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  • Michael Sheetz
Article

Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability

Santos, L. C., Blair, D. A., Kumari, S., Cammer, M., Iskratsch, T., Herbin, O., Alexandropoulos, K., Dustin, M. L. & Sheetz, M. P., Nov 1 2016, In : Immunology and Cell Biology. 94, 10, p. 981-993 13 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Analysis of the local organization and dynamics of cellular actin networks

Luo, W., Yu, C. H., Lieu, Z. Z., Allard, J., Mogilner, A., Sheetz, M. P. & Bershadsky, A. D., 2013, In : Journal of Cell Biology. 202, 7, p. 1057-1073 17 p.

Research output: Contribution to journalArticle

Open Access
62 Scopus citations

Bifunctional nanoarrays for probing the immune response at the single-molecule level

Cai, H., Depoil, D., Palma, M., Sheetz, M., Dustin, M. L. & Wind, S. J., Nov 1 2013, In : Journal of Vacuum Science and Technology B: Microelectronics and Nanometer Structures. 31, 6, 6F902.

Research output: Contribution to journalArticle

12 Scopus citations

Biophysics of substrate interaction: Influence on neural motility, differentiation, and repair

Moore, S. W. & Sheetz, M. P., Nov 2011, In : Developmental Neurobiology. 71, 11, p. 1090-1101 12 p.

Research output: Contribution to journalArticle

51 Scopus citations

Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions

Pandey, P., Hawkes, W., Hu, J., Megone, W. V., Gautrot, J., Anilkumar, N., Zhang, M., Hirvonen, L., Cox, S., Ehler, E., Hone, J., Sheetz, M. & Iskratsch, T., Feb 5 2018, In : Developmental cell. 44, 3, p. 326-336.e3

Research output: Contribution to journalArticle

Open Access
31 Scopus citations

Cell contractility arising from topography and shear flow determines human mesenchymal stem cell fate

Sonam, S., Sathe, S. R., Yim, E. K. F., Sheetz, M. & Lim, C. T., Feb 16 2016, In : Scientific reports. 6, 20415.

Research output: Contribution to journalArticle

Open Access
34 Scopus citations

Cell crawling mediates collective cell migration to close undamaged epithelial gaps

Anon, E., Serra-Picamal, X., Hersen, P., Gauthier, N. C., Sheetz, M. P., Trepat, X. & Ladoux, B., Jul 3 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 27, p. 10891-10896 6 p.

Research output: Contribution to journalArticle

Open Access
113 Scopus citations

Cell response to substrate rigidity is regulated by active and passive cytoskeletal stress

Doss, B. L., Pan, M., Gupta, M., Grenci, G., Mège, R. M., Lim, C. T., Sheetz, M. P., Voituriez, R. & Ladoux, B., Jun 9 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 23, p. 12817-12825 9 p.

Research output: Contribution to journalArticle

Cells test substrate rigidity by local contractions on submicrometer pillars

Ghassemi, S., Meacci, G., Liu, S., Gondarenko, A. A., Mathur, A., Roca-Cusachs, P., Sheetz, M. P. & Hone, J., Apr 3 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 14, p. 5328-5333 6 p.

Research output: Contribution to journalArticle

Open Access
126 Scopus citations

Controlled confinement of DNA at the nanoscale: nanofabrication and surface bio-functionalization.

Palma, M., Abramson, J. J., Gorodetsky, A. A., Nuckolls, C., Sheetz, M. P., Wind, S. J. & Hone, J., 2011, In : Methods in molecular biology (Clifton, N.J.). 749, p. 169-185 17 p.

Research output: Contribution to journalArticle

7 Scopus citations

Cooperative vinculin binding to talin mapped by time-resolved super resolution microscopy

Hu, X., Jing, C., Xu, X., Nakazawa, N., Cornish, V. W., Margadant, F. M. & Sheetz, M. P., Jul 13 2016, In : Nano Letters. 16, 7, p. 4062-4068 7 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Cyclic stretching of soft substrates induces spreading and growth

Cui, Y., Hameed, F. M., Yang, B., Lee, K., Pan, C. Q., Park, S. & Sheetz, M., Feb 23 2015, In : Nature communications. 6, 6333.

