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  • Mariano Garcia-Blanco
Article

A functional alternative splicing mutation in human tryptophan hydroxylase-2

Zhang, X., Nicholls, P. J., Laje, G., Sotnikova, T. D., Gainetdinov, R. R., Albert, P. R., Rajkowska, G., Stockmeier, C. A., Speer, M. C., Steffens, D. C., Austin, M. C., McMahon, F. J., Krishnan, K. R. R., Garcia-Blanco, M. A. & Caron, M. G., Dec 2011, In : Molecular Psychiatry. 16, 12, p. 1169-1176 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation

Muruato, A. E., Fontes-Garfias, C. R., Ren, P., Garcia-Blanco, M. A., Menachery, V. D., Xie, X. & Shi, P. Y., Dec 1 2020, In : Nature communications. 11, 1, 4059.

Research output: Contribution to journalArticle

Open Access

Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer

Wang, B. D., Ceniccola, K., Hwang, S., Andrawis, R., Horvath, A., Freedman, J. A., Olender, J., Knapp, S., Ching, T., Garmire, L., Patel, V., Garcia-Blanco, M. A., Patierno, S. R. & Lee, N. H., Jun 30 2017, In : Nature communications. 8, 15921.

Research output: Contribution to journalArticle

35 Scopus citations

An antibody panel for highly specific detection and differentiation of Zika virus

Kabir, M. A., Soto-Acosta, R., Sharma, S., Bradrick, S. S., Garcia-Blanco, M. A., Caputi, M. & Asghar, W., Dec 1 2020, In : Scientific reports. 10, 1, 11906.

Research output: Contribution to journalArticle

Open Access

Antisense-mediated affinity purification of dengue virus ribonucleoprotein complexes from infected cells

Phillips, S. L., Garcia-Blanco, M. & Bradrick, S., Jul 6 2015, (Accepted/In press) In : Methods.

Research output: Contribution to journalArticle

4 Scopus citations

A rapid and simple quantitative method for specific detection of smaller coterminal RNA by PCR (DeSCo-PCR): Application to the detection of viral subgenomic RNAs

Kanodia, P., Reddisiva Prasanth, K., Roa-Linares, V. C., Bradrick, S. S., Garcia-Blanco, M. A. & Allen Miller, W., Jul 2020, In : RNA. 26, 7, p. 888-901 14 p.

Research output: Contribution to journalArticle

Open Access

A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection

Barrows, N. J., Kroon Campos, R., Powell, S. T., Prasanth, K. R., Schott-Lerner, G., Soto-Acosta, R., Galarza-Munoz, G., McGrath, E. L., Urrabaz-Garza, R., Gao, J., Wu, P., Menon, R., Saade, G., Fernandez-Salas, I., Rossi, S., Vasilakis, N., Routh, A., Bradrick, S. & Garcia-Blanco, M., May 15 2016, (Accepted/In press) In : Cell Host and Microbe.

Research output: Contribution to journalArticle

206 Scopus citations

Biochemistry and Molecular Biology of Flaviviruses

Barrows, N. J., Campos, R. K., Liao, K. C., Prasanth, K. R., Soto-Acosta, R., Yeh, S. C., Schott-Lerner, G., Pompon, J., Sessions, O. M., Bradrick, S. S. & Garcia-Blanco, M. A., Apr 25 2018, In : Chemical Reviews. 118, 8, p. 4448-4482 35 p.

Research output: Contribution to journalArticle

34 Scopus citations

Carcinosarcomas: Tumors in transition?

Somarelli, J. A., Boss, M. K., Epstein, J. I., Armstrong, A. J. & Garcia-Blanco, M., 2015, In : Histology and Histopathology. 30, 6, p. 673-687 15 p.

Research output: Contribution to journalArticle

11 Scopus citations

Cellular migration and invasion uncoupled: Increased migration is not an inexorable consequence of epithelial-to-mesenchymal transition

Schaeffer, D., Somarelli, J. A., Hanna, G., Palmer, G. M. & Garcia-Blanco, M. A., 2014, In : Molecular and cellular biology. 34, 18, p. 3486-3499 14 p.

