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• 3-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics

  Abdollahi Govar, A., Törő, G., Szaniszlo, P., Pavlidou, A., Bibli, S. I., Thanki, K., Resto, V. A., Chao, C., Hellmich, M. R., Szabo, C., Papapetropoulos, A. & Módis, K., Feb 1 2020, In: British Journal of Pharmacology. 177, 4, p. 866-883 18 p.

  Research output: Contribution to journal › Article › peer-review

  • 3-mercaptopyruvic acid
  • Energy Metabolism
  • Endothelial Cells
  • Hydrogen Sulfide
  • Small Interfering RNA
  9 Scopus citations

• Apigenin Decreases Acinar Cell Damage in Pancreatitis

  Mrazek, A. A., Bhatia, V., Falzon, M., Spratt, H., Chao, C. & Hellmich, M. R., May 1 2019, In: Pancreas. 48, 5, p. 711-718 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Apigenin
  • Acinar Cells
  • Pancreatitis
  • Parathyroid Hormone-Related Protein
  • Transforming Growth Factors
  2 Scopus citations

• Apigenin inhibits pancreatic stellate cell activity in pancreatitis

  Mrazek, A. A., Porro, L. J., Bhatia, V., Falzon, M., Spratt, H., Zhou, J., Chao, C. & Hellmich, M. R., Jun 1 2015, In: Journal of Surgical Research. 196, 1, p. 8-16 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Pancreatic Stellate Cells
  • Apigenin
  • Pancreatitis
  • Chronic Pancreatitis
  • Fibrosis
  23 Scopus citations

• Bone morphogenetic protein signaling protects against cerulein-induced pancreatic fibrosis

  Gao, X., Cao, Y., Staloch, D. A., Gonzales, M. A., Aronson, J. F., Chao, C., Hellmich, M. R. & Ko, T. C., Feb 21 2014, In: PloS one. 9, 2, e89114.

  Research output: Contribution to journal › Article › peer-review

  • bone morphogenetic proteins
  • Ceruletide
  • fibrosis
  • Bone Morphogenetic Proteins
  • Pancreatic Stellate Cells
  17 Scopus citations

• CD133+ colon cancer cells are more interactive with the tumor microenvironment than CD133-cells

  Chao, C., Carmical, J. R., Ives, K. L., Wood, T. G., Aronson, J. F., Gomez, G. A., Djukom, C. D. & Hellmich, M. R., Mar 2012, In: Laboratory Investigation. 92, 3, p. 420-436 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Tumor Microenvironment
  • Colonic Neoplasms
  • Fibroblasts
  • Carcinoma
  • Genes
  32 Scopus citations

• Colorectal cancer-associated fibroblasts are genotypically distinct

  Mrazek, A. A., Carmical, J. R., Wood, T. G., Hellmich, M. R., Eltorky, M. & Chao, C., Jan 1 2014, In: Current Cancer Therapy Reviews. 10, 3, p. 97-218 122 p.

  Research output: Contribution to journal › Article › peer-review

  • Cancer-Associated Fibroblasts
  • Colorectal Neoplasms
  • Fibroblasts
  • Carcinoma
  • Methylation
  12 Scopus citations

• Corrigendum to "Role of parathyroid hormone-related protein in the pro-inflammatory and pro-fibrogenic response associated with acute pancreatitis" [Regul Pept 175 (2012) 49-60]

  Bhatia, V., Kim, S. O. K., Aronson, J., Chao, C., Hellmich, M. & Falzon, M., Jun 1 2014, In: Regulatory Peptides. 192, p. 59 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review
  2 Scopus citations

• Design, synthesis, and characterization of novel apigenin analogues that suppress pancreatic stellate cell proliferation in vitro and associated pancreatic fibrosis in vivo

  Chen, H., Mrazek, A. A., Wang, X., Ding, C., Ding, Y., Porro, L. J., Liu, H., Chao, C., Hellmich, M. R. & Zhou, J., Jul 1 2014, In: Bioorganic and Medicinal Chemistry. 22, 13, p. 3393-3404 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Pancreatic Stellate Cells
  • Cell proliferation
  • Apigenin
  • Chronic Pancreatitis
  • Fibrosis
  25 Scopus citations

• Dual inhibition of PI3K and mTOR signaling pathways decreases human pancreatic neuroendocrine tumor metastatic progression

