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• A Hematogenously Disseminated Orientia tsutsugamsushi-Infected Murine Model of Scrub Typhus

  Shelite, T. R., Saito, T. B., Mendell, N. L., Gong, B., Xu, G., Soong, L., Valbuena, G., Bouyer, D. H. & Walker, D. H., Jul 2014, In: PLoS neglected tropical diseases. 8, 7, e2966.

  Research output: Contribution to journal › Article › peer-review

  • Scrub Typhus
  • Orientia tsutsugamushi
  • Infection
  • Inbred C57BL Mouse
  • Trombiculidae
  25 Scopus citations

• An Intradermal Inoculation Mouse Model for Immunological Investigations of Acute Scrub Typhus and Persistent Infection

  Soong, L., Mendell, N. L., Olano, J. P., Rockx-Brouwer, D., Xu, G., Goez-Rivillas, Y., Drom, C., Shelite, T. R., Valbuena, G., Walker, D. H. & Bouyer, D. H., Aug 1 2016, In: PLoS neglected tropical diseases. 10, 8, e0004884.

  Research output: Contribution to journal › Article › peer-review

  • Immunological Models
  • Scrub Typhus
  • Infection
  • Orientia tsutsugamushi
  • Interleukin-9
  15 Scopus citations

• A variant in the promoter of MBL2 is associated with protection against visceral leishmaniasis in Morocco

  Hamdi, S., Ejghal, R., Idrissi, M., Ezzikouri, S., Hida, M., Soong, L., Amarouch, H. & Lemrani, M., Jan 1 2013, In: Infection, Genetics and Evolution. 13, 1, p. 162-167 6 p.

  Research output: Contribution to journal › Article › peer-review

  • leishmaniasis
  • Mannose-Binding Lectin
  • Morocco
  • visceral leishmaniasis
  • Visceral Leishmaniasis
  8 Scopus citations

• CD4⁺ T cell-dependent macrophage activation modulates sustained ps exposure on intracellular amastigotes of leishmania amazonensis

  Wanderley, J. L. M., Deolindo, P., Carlsen, E., Portugal, A. B., DaMatta, R. A., Barcinski, M. A. & Soong, L., 2019, In: Frontiers in Cellular and Infection Microbiology. 9, APR, 105.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Leishmania
  • Phosphatidylserines
  • Macrophage Activation
  • T-Lymphocytes
  • Parasites
  5 Scopus citations

• CD8⁺T cells provide immune protection against murine disseminated endotheliotropic Orientia tsutsugamushi infection

  Xu, G., Mendell, N. L., Liang, Y., Shelite, T. R., Goez-Rivillas, Y., Soong, L., Bouyer, D. H. & Walker, D. H., Jul 19 2017, In: PLoS neglected tropical diseases. 11, 7, e0005763.

  Research output: Contribution to journal › Article › peer-review

  • Scrub Typhus
  • Orientia tsutsugamushi
  • T-Lymphocytes
  • Bacterial Load
  • Immunity
  15 Scopus citations

• Differential, type i interferon-mediated autophagic trafficking of hepatitis C virus proteins in mouse liver

  Desai, M. M., Gong, B., Chan, T., Davey, R. A., Soong, L., Kolokoltsov, A. A. & Sun, J., Aug 2011, In: Gastroenterology. 141, 2, p. 674-685.e6

  Research output: Contribution to journal › Article › peer-review

  • Hepacivirus
  • Interferon-beta
  • Interferons
  • Antiviral Agents
  • Mitochondria
  27 Scopus citations

• Differential microbicidal effects of human histone proteins H2A and H2B on Leishmania promastigotes and amastigotes

  Wang, Y., Chen, Y., Xin, L., Beverley, S. M., Carlsen, E. D., Popov, V., Chang, K. P., Wang, M. & Soong, L., Mar 2011, In: Infection and immunity. 79, 3, p. 1124-1133 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Leishmania
  • Histones
  • Proteins
  • lipophosphonoglycan
  • Recombinant Proteins
  53 Scopus citations

• Downregulation of microRNA-107 in intestinal CD11c⁺ myeloid cells in response to microbiota and proinflammatory cytokines increases IL-23p19 expression