Research output: Contribution to journalArticle

40 Scopus citations

Circulating tumor cells from patients with advanced prostate and breast cancer display both epithelial and mesenchymal markers

Armstrong, A. J., Marengo, M. S., Oltean, S., Kemeny, G., Bitting, R. L., Turnbull, J. D., Herold, C. I., Marcom, P. K., George, D. J. & Garcia-Blanco, M. A., Aug 1 2011, In : Molecular Cancer Research. 9, 8, p. 997-1007 11 p.

Research output: Contribution to journalArticle

429 Scopus citations

Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6

Evsyukova, I., Bradrick, S. S., Gregory, S. G. & Garcia-Blanco, M. A., Jan 1 2013, In : RNA. 19, 1, p. 103-115 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

Comparative loss-of-function screens reveal ABCE1 as an essential cellular host factor for efficient translation of paramyxoviridae and pneumoviridae

Anderson, D. E., Pfeffermann, K., Kim, S. Y., Sawatsky, B., Pearson, J., Kovtun, M., Corcoran, D. L., Krebs, Y., Sigmundsson, K., Jamison, S. F., Yeo, Z. Z. J., Rennick, L. J., Wang, L. F., Talbot, P. J., Duprex, W. P., Garcia-Blanco, M. A. & von Messling, V., May 1 2019, In : mBio. 10, 3, e00826-19.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Dengue subgenomic flaviviral RNA disrupts immunity in mosquito salivary glands to increase virus transmission

Pompon, J., Manuel, M., Ng, G. K., Wong, B., Shan, C., Manokaran, G., Soto-Acosta, R., Bradrick, S. S., Ooi, E. E., Missé, D., Shi, P. Y. & Garcia-Blanco, M. A., Jul 2017, In : PLoS pathogens. 13, 7, e1006535.

Research output: Contribution to journalArticle

36 Scopus citations

Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness

Manokaran, G., Finol, E., Wang, C., Gunaratne, J., Bahl, J., Ong, E. Z., Tan, H. C., Sessions, O. M., Ward, A. M., Gubler, D. J., Harris, E., Garcia-Blanco, M. & Ooi, E. E., Oct 9 2015, In : Science. 350, 6257, p. 217-221 5 p.

Research output: Contribution to journalArticle

172 Scopus citations

Dengue virus selectively annexes endoplasmic reticulum-associated translation machinery as a strategy for co-opting host cell protein synthesis

Reid, D. W., Campos, R. K., Child, J. R., Zheng, T., Chan, K. W. K., Bradrick, S. S., Vasudevan, S. G., Garcia-Blanco, M. A. & Nicchitta, C. V., Apr 1 2018, In : Journal of virology. 92, 7, e01766-17.

Research output: Contribution to journalArticle

16 Scopus citations

Development of a method to isolate circulating tumor cells using mesenchymal-based capture

Bitting, R. L., Boominathan, R., Rao, C., Kemeny, G., Foulk, B., Garcia-Blanco, M. A., Connelly, M. & Armstrong, A. J., Dec 1 2013, In : Methods. 64, 2, p. 129-136 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Development of a novel c-MET-Based CTC detection platform

Zhang, T., Boominathan, R., Foulk, B., Rao, C., Kemeny, G., Strickler, J. H., Abbruzzese, J. L., Harrison, M. R., Hsu, D. S., Healy, P., Li, J., Pi, C., Prendergast, K. M., Hobbs, C., Gemberling, S., George, D. J., Hurwitz, H. I., Connelly, M., Garcia-Blanco, M. A. & Armstrong, A. J., Jun 2016, In : Molecular Cancer Research. 14, 6, p. 539-547 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Discovery of Widespread Host Protein Interactions with the Pre-replicated Genome of CHIKV Using VIR-CLASP

Kim, B., Arcos, S., Rothamel, K., Jian, J., Rose, K. L., McDonald, W. H., Bian, Y., Reasoner, S., Barrows, N. J., Bradrick, S., Garcia-Blanco, M. A. & Ascano, M., May 21 2020, In : Molecular cell. 78, 4, p. 624-640.e7

