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A cDNA Clone-Launched Platform for High-Yield Production of Inactivated Zika Vaccine
Yang, Y., Shan, C., Zou, J., Muruato, A. E., Bruno, D. N., de Almeida Medeiros Daniele, B., Vasconcelos, P. F. C., Rossi, S. L., Weaver, S. C., Xie, X. & Shi, P. Y., Mar 1 2017, In: EBioMedicine. 17, p. 145-156 12 p.Research output: Contribution to journal › Article › peer-review
28 Scopus citations -
A cocrystal structure of dengue capsid protein in complex of inhibitor
Xia, H., Xie, X., Zou, J., Noble, C. G., Russell, W. K., Holthauzen, L. M. F., Choi, K. H., White, M. A. & Shi, P. Y., Jul 28 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 30, p. 17992-18001 10 p.Research output: Contribution to journal › Article › peer-review
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A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation
Muruato, A. E., Fontes-Garfias, C. R., Ren, P., Garcia-Blanco, M. A., Menachery, V. D., Xie, X. & Shi, P. Y., Dec 1 2020, In: Nature communications. 11, 1, 4059.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models
Shan, C., Muruato, A. E., Nunes, B. T. D., Luo, H., Xie, X., Medeiros, D. B. A., Wakamiya, M., Tesh, R. B., Barrett, A. D., Wang, T., Weaver, S. C., Vasconcelos, P. F. C., Rossi, S. L. & Shi, P. Y., Jun 1 2017, In: Nature Medicine. 23, 6, p. 763-767 5 p.Research output: Contribution to journal › Article › peer-review
159 Scopus citations -
A Multiplex Microsphere Immunoassay for Zika Virus Diagnosis
Wong, S. J., Furuya, A., Zou, J., Xie, X., Dupuis, A. P., Kramer, L. D. & Shi, P. Y., Feb 1 2017, In: EBioMedicine. 16, p. 136-140 5 p.Research output: Contribution to journal › Article › peer-review
58 Scopus citations -
A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19
Xie, X., Muruato, A. E., Zhang, X., Lokugamage, K. G., Fontes-Garfias, C. R., Zou, J., Liu, J., Ren, P., Balakrishnan, M., Cihlar, T., Tseng, C. T. K., Makino, S., Menachery, V. D., Bilello, J. P. & Shi, P. Y., Dec 1 2020, In: Nature communications. 11, 1, 5214.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction
Xia, H., Luo, H., Shan, C., Muruato, A. E., Nunes, B. T. D., Medeiros, D. B. A., Zou, J., Xie, X., Giraldo, M. I., Vasconcelos, P. F. C., Weaver, S. C., Wang, T., Rajsbaum, R. & Shi, P. Y., Dec 1 2018, In: Nature communications. 9, 1, 414.Research output: Contribution to journal › Article › peer-review
95 Scopus citations -
Anti-Zika virus RNAi in neural progenitor cells
Xie, X. & Shi, P. Y., Apr 1 2019, In: Cell Research. 29, 4, p. 261-262 2 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
A Rapid Zika Diagnostic Assay to Measure Neutralizing Antibodies in Patients
Shan, C., Xie, X., Ren, P., Loeffelholz, M. J., Yang, Y., Furuya, A., Dupuis, A. P., Kramer, L. D., Wong, S. J. & Shi, P. Y., Mar 1 2017, In: EBioMedicine. 17, p. 157-162 6 p.Research output: Contribution to journal › Article › peer-review
45 Scopus citations -
A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage
Shan, C., Muruato, A. E., Jagger, B. W., Richner, J., Nunes, B. T. D., Medeiros, D. B. A., Xie, X., Nunes, J. G. C., Morabito, K. M., Kong, W. P., Pierson, T. C., Barrett, A. D., Weaver, S. C., Rossi, S. L., Vasconcelos, P. F. C., Graham, B. S., Diamond, M. S. & Shi, P. Y., Dec 1 2017, In: Nature communications. 8, 1, 676.Research output: Contribution to journal › Article › peer-review
