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• An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction

  Xia, H., Luo, H., Shan, C., Muruato, A. E., Nunes, B. T. D., Medeiros, D. B. A., Zou, J., Xie, X., Giraldo, M. I., Vasconcelos, P. F. C., Weaver, S. C., Wang, T., Rajsbaum, R. & Shi, P. Y., Dec 1 2018, In: Nature communications. 9, 1, 414.

  Research output: Contribution to journal › Article › peer-review

  • interferon
  • Zika Virus
  • viruses
  • Viruses
  • mutations
  93 Scopus citations

• Anti-Zika virus RNAi in neural progenitor cells

  Xie, X. & Shi, P. Y., Apr 1 2019, In: Cell Research. 29, 4, p. 261-262 2 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Scopus citations

• A single amino acid in nonstructural protein NS4B Confers virulence to dengue virus in AG129 mice through enhancement of viral RNA synthesis

  Grant, D., Tan, G. K., Qing, M., Ng, J. K. W., Yip, A., Zou, G., Xie, X., Yuan, Z. Y., Schreiber, J., Schul, W., Shi, P. Y. & Alonso, S., Aug 2011, In: Journal of virology. 85, 15, p. 7775-7787 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus
  • dengue
  • Dengue Virus
  • Dengue
  • Viral RNA
  67 Scopus citations

• A Single-Dose Live-Attenuated Zika Virus Vaccine with Controlled Infection Rounds that Protects against Vertical Transmission

  Xie, X., Kum, D. B., Xia, H., Luo, H., Shan, C., Zou, J., Muruato, A. E., Medeiros, D. B. A., Nunes, B. T. D., Dallmeier, K., Rossi, S. L., Weaver, S. C., Neyts, J., Wang, T., Vasconcelos, P. F. C. & Shi, P. Y., Oct 10 2018, In: Cell Host and Microbe. 24, 4, p. 487-499.e5

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Vaccines
  • Infection
  • Attenuated Vaccines
  • Capsid Proteins
  22 Scopus citations

• A single-dose plasmid-launched live-attenuated Zika vaccine induces protective immunity

  Zou, J., Xie, X., Luo, H., Shan, C., Muruato, A. E., Weaver, S. C., Wang, T. & Shi, P. Y., Oct 2018, In: EBioMedicine. 36, p. 92-102 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Attenuated Vaccines
  • Immunity
  • Plasmids
  • Vaccines
  • DNA
  21 Scopus citations

• A translation inhibitor that suppresses dengue virus in vitro and in vivo

  Wang, Q. Y., Kondreddi, R. R., Xie, X., Rao, R., Nilar, S., Xu, H. Y., Qing, M., Chang, D., Dong, H., Yokokawa, F., Lakshminarayana, S. B., Goh, A., Schul, W., Kramer, L., Keller, T. H. & Shi, P. Y., Sep 2011, In: Antimicrobial agents and chemotherapy. 55, 9, p. 4072-4080 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • Benzomorphans
  • Viral RNA
  • In Vitro Techniques
  • Pharmacokinetics
  39 Scopus citations

• Axl promotes zika virus entry and modulates the antiviral state of human sertoli cells

  Strange, D. P., Jiyarom, B., Zarandi, N. P., Xie, X., Baker, C., Sadri-Ardekani, H., Shi, P. Y. & Verma, S., Jul 1 2019, In: mBio. 10, 4, e01372-19.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zika Virus
  • Virus Internalization
  • Sertoli Cells
  • Antiviral Agents
  • Zika Virus Infection
  18 Scopus citations

• Characterization of a candidate tetravalent vaccine based on 2’-O-methyltransferase mutants

  Züst, R., Li, S. H., Xie, X., Velumani, S., Chng, M., Toh, Y. X., Zou, J., Dong, H., Shan, C., Pang, J., Qin, C. F., Newell, E. W., Shi, P. Y. & Fink, K., Jan 2018, In: PloS one. 13, 1, e0189262.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus
  • Dengue Virus
  • Viruses
  • Methyltransferases
  • methyltransferases
  4 Scopus citations

