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• Article

  Activity and the metabolic activation pathway of the potent and selective hepatitis C virus pronucleotide inhibitor PSI-353661

  Furman, P. A., Murakami, E., Niu, C., Lam, A. M., Espiritu, C., Bansal, S., Bao, H., Tolstykh, T., Micolochick Steuer, H., Keilman, M., Zennou, V., Bourne, N., Veselenak, R. L., Chang, W., Ross, B. S., Du, J., Otto, M. J. & Sofia, M. J., Aug 2011, In: Antiviral research. 91, 2, p. 120-132 13 p.

  Research output: Contribution to journal › Article › peer-review

  • 2-((5-(2-amino-6-methoxypurin-9-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy)phenoxyphosphorylamino)propionic acid isopropyl ester
  • Replicon
  • Metabolic Activation
  • Metabolic Networks and Pathways
  • Hepacivirus
  36 Scopus citations

• An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses

  Li, G., Adam, A., Luo, H., Shan, C., Cao, Z., Fontes-Garfias, C. R., Sarathy, V. V., Teleki, C., Winkelmann, E. R., Liang, Y., Sun, J., Bourne, N., Barrett, A. D. T., Shi, P. Y. & Wang, T., Dec 1 2019, In: npj Vaccines. 4, 1, 48.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zika Virus
  • Mutant Proteins
  • Antiviral Agents
  • Attenuated Vaccines
  • Flavivirus
  4 Scopus citations

• An Infectious cDNA Clone of Zika Virus to Study Viral Virulence, Mosquito Transmission, and Antiviral Inhibitors

  Shan, C., Xie, X., Muruato, A. E., Rossi, S. L., Roundy, C. M., Azar, S. R., Yang, Y., Tesh, R. B., Bourne, N., Barrett, A. D., Vasilakis, N., Weaver, S. C. & Shi, P. Y., Jun 8 2016, In: Cell Host and Microbe. 19, 6, p. 891-900 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Culicidae
  • Virulence
  • Antiviral Agents
  • Complementary DNA
  162 Scopus citations

• Attenuation of zika virus by passage in human HeLa cells

  Li, L., Collins, N. D., Widen, S. G., Davis, E. H., Kaiser, J. A., White, M. M., Greenberg, M. B., Barrett, A. D. T., Bourne, N. & Sarathy, V. V., Sep 2019, In: Vaccines. 7, 3, 93.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zika Virus
  • HeLa Cells
  • Flavivirus
  • Culicidae
  • Viremia
  4 Scopus citations

• A Vaxfectin^®-adjuvanted HSV-2 plasmid DNA vaccine is effective for prophylactic and therapeutic use in the guinea pig model of genital herpes

  Veselenak, R. L., Shlapobersky, M., Pyles, R. B., Wei, Q., Sullivan, S. M. & Bourne, N., Nov 19 2012, In: Vaccine. 30, 49, p. 7046-7051 6 p.

  Research output: Contribution to journal › Article › peer-review

  • vaxfectin
  • Herpes Genitalis
  • recombinant vaccines
  • DNA Vaccines
  • genitalia
  39 Scopus citations

• Bioluminescence methodology for the detection of protein-protein interactions within the voltage-gated sodium channel macromolecular complex

  Shavkunov, A., Panova, N., Prasai, A., Veselenak, R., Bourne, N., Stoilova-McPhie, S. & Laezza, F., Apr 1 2012, In: Assay and Drug Development Technologies. 10, 2, p. 148-160 13 p.

  Research output: Contribution to journal › Article › peer-review

  • fibroblast growth factor 14
  • Macromolecular Substances
  • Voltage-Gated Sodium Channels
  • Tail
  • Ion Channels
  31 Scopus citations

• Cultivated human vaginal microbiome communities impact zika and herpes simplex virus replication in ex vivovaginal mucosal cultures

  Amerson-Brown, M. H., Miller, A. L., Maxwell, C. A., White, M. M., Vincent, K. L., Bourne, N. & Pyles, R. B., 2019, In: Frontiers in Microbiology. 10, JAN, 3340.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Simplexvirus
  • Microbiota
  • Virus Replication
  • Zika Virus
  • Epithelial Cells
  3 Scopus citations

• Detection of herpes simplex virus type 2 (HSV-2) -specific cell-mediated immune responses in guinea pigs during latent HSV-2 genital infection