Research output: Contribution to journalArticle

2 Scopus citations

Distinct routes to metastasis: Plasticity-dependent and plasticity-independent pathways

Somarelli, J. A., Schaeffer, D., Marengo, M. S., Bepler, T., Rouse, D., Ware, K. E., Hish, A. J., Zhao, Y., Buckley, A. F., Epstein, J. I., Armstrong, A. J., Virshup, D. M. & Garcia-Blanco, M. A., Aug 18 2016, In : Oncogene. 35, 33, p. 4302-4311 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Dual roles for the ER membrane protein complex in flavivirus infection: viral entry and protein biogenesis

Barrows, N. J., Anglero-Rodriguez, Y., Kim, B., Jamison, S. F., Le Sommer, C., McGee, C. E., Pearson, J. L., Dimopoulos, G., Ascano, M., Bradrick, S. S. & Garcia-Blanco, M. A., Dec 1 2019, In : Scientific reports. 9, 1, 9711.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Epstein-barr virus induces global changes in cellular mRNA isoform usage that are important for the maintenance of latency

Homa, N. J., Salinas, R., Forte, E., Robinson, T. J., Garcia-Blanco, M. A. & Luftig, M. A., 2013, In : Journal of virology. 87, 22, p. 12291-12301 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Fluorescence-based alternative splicing reporters for the study of epithelial plasticity in vivo

Somarelli, J. A., Schaeffer, D., Bosma, R., Bonano, V. I., Sohn, J. W., Kemeny, G., Ettyreddy, A. & Garcia-Blanco, M. A., Jan 2013, In : RNA. 19, 1, p. 116-127 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Fragile X mental retardation protein is a zika virus restriction factor that is antagonized by subgenomic flaviviral RNA

Soto-Acosta, R., Xie, X., Shan, C., Baker, C. K., Shi, P. Y., Rossi, S. L., Garcia-Blanco, M. A. & Bradrick, S., Dec 1 2018, In : eLife. 7, e39023.

Research output: Contribution to journalArticle

13 Scopus citations

Functional Genomics Approach for the Identification of Human Host Factors Supporting Dengue Viral Propagation

Barrows, N. J., Jamison, S. F., Bradrick, S. S., Le Sommer, C., Kim, S. Y., Pearson, J. & Garcia-Blanco, M. A., Jan 1 2014, In : Methods in Molecular Biology. 1138, p. 285-299 15 p.

Research output: Contribution to journalArticle

6 Scopus citations
127 Scopus citations

G Protein-Coupled Receptor Kinase 2 Promotes Flaviviridae Entry and Replication

Le Sommer, C., Barrows, N. J., Bradrick, S. S., Pearson, J. L. & Garcia-Blanco, M. A., Sep 2012, In : PLoS neglected tropical diseases. 6, 9, e1820.

Research output: Contribution to journalArticle

51 Scopus citations

Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk

Galarza-Muñoz, G., Briggs, F. B. S., Evsyukova, I., Schott-Lerner, G., Kennedy, E. M., Nyanhete, T., Wang, L., Bergamaschi, L., Widen, S. G., Tomaras, G. D., Ko, D. C., Bradrick, S. S., Barcellos, L. F., Gregory, S. G. & Garcia-Blanco, M. A., Mar 23 2017, In : Cell. 169, 1, p. 72-84.e13

Research output: Contribution to journalArticle

33 Scopus citations

Identification and characterization of host proteins bound to dengue virus 3' UTR reveal an antiviral role for quaking proteins

Liao, K. C., Chuo, V., Ng, W. C., Neo, S. P., Pompon, J., Gunaratne, J., Ooi, E. E. & Garcia-Blanco, M. A., Jun 2018, In : RNA. 24, 6, p. 803-814 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Identification of dengue RNA binding proteins using RNA chromatography and quantitative mass spectrometry

Ward, A. M., Gunaratne, J. & Garcia-Blanco, M. A., Jan 1 2014, In : Methods in Molecular Biology. 1138, p. 253-270 18 p.