Research output: Contribution to journalArticle

Open Access
113 Scopus citations

Differential mechanical stability of filamin A rod segments

Chen, H., Zhu, X., Cong, P., Sheetz, M. P., Nakamura, F. & Yan, J., Sep 7 2011, In : Biophysical journal. 101, 5, p. 1231-1237 7 p.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations

DNA damage causes rapid accumulation of phosphoinositides for ATR signaling

Wang, Y. H., Hariharan, A., Bastianello, G., Toyama, Y., Shivashankar, G. V., Foiani, M. & Sheetz, M. P., Dec 1 2017, In : Nature communications. 8, 1, 2118.

Research output: Contribution to journalArticle

Open Access
24 Scopus citations
Open Access
128 Scopus citations

EGFR and HER2 activate rigidity sensing only on rigid matrices

Saxena, M., Liu, S., Yang, B., Hajal, C., Changede, R., Hu, J., Wolfenson, H., Hone, J. & Sheetz, M. P., Jul 1 2017, In : Nature Materials. 16, 7, p. 775-781 7 p.

Research output: Contribution to journalArticle

28 Scopus citations

Endoplasmic spreading requires coalescence of vimentin intermediate filaments at force-bearing adhesions

Lynch, C. D., Lazar, A. M., Iskratsch, T., Zhang, X. & Sheetz, M. P., Jan 1 2013, In : Molecular Biology of the Cell. 24, 1, p. 21-30 10 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

Extracellular Matrix Rigidity Modulates Human Cervical Smooth Muscle Contractility—New Insights into Premature Cervical Failure and Spontaneous Preterm Birth

Vink, J., Yu, V., Dahal, S., Lohner, J., Stern-Asher, C., Mourad, M., Davis, G., Xue, Z., Wang, S., Myers, K., Kitajewski, J., Chen, X., Wapner, R. J., Ananth, C. V., Sheetz, M. & Gallos, G., 2020, (Accepted/In press) In : Reproductive Sciences.

Research output: Contribution to journalArticle

F-actin waves, actin cortex disassembly and focal exocytosis driven by actin-phosphoinositide positive feedback

Masters, T. A., Sheetz, M. & Gauthier, N. C., Apr 1 2016, In : Cytoskeleton. 73, 4, p. 180-196 17 p.

Research output: Contribution to journalArticle

10 Scopus citations

FHOD1 is needed for directed forces and adhesion maturation during cell spreading and migration

Iskratsch, T., Yu, C. H., Mathur, A., Liu, S., Stévenin, V., Dwyer, J., Hone, J., Ehler, E. & Sheetz, M., Dec 9 2013, In : Developmental cell. 27, 5, p. 545-559 15 p.

Research output: Contribution to journalArticle

Open Access
61 Scopus citations

Filamin depletion blocks endoplasmic spreading and destabilizes force-bearing adhesions

Lynch, C. D., Gauthier, N. C., Biais, N., Lazar, A. M., Roca-Cusachs, P., Yu, C. H. & Sheetz, M., Apr 15 2011, In : Molecular Biology of the Cell. 22, 8, p. 1263-1273 11 p.

Research output: Contribution to journalArticle

43 Scopus citations

Following nature’s challenges

Sheetz, M. & Kenan, W. R., Jan 1 2012, In : Nature Medicine. 18, 10, p. 1483-1485 3 p.

Research output: Contribution to journalArticle

Force-Induced Calpain Cleavage of Talin Is Critical for Growth, Adhesion Development, and Rigidity Sensing

Saxena, M., Changede, R., Hone, J., Wolfenson, H. & Sheetz, M., Dec 13 2017, In : Nano Letters. 17, 12, p. 7242-7251 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Formin DAAM1 organizes actin filaments in the cytoplasmic nodal actin network

Luo, W., Lieu, Z. Z., Manser, E., Bershadsky, A. D. & Sheetz, M. P., Oct 2016, In : PloS one. 11, 10, e0163915.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Full control of ligand positioning reveals spatial thresholds for T cell receptor triggering

Cai, H., Muller, J., Depoil, D., Mayya, V., Sheetz, M. P., Dustin, M. L. & Wind, S. J., Jul 1 2018, In : Nature Nanotechnology. 13, 7, p. 610-617 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Heart extracellular matrix supports cardiomyocyte differentiation of mouse embryonic stem cells

