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• A cDNA Clone-Launched Platform for High-Yield Production of Inactivated Zika Vaccine

  Yang, Y., Shan, C., Zou, J., Muruato, A. E., Bruno, D. N., de Almeida Medeiros Daniele, B., Vasconcelos, P. F. C., Rossi, S. L., Weaver, S. C., Xie, X. & Shi, P. Y., Mar 1 2017, In: EBioMedicine. 17, p. 145-156 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Inactivated Vaccines
  • Viruses
  • Zika Virus
  • Complementary DNA
  • Clone Cells
  28 Scopus citations

• A cocrystal structure of dengue capsid protein in complex of inhibitor

  Xia, H., Xie, X., Zou, J., Noble, C. G., Russell, W. K., Holthauzen, L. M. F., Choi, K. H., White, M. A. & Shi, P. Y., Jul 28 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 30, p. 17992-18001 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • Dengue
  • Capsid Proteins
  • Capsid
  • Serogroup

• A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation

  Muruato, A. E., Fontes-Garfias, C. R., Ren, P., Garcia-Blanco, M. A., Menachery, V. D., Xie, X. & Shi, P. Y., Dec 1 2020, In: Nature communications. 11, 1, 4059.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • vaccines
  • SARS Virus
  • antibodies
  • Assays
  • Neutralizing Antibodies
  22 Scopus citations

• A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models

  Shan, C., Muruato, A. E., Nunes, B. T. D., Luo, H., Xie, X., Medeiros, D. B. A., Wakamiya, M., Tesh, R. B., Barrett, A. D., Wang, T., Weaver, S. C., Vasconcelos, P. F. C., Rossi, S. L. & Shi, P. Y., Jun 1 2017, In: Nature Medicine. 23, 6, p. 763-767 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Viruses
  • Immunity
  • Vaccines
  • Epidemics
  159 Scopus citations

• A Multiplex Microsphere Immunoassay for Zika Virus Diagnosis

  Wong, S. J., Furuya, A., Zou, J., Xie, X., Dupuis, A. P., Kramer, L. D. & Shi, P. Y., Feb 1 2017, In: EBioMedicine. 16, p. 136-140 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Microspheres
  • Viruses
  • Immunoassay
  • Zika Virus Infection
  58 Scopus citations

• A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19

  Xie, X., Muruato, A. E., Zhang, X., Lokugamage, K. G., Fontes-Garfias, C. R., Zou, J., Liu, J., Ren, P., Balakrishnan, M., Cihlar, T., Tseng, C. T. K., Makino, S., Menachery, V. D., Bilello, J. P. & Shi, P. Y., Dec 1 2020, In: Nature communications. 11, 1, 5214.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • SARS Virus
  • Coronavirus
  • drugs
  • Screening
  • screening
  6 Scopus citations

• Anti-Zika virus RNAi in neural progenitor cells

  Xie, X. & Shi, P. Y., Apr 1 2019, In: Cell Research. 29, 4, p. 261-262 2 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Scopus citations

• A Rapid Zika Diagnostic Assay to Measure Neutralizing Antibodies in Patients

  Shan, C., Xie, X., Ren, P., Loeffelholz, M. J., Yang, Y., Furuya, A., Dupuis, A. P., Kramer, L. D., Wong, S. J. & Shi, P. Y., Mar 1 2017, In: EBioMedicine. 17, p. 157-162 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Viruses
  • Assays
  • Neutralizing Antibodies
  • Zika Virus Infection
  • Neutralization Tests
  45 Scopus citations

• A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage

  Shan, C., Muruato, A. E., Jagger, B. W., Richner, J., Nunes, B. T. D., Medeiros, D. B. A., Xie, X., Nunes, J. G. C., Morabito, K. M., Kong, W. P., Pierson, T. C., Barrett, A. D., Weaver, S. C., Rossi, S. L., Vasconcelos, P. F. C., Graham, B. S., Diamond, M. S. & Shi, P. Y., Dec 1 2017, In: Nature communications. 8, 1, 676.

