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A cocrystal structure of dengue capsid protein in complex of inhibitor
Xia, H., Xie, X., Zou, J., Noble, C. G., Russell, W. K., Holthauzen, L. M. F., Choi, K. H., White, M. A. & Shi, P. Y., Jul 28 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 30, p. 17992-18001 10 p.Research output: Contribution to journal › Article › peer-review
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A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation
Muruato, A. E., Fontes-Garfias, C. R., Ren, P., Garcia-Blanco, M. A., Menachery, V. D., Xie, X. & Shi, P. Y., Dec 1 2020, In: Nature communications. 11, 1, 4059.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19
Xie, X., Muruato, A. E., Zhang, X., Lokugamage, K. G., Fontes-Garfias, C. R., Zou, J., Liu, J., Ren, P., Balakrishnan, M., Cihlar, T., Tseng, C. T. K., Makino, S., Menachery, V. D., Bilello, J. P. & Shi, P. Y., Dec 1 2020, In: Nature communications. 11, 1, 5214.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction
Xia, H., Luo, H., Shan, C., Muruato, A. E., Nunes, B. T. D., Medeiros, D. B. A., Zou, J., Xie, X., Giraldo, M. I., Vasconcelos, P. F. C., Weaver, S. C., Wang, T., Rajsbaum, R. & Shi, P. Y., Dec 1 2018, In: Nature communications. 9, 1, 414.Research output: Contribution to journal › Article › peer-review
95 Scopus citations -
Anti-Zika virus RNAi in neural progenitor cells
Xie, X. & Shi, P. Y., Apr 1 2019, In: Cell Research. 29, 4, p. 261-262 2 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
A single amino acid in nonstructural protein NS4B Confers virulence to dengue virus in AG129 mice through enhancement of viral RNA synthesis
Grant, D., Tan, G. K., Qing, M., Ng, J. K. W., Yip, A., Zou, G., Xie, X., Yuan, Z. Y., Schreiber, J., Schul, W., Shi, P. Y. & Alonso, S., Aug 2011, In: Journal of virology. 85, 15, p. 7775-7787 13 p.Research output: Contribution to journal › Article › peer-review
67 Scopus citations -
A Single-Dose Live-Attenuated Zika Virus Vaccine with Controlled Infection Rounds that Protects against Vertical Transmission
Xie, X., Kum, D. B., Xia, H., Luo, H., Shan, C., Zou, J., Muruato, A. E., Medeiros, D. B. A., Nunes, B. T. D., Dallmeier, K., Rossi, S. L., Weaver, S. C., Neyts, J., Wang, T., Vasconcelos, P. F. C. & Shi, P. Y., Oct 10 2018, In: Cell Host and Microbe. 24, 4, p. 487-499.e5Research output: Contribution to journal › Article › peer-review
23 Scopus citations -
A single-dose plasmid-launched live-attenuated Zika vaccine induces protective immunity
Zou, J., Xie, X., Luo, H., Shan, C., Muruato, A. E., Weaver, S. C., Wang, T. & Shi, P. Y., Oct 2018, In: EBioMedicine. 36, p. 92-102 11 p.Research output: Contribution to journal › Article › peer-review
21 Scopus citations -
A translation inhibitor that suppresses dengue virus in vitro and in vivo
Wang, Q. Y., Kondreddi, R. R., Xie, X., Rao, R., Nilar, S., Xu, H. Y., Qing, M., Chang, D., Dong, H., Yokokawa, F., Lakshminarayana, S. B., Goh, A., Schul, W., Kramer, L., Keller, T. H. & Shi, P. Y., Sep 2011, In: Antimicrobial agents and chemotherapy. 55, 9, p. 4072-4080 9 p.Research output: Contribution to journal › Article › peer-review
39 Scopus citations -
Axl promotes zika virus entry and modulates the antiviral state of human sertoli cells
Strange, D. P., Jiyarom, B., Zarandi, N. P., Xie, X., Baker, C., Sadri-Ardekani, H., Shi, P. Y. & Verma, S., Jul 1 2019, In: mBio. 10, 4, e01372-19.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
A Zika virus envelope mutation preceding the 2015 epidemic enhances virulence and fitness for transmission
Shan, C., Xia, H., Haller, S. L., Azar, S. R., Liu, Y., Liu, J., Muruato, A. E., Chen, R., Rossi, S. L., Wakamiya, M., Vasilakis, N., Pei, R., Fontes-Garfias, C. R., Singh, S. K., Xie, X., Weaver, S. C. & Shi, P. Y., Aug 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 33, p. 20190-20197 8 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Characterization of a candidate tetravalent vaccine based on 2’-O-methyltransferase mutants
Züst, R., Li, S. H., Xie, X., Velumani, S., Chng, M., Toh, Y. X., Zou, J., Dong, H., Shan, C., Pang, J., Qin, C. F., Newell, E. W., Shi, P. Y. & Fink, K., Jan 2018, In: PloS one. 13, 1, e0189262.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Dengue NS2A Protein Orchestrates Virus Assembly