• Characterization of Dengue virus NS4A and NS4B protein interaction

  Zou, J., Xie, X., Wang, Q. Y., Dong, H., Lee, M. Y., Kang, C., Yuan, Z. & Shi, P. Y., 2015, In: Journal of virology. 89, 7, p. 3455-3470 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus NS4A protein
  • Dengue virus NS4B protein
  • Dengue virus
  • virus replication
  • Amino Acids
  69 Scopus citations

• Dengue NS2A Protein Orchestrates Virus Assembly

  Xie, X., Zou, J., Zhang, X., Zhou, Y., Routh, A. L., Kang, C., Popov, V. L., Chen, X., Wang, Q. Y., Dong, H. & Shi, P. Y., Nov 13 2019, In: Cell Host and Microbe. 26, 5, p. 606-622.e8

  Research output: Contribution to journal › Article › peer-review

  • Virus Assembly
  • Dengue
  • Virion
  • Polyproteins
  • Nucleocapsid
  16 Scopus citations

• Design, Synthesis, and Biological Evaluation of Substituted 4,6-Dihydrospiro[[1,2,3]triazolo[4,5- b]pyridine-7,3′-indoline]-2′,5(3 H)-dione Analogues as Potent NS4B Inhibitors for the Treatment of Dengue Virus Infection

  Xu, J., Xie, X., Ye, N., Zou, J., Chen, H., White, M. A., Shi, P. Y. & Zhou, J., Sep 12 2019, In: Journal of medicinal chemistry. 62, 17, p. 7941-7960 20 p.

  Research output: Contribution to journal › Article › peer-review

  • indoline-2,3-dione
  • pyridine
  • Dengue Virus
  • indoline
  • Virus Diseases
  9 Scopus citations

• Determinants of dengue virus NS4A protein oligomerization

  Lee, C. M., Xie, X., Zou, J., Li, S. H., Qi Lee, M. Y., Dong, H., Qin, C. F., Kang, C. & Shi, P. Y., 2015, In: Journal of virology. 89, 12, p. 6171-6183 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus NS4A protein
  • Dengue virus
  • Flavivirus
  • oligomerization
  • Amino Acids
  24 Scopus citations

• Dimerization of flavivirus NS4B protein

  Zou, J., Xie, X., Lee, L. T., Chandrasekaran, R., Reynaud, A., Yap, L., Wang, Q. Y., Dong, H., Kang, C., Yuan, Z., Lescar, J. & Shi, P. Y., Mar 2014, In: Journal of virology. 88, 6, p. 3379-3391 13 p.

  Research output: Contribution to journal › Article › peer-review

  • flavivirus NS4B protein
  • Flavivirus
  • dimerization
  • Dimerization
  • Dengue virus
  43 Scopus citations

• Erratum: Treatment of human glioblastoma with a live attenuated zika virus vaccine candidate (mBio, (2018) 9(5), e01683-18, 10.1128/mBio.01683-18)

  Chen, Q., Wu, J., Ye, Q., Ma, F., Zhu, Q., Wu, Y., Shan, C., Xie, X., Li, D., Zhan, X., Li, C., Li, X. F., Qin, X., Zhao, T., Wu, H., Shi, P. Y., Man, J. & Qin, C. F., Mar 1 2019, In: mBio. 10, 2, e00433-19.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Zika Virus
  • Glioblastoma
  • Names
  • Vaccines

• Fragile X mental retardation protein is a zika virus restriction factor that is antagonized by subgenomic flaviviral RNA

  Soto-Acosta, R., Xie, X., Shan, C., Baker, C. K., Shi, P. Y., Rossi, S. L., Garcia-Blanco, M. A. & Bradrick, S., Dec 1 2018, In: eLife. 7, e39023.