  Research output: Contribution to journal › Article › peer-review

  • vaccines
  • testes
  • pregnancy
  • Zika Virus
  • Attenuated Vaccines
  80 Scopus citations

• Axl promotes zika virus entry and modulates the antiviral state of human sertoli cells

  Strange, D. P., Jiyarom, B., Zarandi, N. P., Xie, X., Baker, C., Sadri-Ardekani, H., Shi, P. Y. & Verma, S., Jul 1 2019, In: mBio. 10, 4, e01372-19.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zika Virus
  • Virus Internalization
  • Sertoli Cells
  • Antiviral Agents
  • Zika Virus Infection
  20 Scopus citations

• A Zika virus envelope mutation preceding the 2015 epidemic enhances virulence and fitness for transmission

  Shan, C., Xia, H., Haller, S. L., Azar, S. R., Liu, Y., Liu, J., Muruato, A. E., Chen, R., Rossi, S. L., Wakamiya, M., Vasilakis, N., Pei, R., Fontes-Garfias, C. R., Singh, S. K., Xie, X., Weaver, S. C. & Shi, P. Y., Aug 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 33, p. 20190-20197 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Viremia
  • Virulence
  • Epidemics
  • Mutation
  8 Scopus citations

• Characterization of Dengue virus NS4A and NS4B protein interaction

  Zou, J., Xie, X., Wang, Q. Y., Dong, H., Lee, M. Y., Kang, C., Yuan, Z. & Shi, P. Y., 2015, In: Journal of virology. 89, 7, p. 3455-3470 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus NS4A protein
  • Dengue virus NS4B protein
  • Dengue virus
  • virus replication
  • Amino Acids
  70 Scopus citations

• Dengue NS2A Protein Orchestrates Virus Assembly

  Xie, X., Zou, J., Zhang, X., Zhou, Y., Routh, A. L., Kang, C., Popov, V. L., Chen, X., Wang, Q. Y., Dong, H. & Shi, P. Y., Nov 13 2019, In: Cell Host and Microbe. 26, 5, p. 606-622.e8

  Research output: Contribution to journal › Article › peer-review

  • Virus Assembly
  • Dengue
  • Virion
  • Polyproteins
  • Nucleocapsid
  17 Scopus citations

• Design, Synthesis, and Biological Evaluation of Substituted 4,6-Dihydrospiro[[1,2,3]triazolo[4,5- b]pyridine-7,3′-indoline]-2′,5(3 H)-dione Analogues as Potent NS4B Inhibitors for the Treatment of Dengue Virus Infection

  Xu, J., Xie, X., Ye, N., Zou, J., Chen, H., White, M. A., Shi, P. Y. & Zhou, J., Sep 12 2019, In: Journal of medicinal chemistry. 62, 17, p. 7941-7960 20 p.

  Research output: Contribution to journal › Article › peer-review

  • indoline-2,3-dione
  • pyridine
  • Dengue Virus
  • indoline
  • Virus Diseases
  10 Scopus citations

• Design, synthesis and biological evaluation of spiropyrazolopyridone derivatives as potent dengue virus inhibitors

  Xu, J., Xie, X., Chen, H., Zou, J., Xue, Y., Ye, N., Shi, P. Y. & Zhou, J., Jun 1 2020, In: Bioorganic and Medicinal Chemistry Letters. 30, 11, 127162.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • Viruses
  • Substitution reactions
  • Nitrogen
  • Derivatives
  1 Scopus citations

• Determinants of dengue virus NS4A protein oligomerization

  Lee, C. M., Xie, X., Zou, J., Li, S. H., Qi Lee, M. Y., Dong, H., Qin, C. F., Kang, C. & Shi, P. Y., 2015, In: Journal of virology. 89, 12, p. 6171-6183 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus NS4A protein
  • Dengue virus
  • Flavivirus
  • oligomerization
  • Amino Acids
  24 Scopus citations

• Dimerization of flavivirus NS4B protein

  Zou, J., Xie, X., Lee, L. T., Chandrasekaran, R., Reynaud, A., Yap, L., Wang, Q. Y., Dong, H., Kang, C., Yuan, Z., Lescar, J. & Shi, P. Y., Mar 2014, In: Journal of virology. 88, 6, p. 3379-3391 13 p.