  Xue, X., Cao, A. T., Cao, X., Yao, S., Carlsen, E. D., Soong, L., Liu, C. G., Liu, X., Liu, Z., Duck, L. W., Elson, C. O. & Cong, Y., Mar 2014, In: European Journal of Immunology. 44, 3, p. 673-682 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-23 Subunit p19
  • Myeloid Cells
  • Microbiota
  • MicroRNAs
  • Down-Regulation
  37 Scopus citations

• Early IL-17 production by intrahepatic T cells is important for adaptive immune responses in viral hepatitis

  Hou, L., Jie, Z., Desai, M., Liang, Y., Soong, L., Wang, T. & Sun, J., Jan 15 2013, In: Journal of Immunology. 190, 2, p. 621-629 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-17
  • Adaptive Immunity
  • Hepatitis
  • Interleukin-7
  • T-Lymphocytes
  37 Scopus citations

• Hepatocyte growth factor in dampening liver immune-mediated pathology in acute viral hepatitis without compromising antiviral activity

  Aguilar-Valenzuela, R., Carlsen, E. D., Liang, Y., Soong, L. & Sun, J., Apr 2014, In: Journal of Gastroenterology and Hepatology (Australia). 29, 4, p. 878-886 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Hepatocyte Growth Factor
  • Hepatitis
  • Antiviral Agents
  • Pathology
  • Liver
  6 Scopus citations

• IFNα/β and autophagy: Tug-of-war between HCV and the host

  Sun, J., Desai, M. M., Soong, L. & Ou, J. H. J., Nov 2011, In: Autophagy. 7, 11, p. 1394-1396 3 p.

  Research output: Contribution to journal › Short survey › peer-review

  • Armed Conflicts
  • Autophagy
  • Hepacivirus
  • Antiviral Agents
  • Viral Nonstructural Proteins
  14 Scopus citations

• IL-33-Dependent Endothelial Activation Contributes to Apoptosis and Renal Injury in Orientia tsutsugamushi-Infected Mice

  Shelite, T. R., Liang, Y., Wang, H., Mendell, N. L., Trent, B. J., Sun, J., Gong, B., Xu, G., Hu, H., Bouyer, D. H. & Soong, L., Mar 4 2016, In: PLoS neglected tropical diseases. 10, 3, e0004467.

  Research output: Contribution to journal › Article › peer-review

  • Orientia tsutsugamushi
  • Interleukin-33
  • Apoptosis
  • Endothelial Cells
  • Kidney
  19 Scopus citations

• IL-33 induces immunosuppressive neutrophils via a type 2 innate lymphoid cell/IL-13/STAT6 axis and protects the liver against injury in LCMV infection-induced viral hepatitis

  Liang, Y., Yi, P., Yuan, D. M. K., Jie, Z., Kwota, Z., Soong, L., Cong, Y. & Sun, J., Feb 1 2019, In: Cellular and Molecular Immunology. 16, 2, p. 126-137 12 p.

  Research output: Contribution to journal › Article › peer-review

  • STAT6 Transcription Factor
  • Interleukin-33
  • Lymphocytic choriomeningitis virus
  • Interleukin-13
  • Hepatitis
  10 Scopus citations

• IL-33 induces nuocytes and modulates liver injury in viral hepatitis

  Liang, Y., Jie, Z., Hou, L., Aguilar-Valenzuela, R., Vu, D., Soong, L. & Sun, J., Jun 1 2013, In: Journal of Immunology. 190, 11, p. 5666-5675 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-33
  • Hepatitis
  • Liver
  • Wounds and Injuries
  • Alarmins
  53 Scopus citations

• Immunomodulatory and antibacterial effects of cystatin 9 against Francisella tularensis

  Eaves-Pyles, T., Patel, J., Arigi, E., Cong, Y., Cao, A., Garg, N., Dhiman, M., Pyles, R. B., Arulanandam, B., Miller, A. L., Popov, V. L., Soong, L., Carlsen, E. D., Coletta, C., Szabo, C. & Almeida, I. C., 2013, In: Molecular Medicine. 19, 1, p. 263-275 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Cystatins
  • Francisella tularensis
  • Macrophages
  • Cysteine Proteinase Inhibitors
  • Phagosomes
  7 Scopus citations