80 Scopus citations -
A Single-Dose Live-Attenuated Zika Virus Vaccine with Controlled Infection Rounds that Protects against Vertical Transmission
Xie, X., Kum, D. B., Xia, H., Luo, H., Shan, C., Zou, J., Muruato, A. E., Medeiros, D. B. A., Nunes, B. T. D., Dallmeier, K., Rossi, S. L., Weaver, S. C., Neyts, J., Wang, T., Vasconcelos, P. F. C. & Shi, P. Y., Oct 10 2018, In: Cell Host and Microbe. 24, 4, p. 487-499.e5Research output: Contribution to journal › Article › peer-review
23 Scopus citations -
A single-dose plasmid-launched live-attenuated Zika vaccine induces protective immunity
Zou, J., Xie, X., Luo, H., Shan, C., Muruato, A. E., Weaver, S. C., Wang, T. & Shi, P. Y., Oct 2018, In: EBioMedicine. 36, p. 92-102 11 p.Research output: Contribution to journal › Article › peer-review
21 Scopus citations -
Axl promotes zika virus entry and modulates the antiviral state of human sertoli cells
Strange, D. P., Jiyarom, B., Zarandi, N. P., Xie, X., Baker, C., Sadri-Ardekani, H., Shi, P. Y. & Verma, S., Jul 1 2019, In: mBio. 10, 4, e01372-19.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
A Zika virus envelope mutation preceding the 2015 epidemic enhances virulence and fitness for transmission
Shan, C., Xia, H., Haller, S. L., Azar, S. R., Liu, Y., Liu, J., Muruato, A. E., Chen, R., Rossi, S. L., Wakamiya, M., Vasilakis, N., Pei, R., Fontes-Garfias, C. R., Singh, S. K., Xie, X., Weaver, S. C. & Shi, P. Y., Aug 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 33, p. 20190-20197 8 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Characterization of a candidate tetravalent vaccine based on 2’-O-methyltransferase mutants
Züst, R., Li, S. H., Xie, X., Velumani, S., Chng, M., Toh, Y. X., Zou, J., Dong, H., Shan, C., Pang, J., Qin, C. F., Newell, E. W., Shi, P. Y. & Fink, K., Jan 2018, In: PloS one. 13, 1, e0189262.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Characterization of Dengue virus NS4A and NS4B protein interaction
Zou, J., Xie, X., Wang, Q. Y., Dong, H., Lee, M. Y., Kang, C., Yuan, Z. & Shi, P. Y., 2015, In: Journal of virology. 89, 7, p. 3455-3470 16 p.Research output: Contribution to journal › Article › peer-review
70 Scopus citations -
Dengue NS2A Protein Orchestrates Virus Assembly
Xie, X., Zou, J., Zhang, X., Zhou, Y., Routh, A. L., Kang, C., Popov, V. L., Chen, X., Wang, Q. Y., Dong, H. & Shi, P. Y., Nov 13 2019, In: Cell Host and Microbe. 26, 5, p. 606-622.e8Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
Design, Synthesis, and Biological Evaluation of Substituted 4,6-Dihydrospiro[[1,2,3]triazolo[4,5- b]pyridine-7,3′-indoline]-2′,5(3 H)-dione Analogues as Potent NS4B Inhibitors for the Treatment of Dengue Virus Infection
Xu, J., Xie, X., Ye, N., Zou, J., Chen, H., White, M. A., Shi, P. Y. & Zhou, J., Sep 12 2019, In: Journal of medicinal chemistry. 62, 17, p. 7941-7960 20 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Design, synthesis and biological evaluation of spiropyrazolopyridone derivatives as potent dengue virus inhibitors
Xu, J., Xie, X., Chen, H., Zou, J., Xue, Y., Ye, N., Shi, P. Y. & Zhou, J., Jun 1 2020, In: Bioorganic and Medicinal Chemistry Letters. 30, 11, 127162.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Determinants of dengue virus NS4A protein oligomerization