  Djukom, C., Porro, L. J., Mrazek, A., Townsend, C. M., Hellmich, M. R. & Chao, C., Jan 2014, In: Pancreas. 43, 1, p. 88-92 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Everolimus
  • Neuroendocrine Tumors
  • TOR Serine-Threonine Kinases
  • Phosphatidylinositol 3-Kinase
  • 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
  15 Scopus citations

• Effect of S-adenosyl-L-methionine (SAM), an allosteric activator of cystathionine-β-synthase (CBS) on colorectal cancer cell proliferation and bioenergetics in vitro

  Módis, K., Coletta, C., Asimakopoulou, A., Szczesny, B., Chao, C., Papapetropoulos, A., Hellmich, M. R. & Szabo, C., Sep 15 2014, In: Nitric Oxide - Biology and Chemistry. 41, p. 146-156 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Cystathionine
  • Cell proliferation
  • S-Adenosylmethionine
  • Energy Metabolism
  • Colorectal Neoplasms
  50 Scopus citations

• Gastrointestinal Peptides: Gastrin, Cholecystokinin, Somatostatin, and Ghrelin

  Chao, C. & Hellmich, M. R., Dec 1 2012, Physiology of the Gastrointestinal Tract. Elsevier Inc., Vol. 1. p. 115-154 40 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
  2 Scopus citations

• Gremlin is a key pro-fibrogenic factor in chronic pancreatitis

  Staloch, D., Gao, X., Liu, K., Xu, M., Feng, X., Aronson, J. F., Falzon, M., Greeley, G. H., Rastellini, C., Chao, C., Hellmich, M. R., Cao, Y. & Ko, T. C., Oct 3 2015, In: Journal of Molecular Medicine. 93, 10, p. 1085-1093 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Chronic Pancreatitis
  • Bone Morphogenetic Proteins
  • Transforming Growth Factors
  • Pancreatic Stellate Cells
  • Mouse Grem1 protein
  22 Scopus citations

• Indications for sentinel lymph node biopsy in multifocal and multicentric breast cancer

  Moody, L. C., Wen, X., Washington, T. M. & Chao, C., Sep 2012, In: Surgery (United States). 152, 3, p. 389-396 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Sentinel Lymph Node Biopsy
  • Breast Neoplasms
  • Contraindications
  • Meta-Analysis
  • Validation Studies
  15 Scopus citations

• Malignant phyllodes tumor of the breast: A case report

  Al-Zoubaidi, M., Qiu, S., Bonnen, M., Joyner, M., Roehl, K., Silva, C. & Chao, C., 2011, In: Open Breast Cancer Journal. 3, p. 45-48 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Phyllodes Tumor
  • Breast Neoplasms
  • Stromal Cells
  • Breast
  2 Scopus citations

• Medical Students’ Evaluation of Scientific Evidence and Their Justifications for Their Clinical Decisions: a Pilot Study

  Cestone, C., Lewis, R., Aronson, J. F. & Chao, C., Dec 15 2018, In: Medical Science Educator. 28, 4, p. 587-590 4 p.

  Research output: Contribution to journal › Article › peer-review

  • clinical decisions
  • Medical Students
  • medical student
  • Clinical Decision-Making
  • evaluation

• Melanoma

  Brown, K. M. & Chao, C., Oct 1 2014, In: Surgical Clinics of North America. 94, 5, p. xv-xvi

  Research output: Contribution to journal › Editorial › peer-review

• Overview of Personalized Medicine in GI Cancers

  Chao, C., Sep 2012, In: Journal of Gastrointestinal Surgery. 16, 9, p. 1641-1644 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Gastrointestinal Neoplasms
  • Precision Medicine
  • Tumor Biomarkers
  • Drug Therapy
  • Neoplasms
  2 Scopus citations

• Patient-derived xenografts from colorectal carcinoma: A temporal and hierarchical study of murine stromal cell replacement

  Chao, C., Widen, S. G., Wood, T. G., Zatarain, J. R., Johnson, P., Gajjar, A., Gomez, G., Qiu, S., Thompson, J., Spratt, H. & Hellmich, M. R., Jul 2017, In: Anticancer Research. 37, 7, p. 3405-3412 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Time and Motion Studies
  • Stromal Cells
  • Heterografts
  • Colorectal Neoplasms
  • Nude Mice
  11 Scopus citations

• Pharmacological inhibition and genetic knockdown of exchange protein directly activated by cAMP 1 reduce pancreatic cancer metastasis in vivos

