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• A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease

  Szymanski, M. R., Yu, W., Gmyrek, A. M., White, M. A., Molineux, I. J., Lee, J. C. & Yin, Y. W., 2017, In: Nature communications. 8, 14959.

  Research output: Contribution to journal › Article › peer-review

  • correxonuclease
  • Endonucleases
  • deoxyribonucleic acid
  • Exonucleases
  • DNA
  9 Scopus citations

• Comparison of the structural and dynamic effects of 5-methylcytosine and 5-chlorocytosine in a CpG dinucleotide sequence

  Theruvathu, J. A., Yin, Y. W., Pettitt, B. M. & Sowers, L. C., Nov 26 2013, In: Biochemistry. 52, 47, p. 8590-8598 9 p.

  Research output: Contribution to journal › Article › peer-review

  • 5-chlorocytosine
  • 5-Methylcytosine
  • Cytosine
  • Oligonucleotides
  • Protons
  7 Scopus citations

• Erratum: Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ (Proceedings of the National Academy of Sciences of the United States of America (2015) 112 (8596-8601) DOI: 10.1073/pnas.1421733112)

  Sohl, C. D., Szymanski, M. R., Mislak, A. C., Shumate, C. K., Amiralaei, S., Schinazi, R. F., Anderson, K. S. & Yin, Y. W., Feb 2 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 5, p. E662

  Research output: Contribution to journal › Comment/debate › peer-review

• Exonuclease of human DNA polymerase gamma disengages its strand displacement function

  He, Q., Shumate, C. K., White, M. A., Molineux, I. J. & Yin, Y. W., Nov 2013, In: Mitochondrion. 13, 6, p. 592-601 10 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA Polymerase gamma
  • Exonucleases
  • Mitochondrial DNA
  • DNA
  • Holoenzymes
  13 Scopus citations

• PARP1 depletion improves mitochondrial and heart function in Chagas disease: Effects on POLG dependent mtDNA maintenance

  Wen, J. J., Yin, Y. W. & Garg, N. J., May 2018, In: PLoS pathogens. 14, 5, e1007065.

  Research output: Contribution to journal › Article › peer-review

  • Poly (ADP-Ribose) Polymerase-1
  • Chagas Disease
  • Mitochondrial DNA
  • Maintenance
  • Heart
  14 Scopus citations

• Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ

  Sohl, C. D., Szymanski, M. R., Mislak, A. C., Shumate, C. K., Amiralaei, S., Schinazi, R. F., Anderson, K. S. & Yin, Y. W., Jul 14 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 28, p. 8596-8601 6 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA Polymerase gamma
  • Reverse Transcriptase Inhibitors
  • Nucleosides
  • Nucleotides
  • HIV Reverse Transcriptase
  14 Scopus citations

• Selective inhibition of bacterial tryptophanyl-tRNA synthetases by indolmycin is mechanism-based

  Williams, T. L., Yin, Y. W. & Carter, C. W., Jan 1 2016, In: Journal of Biological Chemistry. 291, 1, p. 255-265 11 p.

  Research output: Contribution to journal › Article › peer-review

  • indolmycin
  • Tryptophan-tRNA Ligase
  • Tryptophan
  • Adenosine Triphosphate
  • Stabilization
  19 Scopus citations

• Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase

  Szymanski, M. R., Kuznetsov, V. B., Shumate, C., Meng, Q., Lee, Y. S., Patel, G., Patel, S. & Yin, Y. W., 2015, In: EMBO Journal. 34, 14, p. 1959-1970 12 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA replicase
  • Zalcitabine
  • DNA Polymerase gamma
  • Toxicity
  • Mitochondrial DNA
  27 Scopus citations

• Structural insight on processivity, human disease and antiviral drug toxicity

  Yin, Y. W., Feb 2011, In: Current Opinion in Structural Biology. 21, 1, p. 83-91 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • DNA Polymerase gamma
  • HIV Reverse Transcriptase
  • Bacteriophage T7
  • DNA-Directed DNA Polymerase
  • DNA-Directed RNA Polymerases
  2 Scopus citations

• The DNA polymerase gamma R953C mutant is associated with antiretroviral therapy-induced mitochondrial toxicity

  Li, M., Mislak, A. C., Foli, Y., Agbosu, E., Bose, V., Bhandari, S., Szymanski, M. R., Shumate, C. K., Yin, Y. W., Anderson, K. S. & Paintsil, E., Sep 1 2016, In: Antimicrobial agents and chemotherapy. 60, 9, p. 5608-5611 4 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA Polymerase gamma
  • 2'-deoxycytidine 5'-triphosphate
  • triphosphoric acid
  • Nucleotides
  • Binding Sites
  3 Scopus citations

• The yeast mitochondrial RNA polymerase and transcription factor complex catalyzes efficient priming of DNA synthesis on single-stranded DNA

  Ramachandran, A., Nandakumar, D., Deshpande, A. P., Lucas, T. P., R-Bhojappa, R., Tang, G. Q., Raney, K., Yin, Y. W. & Patel, S. S., Aug 5 2016, In: Journal of Biological Chemistry. 291, 32, p. 16828-16839 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Mitochondrial RNA
  • Single-Stranded DNA
  • Yeast
  • DNA-Directed RNA Polymerases
  • Yeasts
  8 Scopus citations

• Transcription yield of fully 2'-modified RNA can be increased by the addition of thermostabilizing mutations to T7 RNA polymerase mutants

  Meyer, A. J., Garry, D. J., Hall, B., Byrom, M. M., McDonald, H. G., Yang, X., Yin, Y. W. & Ellington, A. D., Jul 7 2015, In: Nucleic acids research. 43, 15, p. 7480-7488 9 p.

  Research output: Contribution to journal › Article › peer-review

  • bacteriophage T7 RNA polymerase
  • RNA
  • Mutation
  • Thermotolerance
  • Ribose
  28 Scopus citations

• Yeast mitochondrial transcription factor Mtf1 determines the precision of promoter-directed initiation of RNA polymerase Rpo41

  Yang, X., Chang, H. R. & Yin, Y. W., Sep 2 2015, In: PloS one. 10, 9, e0136879.

  Research output: Contribution to journal › Article › peer-review

  • Yeast
  • DNA-Directed RNA Polymerases
  • Bacteriophages
  • DNA-directed RNA polymerase
  • Mitochondrial RNA
  5 Scopus citations