Lee, C. M., Xie, X., Zou, J., Li, S. H., Qi Lee, M. Y., Dong, H., Qin, C. F., Kang, C. & Shi, P. Y., 2015, In: Journal of virology. 89, 12, p. 6171-6183 13 p.Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
Envelope protein ubiquitination drives entry and pathogenesis of Zika virus
Giraldo, M. I., Xia, H., Aguilera-Aguirre, L., Hage, A., van Tol, S., Shan, C., Xie, X., Sturdevant, G. L., Robertson, S. J., McNally, K. L., Meade-White, K., Azar, S. R., Rossi, S. L., Maury, W., Woodson, M., Ramage, H., Johnson, J. R., Krogan, N. J., Morais, M. C., Best, S. M. & 2 others, , Sep 17 2020, In: Nature. 585, 7825, p. 414-419 6 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Erratum: Treatment of human glioblastoma with a live attenuated zika virus vaccine candidate (mBio, (2018) 9(5), e01683-18, 10.1128/mBio.01683-18)
Chen, Q., Wu, J., Ye, Q., Ma, F., Zhu, Q., Wu, Y., Shan, C., Xie, X., Li, D., Zhan, X., Li, C., Li, X. F., Qin, X., Zhao, T., Wu, H., Shi, P. Y., Man, J. & Qin, C. F., Mar 1 2019, In: mBio. 10, 2, e00433-19.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Evasion of Type I Interferon by SARS-CoV-2
Xia, H., Cao, Z., Xie, X., Zhang, X., Chen, J. Y. C., Wang, H., Menachery, V. D., Rajsbaum, R. & Shi, P. Y., Oct 6 2020, In: Cell Reports. 33, 1, 108234.Research output: Contribution to journal › Article › peer-review
Open Access24 Scopus citations -
Fragile X mental retardation protein is a zika virus restriction factor that is antagonized by subgenomic flaviviral RNA
Soto-Acosta, R., Xie, X., Shan, C., Baker, C. K., Shi, P. Y., Rossi, S. L., Garcia-Blanco, M. A. & Bradrick, S., Dec 1 2018, In: eLife. 7, e39023.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
Functional Analysis of Glycosylation of Zika Virus Envelope Protein
Fontes-Garfias, C. R., Shan, C., Luo, H., Muruato, A. E., Medeiros, D. B. A., Mays, E., Xie, X., Zou, J., Roundy, C. M., Wakamiya, M., Rossi, S. L., Wang, T., Weaver, S. C. & Shi, P. Y., Oct 31 2017, In: Cell Reports. 21, 5, p. 1180-1190 11 p.Research output: Contribution to journal › Article › peer-review
62 Scopus citations -
Genetic and biochemical characterizations of Zika virus NS2A protein
Zhang, X., Xie, X., Zou, J., Xia, H., Shan, C., Chen, X. & Shi, P. Y., Jan 1 2019, In: Emerging Microbes and Infections. 8, 1, p. 585-602 18 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Identifying optimal capsid duplication length for the stability of reporter flaviviruses
Baker, C., Liu, Y., Zou, J., Muruato, A., Xie, X. & Shi, P. Y., Jan 1 2020, In: Emerging Microbes and Infections. 9, 1, p. 2256-2265 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Inhibition of coronavirus entry in vitro and ex vivo by a lipid-conjugated peptide derived from the sars-cov-2 spike glycoprotein hrc domain
Outlaw, V. K., Bovier, F. T., Mears, M. C., Cajimat, M. N., Zhu, Y., Lin, M. J., Addetia, A., Lieberman, N. A. P., Peddu, V., Xie, X., Shi, P. Y., Greninger, A. L., Gellman, S. H., Bente, D. A., Moscona, A. & Porotto, M., Sep 1 2020, In: mBio. 11, 5, p. 1-14 14 p., e01935-20.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Inhibition of japanese encephalitis virus infection by flavivirus recombinant e protein domain III