  Almahariq, M., Chao, C., Mei, F. C., Hellmich, M. R., Patrikeev, I., Motamedi, M. & Cheng, X., Feb 1 2015, In: Molecular pharmacology. 87, 2, p. 142-149 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Pancreatic Neoplasms
  • Adenocarcinoma
  • Pharmacology
  • Neoplasm Metastasis
  • Proteins
  28 Scopus citations

• Raf-1 kinase inhibitory protein (RKIP) mediates ethanol-induced sensitization of secretagogue signaling in pancreatic acinar cells

  Kim, S. O., Ives, K. L., Wang, X., Davey, R. A., Chao, C. & Hellmich, M. R., Sep 28 2012, In: Journal of Biological Chemistry. 287, 40, p. 33377-33388 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Proto-Oncogene Proteins c-raf
  • Secretagogues
  • Acinar Cells
  • Cholecystokinin
  • Ethanol
  8 Scopus citations

• Regulation of bombesin-stimulated cyclooxygenase-2 expression in prostate cancer cells

  Wen, X., Chao, C., Ives, K. & Hellmich, M. R., Jul 11 2011, In: BMC Molecular Biology. 12, 29.

  Research output: Contribution to journal › Article › peer-review

  • Bombesin
  • Cyclooxygenase 2
  • Prostatic Neoplasms
  • Phosphatidylinositol 3-Kinases
  • NF-kappa B
  8 Scopus citations

• Role of parathyroid hormone-related protein in the pro-inflammatory and pro-fibrogenic response associated with acute pancreatitis

  Bhatia, V., Kim, S. O. K., Aronson, J. F., Chao, C., Hellmich, M. R. & Falzon, M., Apr 10 2012, In: Regulatory Peptides. 175, 1-3, p. 49-60 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Parathyroid Hormone-Related Protein
  • Pancreatitis
  • Ceruletide
  • Acinar Cells
  • Procollagen
  15 Scopus citations

• Surviving Cutaneous Melanoma: A Clinical Review of Follow-up Practices, Surveillance, and Management of Recurrence

  Mrazek, A. A. & Chao, C., Oct 1 2014, In: Surgical Clinics of North America. 94, 5, p. 989-1002 14 p.

  Research output: Contribution to journal › Review article › peer-review

  • Practice Management
  • Melanoma
  • Survivorship
  • Recurrence
  • Skin
  19 Scopus citations

• Suspected liposarcoma of the hip by magnetic resonance imaging 3 years after large-volume fat grafting for buttock augmentation

  Bauer, J. D., Riascos, R., Qiu, S. & Chao, C., Sep 1 2014, In: Aesthetic surgery journal / the American Society for Aesthetic Plastic surgery. 34, 7, p. NP66-NP69

  Research output: Contribution to journal › Article › peer-review

• The therapeutic potential of cystathionine β-Synthetase/hydrogen sulfide inhibition in cancer

  Hellmich, M. R., Coletta, C., Chao, C. & Szabo, C., Feb 10 2015, In: Antioxidants and Redox Signaling. 22, 5, p. 424-448 25 p.

  Research output: Contribution to journal › Review article › peer-review

  • Cystathionine beta-Synthase
  • Hydrogen Sulfide
  • Cells
  • Tumors
  • Energy Metabolism
  114 Scopus citations

• Triple negative breast cancer: A review of clinicopathologic characteristics and treatment options

  Porro, L. J., Mrazek, A. A., Washington, T. M. & Chao, C., May 12 2014, In: Open Breast Cancer Journal. 6, 1, p. 1-8 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Triple Negative Breast Neoplasms
  • Breast Neoplasms
  • estrophilin
  • Hormones
  • Poly(ADP-ribose) Polymerase Inhibitors
  1 Scopus citations

• Upregulation of cystathionine-β-synthase in colonic epithelia reprograms metabolism and promotes carcinogenesis

  Phillips, CN. M., Zatarain, J. R., Nicholls, M. E., Porter, C., Widen, S. G., Thanki, K., Johnson, P., Jawad, M. U., Moyer, M. P., Randall, J. W., Hellmich, J. L., Maskey, M., Qiu, S., Wood, T. G., Druzhyna, N., Szczesny, B., Módis, K., Szabo, C., Chao, C. & Hellmich, M. R., Nov 1 2017, In: Cancer Research. 77, 21, p. 5741-5754 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Cystathionine
  • Carcinogenesis
  • Epithelium
  • Up-Regulation
  • Genes
  30 Scopus citations