Xie, X., Zou, J., Zhang, X., Zhou, Y., Routh, A. L., Kang, C., Popov, V. L., Chen, X., Wang, Q. Y., Dong, H. & Shi, P. Y., Nov 13 2019, In: Cell Host and Microbe. 26, 5, p. 606-622.e8Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
Design, Synthesis, and Biological Evaluation of Substituted 4,6-Dihydrospiro[[1,2,3]triazolo[4,5- b]pyridine-7,3′-indoline]-2′,5(3 H)-dione Analogues as Potent NS4B Inhibitors for the Treatment of Dengue Virus Infection
Xu, J., Xie, X., Ye, N., Zou, J., Chen, H., White, M. A., Shi, P. Y. & Zhou, J., Sep 12 2019, In: Journal of medicinal chemistry. 62, 17, p. 7941-7960 20 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Design, synthesis and biological evaluation of spiropyrazolopyridone derivatives as potent dengue virus inhibitors
Xu, J., Xie, X., Chen, H., Zou, J., Xue, Y., Ye, N., Shi, P. Y. & Zhou, J., Jun 1 2020, In: Bioorganic and Medicinal Chemistry Letters. 30, 11, 127162.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Envelope protein ubiquitination drives entry and pathogenesis of Zika virus
Giraldo, M. I., Xia, H., Aguilera-Aguirre, L., Hage, A., van Tol, S., Shan, C., Xie, X., Sturdevant, G. L., Robertson, S. J., McNally, K. L., Meade-White, K., Azar, S. R., Rossi, S. L., Maury, W., Woodson, M., Ramage, H., Johnson, J. R., Krogan, N. J., Morais, M. C., Best, S. M. & 2 others, , Sep 17 2020, In: Nature. 585, 7825, p. 414-419 6 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Erratum: Treatment of human glioblastoma with a live attenuated zika virus vaccine candidate (mBio, (2018) 9(5), e01683-18, 10.1128/mBio.01683-18)
Chen, Q., Wu, J., Ye, Q., Ma, F., Zhu, Q., Wu, Y., Shan, C., Xie, X., Li, D., Zhan, X., Li, C., Li, X. F., Qin, X., Zhao, T., Wu, H., Shi, P. Y., Man, J. & Qin, C. F., Mar 1 2019, In: mBio. 10, 2, e00433-19.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Evasion of Type I Interferon by SARS-CoV-2
Xia, H., Cao, Z., Xie, X., Zhang, X., Chen, J. Y. C., Wang, H., Menachery, V. D., Rajsbaum, R. & Shi, P. Y., Oct 6 2020, In: Cell Reports. 33, 1, 108234.Research output: Contribution to journal › Article › peer-review
Open Access24 Scopus citations -
Fragile X mental retardation protein is a zika virus restriction factor that is antagonized by subgenomic flaviviral RNA
Soto-Acosta, R., Xie, X., Shan, C., Baker, C. K., Shi, P. Y., Rossi, S. L., Garcia-Blanco, M. A. & Bradrick, S., Dec 1 2018, In: eLife. 7, e39023.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
Genetic and biochemical characterizations of Zika virus NS2A protein
Zhang, X., Xie, X., Zou, J., Xia, H., Shan, C., Chen, X. & Shi, P. Y., Jan 1 2019, In: Emerging Microbes and Infections. 8, 1, p. 585-602 18 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Identifying optimal capsid duplication length for the stability of reporter flaviviruses
Baker, C., Liu, Y., Zou, J., Muruato, A., Xie, X. & Shi, P. Y., Jan 1 2020, In: Emerging Microbes and Infections. 9, 1, p. 2256-2265 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Inhibition of coronavirus entry in vitro and ex vivo by a lipid-conjugated peptide derived from the sars-cov-2 spike glycoprotein hrc domain
Outlaw, V. K., Bovier, F. T., Mears, M. C., Cajimat, M. N., Zhu, Y., Lin, M. J., Addetia, A., Lieberman, N. A. P., Peddu, V., Xie, X., Shi, P. Y., Greninger, A. L., Gellman, S. H., Bente, D. A., Moscona, A. & Porotto, M., Sep 1 2020, In: mBio. 11, 5, p. 1-14 14 p., e01935-20.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Inhibition of dengue virus by targeting viral NS4B protein
Xie, X., Wang, Q. Y., Xu, H. Y., Qing, M., Kramer, L., Yuan, Z. & Shi, P. Y., Nov 2011, In: Journal of virology. 85, 21, p. 11183-11195 13 p.Research output: Contribution to journal › Article › peer-review
93 Scopus citations -
Inhibition of japanese encephalitis virus infection by flavivirus recombinant e protein domain III
Fan, J., Liu, Y., Xie, X., Zhang, B. & Yuan, Z., Jun 2013, In: Virologica Sinica. 28, 3, p. 152-160 9 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Maternal vaccination and protective immunity against Zika virus vertical transmission