Fan, J., Liu, Y., Xie, X., Zhang, B. & Yuan, Z., Jun 2013, In: Virologica Sinica. 28, 3, p. 152-160 9 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Mapping the interactions between the NS4B and NS3 proteins of dengue virus
Zou, J., Lee, L. T., Wang, Q. Y., Xie, X., Lu, S., Yau, Y. H., Yuan, Z., Shochat, S. G., Kang, C., Lescar, J. & Shi, P. Y., Jan 1 2015, In: Journal of virology. 89, 7, p. 3471-3483 13 p.Research output: Contribution to journal › Article › peer-review
49 Scopus citations -
Maternal vaccination and protective immunity against Zika virus vertical transmission
Shan, C., Xie, X., Luo, H., Muruato, A. E., Liu, Y., Wakamiya, M., La, J. H., Chung, J. M., Weaver, S. C., Wang, T. & Shi, P. Y., Dec 1 2019, In: Nature communications. 10, 1, 5677.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Membrane topology and function of dengue virus NS2A protein
Xie, X., Gayen, S., Kang, C. B., Yuan, Z. & Shi, P. Y., Apr 2013, In: Journal of virology. 87, 8, p. 4609-4622 14 p.Research output: Contribution to journal › Article › peer-review
118 Scopus citations -
Potential Mechanisms for Enhanced Zika Epidemic and Disease
Xia, H., Xie, X., Shan, C. & Shi, P. Y., May 11 2018, In: ACS Infectious Diseases. 4, 5, p. 656-659 4 p.Research output: Contribution to journal › Review article › peer-review
5 Scopus citations -
Rational design of a flavivirus vaccine by abolishing viral RNA 2′-O methylation
Li, S. H., Dong, H., Li, X. F., Xie, X., Zhao, H., Deng, Y. Q., Wang, X. Y., Ye, Q., Zhu, S. Y., Wang, H. J., Zhang, B., Leng, Q. B., Zuest, R., Qin, E. D., Qin, C. F. & Shi, P. Y., May 2013, In: Journal of virology. 87, 10, p. 5812-5819 8 p.Research output: Contribution to journal › Article › peer-review
67 Scopus citations -
Repurposing an HIV Drug for Zika Virus Therapy
Xie, X. & Shi, P. Y., Dec 4 2019, In: Molecular Therapy. 27, 12, p. 2064-2066 3 p.Research output: Contribution to journal › Short survey › peer-review
1 Scopus citations -
Reverse genetics of Zika virus
Shan, C., Xie, X. & Shi, P-Y., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1602. p. 47-58 12 p. (Methods in Molecular Biology; vol. 1602).Research output: Chapter in Book/Report/Conference proceeding › Chapter
4 Scopus citations -
Role of microglia in the dissemination of zika virus from mother to fetal brain
Xu, P., Shan, C., Dunn, T. J., Xie, X., Xia, H., Gao, J., Labastida, J. A., Zou, J., Villarreal, P. P., Schlagal, C. R., Yu, Y., Vargas, G., Rossi, S. L., Vasilakis, N., Shi, P. Y., Weaver, S. C. & Wu, P., Jul 2020, In: PLoS neglected tropical diseases. 14, 7, p. 1-21 21 p., e0008413.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
RPLP1 and RPLP2 are essential flavivirus host factors that promote early viral protein accumulation
Campos, R. K., Wong, B., Xie, X., Lu, Y. F., Shi, P. Y., Pompon, J., Garcia-Blanco, M. A. & Bradrick, S. S., 2017, In: Journal of virology. 91, 4, e01706-16.Research output: Contribution to journal › Article › peer-review
29 Scopus citations -
Secondary structure and membrane topology of dengue virus NS4B N-terminal 125 amino acids
Li, Y., Kim, Y. M., Zou, J., Wang, Q. Y., Gayen, S., Wong, Y. L., Lee, L. T., Xie, X., Huang, Q., Lescar, J., Shi, P. Y. & Kang, C., Dec 1 2015, In: Biochimica et Biophysica Acta - Biomembranes. 1848, 12, p. 3150-3157 8 p.Research output: Contribution to journal › Article › peer-review
21 Scopus citations -
Small Molecules and Antibodies for Zika Therapy