Research output: Contribution to journalArticle

10 Scopus citations

Identification of proteins bound to dengue viral RNA In Vivo reveals new host proteins important for virus replication

Phillips, S. L., Soderblom, E. J., Bradrick, S. S. & Garcia-Blanco, M. A., Jan 5 2016, In : mBio. 7, 1, e01865-15.

Research output: Contribution to journalArticle

21 Scopus citations

Identification of Tat-SF1 cellular targets by exon array analysis reveals dual roles in transcription and splicing

Miller, H. B., Robinson, T. J., Gordân, R., Hartemink, A. J. & Garcia-Blanco, M. A., Apr 1 2011, In : RNA. 17, 4, p. 665-674 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Mesenchymal-epithelial transition in sarcomas is controlled by the combinatorial expression of microRNA 200s and GRHL2

Somarelli, J. A., Shetler, S., Jolly, M. K., Wang, X., Bartholf Dewitt, S., Hish, A. J., Gilja, S., Eward, W. C., Ware, K. E., Levine, H., Armstrong, A. J. & Garcia-Blanco, M. A., Jan 1 2016, In : Molecular and cellular biology. 36, 19, p. 2503-2513 11 p.

Research output: Contribution to journalArticle

31 Scopus citations

N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection

Gokhale, N. S., McIntyre, A. B. R., McFadden, M. J., Roder, A. E., Kennedy, E. M., Gandara, J. A., Hopcraft, S. E., Quicke, K. M., Vazquez, C., Willer, J., Ilkayeva, O. R., Law, B. A., Holley, C. L., Garcia-Blanco, M. A., Evans, M. J., Suthar, M. S., Bradrick, S. S., Mason, C. E. & Horner, S. M., Nov 9 2016, In : Cell Host and Microbe. 20, 5, p. 654-665 12 p.

Research output: Contribution to journalArticle

139 Scopus citations

Provider-patient communication about Zika during prenatal visits

Guo, F., Norton, A. R., Fuchs, E. L., Hirth, J. M., Garcia-Blanco, M. A. & Berenson, A. B., Sep 2017, In : Preventive Medicine Reports. 7, p. 26-29 4 p.

Research output: Contribution to journalArticle

11 Scopus citations

Quantitative mass spectrometry of DENV-2 RNA-interacting proteins reveals that the DEAD-box RNA helicase DDX6 binds the DB1 and DB2 3′ UTR structures

Ward, A. M., Bidet, K., Yinglin, A., Ler, S. G., Hogue, K., Blackstock, W., Gunaratne, J. & Garcia-Blanco, M. A., Jan 1 2011, In : RNA Biology. 8, 6

Research output: Contribution to journalArticle

110 Scopus citations

Replication of many human viruses is refractory to inhibition by endogenous cellular MicroRNAs

Bogerd, H. P., Skalsky, R. L., Kennedy, E. M., Furuse, Y., Whisnant, A. W., Flores, O., Schultz, K. L. W., Putnam, N., Barrows, N. J., Sherry, B., Scholle, F., Garcia-Blanco, M. A., Griffin, D. E. & Cullen, B. R., Jul 2014, In : Journal of virology. 88, 14, p. 8065-8076 12 p.

Research output: Contribution to journalArticle

102 Scopus citations

RNA-based methods in virology

Bradrick, S. & Garcia-Blanco, M., 2015, In : Methods. 91, p. 1-2 2 p.

Research output: Contribution to journalArticle

Role of RNA-binding proteins during the late stages of Flavivirus replication cycle

Diosa-Toro, M., Prasanth, K. R., Bradrick, S. S. & Garcia Blanco, M. A., Apr 25 2020, In : Virology journal. 17, 1, 60.

Research output: Contribution to journalArticle

Open Access

RPLP1 and RPLP2 are essential flavivirus host factors that promote early viral protein accumulation

Campos, R. K., Wong, B., Xie, X., Lu, Y. F., Shi, P. Y., Pompon, J., Garcia-Blanco, M. A. & Bradrick, S. S., 2017, In : Journal of virology. 91, 4, e01706-16.