  Research output: Contribution to journal › Article › peer-review

  • Fragile X Mental Retardation Protein
  • Zika Virus
  • Viruses
  • RNA
  • Zika Virus Infection
  17 Scopus citations

• Generation and characterization of mouse monoclonal antibodies against NS4B protein of dengue virus

  Xie, X., Zou, J., Wang, Q. Y., Noble, C. G., Lescar, J. & Shi, P. Y., Feb 1 2014, In: Virology. 450-451, p. 250-257 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus NS4B protein
  • Monoclonal Antibodies
  • Epitopes
  • Proteins
  • Cytosol
  13 Scopus citations

• Genetic and biochemical characterizations of Zika virus NS2A protein

  Zhang, X., Xie, X., Zou, J., Xia, H., Shan, C., Chen, X. & Shi, P. Y., Jan 1 2019, In: Emerging Microbes and Infections. 8, 1, p. 585-602 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zika Virus
  • Virion
  • Molecular Biology
  • Viral Nonstructural Proteins
  • Proteins
  13 Scopus citations

• Inhibition of dengue virus by targeting viral NS4B protein

  Xie, X., Wang, Q. Y., Xu, H. Y., Qing, M., Kramer, L., Yuan, Z. & Shi, P. Y., Nov 2011, In: Journal of virology. 85, 21, p. 11183-11195 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus
  • Dengue Virus
  • viral proteins
  • Viral Proteins
  • Replicon
  92 Scopus citations

• Inhibition of japanese encephalitis virus infection by flavivirus recombinant e protein domain III

  Fan, J., Liu, Y., Xie, X., Zhang, B. & Yuan, Z., Jun 1 2013, In: Virologica Sinica. 28, 3, p. 152-160 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Flavivirus Infections
  • Japanese Encephalitis Virus
  • Flavivirus
  • Protein Domains
  • Recombinant Proteins
  8 Scopus citations

• Mapping the interactions between the NS4B and NS3 proteins of dengue virus

  Zou, J., Lee, L. T., Wang, Q. Y., Xie, X., Lu, S., Yau, Y. H., Yuan, Z., Shochat, S. G., Kang, C., Lescar, J. & Shi, P. Y., Jan 1 2015, In: Journal of virology. 89, 7, p. 3471-3483 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus NS4B protein
  • flavivirus NS3 protein
  • Dengue virus
  • Flavivirus
  • Dengue Virus
  48 Scopus citations

• Maternal vaccination and protective immunity against Zika virus vertical transmission

  Shan, C., Xie, X., Luo, H., Muruato, A. E., Liu, Y., Wakamiya, M., La, J. H., Chung, J. M., Weaver, S. C., Wang, T. & Shi, P. Y., Dec 1 2019, In: Nature communications. 10, 1, 5677.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zika Virus
  • infectious diseases
  • viruses
  • Viruses
  • immunity
  4 Scopus citations

• Membrane topology and function of dengue virus NS2A protein

  Xie, X., Gayen, S., Kang, C. B., Yuan, Z. & Shi, P. Y., Apr 2013, In: Journal of virology. 87, 8, p. 4609-4622 14 p.

  Research output: Contribution to journal › Article › peer-review

  • virus protein 2A
  • Dengue virus
  • Dengue Virus
  • topology
  • Flavivirus
  116 Scopus citations

• Potential Mechanisms for Enhanced Zika Epidemic and Disease

  Xia, H., Xie, X., Shan, C. & Shi, P-Y., May 11 2018, In: ACS Infectious Diseases. 4, 5, p. 656-659 4 p.

  Research output: Contribution to journal › Review article › peer-review

  • Zika Virus Infection
  • Epidemics
  • Herd Immunity
  • Flavivirus
  • Mutation
  5 Scopus citations

• Rational design of a flavivirus vaccine by abolishing viral RNA 2′-O methylation

  Li, S. H., Dong, H., Li, X. F., Xie, X., Zhao, H., Deng, Y. Q., Wang, X. Y., Ye, Q., Zhu, S. Y., Wang, H. J., Zhang, B., Leng, Q. B., Zuest, R., Qin, E. D., Qin, C. F. & Shi, P. Y., May 2013, In: Journal of virology. 87, 10, p. 5812-5819 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Flavivirus
  • Viral RNA
  • methylation
  • Methylation
  • vaccines
  67 Scopus citations

• Repurposing an HIV Drug for Zika Virus Therapy

  Xie, X. & Shi, P. Y., Dec 4 2019, In: Molecular Therapy. 27, 12, p. 2064-2066 3 p.