  Perry, C. L., Banasik, B. N., Gorder, S. R., Xia, J., Auclair, S., Bourne, N. & Milligan, G. N., Dec 1 2016, In: Journal of Immunological Methods. 439, p. 1-7 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Herpes Genitalis
  • Guinea Pigs
  • Virus Latency
  • Infection
  • Enzyme-Linked Immunospot Assay
  2 Scopus citations

• Development of an anti-guinea pig CD4 monoclonal antibody for depletion of CD4+ T cells in vivo

  Banasik, B. N., Perry, C. L., Keith, C. A., Bourne, N., Schäfer, H. & Milligan, G. N., Nov 2019, In: Journal of Immunological Methods. 474, 112654.

  Research output: Contribution to journal › Article › peer-review

  • Guinea Pigs
  • Monoclonal Antibodies
  • T-Lymphocytes
  • Active Immunotherapy
  • Investigational Therapies

• Development of disease and immunity at the genital epithelium following intrarectal inoculation of male guinea pigs with herpes simplex virus type 2

  Bourne, N., Banasik, B. N., Perry, C. L., Miller, A. L., White, M., Pyles, R. B. & Milligan, G. N., Jan 2 2019, In: Virology. 526, p. 180-188 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Genitalia
  • Virus Shedding
  • Foreskin
  • Guinea Pigs
  • Perineum
  2 Scopus citations

• Enhancing the utility of a prM/E-expressing chimeric vaccine for Japanese encephalitis by addition of the JEV NS1 gene

  Ishikawa, T., Wang, G., Widman, D. G., Infante, E., Winkelmann, E. R., Bourne, N. & Mason, P. W., Oct 6 2011, In: Vaccine. 29, 43, p. 7444-7455 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Japanese Encephalitis Vaccines
  • Japanese Encephalitis
  • encephalitis
  • vaccines
  • West Nile virus
  15 Scopus citations

• Image-based noninvasive evaluation of colorectal mucosal injury in sheep after topical application of microbicides

  Vincent, K. L., Vargas, G., Bourne, N., Galvan-Turner, V., Saada, J. I., Lee, G. H., Sbrana, E. & Motamedi, M., Nov 2013, In: Sexually Transmitted Diseases. 40, 11, p. 854-859 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Local Anti-Infective Agents
  • Optical Coherence Tomography
  • Sheep
  • Benzalkonium Compounds
  • Colonoscopy
  5 Scopus citations

• Increased frequency of virus shedding by herpes simplex virus 2-infected Guinea pigs in the absence of CD4 T lymphocytes

  Bourne, N., Perry, C. L., Banasik, B. N., Miller, A. L., White, M., Pyles, R. B., Schäfer, H. & Milligan, G. N., Feb 1 2019, In: Journal of virology. 93, 4, e0172118.

  Research output: Contribution to journal › Article › peer-review

  • Human herpesvirus 2
  • viral shedding
  • Virus Shedding
  • T-lymphocytes
  • Guinea Pigs
  6 Scopus citations

• Influence of methamphetamine on genital herpes simplex virus type 2 infection in a mouse model

  Valencia, F., Bubar, M. J., Milligan, G., Cunningham, K. A. & Bourne, N., Sep 2012, In: Sexually Transmitted Diseases. 39, 9, p. 720-725 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Herpes Genitalis
  • Methamphetamine
  • Herpes Simplex
  • Cytokines
  • Sexually Transmitted Diseases
  10 Scopus citations

• Inhibition of hepatitis C virus replicon RNA synthesis by PSI-352938, a cyclic phosphate prodrug of β-D-2′-deoxy-2′-α-fluoro- 2′-β-C-methylguanosine

  Lam, A. M., Espiritu, C., Murakami, E., Zennou, V., Bansal, S., Micolochick Steuer, H. M., Niu, C., Keilman, M., Bao, H., Bourne, N., Veselenak, R. L., Reddy, P. G., Chang, W., Du, J., Nagarathnam, D., Sofia, M. J., Otto, M. J. & Furman, P. A., Jun 2011, In: Antimicrobial agents and chemotherapy. 55, 6, p. 2566-2575 10 p.

