain, J. R., Ding, Y., Coletta, C., Mrazek, A. A., Druzhyna, N., Johnson, P., Chen, H., Hellmich, J. L., Asimakopoulou, A., Yanagi, K., Olah, G., Szoleczky, P., Törö, G., Bohanon, F. J., Cheema, M., Lewis, R., Eckelbarger, D., Ahmad, A., Módis, K. & 6 others, Untereiner, A., Szczesny, B., Papapetropoulos, A., Zhou, J., Hellmich, M. R. & Szabo, C., 2016, In : Molecular Medicine. 22, p. 361-379 19 p.

Research output: Contribution to journalArticle

23 Scopus citations

Bidirectional modulation of the voltage-gated sodium (Nav1.6) channel by rationally designed peptidomimetics

Dvorak, N. M., Wadsworth, P. A., Wang, P., Chen, H., Zhou, J. & Laezza, F., Aug 2020, In : Molecules. 25, 15, 3365.

Research output: Contribution to journalArticle

Open Access

Applications of bioorthogonal chemistry in tumor-targeted drug discovery

Liu, G., Wold, E. A. & Zhou, J., Jan 1 2019, In : Current topics in medicinal chemistry. 19, 11, p. 892-897 6 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Antifibrosis effect of novel oridonin analog CYD0618 via suppression of the NF-κB pathway

Cummins, C. B., Wang, X., Xu, J., Hughes, B. D., Ding, Y., Chen, H., Zhou, J. & Radhakrishnan, R. S., Dec 2018, In : Journal of Surgical Research. 232, p. 283-292 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

An NPY Y1 receptor antagonist unmasks latent sensitization and reveals the contribution of protein kinase A and Epac to chronic inflammatory pain

Fu, W., Nelson, T. S., Santos, D. F., Doolen, S., Gutierrez, J. J. P., Ye, N., Zhou, J. & Taylor, B. K., Aug 1 2019, In : Pain. 160, 8, p. 1754-1765 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

A new oridonin analog suppresses triple-negative breast cancer cells and tumor growth via the induction of death receptor 5

Wu, J., Ding, Y., Chen, C. H., Zhou, Z., Ding, C., Chen, H., Zhou, J. & Chen, C., Oct 1 2016, In : Cancer Letters. 380, 2, p. 393-402 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

AMPA receptor positive allosteric modulators attenuate morphine tolerance and dependence

Hu, X., Tian, X., Guo, X., He, Y., Chen, H., Zhou, J. & Wang, Z. J., Jul 15 2018, In : Neuropharmacology. 137, p. 50-58 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts

Wold, E. A., Chen, J., Cunningham, K. A. & Zhou, J., Oct 1 2019, In : Journal of medicinal chemistry. 62, 1, p. 88-127 40 p.

Research output: Contribution to journalArticle

18 Scopus citations

A Bromodomain-Containing Protein 4 (BRD4) Inhibitor Suppresses Angiogenesis by Regulating AP-1 Expression

Zhou, Z., Li, X., Liu, Z., Huang, L., Yao, Y., Li, L., Chen, J., Zhang, R., Zhou, J., Wang, L. & Zhang, Q. Q., Jul 10 2020, In : Frontiers in Pharmacology. 11, 1043.

Research output: Contribution to journalArticle

Open Access