Higuchi, S., Lin, Q., Wang, J., Lim, T. K., Joshi, S. B., Anand, G. S., Chung, M. C. M., Sheetz, M. P. & Fujita, H., Mar 2013, In : Journal of Bioscience and Bioengineering. 115, 3, p. 320-325 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

High-Throughput Mechanobiology Screening Platform Using Micro- and Nanotopography

Hu, J., Gondarenko, A. A., Dang, A. P., Bashour, K. T., O'Connor, R. S., Lee, S., Liapis, A., Ghassemi, S., Milone, M. C., Sheetz, M. P., Dustin, M. L., Kam, L. C. & Hone, J. C., Apr 13 2016, In : Nano Letters. 16, 4, p. 2198-2204 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Integrin and cadherin clusters: A robust way to organize adhesions for cell mechanics

Changede, R. & Sheetz, M., Jan 1 2017, In : BioEssays. 39, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

Open Access
36 Scopus citations

Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force

Yu, C. H., Rafiq, N. B. M., Cao, F., Zhou, Y., Krishnasamy, A., Biswas, K. H., Ravasio, A., Chen, Z., Wang, Y. H., Kawauchi, K., Jones, G. E. & Sheetz, M. P., Oct 28 2015, In : Nature communications. 6, 8672.

Research output: Contribution to journalArticle

Open Access
39 Scopus citations

Integrin-dependent force transmission to the extracellular matrix by α-actinin triggers adhesion maturation

Roca-Cusachs, P., Del Rio, A., Puklin-Faucher, E., Gauthier, N. C., Biais, N. & Sheetz, M. P., Apr 9 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 15, p. E1361-E1370

Research output: Contribution to journalArticle

Open Access
161 Scopus citations

Integrin-matrix clusters form podosome-like adhesions in the absence of traction forces

Yu, C. H., Rafiq, N. B. M., Krishnasamy, A., Hartman, K. L., Jones, G. E., Bershadsky, A. D. & Sheetz, M. P., Dec 12 2013, In : Cell Reports. 5, 5, p. 1456-1468 13 p.

Research output: Contribution to journalArticle

Open Access
89 Scopus citations

Integrin Mechano-chemical Signaling Generates Plasma Membrane Nanodomains that Promote Cell Spreading

Kalappurakkal, J. M., Anilkumar, A. A., Patra, C., van Zanten, T. S., Sheetz, M. P. & Mayor, S., Jun 13 2019, In : Cell. 177, 7, p. 1738-1756.e23

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Integrin nanoclusters can bridge thin matrix fibres to form cell–matrix adhesions

Changede, R., Cai, H., Wind, S. J. & Sheetz, M. P., Dec 1 2019, In : Nature Materials. 18, 12, p. 1366-1375 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Large and reversible myosin-dependent forces in rigidity sensing

Lohner, J., Rupprecht, J. F., Hu, J., Mandriota, N., Saxena, M., de Araujo, D. P., Hone, J., Sahin, O., Prost, J. & Sheetz, M., Jul 1 2019, In : Nature Physics. 15, 7, p. 689-695 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Matrix mechanics controls FHL2 movement to the nucleus to activate p21 expression

Nakazawa, N., Sathe, A. R., Shivashankar, G. V. & Sheetz, M. P., Nov 1 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 44, p. E6813-E6822

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

MDia1 senses both force and torque during F-actin filament polymerization

Yu, M., Yuan, X., Lu, C., Le, S., Kawamura, R., Efremov, A. K., Zhao, Z., Kozlov, M. M., Sheetz, M., Bershadsky, A. & Yan, J., Dec 1 2017, In : Nature communications. 8, 1, 1650.

Research output: Contribution to journalArticle

Open Access
32 Scopus citations

Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation

Yao, M., Goult, B. T., Chen, H., Cong, P., Sheetz, M. P. & Yan, J., Apr 9 2014, In : Scientific reports. 4, 4610.

Research output: Contribution to journalArticle

Open Access
151 Scopus citations

Mechanical confinement triggers glioma linear migration dependent on formin FHOD3

Monzo, P., Chong, Y. K., Guetta-Terrier, C., Krishnasamy, A., Sathe, S. R., Yim, E. K. F., Ng, W. H., Ang, B. T., Tang, C., Ladoux, B., Gauthier, N. C. & Sheetz, M., Apr 15 2016, In : Molecular Biology of the Cell. 27, 8, p. 1246-1261 16 p.