  Research output: Contribution to journal › Article › peer-review

  • PSI 352938
  • 8-methylguanosine
  • Replicon
  • Prodrugs
  • Hepacivirus
  28 Scopus citations

• Intrinsic adjuvanting of a novel single-cycle flavivirus vaccine in the absence of type I interferon receptor signaling

  Winkelmann, E. R., Widman, D. G., Xia, J., Ishikawa, T., Miller-Kittrell, M., Nelson, M. H., Bourne, N., Scholle, F., Mason, P. W. & Milligan, G. N., Feb 14 2012, In: Vaccine. 30, 8, p. 1465-1475 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Interferon alpha-beta Receptor
  • Flavivirus
  • interferons
  • vaccines
  • Vaccines
  10 Scopus citations

• In vivo rectal mucosal barrier function imaging in a large-animal model by using confocal endomicroscopy: Implications for injury assessment and use in HIV prevention studies

  Vargas, G., Vincent, K. L., Zhu, Y., Szafron, D., Brown, T. C., Villarreal, P. P., Bourne, N., Milligan, G. N. & Motamedib, M., Aug 2016, In: Antimicrobial agents and chemotherapy. 60, 8, p. 4600-4609 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Animal Models
  • HIV
  • Wounds and Injuries
  • Mucous Membrane
  • Benzalkonium Compounds
  1 Scopus citations

• Monitoring vaginal epithelial thickness changes noninvasively in sheep using optical coherence tomography

  Vincent, K. L., Vargas, G., Wei, J., Bourne, N. & Motamedi, M., Apr 2013, In: American journal of obstetrics and gynecology. 208, 4, p. 282.e1-282.e7

  Research output: Contribution to journal › Article › peer-review

  • Nonoxynol
  • Optical Coherence Tomography
  • Sheep
  • Placebos
  • Histology
  11 Scopus citations

• Optical coherence tomography for assessment of microbicide safety in a small animal model

  Bell, B. A., Vincent, K. L., Bourne, N., Vargas, G. & Motamedi, M., Apr 2013, In: Journal of Biomedical Optics. 18, 4, 046010.

  Research output: Contribution to journal › Article › peer-review

  • Optical tomography
  • animal models
  • Anti-Infective Agents
  • Animals
  • safety
  4 Scopus citations

• Quantitative assessment of microbicide-induced injury in the ovine vaginal epithelium using confocal microendoscopy

  Vargas, G., Patrikeev, I., Wei, J., Bell, B., Vincent, K., Bourne, N. & Motamedi, M., Feb 29 2012, In: BMC Infectious Diseases. 12, 48.

  Research output: Contribution to journal › Article › peer-review

  • Benzalkonium Compounds
  • Anti-Infective Agents
  • Sheep
  • Epithelium
  • Wounds and Injuries
  7 Scopus citations

• The fibroblast growth factor 14·voltage-gated sodium channel complex is a new target of glycogen synthase kinase 3 (GSK3)

  Shavkunov, A. S., Wildburger, N. C., Nenov, M. N., James, T. F., Buzhdygan, T. P., Panova-Elektronova, N. I., Green, T. A., Veselenak, R. L., Bourne, N. & Laezza, F., Jul 5 2013, In: Journal of Biological Chemistry. 288, 27, p. 19370-19385 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Glycogen Synthase Kinase 3
  • Fibroblast Growth Factors
  • Sodium Channels
  • Proteins
  • Electrophysiology
  60 Scopus citations

• Topical injury evaluation of the murine colorectal mucosa using confocal endomicrosopy: a valuable method for assessing mucosal injuries associated with risk of pathogen transmission

  Vargas, G., Vincent, K. L., Wei, J., Bourne, N. & Motamedi, M., Nov 1 2016, In: Journal of Microscopy. 264, 2, p. 227-237 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Infectious Disease Transmission
  • Mucous Membrane
  • Benzalkonium Compounds
  • Wounds and Injuries
  • Histology
  1 Scopus citations
• Chapter

  In vivo evaluation of antiviral efficacy against genital herpes using mouse and guinea pig models

  Valencia, F., Veselenak, R. L. & Bourne, N., Jul 18 2013, Antiviral Methods and Protocols. p. 315-326 12 p. (Methods in Molecular Biology; vol. 1030).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Herpes Genitalis
  • Virus Shedding
  • Guinea Pigs
  • Antiviral Agents
  • Genitalia
  12 Scopus citations