• Immunotherapy using anti-PD-1 and anti-PD-L1 in Leishmania amazonensis-infected BALB/c mice reduce parasite load

  da Fonseca-Martins, A. M., Ramos, T. D., Pratti, J. E. S., Firmino-Cruz, L., Gomes, D. C. O., Soong, L., Saraiva, E. M. & de Matos Guedes, H. L., Dec 1 2019, In: Scientific reports. 9, 1, 20275.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Parasite Load
  • Leishmania
  • Immunotherapy
  • T-Lymphocytes
  • Diffuse Cutaneous Leishmaniasis
  3 Scopus citations

• Interferon gamma in leishmaniasis

  Kima, P. E. & Soong, L., 2013, In: Frontiers in immunology. 4, JUN, Article 156.

  Research output: Contribution to journal › Short survey › peer-review

  • Leishmaniasis
  • Leishmania
  • Interferon-gamma
  • Parasites
  • Infection
  48 Scopus citations

• Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in viral infection

  Jie, Z., Liang, Y., Hou, L., Dong, C., Iwakura, Y., Soong, L., Cong, Y. & Sun, J., Apr 1 2014, In: Journal of Immunology. 192, 7, p. 3289-3300 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-17
  • Virus Diseases
  • Lymphocytes
  • T-Lymphocytes
  • Adenoviridae Infections
  28 Scopus citations

• Leishmania amazonensis Amastigotes Highly Express a Tryparedoxin Peroxidase Isoform That Increases Parasite Resistance to Macrophage Antimicrobial Defenses and Fosters Parasite Virulence

  Henard, C. A., Carlsen, E. D., Hay, C., Kima, P. E. & Soong, L., Jul 2014, In: PLoS neglected tropical diseases. 8, 7, e3000.

  Research output: Contribution to journal › Article › peer-review

  • tryparedoxin peroxidase
  • Leishmania
  • Nitric Oxide Synthase Type II
  • Virulence
  • Parasites
  17 Scopus citations

• Leishmania amazonensis amastigotes trigger neutrophil activation but resist neutrophil microbicidal mechanisms

  Carlsen, E. D., Hay, C., Henard, C. A., Popov, V., Garg, N. J. & Soong, L., Nov 2013, In: Infection and immunity. 81, 11, p. 3966-3974 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Neutrophil Activation
  • Leishmania
  • Neutrophils
  • Parasites
  • Axenic Culture
  24 Scopus citations

• MTOR mediates IL-23 induction of neutrophil IL-17 and IL-22 production

  Chen, F., Cao, A., Yao, S., Evans-Marin, H. L., Liu, H., Wu, W., Carlsen, E. D., Dann, S. M., Soong, L., Sun, J., Zhao, Q. & Cong, Y., May 15 2016, In: Journal of Immunology. 196, 10, p. 4390-4399 10 p.

  Research output: Contribution to journal › Article › peer-review

  • interleukin-22
  • Interleukin-23
  • Interleukin-17
  • Neutrophils
  • Colitis
  45 Scopus citations

• Multistrain influenza protection induced by a nanoparticulate mucosal immunotherapeutic

  Tai, W., Roberts, L., Seryshev, A., Gubatan, J. M., Bland, C. S., Zabriskie, R., Kulkarni, S., Soong, L., Mbawuike, I., Gilbert, B., Kheradmand, F. & Corry, D. B., Mar 2011, In: Mucosal Immunology. 4, 2, p. 197-207 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Human Influenza
  • Pandemics
  • Epidemics
  • Antiviral Agents
  • Viruses
  22 Scopus citations

• Outcomes of Congenital Zika Disease Depend on Timing of Infection and Maternal-Fetal Interferon Action

  Chen, J., Liang, Y., Yi, P., Xu, L., Hawkins, H. K., Rossi, S. L., Soong, L., Cai, J., Menon, R. & Sun, J., Nov 7 2017, In: Cell Reports. 21, 6, p. 1588-1599 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Viruses
  • Interferons
  • Mothers
  • Infection
  46 Scopus citations

• Parenchymal expression of CD40 exacerbates adenovirus-induced hepatitis in mice