Research output: Contribution to journalArticle

25 Scopus citations

Snail promotes resistance to enzalutamide through regulation of androgen receptor activity in prostate cancer

Ware, K. E., Somarelli, J. A., Schaeffer, D., Li, J., Zhang, T., Park, S., Patierno, S. R., Freedman, J., Foo, W. C., Garcia-Blanco, M. A. & Armstrong, A. J., 2016, In : Oncotarget. 7, 31, p. 50525-50539 15 p.

Research output: Contribution to journalArticle

17 Scopus citations

SplicerEX: A tool for the automated detection and classification of mRNA changes from conventional and splice-sensitive microarray expression data

Robinson, T. J., Forte, E., Salinas, R. E., Puri, S., Marengo, M., Garcia-Blanco, M. A. & Luftig, M. A., Aug 1 2012, In : RNA. 18, 8, p. 1435-1445 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Staufen1 interacts with multiple components of the ebola virus ribonucleoprotein and enhances viral RNA synthesis

Fang, J., Pietzsch, C., Ramanathan, P., Santos, R. I., Ilinykh, P. A., Garcia-Blanco, M. A., Bukreyev, A. & Bradrick, S. S., Sep 1 2018, In : mBio. 9, 5, e01771-18.

Research output: Contribution to journalArticle

4 Scopus citations

The Golgi associated ERI3 is a Flavivirus host factor

Ward, A. M., Calvert, M. E. K., Read, L. R., Kang, S., Levitt, B. E., Dimopoulos, G., Bradrick, S., Gunaratne, J. & Garcia-Blanco, M., Sep 29 2016, In : Scientific Reports. 6, 34379.

Research output: Contribution to journalArticle

17 Scopus citations

The kinase inhibitor sfv785 dislocates dengue virus envelope protein from the replication complex and blocks virus assembly

Anwar, A., Hosoya, T., Leong, K. M., Onogi, H., Okuno, Y., Hiramatsu, T., Koyama, H., Suzuki, M., Hagiwara, M. & Garcia-Blanco, M. A., 2011, In : PloS one. 6, 8, e23246.

Research output: Contribution to journalArticle

28 Scopus citations

The RNA binding protein Quaking represses host interferon response by downregulating MAVS

Liao, K. C., Chuo, V., Fagg, W. S., Bradrick, S., Pompon, J. & Garcia-Blanco, M. A., Mar 3 2020, In : RNA Biology. 17, 3, p. 366-380 15 p.

Research output: Contribution to journalArticle

The role of epithelial plasticity in prostate cancer dissemination and treatment resistance

Bitting, R. L., Schaeffer, D., Somarelli, J. A., Garcia-Blanco, M. A. & Armstrong, A. J., Sep 2014, In : Cancer and Metastasis Reviews. 33, 2-3, p. 441-468 28 p.

Research output: Contribution to journalArticle

40 Scopus citations

Topoisomerase III-β is required for efficient replication of positive-sense RNA viruses

Kambham, R., Hirano, M., Fagg, W. S., McAnarney, E. T., Shan, C., Xie, X., Hage, A., Pietzsch, C. A., Bukreyev, A., Rajsbaum Gorodezky, R., Shi, P. Y., Bedford, M. T., Bradrick, S., Menachery, V. & Garcia-Blanco, M., Oct 2020, In : Antiviral research. 182, 104874.

Research output: Contribution to journalArticle

Open Access

Transcription elongation regulator 1 (TCERG1) regulates competent RNA polymerase II-mediated elongation of HIV-1 transcription and facilitates efficient viral replication

Coiras, M., Montes, M., Montanuy, I., López-Huertas, M. R., Mateos, E., Le Sommer, C., Garcia-Blanco, M. A., Hernández-Munain, C., Alcamí, J. & Suñé, C., Oct 28 2013, In : Retrovirology. 10, 1, 124.

Research output: Contribution to journalArticle

9 Scopus citations

Using circulating tumor cells to inform on prostate cancer biology and clinical utility

Li, J., Gregory, S. G., Garcia-Blanco, M. & Armstrong, A. J., Jul 4 2015, In : Critical Reviews in Clinical Laboratory Sciences. 52, 4, p. 191-210 20 p.

Research output: Contribution to journalArticle

17 Scopus citations