  Research output: Contribution to journal › Short survey › peer-review
  1 Scopus citations

• Secondary structure and membrane topology of dengue virus NS4B N-terminal 125 amino acids

  Li, Y., Kim, Y. M., Zou, J., Wang, Q. Y., Gayen, S., Wong, Y. L., Lee, L. T., Xie, X., Huang, Q., Lescar, J., Shi, P. Y. & Kang, C., Dec 1 2015, In: Biochimica et Biophysica Acta - Biomembranes. 1848, 12, p. 3150-3157 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • Viruses
  • Membranes
  • Micelles
  • Dengue virus NS4B protein
  21 Scopus citations

• Targeting dengue virus NS4B protein for drug discovery

  Xie, X., Zou, J., Wang, Q. Y. & Shi, P. Y., Jun 2015, In: Antiviral research. 118, p. 39-45 7 p., 3603.

  Research output: Contribution to journal › Review article › peer-review

  • Dengue virus NS4B protein
  • Drug Discovery
  • Flavivirus
  • Proteins
  • Antiviral Agents
  44 Scopus citations

• Treatment of human glioblastoma with a live attenuated Zika virus vaccine candidate

  Chen, Q., Wu, J., Ye, Q., Ma, F., Zhu, Q., Wu, Y., Shan, C., Xie, X., Li, D., Zhan, X., Li, C., Li, X. F., Qin, X., Zhao, T., Wu, H., Shi, P. Y., Man, J. & Qin, C. F., Sep 1 2018, In: mBio. 9, 5, e01683-18.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Glioblastoma
  • Vaccines
  • Glioma
  • Stem Cells
  30 Scopus citations

• Two distinct sets of NS2A molecules are responsible for dengue virus RNA synthesis and virion assembly

  Xie, X., Zou, J., Puttikhunt, C., Yuan, Z. & Shi, P. Y., 2015, In: Journal of virology. 89, 2, p. 1298-1313 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus
  • Dengue Virus
  • virion
  • Virion
  • RNA
  53 Scopus citations

• U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication

  Poh, M. K., Shui, G., Xie, X., Shi, P. Y., Wenk, M. R. & Gu, F., Jan 2012, In: Antiviral research. 93, 1, p. 191-198 8 p.

  Research output: Contribution to journal › Article › peer-review

  • 3-beta-(2-(diethylamino)ethoxy)androst-5-en-17-one
  • Anticholesteremic Agents
  • Virus Internalization
  • Dengue Virus
  • Virus Replication
  72 Scopus citations

• Using a virion assembly-defective dengue virus as a vaccine approach

  Shan, C., Xie, X., Zou, J., Züst, R., Zhang, B., Ambrose, R., Mackenzie, J., Fink, K. & Shi, P. Y., Nov 1 2018, In: Journal of virology. 92, 21, e01002.

  Research output: Contribution to journal › Article › peer-review

  • Defective Viruses
  • Dengue virus
  • Dengue Virus
  • virion
  • Virion
  10 Scopus citations

• Zika virus NS2A-mediated virion assembly

  Zhang, X., Xie, X., Xia, H., Zou, J., Huang, L., Popov, V. L., Chen, X. & Shi, P. Y., 2019, In: mBio. 10, 5, e02375-19.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zika Virus
  • Virion
  • Viral RNA
  • Flavivirus
  • RNA
  16 Scopus citations

• Zika Virus Vaccine: Progress and Challenges

  Shan, C., Xie, X. & Shi, P. Y., Jul 11 2018, In: Cell Host and Microbe. 24, 1, p. 12-17 6 p.

  Research output: Contribution to journal › Review article › peer-review

  • Zika Virus
  • Vaccines
  • Eye Abnormalities
  • Flavivirus
  • Explosive Agents
  34 Scopus citations