  Research output: Contribution to journal › Article › peer-review

  • flavivirus NS4B protein
  • Flavivirus
  • dimerization
  • Dimerization
  • Dengue virus
  44 Scopus citations

• Envelope protein ubiquitination drives entry and pathogenesis of Zika virus

  Giraldo, M. I., Xia, H., Aguilera-Aguirre, L., Hage, A., van Tol, S., Shan, C., Xie, X., Sturdevant, G. L., Robertson, S. J., McNally, K. L., Meade-White, K., Azar, S. R., Rossi, S. L., Maury, W., Woodson, M., Ramage, H., Johnson, J. R., Krogan, N. J., Morais, M. C., Best, S. M. & 2 others, Shi, P. Y. & Rajsbaum, R., Sep 17 2020, In: Nature. 585, 7825, p. 414-419 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Ubiquitination
  • Virus Internalization
  • Polyubiquitin
  • Proteins
  6 Scopus citations

• Erratum: Treatment of human glioblastoma with a live attenuated zika virus vaccine candidate (mBio, (2018) 9(5), e01683-18, 10.1128/mBio.01683-18)

  Chen, Q., Wu, J., Ye, Q., Ma, F., Zhu, Q., Wu, Y., Shan, C., Xie, X., Li, D., Zhan, X., Li, C., Li, X. F., Qin, X., Zhao, T., Wu, H., Shi, P. Y., Man, J. & Qin, C. F., Mar 1 2019, In: mBio. 10, 2, e00433-19.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Zika Virus
  • Glioblastoma
  • Names
  • Vaccines

• Evasion of Type I Interferon by SARS-CoV-2

  Xia, H., Cao, Z., Xie, X., Zhang, X., Chen, J. Y. C., Wang, H., Menachery, V. D., Rajsbaum, R. & Shi, P. Y., Oct 6 2020, In: Cell Reports. 33, 1, 108234.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Severe Acute Respiratory Syndrome
  • Coronavirus
  • Interferon Type I
  • Phosphorylation
  • Interferon Regulatory Factor-3
  24 Scopus citations

• Functional Analysis of Glycosylation of Zika Virus Envelope Protein

  Fontes-Garfias, C. R., Shan, C., Luo, H., Muruato, A. E., Medeiros, D. B. A., Mays, E., Xie, X., Zou, J., Roundy, C. M., Wakamiya, M., Rossi, S. L., Wang, T., Weaver, S. C. & Shi, P. Y., Oct 31 2017, In: Cell Reports. 21, 5, p. 1180-1190 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Glycosylation
  • Viral Envelope Proteins
  • Zika Virus
  • Functional analysis
  • Viruses
  62 Scopus citations

• Generation and characterization of mouse monoclonal antibodies against NS4B protein of dengue virus

  Xie, X., Zou, J., Wang, Q. Y., Noble, C. G., Lescar, J. & Shi, P. Y., Feb 2014, In: Virology. 450-451, p. 250-257 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus NS4B protein
  • Monoclonal Antibodies
  • Epitopes
  • Proteins
  • Cytosol
  13 Scopus citations

• Genetic and biochemical characterizations of Zika virus NS2A protein

  Zhang, X., Xie, X., Zou, J., Xia, H., Shan, C., Chen, X. & Shi, P. Y., Jan 1 2019, In: Emerging Microbes and Infections. 8, 1, p. 585-602 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zika Virus
  • Virion
  • Molecular Biology
  • Viral Nonstructural Proteins
  • Proteins
  13 Scopus citations

• Identifying optimal capsid duplication length for the stability of reporter flaviviruses

  Baker, C., Liu, Y., Zou, J., Muruato, A., Xie, X. & Shi, P. Y., Jan 1 2020, In: Emerging Microbes and Infections. 9, 1, p. 2256-2265 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Flavivirus
  • Capsid
  • Zika Virus
  • Culicidae
  • Viruses

• Inhibition of coronavirus entry in vitro and ex vivo by a lipid-conjugated peptide derived from the sars-cov-2 spike glycoprotein hrc domain

