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  • Thomas Smith

A high-throughput drop microfluidic system for virus culture and analysis

Fischer, A. E., Wu, S. K., Proescher, J. B. G., Rotem, A., Chang, C. B., Zhang, H., Tao, Y., Mehoke, T. S., Thielen, P. M., Kolawole, A. O., Smith, T. J., Wobus, C. E., Weitz, D. A., Lin, J. S., Feldman, A. B. & Wolfe, J. T., Mar 1 2015, In : Journal of Virological Methods. 213, p. 111-117 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Allosteric discrimination at the NADH/ADP regulatory site of glutamate dehydrogenase

Nassar, O. M., Wong, K. Y., Lynch, G. C., Smith, T. J. & Pettitt, B. M., Dec 1 2019, In : Protein Science. 28, 12, p. 2080-2088 9 p.

Research output: Contribution to journalArticle

A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis

Bailey, J., Powell, L., Sinanan, L., Neal, J., Li, M., Smith, T. & Bell, E., Sep 2011, In : FEBS Journal. 278, 17, p. 3140-3151 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Antibody-induced uncoating of human rhinovirus B14

Dong, Y., Liu, Y., Jiang, W., Smith, T. J., Xu, Z. & Rossmann, M. G., Jul 25 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 30, p. 8017-8022 6 p.

Research output: Contribution to journalArticle

26 Scopus citations

A severe case of hyperinsulinism due to hemizygous activating mutation of glutamate dehydrogenase

Barrosse-Antle, M., Su, C., Chen, P., Boodhansingh, K. E., Smith, T. J., Stanley, C. A., De León, D. D. & Li, C., Dec 2017, In : Pediatric Diabetes. 18, 8, p. 911-916 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Atomic structure of cucumber necrosis virus and the role of the capsid in vector transmission

Li, M., Kakani, K., Katpally, U., Johnson, S., Rochon, DA. & Smith, T. J., 2013, In : Journal of virology. 87, 22, p. 12166-12175 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Atomic structure of salutaridine reductase from the opium poppy (Papaver somniferum)

Higashi, Y., Kutchan, T. M. & Smith, T. J., Feb 25 2011, In : Journal of Biological Chemistry. 286, 8, p. 6532-6541 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Bile Salts Alter the Mouse Norovirus Capsid Conformation: Possible Implications for Cell Attachment and Immune Evasion

Sherman, M. B., Williams, A. N., Smith, H. Q., Nelson, C., Wilen, C. B., Fremont, D. H., Virgin, H. W. & Smith, T. J., Oct 1 2019, In : Journal of virology. 93, 19

Research output: Contribution to journalArticle

9 Scopus citations

Cellular production of a counterfeit viral protein confers immunity to infection by a related virus

Warner, B. E., Ballinger, M. J., Yerramsetty, P., Reed, J., Taylor, D. J., Smith, T. J. & Bruenn, J. A., 2018, In : PeerJ. 2018, 9, e5679.

Research output: Contribution to journalArticle

3 Scopus citations

Correction to: Fungal Secretome Analysis Via PepSAVI-MS: Identification of the Bioactive Peptide KP4 from Ustilago maydis (Journal of The American Society for Mass Spectrometry, (2018), 29, 5, (859-865), 10.1007/s13361-017-1880-z)

Kirkpatrick, C. L., Parsley, N. C., Bartges, T. E., Cooke, M. E., Evans, W. S., Heil, L. R., Smith, T. & Hicks, L. M., Sep 1 2018, In : Journal of the American Society for Mass Spectrometry. 29, 9, 1 p.

Research output: Contribution to journalComment/debate

Dissecting the Antenna in Human Glutamate Dehydrogenase: Understanding Its Role in Subunit Communication and Allosteric Regulation

Hoffpauir, Z. A., Sherman, E. & Smith, T. J., Oct 15 2019, In : Biochemistry. 58, 41, p. 4195-4206 12 p.

Research output: Contribution to journalArticle

Editorial overview: Theory and simulation: Macromolecular machines

Hopfner, K. P. & Smith, T. J., Apr 2014, In : Current Opinion in Structural Biology. 25, p. 6-8 3 p.

Research output: Contribution to journalEditorial

Evolution on the biophysical fitness landscape of an RNA virus

Rotem, A., Serohijos, A. W. R., Chang, C. B., Wolfe, J. T., Fischer, A. E., Mehoke, T. S., Zhang, H., Tao, Y., Lloyd Ung, W., Choi, J. M., Rodrigues, J. V., Kolawole, A. O., Koehler, S. A., Wu, S., Thielen, P. M., Cui, N., Demirev, P. A., Giacobbi, N. S., Julian, T. R., Schwab, K. & 7 others, Lin, J. S., Smith, T. J., Pipas, J. M., Wobus, C. E., Feldman, A. B., Weitz, D. A. & Shakhnovich, E. I., Jan 1 2018, In : Molecular biology and evolution. 35, 10, p. 2390-2400 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Explorative study on isolation and characterization of a microviridae G4 bacteriophage, EMCL318, against multi-drug-resistant Escherichia coli 15-318

Ghosh, S., Persad, E., Shiue, T. Y., Lam, C., Islam, A., Mascibroda, L. G., Sherman, M. B., Smith, T. & Cheeptham, N., Dec 2018, In : Antibiotics. 7, 4, 92.