  Yan, J., Jie, Z., Hou, L., Wanderley, J. L., Soong, L., Gupta, S., Qiu, S., Chan, T. & Sun, J., May 2011, In: Hepatology. 53, 5, p. 1455-1467 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Adenoviridae
  • Hepatitis
  • Liver
  • Cre recombinase
  • Major Histocompatibility Complex
  12 Scopus citations

• Phosphatidylserine exposure on the surface of Leishmania amazonensis amastigotes modulates in vivo infection and dendritic cell function

  Wanderley, J. L. M., Thorpe, P. E., Barcinski, M. A. & Soong, L., Mar 2013, In: Parasite Immunology. 35, 3-4, p. 109-119 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Leishmania
  • Phosphatidylserines
  • Dendritic Cells
  • Parasites
  • Leishmaniasis
  15 Scopus citations

• Priming and activation of inflammasome by canarypox virus vector alvac via the CGAS/IFI16-sting-type I IFN pathway and AIM2 sensor

  Liu, F., Niu, Q., Fan, X., Liu, C., Zhang, J., Wei, Z., Hou, W., Kanneganti, T. D., Robb, M. L., Kim, J. H., Michael, N. L., Sun, J., Soong, L. & Hu, H., Nov 1 2017, In: Journal of Immunology. 199, 9, p. 3293-3305 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Inflammasomes
  • Bites and Stings
  • ALVAC vaccine
  • Vaccines
  • Poxviridae
  16 Scopus citations

• Retinoic acid regulates immune responses by promoting IL-22 and modulating S100 proteins in viral hepatitis

  Jie, Z., Liang, Y., Yi, P., Tang, H., Soong, L., Cong, Y., Zhang, K. & Sun, J., May 1 2017, In: Journal of Immunology. 198, 9, p. 3448-3460 13 p.

  Research output: Contribution to journal › Article › peer-review

  • interleukin-22
  • S100 Proteins
  • Tretinoin
  • Hepatitis
  • T-Lymphocytes
  16 Scopus citations

• Scrub Typhus Pathogenesis: Innate Immune Response and Lung Injury During Orientia tsutsugamushi Infection

  Trent, B., Fisher, J. & Soong, L., Sep 6 2019, In: Frontiers in Microbiology. 10, 2065.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Scrub Typhus
  • Lung Injury
  • Innate Immunity
  • Adult Respiratory Distress Syndrome
  • Lung
  3 Scopus citations

• Sequential Dysfunction and Progressive Depletion of Candida albicans-Specific CD4 T Cell Response in HIV-1 Infection

  Liu, F., Fan, X., Auclair, S., Ferguson, M., Sun, J., Soong, L., Hou, W., Redfield, R. R., Birx, D. L., Ratto-Kim, S., Robb, M. L., Kim, J. H., Michael, N. L. & Hu, H., Jun 2016, In: PLoS pathogens. 12, 6, e1005663.

  Research output: Contribution to journal › Article › peer-review

  • Candida albicans
  • HIV Infections
  • HIV-1
  • HIV
  • T-Lymphocytes
  14 Scopus citations

• Sphingolipid degradation by Leishmania major is required for its resistance to acidic pH in the mammalian host

  Xu, W., Xin, L., Soong, L. & Zhang, K., Aug 2011, In: Infection and immunity. 79, 8, p. 3377-3387 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Leishmania major
  • Sphingolipids
  • Leishmania
  • Nitrosative Stress
  • Parasites
  19 Scopus citations

• Splenic CD4⁺ T cells in progressive visceral leishmaniasis show a mixed effector-regulatory phenotype and impair macrophage effector function through inhibitory receptor expression

  Medina-Colorado, A. A., Osorio, E. Y., Saldarriaga, O. A., Travi, B. L., Kong, F., Spratt, H., Soong, L. & Melby, P. C., Jan 2017, In: PloS one. 12, 1, e0169496.