Xie, X., Zou, J., Shan, C. & Shi, P. Y., 2017, In: Journal of Infectious Diseases. 216, p. S945-S950Research output: Contribution to journal › Review article › peer-review
15 Scopus citations -
Spike mutation D614G alters SARS-CoV-2 fitness
Plante, J. A., Liu, Y., Liu, J., Xia, H., Johnson, B. A., Lokugamage, K. G., Zhang, X., Muruato, A. E., Zou, J., Fontes-Garfias, C. R., Mirchandani, D., Scharton, D., Bilello, J. P., Ku, Z., An, Z., Kalveram, B., Freiberg, A. N., Menachery, V. D., Xie, X., Plante, K. S. & 2 others, , 2020, (Accepted/In press) In: Nature.Research output: Contribution to journal › Article › peer-review
35 Scopus citations -
Targeting dengue virus NS4B protein for drug discovery
Xie, X., Zou, J., Wang, Q. Y. & Shi, P. Y., Jun 2015, In: Antiviral research. 118, p. 39-45 7 p., 3603.Research output: Contribution to journal › Review article › peer-review
44 Scopus citations -
Topoisomerase III-β is required for efficient replication of positive-sense RNA viruses
Prasanth, K. R., Hirano, M., Fagg, W. S., McAnarney, E. T., Shan, C., Xie, X., Hage, A., Pietzsch, C. A., Bukreyev, A., Rajsbaum, R., Shi, P. Y., Bedford, M. T., Bradrick, S. S., Menachery, V. & Garcia-Blanco, M. A., Oct 2020, In: Antiviral research. 182, 104874.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Treatment of human glioblastoma with a live attenuated Zika virus vaccine candidate
Chen, Q., Wu, J., Ye, Q., Ma, F., Zhu, Q., Wu, Y., Shan, C., Xie, X., Li, D., Zhan, X., Li, C., Li, X. F., Qin, X., Zhao, T., Wu, H., Shi, P. Y., Man, J. & Qin, C. F., Sep 1 2018, In: mBio. 9, 5, e01683-18.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
Two distinct sets of NS2A molecules are responsible for dengue virus RNA synthesis and virion assembly
Xie, X., Zou, J., Puttikhunt, C., Yuan, Z. & Shi, P. Y., 2015, In: Journal of virology. 89, 2, p. 1298-1313 16 p.Research output: Contribution to journal › Article › peer-review
53 Scopus citations -
Understanding zika virus stability and developing a chimeric vaccine through functional analysis
Xie, X., Yang, Y., Muruato, A. E., Zou, J., Shan, C., Nunes, B. T. D., Medeiros, D. B. A., Vasconcelos, P. F. C., Weaver, S. C., Rossi, S. L. & Shi, P. Y., Jan 1 2017, In: mBio. 8, 1, e02134-16.Research output: Contribution to journal › Article › peer-review
62 Scopus citations -
Using a virion assembly-defective dengue virus as a vaccine approach
Shan, C., Xie, X., Zou, J., Züst, R., Zhang, B., Ambrose, R., Mackenzie, J., Fink, K. & Shi, P. Y., Nov 1 2018, In: Journal of virology. 92, 21, e01002.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Using recombination-dependent lethal mutations to stabilize reporter flaviviruses for rapid serodiagnosis and drug discovery
Baker, C., Xie, X., Zou, J., Muruato, A., Fink, K. & Shi, P. Y., Jul 2020, In: EBioMedicine. 57, 102838.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Zika virus NS2A-mediated virion assembly
Zhang, X., Xie, X., Xia, H., Zou, J., Huang, L., Popov, V. L., Chen, X. & Shi, P. Y., 2019, In: mBio. 10, 5, e02375-19.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Zika Virus Vaccine: Progress and Challenges
Shan, C., Xie, X. & Shi, P. Y., Jul 11 2018, In: Cell Host and Microbe. 24, 1, p. 12-17 6 p.Research output: Contribution to journal › Review article › peer-review
36 Scopus citations