  Outlaw, V. K., Bovier, F. T., Mears, M. C., Cajimat, M. N., Zhu, Y., Lin, M. J., Addetia, A., Lieberman, N. A. P., Peddu, V., Xie, X., Shi, P. Y., Greninger, A. L., Gellman, S. H., Bente, D. A., Moscona, A. & Porotto, M., Sep 1 2020, In: mBio. 11, 5, p. 1-14 14 p., e01935-20.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Severe Acute Respiratory Syndrome
  • Coronavirus
  • Glycoproteins
  • Lipopeptides
  • Lipids
  1 Scopus citations

• Mapping the interactions between the NS4B and NS3 proteins of dengue virus

  Zou, J., Lee, L. T., Wang, Q. Y., Xie, X., Lu, S., Yau, Y. H., Yuan, Z., Shochat, S. G., Kang, C., Lescar, J. & Shi, P. Y., Jan 1 2015, In: Journal of virology. 89, 7, p. 3471-3483 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus NS4B protein
  • flavivirus NS3 protein
  • Dengue virus
  • Flavivirus
  • Dengue Virus
  49 Scopus citations

• Maternal vaccination and protective immunity against Zika virus vertical transmission

  Shan, C., Xie, X., Luo, H., Muruato, A. E., Liu, Y., Wakamiya, M., La, J. H., Chung, J. M., Weaver, S. C., Wang, T. & Shi, P. Y., Dec 1 2019, In: Nature communications. 10, 1, 5677.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zika Virus
  • infectious diseases
  • viruses
  • Viruses
  • immunity
  5 Scopus citations

• Repurposing an HIV Drug for Zika Virus Therapy

  Xie, X. & Shi, P. Y., Dec 4 2019, In: Molecular Therapy. 27, 12, p. 2064-2066 3 p.

  Research output: Contribution to journal › Short survey › peer-review
  1 Scopus citations

• Reverse genetics of Zika virus

  Shan, C., Xie, X. & Shi, P-Y., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1602. p. 47-58 12 p. (Methods in Molecular Biology; vol. 1602).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Zika Virus
  • Reverse Genetics
  • Complementary DNA
  • Clone Cells
  • Hepatitis Delta Virus
  4 Scopus citations

• Role of microglia in the dissemination of zika virus from mother to fetal brain

  Xu, P., Shan, C., Dunn, T. J., Xie, X., Xia, H., Gao, J., Labastida, J. A., Zou, J., Villarreal, P. P., Schlagal, C. R., Yu, Y., Vargas, G., Rossi, S. L., Vasilakis, N., Shi, P. Y., Weaver, S. C. & Wu, P., Jul 2020, In: PLoS neglected tropical diseases. 14, 7, p. 1-21 21 p., e0008413.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zika Virus
  • Yolk Sac
  • Microglia
  • Zika Virus Infection
  • Microcephaly
  2 Scopus citations

• RPLP1 and RPLP2 are essential flavivirus host factors that promote early viral protein accumulation

  Campos, R. K., Wong, B., Xie, X., Lu, Y. F., Shi, P. Y., Pompon, J., Garcia-Blanco, M. A. & Bradrick, S. S., 2017, In: Journal of virology. 91, 4, e01706-16.

  Research output: Contribution to journal › Article › peer-review

  • Flavivirus
  • Dengue virus
  • Dengue Virus
  • viral proteins
  • Viral Proteins
  29 Scopus citations

• Secondary structure and membrane topology of dengue virus NS4B N-terminal 125 amino acids

  Li, Y., Kim, Y. M., Zou, J., Wang, Q. Y., Gayen, S., Wong, Y. L., Lee, L. T., Xie, X., Huang, Q., Lescar, J., Shi, P. Y. & Kang, C., Dec 1 2015, In: Biochimica et Biophysica Acta - Biomembranes. 1848, 12, p. 3150-3157 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • Viruses
  • Membranes
  • Micelles
  • Dengue virus NS4B protein
  21 Scopus citations

• Small Molecules and Antibodies for Zika Therapy

  Xie, X., Zou, J., Shan, C. & Shi, P. Y., 2017, In: Journal of Infectious Diseases. 216, p. S945-S950