Research output: Contribution to journalArticle

1 Scopus citations

Flexibility in surface-exposed loops in a virus capsid mediates escape from antibody neutralization

Kolawole, A. O., Li, M., Xia, C., Fischer, A. E., Giacobbi, N. S., Rippinger, C. M., Proescher, J. B. G., Wu, S. K., Bessling, S. L., Gamez, M., Yu, C., Zhang, R., Mehoke, T. S., Pipas, J. M., Wolfe, J. T., Lin, J. S., Feldman, A. B., Smith, T. J. & Wobus, C. E., Apr 2014, In : Journal of virology. 88, 8, p. 4543-4557 15 p.

Research output: Contribution to journalArticle

23 Scopus citations

Fungal Secretome Analysis via PepSAVI-MS: Identification of the Bioactive Peptide KP4 from Ustilago maydis

Kirkpatrick, C. L., Parsley, N. C., Bartges, T. E., Cooke, M. E., Evans, W. S., Heil, L. R., Smith, T. J. & Hicks, L. M., May 1 2018, In : Journal of the American Society for Mass Spectrometry. 29, 5, p. 859-865 7 p.

Research output: Contribution to journalArticle

3 Scopus citations
3 Scopus citations

Glutamate dehydrogenase: Structure, regulation, and its role in insulin homeostasis

Smith, T. J., Apr 4 2012, Monogenic Hyperinsulinemic Hypoglycemia Disorders. Charles, S. & Diva, D. L. (eds.). p. 87-99 13 p. (Frontiers in Diabetes; vol. 21).

Research output: Chapter in Book/Report/Conference proceedingChapter

Glutamate dehydrogenase

Smith, T. J. & Stanley, C. A., Nov 24 2011, Amino Acids in Human Nutrition and Health. CABI Publishing, p. 1-23 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Glutamate dehydrogenase: Structure, allosteric regulation, and role in insulin homeostasis

Li, M., Li, C., Allen, A., Stanley, C. A. & Smith, T. J., Mar 1 2014, In : Neurochemical Research. 39, 3, p. 433-445 13 p.

Research output: Contribution to journalReview article

28 Scopus citations

Glutamate Dehydrogenase, a Complex Enzyme at a Crucial Metabolic Branch Point

Smith, H. Q., Li, C., Stanley, C. A. & Smith, T. J., Jan 15 2019, In : Neurochemical Research. 44, 1, p. 117-132 16 p.

Research output: Contribution to journalArticle

9 Scopus citations

Green Tea and Control of Glutamate Dehydrogenase Activity

Smith, T. J., Aug 29 2013, Tea in Health and Disease Prevention. Elsevier Inc., p. 1029-1038 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Green tea polyphenols control dysregulated glutamate dehydrogenase in transgenic mice by hijacking the ADP activation site

Li, C., Li, M., Chen, P., Narayan, S., Matschinsky, F. M., Bennett, M. J., Stanley, C. A. & Smith, T. J., Oct 30 2011, In : Journal of Biological Chemistry. 286, 39, p. 34164-34174 11 p.

Research output: Contribution to journalArticle

47 Scopus citations

Green tea polyphenols in drug discovery: A success or failure?

Smith, T. J., Jun 1 2011, In : Expert Opinion on Drug Discovery. 6, 6, p. 589-595 7 p.

Research output: Contribution to journalReview article

24 Scopus citations

Multidomain carbohydrate-binding proteins involved in Bacteroides thetaiotaomicron starch metabolism

Cameron, E. A., Maynard, M. A., Smith, C. J., Smith, T. J., Koropatkin, N. M. & Martens, E. C., Oct 5 2012, In : Journal of Biological Chemistry. 287, 41, p. 34614-34625 12 p.

Research output: Contribution to journalArticle

54 Scopus citations

Newly isolated mAbs broaden the neutralizing epitope in murine norovirus

Kolawole, A. O., Xia, C., Li, M., Gamez, M., Yu, C., Rippinger, C. M., Yucha, R. E., Smith, T. J. & Wobus, C. E., Sep 2014, In : Journal of General Virology. 95, PART 9, p. 1958-1968 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Norovirus escape from broadly neutralizing antibodies is limited to allostery-like mechanisms

Kolawole, A. O., Smith, H. Q., Svoboda, S. A., Lewis, M. S., Sherman, M. B., Lynch, G. C., Pettitt, B. M., Smith, T. J. & Wobus, C. E., Sep 1 2017, In : mSphere. 2, 5, e00334-17.