Research output: Contribution to journalArticle

23 Scopus citations

Mechanical perturbation of filamin A immunoglobulin repeats 20-21 reveals potential non-equilibrium mechanochemical partner binding function

Chen, H., Chandrasekar, S., Sheetz, M. P., Stossel, T. P., Nakamura, F. & Yan, J., Apr 10 2013, In : Scientific reports. 3, 1642.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations

Mechanosensing Controlled Directly by Tyrosine Kinases

Yang, B., Lieu, Z. Z., Wolfenson, H., Hameed, F. M., Bershadsky, A. D. & Sheetz, M. P., Sep 14 2016, In : Nano Letters. 16, 9, p. 5951-5961 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Mechanotransduction in vivo by repeated talin stretch-relaxation events depends upon vinculin

Margadant, F., Chew, L. L., Hu, X., Yu, H., Bate, N., Zhang, X. & Sheetz, M., Dec 2011, In : PLoS Biology. 9, 12, e1001223.

Research output: Contribution to journalArticle

Open Access
129 Scopus citations

Mechanotransmission and Mechanosensing of Human alpha-Actinin 1

Le, S., Hu, X., Yao, M., Chen, H., Yu, M., Xu, X., Nakazawa, N., Margadant, F. M., Sheetz, M. & Yan, J., Dec 5 2017, In : Cell Reports. 21, 10, p. 2714-2723 10 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Microarray with micro- and nano-topographies enables identification of the optimal topography for directing the differentiation of primary murine neural progenitor cells

Moe, A. A. K., Suryana, M., Marcy, G., Lim, S. K., Ankam, S., Goh, J. Z. W., Jin, J., Teo, B. K. K., Law, J. B. K., Low, H. Y., Goh, E. L. K., Sheetz, M. & Yim, E. K. F., Oct 8 2012, In : Small. 8, 19, p. 3050-3061 12 p.

Research output: Contribution to journalArticle

77 Scopus citations

Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells

Tabdanov, E., Gondarenko, S., Kumari, S., Liapis, A., Dustin, M. L., Sheetz, M. P., Kam, L. C. & Iskratsch, T., Oct 1 2015, In : Integrative Biology (United Kingdom). 7, 10, p. 1272-1284 13 p.

Research output: Contribution to journalArticle

Open Access
36 Scopus citations

Micro-stepping extended focus reduces photobleaching and preserves structured illumination super-resolution features

Hu, X., Jalal, S., Sheetz, M., Bakke, O. & Margadant, F., May 2020, In : Journal of Cell Science. 133, 10, 240796.

Research output: Contribution to journalArticle

Open Access

Molecular Occupancy of Nanodot Arrays

Cai, H., Wolfenson, H., Depoil, D., Dustin, M. L., Sheetz, M. P. & Wind, S. J., Apr 26 2016, In : ACS Nano. 10, 4, p. 4173-4183 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Myosin 1E localizes to actin polymerization sites in lamellipodia, affecting actin dynamics and adhesion formation

Gupta, P., Gauthier, N. C., Cheng-Han, Y., Zuanning, Y., Pontes, B., Ohmstede, M., Martin, R., Knölker, H. J., Döbereiner, H. G., Krendel, M. & Sheetz, M., 2013, In : Biology Open. 2, 12, p. 1-12 12 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion

Alieva, N. O., Efremov, A. K., Hu, S., Oh, D., Chen, Z., Natarajan, M., Ong, H. T., Jégou, A., Romet-Lemonne, G., Groves, J. T., Sheetz, M. P., Yan, J. & Bershadsky, A. D., Dec 1 2019, In : Nature communications. 10, 1, 3593.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Nanolithographic control of the spatial organization of cellular adhesion receptors at the single-molecule level

Schvartzman, M., Palma, M., Sable, J., Abramson, J., Hu, X., Sheetz, M. & Wind, S. J., Mar 9 2011, In : Nano Letters. 11, 3, p. 1306-1312 7 p.

Research output: Contribution to journalArticle

149 Scopus citations

Nascent Integrin Adhesions Form on All Matrix Rigidities after Integrin Activation

Changede, R., Xu, X., Margadant, F. & Sheetz, M., Jan 1 2015, In : Developmental Cell. 35, 5, p. 614-621 8 p.

Research output: Contribution to journalArticle

Open Access
52 Scopus citations