Shan, C., Xie, X., Luo, H., Muruato, A. E., Liu, Y., Wakamiya, M., La, J. H., Chung, J. M., Weaver, S. C., Wang, T. & Shi, P. Y., Dec 1 2019, In: Nature communications. 10, 1, 5677.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Membrane topology and function of dengue virus NS2A protein
Xie, X., Gayen, S., Kang, C. B., Yuan, Z. & Shi, P. Y., Apr 2013, In: Journal of virology. 87, 8, p. 4609-4622 14 p.Research output: Contribution to journal › Article › peer-review
118 Scopus citations -
Potential Mechanisms for Enhanced Zika Epidemic and Disease
Xia, H., Xie, X., Shan, C. & Shi, P. Y., May 11 2018, In: ACS Infectious Diseases. 4, 5, p. 656-659 4 p.Research output: Contribution to journal › Review article › peer-review
5 Scopus citations -
Rational design of a flavivirus vaccine by abolishing viral RNA 2′-O methylation
Li, S. H., Dong, H., Li, X. F., Xie, X., Zhao, H., Deng, Y. Q., Wang, X. Y., Ye, Q., Zhu, S. Y., Wang, H. J., Zhang, B., Leng, Q. B., Zuest, R., Qin, E. D., Qin, C. F. & Shi, P. Y., May 2013, In: Journal of virology. 87, 10, p. 5812-5819 8 p.Research output: Contribution to journal › Article › peer-review
67 Scopus citations -
Repurposing an HIV Drug for Zika Virus Therapy
Xie, X. & Shi, P. Y., Dec 4 2019, In: Molecular Therapy. 27, 12, p. 2064-2066 3 p.Research output: Contribution to journal › Short survey › peer-review
1 Scopus citations -
Role of microglia in the dissemination of zika virus from mother to fetal brain
Xu, P., Shan, C., Dunn, T. J., Xie, X., Xia, H., Gao, J., Labastida, J. A., Zou, J., Villarreal, P. P., Schlagal, C. R., Yu, Y., Vargas, G., Rossi, S. L., Vasilakis, N., Shi, P. Y., Weaver, S. C. & Wu, P., Jul 2020, In: PLoS neglected tropical diseases. 14, 7, p. 1-21 21 p., e0008413.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Spike mutation D614G alters SARS-CoV-2 fitness
Plante, J. A., Liu, Y., Liu, J., Xia, H., Johnson, B. A., Lokugamage, K. G., Zhang, X., Muruato, A. E., Zou, J., Fontes-Garfias, C. R., Mirchandani, D., Scharton, D., Bilello, J. P., Ku, Z., An, Z., Kalveram, B., Freiberg, A. N., Menachery, V. D., Xie, X., Plante, K. S. & 2 others, , 2020, (Accepted/In press) In: Nature.Research output: Contribution to journal › Article › peer-review
35 Scopus citations -
Topoisomerase III-β is required for efficient replication of positive-sense RNA viruses
Prasanth, K. R., Hirano, M., Fagg, W. S., McAnarney, E. T., Shan, C., Xie, X., Hage, A., Pietzsch, C. A., Bukreyev, A., Rajsbaum, R., Shi, P. Y., Bedford, M. T., Bradrick, S. S., Menachery, V. & Garcia-Blanco, M. A., Oct 2020, In: Antiviral research. 182, 104874.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Treatment of human glioblastoma with a live attenuated Zika virus vaccine candidate
Chen, Q., Wu, J., Ye, Q., Ma, F., Zhu, Q., Wu, Y., Shan, C., Xie, X., Li, D., Zhan, X., Li, C., Li, X. F., Qin, X., Zhao, T., Wu, H., Shi, P. Y., Man, J. & Qin, C. F., Sep 1 2018, In: mBio. 9, 5, e01683-18.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication
Poh, M. K., Shui, G., Xie, X., Shi, P. Y., Wenk, M. R. & Gu, F., Jan 2012, In: Antiviral research. 93, 1, p. 191-198 8 p.Research output: Contribution to journal › Article › peer-review
72 Scopus citations -
Using a virion assembly-defective dengue virus as a vaccine approach
Shan, C., Xie, X., Zou, J., Züst, R., Zhang, B., Ambrose, R., Mackenzie, J., Fink, K. & Shi, P. Y., Nov 1 2018, In: Journal of virology. 92, 21, e01002.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Using recombination-dependent lethal mutations to stabilize reporter flaviviruses for rapid serodiagnosis and drug discovery
Baker, C., Xie, X., Zou, J., Muruato, A., Fink, K. & Shi, P. Y., Jul 2020, In: EBioMedicine. 57, 102838.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Zika virus NS2A-mediated virion assembly
Zhang, X., Xie, X., Xia, H., Zou, J., Huang, L., Popov, V. L., Chen, X. & Shi, P. Y., 2019, In: mBio. 10, 5, e02375-19.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Zika Virus Vaccine: Progress and Challenges
Shan, C., Xie, X. & Shi, P. Y., Jul 11 2018, In: Cell Host and Microbe. 24, 1, p. 12-17 6 p.Research output: Contribution to journal › Review article › peer-review
36 Scopus citations