Research output: Contribution to journalArticle

18 Scopus citations

Protruding domain of capsid protein is necessary and sufficient to determine murine norovirus replication and pathogenesis in vivo

Strong, D. W., Thackray, L. B., Smith, T. J. & Virgin, H. W., Mar 1 2012, In : Journal of virology. 86, 6, p. 2950-2958 9 p.

Research output: Contribution to journalArticle

53 Scopus citations

Stability of cucumber necrosis virus at the quasi-6-fold axis affects zoospore transmission

Sherman, M. B., Kakani, K., Rochon, DA., Jiang, W., Voss, N. R. & Smith, T. J., Oct 1 2017, In : Journal of virology. 91, 19, e01030-17.

Research output: Contribution to journalArticle

2 Scopus citations

Structural and functional studies of a phosphatidic acid-binding antifungal plant defensin MtDef4: Identification of an RGFRRR motif governing fungal cell entry

Sagaram, U. S., El-Mounadi, K., Buchko, G. W., Berg, H. R., Kaur, J., Pandurangi, R. S., Smith, T. J. & Shah, D. M., Dec 4 2013, In : PloS one. 8, 12, e82485.

Research output: Contribution to journalArticle

76 Scopus citations

Structural basis for broad detection of genogroup II noroviruses by a monoclonal antibody that binds to a site occluded in the viral particle

Hansman, G. S., Taylor, D. W., McLellan, J. S., Smith, T. J., Georgiev, I., Tame, J. R. H., Park, S. Y., Yamazaki, M., Gondaira, F., Miki, M., Katayama, K., Murata, K. & Kwong, P. D., Apr 2012, In : Journal of virology. 86, 7, p. 3635-3646 12 p.

Research output: Contribution to journalArticle

49 Scopus citations

Structural basis for murine norovirus engagement of bile acids and the CD300lf receptor

Nelson, C. A., Wilen, C. B., Dai, Y. N., Orchard, R. C., Kim, A. S., Stegeman, R. A., Hsieh, L. L., Smith, T. J., Virgin, H. W. & Fremont, D. H., Sep 25 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 39, p. E9201-E9210

Research output: Contribution to journalArticle

28 Scopus citations

Structural studies on antibody recognition and neutralization of viruses

Smith, T. J., Aug 2011, In : Current Opinion in Virology. 1, 2, p. 150-156 7 p.

Research output: Contribution to journalReview article

6 Scopus citations

Structure-activity determinants in antifungal plant defensins msdef1 and mtdef4 with different modes of action against fusarium graminearum

Sagaram, U. S., Pandurangi, R., Kaur, J., Smith, T. J. & Shah, D. M., 2011, In : PloS one. 6, 4, e18550.

Research output: Contribution to journalArticle

98 Scopus citations

The atomic structure of the virally encoded antifungal protein, KP6

Allen, A., Chatt, E. & Smith, T. J., Feb 8 2013, In : Journal of Molecular Biology. 425, 3, p. 609-621 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

The dynamic capsid structures of the noroviruses

Smith, H. Q. & Smith, T. J., Mar 2019, In : Viruses. 11, 3, 235.

Research output: Contribution to journalReview article

Open Access
5 Scopus citations

The dynamic life of virus capsids

Sherman, M. B., Smith, H. Q. & Smith, T. J., Jun 2020, In : Viruses. 12, 6, 618.

Research output: Contribution to journalReview article

Open Access

The structure and allosteric regulation of glutamate dehydrogenase

Li, M., Li, C., Allen, A., Stanley, C. A. & Smith, T. J., Sep 2011, In : Neurochemistry International. 59, 4, p. 445-455 11 p.

Research output: Contribution to journalReview article

28 Scopus citations

The structure and allosteric regulation of mammalian glutamate dehydrogenase

Li, M., Li, C., Allen, A., Stanley, C. A. & Smith, T. J., Mar 15 2012, In : Archives of Biochemistry and Biophysics. 519, 2, p. 69-80 12 p.

Research output: Contribution to journalReview article

77 Scopus citations

The virally encoded killer proteins from Ustilago maydis

Allen, A., Islamovic, E., Kaur, J., Gold, S., Shah, D. & Smith, T. J., Jan 1 2013, In : Fungal Biology Reviews. 26, 4, p. 166-173 8 p.

Research output: Contribution to journalReview article

5 Scopus citations

Transgenic maize plants expressing the Totivirus antifungal protein, KP4, are highly resistant to corn smut

Allen, A., Islamovic, E., Kaur, J., Gold, S., Shah, D. & Smith, T. J., Oct 2011, In : Plant Biotechnology Journal. 9, 8, p. 857-864 8 p.

Research output: Contribution to journalArticle

22 Scopus citations