  Research output: Contribution to journal › Article › peer-review

  • Macrophages
  • T-cells
  • visceral leishmaniasis
  • Visceral Leishmaniasis
  • T-lymphocytes
  19 Scopus citations

• Strong Type 1, but Impaired Type 2, Immune Responses Contribute to Orientia tsutsugamushi-Induced Pathology in Mice

  Soong, L., Wang, H., Shelite, T. R., Liang, Y., Mendell, N. L., Sun, J., Gong, B., Valbuena, G. A., Bouyer, D. H. & Walker, D. H., Sep 1 2014, In: PLoS neglected tropical diseases. 8, 9

  Research output: Contribution to journal › Article › peer-review

  • Orientia tsutsugamushi
  • Scrub Typhus
  • Angiopoietin-2
  • Pathology
  • Angiopoietin-1
  22 Scopus citations

• The burden of leishmaniasis in Iran, acquired from the global burden of disease during 1990-2010

  Badirzadeh, A., Mohebali, M., Asadgol, Z., Soong, L., Zeinali, M., Mokhayeri, Y., Shirzadi, M. R. & Spotin, A., Sep 1 2017, In: Asian Pacific Journal of Tropical Disease. 7, 9, p. 513-518 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Global Burden of Disease
  • Leishmaniasis
  • Iran
  • Visceral Leishmaniasis
  • Quality-Adjusted Life Years
  13 Scopus citations

• The co-stimulatory effects of MyD88-dependent toll-like receptor signaling on activation of murine γδ T Cells

  Zhang, J., Wang, J., Pang, L., Xie, G., Welte, T., Saxena, V., Wicker, J., Mann, B., Soong, L., Barrett, A., Born, W., O'Brien, R. & Wang, T., Sep 18 2014, In: PloS one. 9, 9, A1350.

  Research output: Contribution to journal › Article › peer-review

  • T-cells
  • Toll-like receptors
  • Toll-Like Receptors
  • T-lymphocytes
  • Chemical activation
  12 Scopus citations

• The magnitude of CD4⁺ T-cell activation rather than TCR diversity determines the outcome of Leishmania infection in mice

  Xin, L., Wanderley, J. L., Wang, Y., Vargas-Inchaustegui, D. A. & Soong, L., Mar 2011, In: Parasite Immunology. 33, 3, p. 170-180 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Leishmaniasis
  • T-Cell Antigen Receptor
  • T-Lymphocytes
  • Infection
  • Cross Protection
  11 Scopus citations

• The MET Receptor Tyrosine Kinase Confers Repair of Murine Pancreatic Acinar Cells following Acute and Chronic Injury

  Gaziova, I., Jackson, D., Boor, P. J., Carter, D., Cruz-Monserrate, Z., Elferink, C. J., Joshi, A. D., Kaphalia, B., Logsdon, C. D., De Castro, K. P., Soong, L., Tao, X., Qiu, S. & Elferink, L. A., Oct 2016, In: PloS one. 11, 10, 0165485.

  Research output: Contribution to journal › Article › peer-review

  • Proto-Oncogene Proteins c-met
  • acinar cells
  • Acinar Cells
  • tyrosine
  • phosphotransferases (kinases)
  1 Scopus citations

• Type 1-skewed neuroinflammation and vascular damage associated with Orientia tsutsugamushi infection in mice

  Soong, L., Shelite, H. T. R., Xing, Y., Kodakandla, H., Liang, Y., Trent, B. J., Horton, P., Smith, K. C., Zhao, Z., Sun, J., Bouyer, D. H. & Cai, J., Jul 24 2017, In: PLoS neglected tropical diseases. 11, 7, e0005765.

  Research output: Contribution to journal › Article › peer-review

  • Scrub Typhus
  • Orientia tsutsugamushi
  • Phagocytes
  • Blood Vessels
  • Brain
  5 Scopus citations

• Viral retinopathy in experimental models of zika infection

  Zhao, Z., Yang, M., Azar, S. R., Soong, L., Weaver, S. C., Sun, J., Chen, Y., Rossi, S. L. & Cai, J., Aug 2017, In: Investigative Ophthalmology and Visual Science. 58, 10, p. 4075-4085 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Theoretical Models
  • Infection
  • Retinal Pigments
  • Eye
  31 Scopus citations

• γδ T cells as a major source of IL-17 production during age-dependent RPE degeneration

  Zhao, Z., Xu, P., Jie, Z., Zuo, Y., Yu, B., Soong, L., Sun, J., Chen, Y. & Cai, J., 2014, In: Investigative ophthalmology & visual science. 55, 10, p. 6580-6589 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Retinal Pigment Epithelium
  • Interleukin-17
  • Macular Degeneration
  • T-Lymphocytes
  • Retina
  21 Scopus citations