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• A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease

  Szymanski, M. R., Yu, W., Gmyrek, A. M., White, M. A., Molineux, I. J., Lee, J. C. & Yin, Y. W., 2017, In: Nature communications. 8, 14959.

  Research output: Contribution to journal › Article › peer-review

  • correxonuclease
  • Endonucleases
  • deoxyribonucleic acid
  • Exonucleases
  • DNA
  9 Scopus citations

• Comparison of the structural and dynamic effects of 5-methylcytosine and 5-chlorocytosine in a CpG dinucleotide sequence

  Theruvathu, J. A., Yin, Y. W., Pettitt, B. M. & Sowers, L. C., Nov 26 2013, In: Biochemistry. 52, 47, p. 8590-8598 9 p.

  Research output: Contribution to journal › Article › peer-review

  • 5-chlorocytosine
  • 5-Methylcytosine
  • Cytosine
  • Oligonucleotides
  • Protons
  7 Scopus citations

• Erratum: Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ (Proceedings of the National Academy of Sciences of the United States of America (2015) 112 (8596-8601) DOI: 10.1073/pnas.1421733112)

  Sohl, C. D., Szymanski, M. R., Mislak, A. C., Shumate, C. K., Amiralaei, S., Schinazi, R. F., Anderson, K. S. & Yin, Y. W., Feb 2 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 5, p. E662

  Research output: Contribution to journal › Comment/debate › peer-review

• Excessive excision of correct nucleotides during DNA synthesis explained by replication hurdles

  Singh, A., Pandey, M., Nandakumar, D., Raney, K. D., Yin, Y. W. & Patel, S. S., Mar 16 2020, In: EMBO Journal. 39, 6, e103367.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Exonucleases
  • DNA-Directed DNA Polymerase
  • Nucleotides
  • DNA
  • Catalytic Domain
  2 Scopus citations

• Exonuclease of human DNA polymerase gamma disengages its strand displacement function

  He, Q., Shumate, C. K., White, M. A., Molineux, I. J. & Yin, Y. W., Nov 2013, In: Mitochondrion. 13, 6, p. 592-601 10 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA Polymerase gamma
  • Exonucleases
  • Mitochondrial DNA
  • DNA
  • Holoenzymes
  14 Scopus citations

• Oxidative damage diminishes mitochondrial DNA polymerase replication fidelity

  Anderson, A. P., Luo, X., Russell, W. & Yin, Y. W., Jan 24 2020, In: Nucleic acids research. 48, 2, p. 817-829 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA Polymerase gamma
  • Exonucleases
  • DNA Replication
  • Mitochondrial DNA
  • Mutation
  7 Scopus citations

• PARP1 depletion improves mitochondrial and heart function in Chagas disease: Effects on POLG dependent mtDNA maintenance

  Wen, J. J., Yin, Y. W. & Garg, N. J., May 2018, In: PLoS pathogens. 14, 5, e1007065.

  Research output: Contribution to journal › Article › peer-review

  • Poly (ADP-Ribose) Polymerase-1
  • Chagas Disease
  • Mitochondrial DNA
  • Maintenance
  • Heart
  15 Scopus citations

• Selective inhibition of bacterial tryptophanyl-tRNA synthetases by indolmycin is mechanism-based

  Williams, T. L., Yin, Y. W. & Carter, C. W., Jan 1 2016, In: Journal of Biological Chemistry. 291, 1, p. 255-265 11 p.

  Research output: Contribution to journal › Article › peer-review

  • indolmycin
  • Tryptophan-tRNA Ligase
  • Tryptophan
  • Adenosine Triphosphate
  • Stabilization
  19 Scopus citations

• Structural Energy Landscapes and Plasticity of the Microstates of Apo Escherichia coli cAMP Receptor Protein

  Chkheidze, R., Evangelista, W., White, M. A., Yin, Y. W. & Lee, J. C., Feb 4 2020, In: Biochemistry. 59, 4, p. 460-470 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Cyclic AMP Receptor Protein
  • Escherichia coli
  • Escherichia coli Proteins
  • Plasticity
  • X ray scattering
  1 Scopus citations

• Structural insight on processivity, human disease and antiviral drug toxicity

  Yin, Y. W., Feb 2011, In: Current Opinion in Structural Biology. 21, 1, p. 83-91 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • DNA Polymerase gamma
  • HIV Reverse Transcriptase
  • Bacteriophage T7
  • DNA-Directed DNA Polymerase
  • DNA-Directed RNA Polymerases
  2 Scopus citations

• The DNA polymerase gamma R953C mutant is associated with antiretroviral therapy-induced mitochondrial toxicity

  Li, M., Mislak, A. C., Foli, Y., Agbosu, E., Bose, V., Bhandari, S., Szymanski, M. R., Shumate, C. K., Yin, Y. W., Anderson, K. S. & Paintsil, E., Sep 1 2016, In: Antimicrobial agents and chemotherapy. 60, 9, p. 5608-5611 4 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA Polymerase gamma
  • 2'-deoxycytidine 5'-triphosphate
  • triphosphoric acid
  • Nucleotides
  • Binding Sites
  3 Scopus citations

• The yeast mitochondrial RNA polymerase and transcription factor complex catalyzes efficient priming of DNA synthesis on single-stranded DNA

  Ramachandran, A., Nandakumar, D., Deshpande, A. P., Lucas, T. P., R-Bhojappa, R., Tang, G. Q., Raney, K., Yin, Y. W. & Patel, S. S., Aug 5 2016, In: Journal of Biological Chemistry. 291, 32, p. 16828-16839 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Mitochondrial RNA
  • Single-Stranded DNA
  • Yeast
  • DNA-Directed RNA Polymerases
  • Yeasts
  8 Scopus citations

• Transcription polymerase-catalyzed emergence of novel RNA replicons

  Jain, N., Blauch, L. R., Szymanski, M. R., Das, R., Tang, S. K. Y., Yin, Y. W. & Fire, A. Z., Apr 10 2020, In: Science. 368, 6487, eaay0688.

  Research output: Contribution to journal › Article › peer-review

  • Replicon
  • RNA
  • Viroids
  • Bacteriophage T7
  • Hepatitis Delta Virus
  1 Scopus citations