  Research output: Contribution to journal › Review article › peer-review

  • Zika Virus Infection
  • Zika Virus
  • Antibodies
  • Clinical Trials
  • Pregnant Women
  15 Scopus citations

• Spike mutation D614G alters SARS-CoV-2 fitness

  Plante, J. A., Liu, Y., Liu, J., Xia, H., Johnson, B. A., Lokugamage, K. G., Zhang, X., Muruato, A. E., Zou, J., Fontes-Garfias, C. R., Mirchandani, D., Scharton, D., Bilello, J. P., Ku, Z., An, Z., Kalveram, B., Freiberg, A. N., Menachery, V. D., Xie, X., Plante, K. S. & 2 others, Weaver, S. C. & Shi, P. Y., 2020, (Accepted/In press) In: Nature.

  Research output: Contribution to journal › Article › peer-review

  • SARS Virus
  • Viral Vaccines
  • Mutation
  • Cricetinae
  • Viruses
  35 Scopus citations

• Targeting dengue virus NS4B protein for drug discovery

  Xie, X., Zou, J., Wang, Q. Y. & Shi, P. Y., Jun 2015, In: Antiviral research. 118, p. 39-45 7 p., 3603.

  Research output: Contribution to journal › Review article › peer-review

  • Dengue virus NS4B protein
  • Drug Discovery
  • Flavivirus
  • Proteins
  • Antiviral Agents
  44 Scopus citations

• Topoisomerase III-β is required for efficient replication of positive-sense RNA viruses

  Prasanth, K. R., Hirano, M., Fagg, W. S., McAnarney, E. T., Shan, C., Xie, X., Hage, A., Pietzsch, C. A., Bukreyev, A., Rajsbaum, R., Shi, P. Y., Bedford, M. T., Bradrick, S. S., Menachery, V. & Garcia-Blanco, M. A., Oct 2020, In: Antiviral research. 182, 104874.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA topoisomerase III
  • Yellow fever virus
  • SARS Virus
  • Dengue Virus
  • RNA Viruses
  3 Scopus citations

• Two distinct sets of NS2A molecules are responsible for dengue virus RNA synthesis and virion assembly

  Xie, X., Zou, J., Puttikhunt, C., Yuan, Z. & Shi, P. Y., 2015, In: Journal of virology. 89, 2, p. 1298-1313 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus
  • Dengue Virus
  • virion
  • Virion
  • RNA
  53 Scopus citations

• U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication

  Poh, M. K., Shui, G., Xie, X., Shi, P. Y., Wenk, M. R. & Gu, F., Jan 2012, In: Antiviral research. 93, 1, p. 191-198 8 p.

  Research output: Contribution to journal › Article › peer-review

  • 3-beta-(2-(diethylamino)ethoxy)androst-5-en-17-one
  • Anticholesteremic Agents
  • Virus Internalization
  • Dengue Virus
  • Virus Replication
  72 Scopus citations

• Understanding zika virus stability and developing a chimeric vaccine through functional analysis

  Xie, X., Yang, Y., Muruato, A. E., Zou, J., Shan, C., Nunes, B. T. D., Medeiros, D. B. A., Vasconcelos, P. F. C., Weaver, S. C., Rossi, S. L. & Shi, P. Y., Jan 1 2017, In: mBio. 8, 1, e02134-16.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Vaccines
  • Viruses
  • Hydrogen
  • Virion
  62 Scopus citations

• Using recombination-dependent lethal mutations to stabilize reporter flaviviruses for rapid serodiagnosis and drug discovery

  Baker, C., Xie, X., Zou, J., Muruato, A., Fink, K. & Shi, P. Y., Jul 2020, In: EBioMedicine. 57, 102838.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Drug Discovery
  • Flavivirus
  • Viruses
  • Serologic Tests
  • Genetic Recombination
  4 Scopus citations

• Zika virus NS2A-mediated virion assembly

  Zhang, X., Xie, X., Xia, H., Zou, J., Huang, L., Popov, V. L., Chen, X. & Shi, P. Y., 2019, In: mBio. 10, 5, e02375-19.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zika Virus
  • Virion
  • Viral RNA
  • Flavivirus
  • RNA
  16 Scopus citations